YGR270W / YTA7

Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR270W / YTA7

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:8.43|P-value:1.11E-12 ID:SGTC_116|Compound:0155-0182|FD-Score:5.33|P-value:4.68E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:5.95|P-value:3.87E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:5.49|P-value:2.51E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.47|P-value:2.78E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:3.79|P-value:8.41E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.65|P-value:5.58E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:5.11|P-value:1.11E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.57|P-value:7.37E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:5.75|P-value:8.71E-7 ID:SGTC_394|Compound:menadione|FD-Score:4.18|P-value:2.60E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.85|P-value:6.08E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-4.56|P-value:6.34E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-6.58|P-value:1.77E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:4.12|P-value:3.14E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.55|P-value:2.03E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:4.96|P-value:1.93E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:-4.13|P-value:2.59E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-8.64|P-value:2.38E-13 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.14|P-value:2.99E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.92|P-value:5.68E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.80|P-value:8.23E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.75|P-value:9.47E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:7.71|P-value:7.18E-11 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.24|P-value:2.20E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.73|P-value:8.53E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.54|P-value:2.07E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.08|P-value:3.60E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-4.17|P-value:2.26E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-4.20|P-value:2.09E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.79|P-value:8.31E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:8.75|P-value:1.62E-13 ID:SGTC_1800|Compound:st050079|FD-Score:4.42|P-value:1.24E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.12|P-value:3.16E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.64|P-value:5.95E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.94|P-value:5.39E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-4.14|P-value:2.50E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-4.15|P-value:2.41E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.36|P-value:1.25E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.19|P-value:2.16E-4 ID:SGTC_2364|Compound:9055074|FD-Score:6.21|P-value:1.23E-7 ID:SGTC_2382|Compound:9035899|FD-Score:-4.60|P-value:5.70E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.74|P-value:9.71E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.84|P-value:7.30E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.31|P-value:1.77E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:8.43|P-value:1.11E-12 ID:SGTC_116|Compound:0155-0182|FD-Score:5.33|P-value:4.68E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:5.95|P-value:3.87E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:5.49|P-value:2.51E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.47|P-value:2.78E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:3.79|P-value:8.41E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.65|P-value:5.58E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:5.11|P-value:1.11E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.57|P-value:7.37E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:5.75|P-value:8.71E-7 ID:SGTC_394|Compound:menadione|FD-Score:4.18|P-value:2.60E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.85|P-value:6.08E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-4.56|P-value:6.34E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-6.58|P-value:1.77E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:4.12|P-value:3.14E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.55|P-value:2.03E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:4.96|P-value:1.93E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:-4.13|P-value:2.59E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-8.64|P-value:2.38E-13 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.14|P-value:2.99E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.92|P-value:5.68E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.80|P-value:8.23E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.75|P-value:9.47E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:7.71|P-value:7.18E-11 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.24|P-value:2.20E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.73|P-value:8.53E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.54|P-value:2.07E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.08|P-value:3.60E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-4.17|P-value:2.26E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-4.20|P-value:2.09E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.79|P-value:8.31E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:8.75|P-value:1.62E-13 ID:SGTC_1800|Compound:st050079|FD-Score:4.42|P-value:1.24E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.12|P-value:3.16E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.64|P-value:5.95E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.94|P-value:5.39E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-4.14|P-value:2.50E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-4.15|P-value:2.41E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.36|P-value:1.25E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.19|P-value:2.16E-4 ID:SGTC_2364|Compound:9055074|FD-Score:6.21|P-value:1.23E-7 ID:SGTC_2382|Compound:9035899|FD-Score:-4.60|P-value:5.70E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.74|P-value:9.71E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.84|P-value:7.30E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.31|P-value:1.77E-4

Top fitness defect scores for YGR270W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1788 fluconazole 8.75 20.0 µM 1.62E-13 azole & statin 15 1.06E-18
2 SGTC_1 0258-0098 8.43 57.4 µM 1.11E-12 heme biosynthesis & mitochondrial translocase 1 1.66E-17
3 SGTC_1310 1188-0297 7.71 994.0 nM 7.18E-11 azole & statin 4 6.47E-15
4 SGTC_2364 9055074 6.21 200.0 µM 1.23E-7 5 2.70E-10
5 SGTC_141 0443-0274 5.95 32.3 µM 3.87E-7 mitochondrial response to ROS 17 1.38E-9
6 SGTC_383 2324-0395 5.75 7.4 µM 8.71E-7 azole & statin 17 4.38E-9
7 SGTC_682 0kpi-0099 5.55 17.0 µM 2.03E-6 28 1.46E-8
8 SGTC_1347 1493-0251 5.54 600.0 nM 2.07E-6 mitochondrial response to ROS 4 1.51E-8
9 SGTC_210 3551-0445 5.49 56.8 µM 2.51E-6 31 1.98E-8
10 SGTC_221 trifluoperazine 5.47 10.3 µM 2.78E-6 NEO1-PIK1 145 2.29E-8
11 SGTC_116 0155-0182 5.33 31.8 µM 4.68E-6 mitochondrial response to ROS 35 4.80E-8
12 SGTC_299 1273-0059 5.11 1.4 µM 1.11E-5 13 1.64E-7
13 SGTC_778 3456-2434 4.96 196.0 µM 1.93E-5 mitochondrial response to ROS 47 3.61E-7
14 SGTC_258 haloperidol 4.65 50.8 µM 5.58E-5 fatty acid desaturase (OLE1) 18 1.62E-6
15 SGTC_1803 st050068 4.64 52.4 µM 5.95E-5 NEO1-PIK1 133 1.78E-6
16 SGTC_379 3970-0972 4.57 5.9 µM 7.37E-5 tubulin folding & SWR complex 18 2.41E-6
17 SGTC_1800 st050079 4.42 29.1 µM 1.24E-4 NEO1-PIK1 101 5.02E-6
18 SGTC_3304 9125678 4.31 46.1 µM 1.77E-4 36 8.32E-6
19 SGTC_1317 1273-0028 4.24 910.0 nM 2.20E-4 azole & statin 43 1.14E-5
20 SGTC_394 menadione 4.18 8.3 µM 2.60E-4 superoxide 24 1.44E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 2.94E-39 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.217 3.30E-37 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.216 9.18E-37 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.216 1.01E-36 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.213 6.93E-36 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.197 1.14E-30 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.186 1.86E-27 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.182 2.29E-26 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.173 6.43E-24 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.169 9.00E-23 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.163 2.34E-21 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.159 2.07E-20 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.156 7.81E-20 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.156 9.83E-20 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.156 1.00E-19 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes