YGR267C / FOL2

GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR267C / FOL2

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.79|P-value:2.83E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.12|P-value:4.53E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.07|P-value:5.93E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:2.95|P-value:8.93E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.31|P-value:2.18E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.11|P-value:4.80E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.94|P-value:1.51E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.14|P-value:4.47E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.60|P-value:6.99E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.01|P-value:7.19E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.14|P-value:4.45E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.09|P-value:5.52E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.58|P-value:7.69E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-4.58|P-value:5.76E-7 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.81|P-value:2.83E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.24|P-value:3.10E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:7.27|P-value:6.67E-15 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.78|P-value:3.42E-13 ID:SGTC_1793|Compound:st048256|FD-Score:3.38|P-value:1.75E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.40|P-value:1.59E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-2.97|P-value:7.99E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.71|P-value:4.26E-5 ID:SGTC_2046|Compound:4110841|FD-Score:4.15|P-value:5.56E-6 ID:SGTC_2123|Compound:5259487|FD-Score:4.01|P-value:1.08E-5 ID:SGTC_2156|Compound:5649887|FD-Score:-3.02|P-value:6.63E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-2.97|P-value:7.92E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.26|P-value:2.66E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.37|P-value:1.85E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.13|P-value:4.63E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.07|P-value:5.90E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.13|P-value:4.68E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:2.98|P-value:8.07E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:9.38|P-value:1.41E-23 ID:SGTC_2619|Compound:obliquin|FD-Score:3.01|P-value:7.32E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.05|P-value:6.30E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-2.98|P-value:7.77E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:5.45|P-value:4.07E-9 ID:SGTC_2727|Compound:riluzole|FD-Score:-2.94|P-value:8.99E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:5.21|P-value:1.74E-8 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.50|P-value:1.07E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-4.71|P-value:2.81E-7 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:46.00|P-value:0 ID:SGTC_2836|Compound:9010338|FD-Score:2.93|P-value:9.82E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.82|P-value:2.67E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.21|P-value:3.37E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.19|P-value:3.45E-4 ID:SGTC_3180|Compound:9109287|FD-Score:-3.52|P-value:9.44E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.62|P-value:6.44E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.79|P-value:2.83E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.12|P-value:4.53E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.07|P-value:5.93E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:2.95|P-value:8.93E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.31|P-value:2.18E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.11|P-value:4.80E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.94|P-value:1.51E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.14|P-value:4.47E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.60|P-value:6.99E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.01|P-value:7.19E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.14|P-value:4.45E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.09|P-value:5.52E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.58|P-value:7.69E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-4.58|P-value:5.76E-7 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.81|P-value:2.83E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.24|P-value:3.10E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:7.27|P-value:6.67E-15 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.78|P-value:3.42E-13 ID:SGTC_1793|Compound:st048256|FD-Score:3.38|P-value:1.75E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.40|P-value:1.59E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-2.97|P-value:7.99E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.71|P-value:4.26E-5 ID:SGTC_2046|Compound:4110841|FD-Score:4.15|P-value:5.56E-6 ID:SGTC_2123|Compound:5259487|FD-Score:4.01|P-value:1.08E-5 ID:SGTC_2156|Compound:5649887|FD-Score:-3.02|P-value:6.63E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-2.97|P-value:7.92E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.26|P-value:2.66E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.37|P-value:1.85E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.13|P-value:4.63E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.07|P-value:5.90E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.13|P-value:4.68E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:2.98|P-value:8.07E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:9.38|P-value:1.41E-23 ID:SGTC_2619|Compound:obliquin|FD-Score:3.01|P-value:7.32E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.05|P-value:6.30E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-2.98|P-value:7.77E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:5.45|P-value:4.07E-9 ID:SGTC_2727|Compound:riluzole|FD-Score:-2.94|P-value:8.99E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:5.21|P-value:1.74E-8 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.50|P-value:1.07E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-4.71|P-value:2.81E-7 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:46.00|P-value:0 ID:SGTC_2836|Compound:9010338|FD-Score:2.93|P-value:9.82E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.82|P-value:2.67E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.21|P-value:3.37E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.19|P-value:3.45E-4 ID:SGTC_3180|Compound:9109287|FD-Score:-3.52|P-value:9.44E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.62|P-value:6.44E-5

Top fitness defect scores for YGR267C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2779 methotrexate 46.00 400.0 µM 0 1 0 30.10
2 SGTC_2617 dihydrotanshinone i 9.38 20.8 µM 1.41E-23 copper-dependent oxidative stress 3 3.15E-21 0.61
3 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 7.27 67.5 µM 6.67E-15 3 1.74E-13 1.92
4 SGTC_1788 fluconazole 6.78 20.0 µM 3.42E-13 azole & statin 2 5.84E-12 0.18
5 SGTC_2718 lomofungin 5.45 53.0 µM 4.07E-9 mitochondrial processes 3 2.56E-8 1.07
6 SGTC_2761 levamisole 5.21 97.9 µM 1.74E-8 1 9.39E-8 0.61
7 SGTC_2046 4110841 4.15 106.0 µM 5.56E-6 iron homeostasis 9 1.64E-5 0.21
8 SGTC_2123 5259487 4.01 200.0 µM 1.08E-5 1 2.98E-5 0.26
9 SGTC_556 4058-0063 3.94 51.5 µM 1.51E-5 5 4.01E-5 0.35
10 SGTC_2844 9010103 3.82 26.0 µM 2.67E-5 10 6.70E-5 0.30
11 SGTC_1589 2',5'-dimethoxyflavone 3.81 47.2 µM 2.83E-5 6 7.04E-5 0.08
12 SGTC_1961 st076550 3.71 68.7 µM 4.26E-5 10 1.02E-4 0.16
13 SGTC_3189 9110682 3.62 49.5 µM 6.44E-5 11 1.48E-4 0.20
14 SGTC_969 1313-0238 3.60 134.0 µM 6.99E-5 mitochondrial processes 25 1.59E-4 0.08
15 SGTC_1395 3486-0190 3.58 4.3 µM 7.69E-5 4 1.73E-4 0.17
16 SGTC_2766 oltipraz 3.50 83.9 µM 1.07E-4 heme requiring 28 2.33E-4 0.35
17 SGTC_1861 st057647 3.40 17.4 µM 1.59E-4 10 3.33E-4 0.05
18 SGTC_1793 st048256 3.38 72.2 µM 1.75E-4 7 3.61E-4 0.22
19 SGTC_2336 9001819 3.37 198.7 µM 1.85E-4 heme biosynthesis & mitochondrial translocase 47 3.80E-4 0.01
20 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.24 54.9 µM 3.10E-4 redox potentiating 13 6.05E-4 0.26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.506 5.47E-218 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.502 7.71E-214 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.255 3.99E-51 YIR039C YPS6 hom Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance
0.233 1.07E-42 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
0.226 3.10E-40 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.226 4.02E-40 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.223 5.23E-39 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.214 6.29E-36 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.182 2.51E-26 YNL256W FOL1 het Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
0.171 2.26E-23 YBR252W DUT1 het deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
0.164 1.33E-21 YGL047W ALG13 het Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress
0.164 1.56E-21 YGL124C MON1 hom Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
0.157 5.19E-20 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.157 6.78E-20 YDL030W PRP9 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
0.152 6.61E-19 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1