YGR268C / HUA1

Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR268C / HUA1

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.64|P-value:3.39E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.57|P-value:4.22E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.30|P-value:2.98E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.29|P-value:3.02E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.42|P-value:7.09E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.97|P-value:1.68E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:4.22|P-value:3.96E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.45|P-value:6.41E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.48|P-value:1.41E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.32|P-value:9.69E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.32|P-value:9.57E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:5.55|P-value:1.04E-7 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.35|P-value:8.64E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.88|P-value:1.42E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.74|P-value:2.37E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.82|P-value:3.33E-6 ID:SGTC_1619|Compound:st003326|FD-Score:4.34|P-value:2.46E-5 ID:SGTC_1625|Compound:st003711|FD-Score:-4.60|P-value:8.18E-6 ID:SGTC_1866|Compound:st057638|FD-Score:-3.35|P-value:8.47E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.38|P-value:2.13E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.76|P-value:2.18E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-3.80|P-value:1.89E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.93|P-value:1.21E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.74|P-value:2.36E-4 ID:SGTC_2226|Compound:7298446|FD-Score:5.67|P-value:5.80E-8 ID:SGTC_2253|Compound:7938677|FD-Score:3.73|P-value:2.50E-4 ID:SGTC_2337|Compound:9009472|FD-Score:6.24|P-value:2.65E-9 ID:SGTC_2481|Compound:5478948|FD-Score:3.90|P-value:1.34E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.61|P-value:3.58E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.43|P-value:6.68E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.70|P-value:2.72E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.57|P-value:4.12E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-4.42|P-value:1.76E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.12|P-value:5.82E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.86|P-value:1.53E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:5.10|P-value:9.42E-7 ID:SGTC_2792|Compound:7535235|FD-Score:-3.56|P-value:4.28E-4 ID:SGTC_2801|Compound:7907800|FD-Score:4.11|P-value:6.16E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.92|P-value:1.24E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.41|P-value:7.24E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.40|P-value:7.33E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.76|P-value:2.18E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.87|P-value:1.50E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.93|P-value:2.05E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.69|P-value:2.82E-4 ID:SGTC_3199|Compound:9111318|FD-Score:5.91|P-value:1.66E-8 ID:SGTC_3208|Compound:9114115|FD-Score:-4.65|P-value:6.84E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-3.72|P-value:2.46E-4 ID:SGTC_3340|Compound:9146634|FD-Score:4.03|P-value:8.25E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.64|P-value:3.39E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.57|P-value:4.22E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.30|P-value:2.98E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.29|P-value:3.02E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.42|P-value:7.09E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.97|P-value:1.68E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:4.22|P-value:3.96E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.45|P-value:6.41E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.48|P-value:1.41E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.32|P-value:9.69E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.32|P-value:9.57E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:5.55|P-value:1.04E-7 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.35|P-value:8.64E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.88|P-value:1.42E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.74|P-value:2.37E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.82|P-value:3.33E-6 ID:SGTC_1619|Compound:st003326|FD-Score:4.34|P-value:2.46E-5 ID:SGTC_1625|Compound:st003711|FD-Score:-4.60|P-value:8.18E-6 ID:SGTC_1866|Compound:st057638|FD-Score:-3.35|P-value:8.47E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.38|P-value:2.13E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.76|P-value:2.18E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-3.80|P-value:1.89E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.93|P-value:1.21E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.74|P-value:2.36E-4 ID:SGTC_2226|Compound:7298446|FD-Score:5.67|P-value:5.80E-8 ID:SGTC_2253|Compound:7938677|FD-Score:3.73|P-value:2.50E-4 ID:SGTC_2337|Compound:9009472|FD-Score:6.24|P-value:2.65E-9 ID:SGTC_2481|Compound:5478948|FD-Score:3.90|P-value:1.34E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.61|P-value:3.58E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.43|P-value:6.68E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.70|P-value:2.72E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.57|P-value:4.12E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-4.42|P-value:1.76E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.12|P-value:5.82E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.86|P-value:1.53E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:5.10|P-value:9.42E-7 ID:SGTC_2792|Compound:7535235|FD-Score:-3.56|P-value:4.28E-4 ID:SGTC_2801|Compound:7907800|FD-Score:4.11|P-value:6.16E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.92|P-value:1.24E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.41|P-value:7.24E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.40|P-value:7.33E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.76|P-value:2.18E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.87|P-value:1.50E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.93|P-value:2.05E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.69|P-value:2.82E-4 ID:SGTC_3199|Compound:9111318|FD-Score:5.91|P-value:1.66E-8 ID:SGTC_3208|Compound:9114115|FD-Score:-4.65|P-value:6.84E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-3.72|P-value:2.46E-4 ID:SGTC_3340|Compound:9146634|FD-Score:4.03|P-value:8.25E-5

Top fitness defect scores for YGR268C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2337 9009472 6.24 200.0 µM 2.65E-9 5 2.12E-10
2 SGTC_3199 9111318 5.91 49.5 µM 1.66E-8 5 1.72E-9
3 SGTC_2226 7298446 5.67 200.0 µM 5.80E-8 1 7.15E-9
4 SGTC_990 3985-0011 5.55 41.3 µM 1.04E-7 amide catabolism 4 1.39E-8
5 SGTC_2772 vinpocetine 5.10 57.1 µM 9.42E-7 8 1.71E-7
6 SGTC_704 1310-0270 4.97 142.0 µM 1.68E-6 14 3.32E-7
7 SGTC_3059 1327-0034 4.93 3.0 µM 2.05E-6 36 4.16E-7
8 SGTC_1454 4239-0054 4.82 42.6 µM 3.33E-6 13 7.21E-7
9 SGTC_915 methyl methanesulfonate (MMS) 4.48 110.0 mM 1.41E-5 DNA damage response 28 3.72E-6
10 SGTC_1879 gemcitabine 4.38 100.0 µM 2.13E-5 8 5.94E-6
11 SGTC_1619 st003326 4.34 88.7 µM 2.46E-5 60S ribosome export 12 7.02E-6
12 SGTC_367 0335-0881 4.30 7.1 µM 2.98E-5 ubiquinone biosynthesis & proteasome 59 8.72E-6
13 SGTC_402 epigallocatechin gallate 4.29 10.0 µM 3.02E-5 18 8.85E-6
14 SGTC_718 1130-0073 4.22 349.0 µM 3.96E-5 13 1.20E-5
15 SGTC_2596 sinensetin 4.12 100.0 µM 5.82E-5 29 1.87E-5
16 SGTC_2801 7907800 4.11 81.8 µM 6.16E-5 24 1.99E-5
17 SGTC_3340 9146634 4.03 11.1 µM 8.25E-5 12 2.77E-5
18 SGTC_2163 5671233 3.93 125.0 µM 1.21E-4 27 4.29E-5
19 SGTC_2873 9040596 3.92 71.4 µM 1.24E-4 50 4.39E-5
20 SGTC_2481 5478948 3.90 45.2 µM 1.34E-4 PDR1 37 4.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.080 3.67E-6 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.077 7.65E-6 YPL009C TAE2 hom Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.074 1.61E-5 YBR159W IFA38 hom Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
0.073 2.06E-5 YGL202W ARO8 hom Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
0.072 3.09E-5 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.072 3.27E-5 YNR061C YNR061C hom Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.070 5.33E-5 YLR227C ADY4 hom Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
0.070 5.41E-5 YIL168W YIL168W hom Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase
0.069 7.00E-5 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.068 8.43E-5 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.068 8.71E-5 YAR002C-A ERP1 hom Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication
0.067 1.01E-4 YLR434C_d YLR434C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W
0.067 1.11E-4 YJR048W CYC1 hom Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication
0.066 1.16E-4 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.066 1.40E-4 YKR025W RPC37 het RNA polymerase III subunit C37