YGR271W / SLH1

Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR271W / SLH1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.74|P-value:2.06E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.93|P-value:9.51E-7 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.73|P-value:3.75E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.29|P-value:2.49E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.14|P-value:4.64E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.35|P-value:5.84E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.39|P-value:5.00E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.34|P-value:6.06E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.70|P-value:2.38E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:4.21|P-value:2.30E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:4.13|P-value:3.22E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:4.18|P-value:2.62E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.49|P-value:4.98E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-4.05|P-value:6.56E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.73|P-value:1.54E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.71|P-value:1.65E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.30|P-value:6.87E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.82|P-value:1.61E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:3.65|P-value:2.01E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:6.11|P-value:1.97E-9 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.86|P-value:1.35E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.60|P-value:2.41E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.46|P-value:3.97E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.27|P-value:1.79E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.06|P-value:5.10E-7 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.29|P-value:7.10E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.45|P-value:8.33E-6 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.74|P-value:1.47E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.98|P-value:4.14E-9 ID:SGTC_1637|Compound:st007924|FD-Score:3.27|P-value:7.47E-4 ID:SGTC_1689|Compound:st020265|FD-Score:5.19|P-value:2.72E-7 ID:SGTC_1797|Compound:st048695|FD-Score:-3.34|P-value:8.18E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.51|P-value:4.71E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-4.49|P-value:1.11E-5 ID:SGTC_1898|Compound:st060199|FD-Score:4.46|P-value:8.05E-6 ID:SGTC_1903|Compound:st060211|FD-Score:3.99|P-value:5.61E-5 ID:SGTC_1923|Compound:st058458|FD-Score:6.49|P-value:2.05E-10 ID:SGTC_1925|Compound:st057770|FD-Score:-4.08|P-value:5.79E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.39|P-value:5.09E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.25|P-value:7.93E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.47|P-value:3.84E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.29|P-value:7.07E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.49|P-value:7.16E-6 ID:SGTC_2111|Compound:5486399|FD-Score:3.32|P-value:6.47E-4 ID:SGTC_2141|Compound:5621638|FD-Score:-4.50|P-value:1.04E-5 ID:SGTC_2158|Compound:5657123|FD-Score:-3.40|P-value:6.81E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.46|P-value:4.00E-4 ID:SGTC_2382|Compound:9035899|FD-Score:5.16|P-value:3.22E-7 ID:SGTC_2525|Compound:harmine|FD-Score:3.45|P-value:4.07E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.64|P-value:2.96E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.27|P-value:7.53E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.50|P-value:3.50E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-4.86|P-value:2.11E-6 ID:SGTC_2995|Compound:9067767|FD-Score:3.54|P-value:2.98E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.69|P-value:1.78E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.41|P-value:4.78E-4 ID:SGTC_3082|Compound:9117008|FD-Score:6.31|P-value:6.17E-10 ID:SGTC_3091|Compound:9116372|FD-Score:3.19|P-value:9.80E-4 ID:SGTC_3099|Compound:9120367|FD-Score:-4.72|P-value:4.02E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.87|P-value:9.08E-5 ID:SGTC_3339|Compound:9145883|FD-Score:-3.49|P-value:5.09E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.74|P-value:2.06E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.93|P-value:9.51E-7 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.73|P-value:3.75E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.29|P-value:2.49E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.14|P-value:4.64E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.35|P-value:5.84E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.39|P-value:5.00E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.34|P-value:6.06E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.70|P-value:2.38E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:4.21|P-value:2.30E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:4.13|P-value:3.22E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:4.18|P-value:2.62E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.49|P-value:4.98E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-4.05|P-value:6.56E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.73|P-value:1.54E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.71|P-value:1.65E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.30|P-value:6.87E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.82|P-value:1.61E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:3.65|P-value:2.01E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:6.11|P-value:1.97E-9 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.86|P-value:1.35E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.60|P-value:2.41E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.46|P-value:3.97E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.27|P-value:1.79E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.06|P-value:5.10E-7 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.29|P-value:7.10E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.45|P-value:8.33E-6 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.74|P-value:1.47E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.98|P-value:4.14E-9 ID:SGTC_1637|Compound:st007924|FD-Score:3.27|P-value:7.47E-4 ID:SGTC_1689|Compound:st020265|FD-Score:5.19|P-value:2.72E-7 ID:SGTC_1797|Compound:st048695|FD-Score:-3.34|P-value:8.18E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.51|P-value:4.71E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-4.49|P-value:1.11E-5 ID:SGTC_1898|Compound:st060199|FD-Score:4.46|P-value:8.05E-6 ID:SGTC_1903|Compound:st060211|FD-Score:3.99|P-value:5.61E-5 ID:SGTC_1923|Compound:st058458|FD-Score:6.49|P-value:2.05E-10 ID:SGTC_1925|Compound:st057770|FD-Score:-4.08|P-value:5.79E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.39|P-value:5.09E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.25|P-value:7.93E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.47|P-value:3.84E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.29|P-value:7.07E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.49|P-value:7.16E-6 ID:SGTC_2111|Compound:5486399|FD-Score:3.32|P-value:6.47E-4 ID:SGTC_2141|Compound:5621638|FD-Score:-4.50|P-value:1.04E-5 ID:SGTC_2158|Compound:5657123|FD-Score:-3.40|P-value:6.81E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.46|P-value:4.00E-4 ID:SGTC_2382|Compound:9035899|FD-Score:5.16|P-value:3.22E-7 ID:SGTC_2525|Compound:harmine|FD-Score:3.45|P-value:4.07E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.64|P-value:2.96E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.27|P-value:7.53E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.50|P-value:3.50E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-4.86|P-value:2.11E-6 ID:SGTC_2995|Compound:9067767|FD-Score:3.54|P-value:2.98E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.69|P-value:1.78E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.41|P-value:4.78E-4 ID:SGTC_3082|Compound:9117008|FD-Score:6.31|P-value:6.17E-10 ID:SGTC_3091|Compound:9116372|FD-Score:3.19|P-value:9.80E-4 ID:SGTC_3099|Compound:9120367|FD-Score:-4.72|P-value:4.02E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.87|P-value:9.08E-5 ID:SGTC_3339|Compound:9145883|FD-Score:-3.49|P-value:5.09E-4

Top fitness defect scores for YGR271W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1923 st058458 6.49 19.1 µM 2.05E-10 6 4.34E-11
2 SGTC_3082 9117008 6.31 49.5 µM 6.17E-10 2 1.43E-10
3 SGTC_994 3910-0338 6.11 138.0 µM 1.97E-9 calcium & mitochondrial duress 13 5.01E-10
4 SGTC_1493 4348-0038 5.98 111.0 µM 4.14E-9 RSC complex & mRNA processing 3 1.12E-9
5 SGTC_1689 st020265 5.19 53.5 µM 2.72E-7 6 1.04E-7
6 SGTC_2382 9035899 5.16 200.0 µM 3.22E-7 60S ribosome export 6 1.25E-7
7 SGTC_1103 duloxetine 5.06 36.1 µM 5.10E-7 9 2.05E-7
8 SGTC_47 0149-0135 4.93 24.2 µM 9.51E-7 TSC3-RPN4 7 4.03E-7
9 SGTC_927 2425-1185 4.82 123.0 µM 1.61E-6 9 7.11E-7
10 SGTC_2092 5303694 4.49 80.7 µM 7.16E-6 TSC3-RPN4 24 3.57E-6
11 SGTC_1898 st060199 4.46 18.6 µM 8.05E-6 7 4.05E-6
12 SGTC_1162 k048-0130 4.45 20.1 µM 8.33E-6 Golgi 13 4.20E-6
13 SGTC_1097 itavastatin 4.27 7.2 µM 1.79E-5 azole & statin 15 9.56E-6
14 SGTC_519 k048-0011 4.21 62.8 µM 2.30E-5 14 1.26E-5
15 SGTC_591 4299-0174 4.18 154.0 µM 2.62E-5 6 1.44E-5
16 SGTC_520 3584-0023 4.13 682.0 µM 3.22E-5 23 1.81E-5
17 SGTC_1903 st060211 3.99 78.3 µM 5.61E-5 28 3.29E-5
18 SGTC_3232 9132874 3.87 49.5 µM 9.08E-5 RPP1 & pyrimidine depletion 16 5.51E-5
19 SGTC_1345 1488-0192 3.74 31.4 µM 1.47E-4 21 9.29E-5
20 SGTC_717 1532-0246 3.73 73.2 µM 1.54E-4 Golgi 42 9.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 8.97E-9 YDL120W YFH1 het Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
0.092 1.01E-7 YMR242C RPL20A hom Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
0.084 1.14E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.082 2.06E-6 YDR259C YAP6 hom Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication
0.078 6.19E-6 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.078 6.87E-6 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.075 1.38E-5 YAL040C CLN3 hom G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
0.074 1.76E-5 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.072 3.00E-5 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.071 3.88E-5 YDL035C GPR1 hom Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
0.070 4.97E-5 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.070 5.41E-5 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.069 6.71E-5 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.067 9.38E-5 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.066 1.46E-4 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components