YGR269W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR269W / YGR269W

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:-3.31|P-value:1.09E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:2.96|P-value:9.98E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-2.79|P-value:8.68E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-2.81|P-value:8.20E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.11|P-value:5.70E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.35|P-value:2.15E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.97|P-value:9.41E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:2.97|P-value:9.50E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.05|P-value:3.24E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.22|P-value:3.71E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.44|P-value:1.49E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.58|P-value:6.28E-7 ID:SGTC_801|Compound:0866-0028|FD-Score:3.13|P-value:5.21E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.29|P-value:2.75E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.66|P-value:5.76E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.08|P-value:6.34E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.57|P-value:8.45E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:-4.03|P-value:3.81E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.10|P-value:2.60E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.50|P-value:9.52E-7 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.84|P-value:9.64E-6 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.05|P-value:7.05E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.27|P-value:1.08E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.47|P-value:5.57E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-2.93|P-value:5.23E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.97|P-value:1.39E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.53|P-value:1.01E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.02|P-value:7.91E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.32|P-value:2.47E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.65|P-value:5.94E-5 ID:SGTC_2199|Compound:6590217|FD-Score:3.25|P-value:3.19E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.21|P-value:3.80E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.23|P-value:3.95E-6 ID:SGTC_2387|Compound:9077560|FD-Score:3.51|P-value:1.09E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.15|P-value:4.80E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.64|P-value:6.40E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.19|P-value:1.78E-8 ID:SGTC_2513|Compound:baicalein|FD-Score:-2.94|P-value:4.94E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.14|P-value:5.07E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.36|P-value:2.07E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-2.93|P-value:5.21E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.07|P-value:6.53E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.99|P-value:8.88E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.93|P-value:1.72E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-2.76|P-value:9.69E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.47|P-value:1.31E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.67|P-value:2.24E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.57|P-value:8.49E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.02|P-value:7.91E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.28|P-value:2.88E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.44|P-value:1.47E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.00|P-value:8.45E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.43|P-value:1.57E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.18|P-value:5.04E-6 ID:SGTC_3298|Compound:9116858|FD-Score:3.41|P-value:1.67E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.31|P-value:1.09E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:2.96|P-value:9.98E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-2.79|P-value:8.68E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-2.81|P-value:8.20E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.11|P-value:5.70E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.35|P-value:2.15E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.97|P-value:9.41E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:2.97|P-value:9.50E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.05|P-value:3.24E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.22|P-value:3.71E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.44|P-value:1.49E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.58|P-value:6.28E-7 ID:SGTC_801|Compound:0866-0028|FD-Score:3.13|P-value:5.21E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.29|P-value:2.75E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.66|P-value:5.76E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.08|P-value:6.34E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.57|P-value:8.45E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:-4.03|P-value:3.81E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.10|P-value:2.60E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.50|P-value:9.52E-7 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.84|P-value:9.64E-6 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.05|P-value:7.05E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.27|P-value:1.08E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.47|P-value:5.57E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-2.93|P-value:5.23E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.97|P-value:1.39E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.53|P-value:1.01E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.02|P-value:7.91E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.32|P-value:2.47E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.65|P-value:5.94E-5 ID:SGTC_2199|Compound:6590217|FD-Score:3.25|P-value:3.19E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.21|P-value:3.80E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.23|P-value:3.95E-6 ID:SGTC_2387|Compound:9077560|FD-Score:3.51|P-value:1.09E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.15|P-value:4.80E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.64|P-value:6.40E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.19|P-value:1.78E-8 ID:SGTC_2513|Compound:baicalein|FD-Score:-2.94|P-value:4.94E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.14|P-value:5.07E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.36|P-value:2.07E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-2.93|P-value:5.21E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.07|P-value:6.53E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.99|P-value:8.88E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.93|P-value:1.72E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-2.76|P-value:9.69E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.47|P-value:1.31E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.67|P-value:2.24E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.57|P-value:8.49E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.02|P-value:7.91E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.28|P-value:2.88E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.44|P-value:1.47E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.00|P-value:8.45E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.43|P-value:1.57E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.18|P-value:5.04E-6 ID:SGTC_3298|Compound:9116858|FD-Score:3.41|P-value:1.67E-4

Top fitness defect scores for YGR269W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2496 diffractaic acid 5.19 79.8 µM 1.78E-8 7 1.05E-7
2 SGTC_797 k781-0471 4.58 270.0 µM 6.28E-7 RPP1 & pyrimidine depletion 8 2.37E-6
3 SGTC_1478 0453-0656 4.50 35.7 µM 9.52E-7 11 3.41E-6
4 SGTC_2382 9035899 4.23 200.0 µM 3.95E-6 60S ribosome export 11 1.19E-5
5 SGTC_3289 9119912 4.18 71.4 µM 5.04E-6 13 1.47E-5
6 SGTC_1771 st048882 3.97 4.2 µM 1.39E-5 RPP1 & pyrimidine depletion 20 3.59E-5
7 SGTC_2815 7968870 3.93 71.4 µM 1.72E-5 24 4.33E-5
8 SGTC_1106 tegaserod maleate 3.66 11.7 µM 5.76E-5 32 1.25E-4
9 SGTC_2065 5221596 3.65 34.3 µM 5.94E-5 23 1.29E-4
10 SGTC_2423 st077119 3.64 87.2 µM 6.40E-5 19 1.37E-4
11 SGTC_1360 1598-0022 3.57 39.8 µM 8.45E-5 ERG2 46 1.76E-4
12 SGTC_3108 9121785 3.57 49.5 µM 8.49E-5 25 1.76E-4
13 SGTC_1787 fluconazole 3.53 80.0 µM 1.01E-4 iron homeostasis 43 2.06E-4
14 SGTC_2387 9077560 3.51 195.1 µM 1.09E-4 29 2.20E-4
15 SGTC_2986 9022445 3.47 71.4 µM 1.31E-4 30 2.59E-4
16 SGTC_3232 9132874 3.44 49.5 µM 1.47E-4 RPP1 & pyrimidine depletion 32 2.86E-4
17 SGTC_604 1000-0114 3.44 314.0 µM 1.49E-4 43 2.89E-4
18 SGTC_3269 9137823 3.43 49.5 µM 1.57E-4 60S ribosome export 32 3.04E-4
19 SGTC_3298 9116858 3.41 71.4 µM 1.67E-4 26 3.21E-4
20 SGTC_2633 5,7-dihydroxyisoflavone 3.36 100.0 µM 2.07E-4 51 3.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.77E-14 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.103 2.28E-9 YNL190W_p YNL190W_p hom Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site
0.100 7.28E-9 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.088 2.96E-7 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.085 7.63E-7 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 7.89E-7 YPR094W RDS3 het Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
0.082 1.78E-6 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.080 3.05E-6 YLR412C-A_p YLR412C-A_p hom Putative protein of unknown function
0.079 5.26E-6 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.078 5.65E-6 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.075 1.19E-5 YOR197W MCA1 hom Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization
0.074 1.67E-5 YNL127W FAR11 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2
0.074 1.70E-5 YLR305C STT4 het Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
0.074 1.93E-5 YPR069C SPE3 hom Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
0.073 2.44E-5 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally