YGR273C_p

Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR273C / YGR273C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.32|P-value:6.13E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.62|P-value:2.18E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.71|P-value:1.54E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.88|P-value:8.02E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.20|P-value:9.22E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.29|P-value:6.86E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.47|P-value:3.69E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.86|P-value:1.11E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:3.27|P-value:7.45E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-5.29|P-value:1.22E-7 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.61|P-value:2.14E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.56|P-value:2.65E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.30|P-value:6.63E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.33|P-value:6.03E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.47|P-value:3.51E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.23|P-value:8.32E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.28|P-value:7.02E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.24|P-value:8.23E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.29|P-value:6.93E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.40|P-value:4.66E-4 ID:SGTC_1908|Compound:st060353|FD-Score:6.38|P-value:2.63E-10 ID:SGTC_1910|Compound:st062352|FD-Score:-3.34|P-value:5.55E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-5.54|P-value:3.25E-8 ID:SGTC_1919|Compound:st067113|FD-Score:4.88|P-value:1.01E-6 ID:SGTC_1957|Compound:st077035|FD-Score:3.36|P-value:5.34E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.46|P-value:7.04E-6 ID:SGTC_1961|Compound:st076550|FD-Score:-3.59|P-value:2.26E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.64|P-value:2.00E-4 ID:SGTC_2017|Compound:5132927|FD-Score:5.07|P-value:4.04E-7 ID:SGTC_2021|Compound:4019055|FD-Score:3.48|P-value:3.50E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.74|P-value:1.35E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-3.59|P-value:2.29E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.88|P-value:7.51E-5 ID:SGTC_2324|Compound:6149169|FD-Score:4.70|P-value:2.33E-6 ID:SGTC_2373|Compound:9071805|FD-Score:-5.11|P-value:3.09E-7 ID:SGTC_2381|Compound:9035592|FD-Score:-4.70|P-value:2.26E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-3.27|P-value:7.04E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.46|P-value:3.86E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.35|P-value:5.67E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.80|P-value:1.04E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.20|P-value:8.79E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.31|P-value:6.45E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.35|P-value:5.64E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.81|P-value:1.41E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.40|P-value:4.53E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.90|P-value:4.54E-9 ID:SGTC_2761|Compound:levamisole|FD-Score:4.11|P-value:3.17E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.62|P-value:3.38E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.28|P-value:1.56E-5 ID:SGTC_3035|Compound:9091303|FD-Score:-3.49|P-value:3.26E-4 ID:SGTC_3181|Compound:9108277|FD-Score:5.06|P-value:4.27E-7 ID:SGTC_3202|Compound:9113761|FD-Score:3.34|P-value:5.81E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.35|P-value:5.59E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.23|P-value:8.38E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.61|P-value:2.21E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.71|P-value:1.46E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.32|P-value:6.13E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.62|P-value:2.18E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.71|P-value:1.54E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.88|P-value:8.02E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.20|P-value:9.22E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.29|P-value:6.86E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.47|P-value:3.69E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.86|P-value:1.11E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:3.27|P-value:7.45E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-5.29|P-value:1.22E-7 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.61|P-value:2.14E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.56|P-value:2.65E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.30|P-value:6.63E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.33|P-value:6.03E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.47|P-value:3.51E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.23|P-value:8.32E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.28|P-value:7.02E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.24|P-value:8.23E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.29|P-value:6.93E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.40|P-value:4.66E-4 ID:SGTC_1908|Compound:st060353|FD-Score:6.38|P-value:2.63E-10 ID:SGTC_1910|Compound:st062352|FD-Score:-3.34|P-value:5.55E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-5.54|P-value:3.25E-8 ID:SGTC_1919|Compound:st067113|FD-Score:4.88|P-value:1.01E-6 ID:SGTC_1957|Compound:st077035|FD-Score:3.36|P-value:5.34E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.46|P-value:7.04E-6 ID:SGTC_1961|Compound:st076550|FD-Score:-3.59|P-value:2.26E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.64|P-value:2.00E-4 ID:SGTC_2017|Compound:5132927|FD-Score:5.07|P-value:4.04E-7 ID:SGTC_2021|Compound:4019055|FD-Score:3.48|P-value:3.50E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.74|P-value:1.35E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-3.59|P-value:2.29E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.88|P-value:7.51E-5 ID:SGTC_2324|Compound:6149169|FD-Score:4.70|P-value:2.33E-6 ID:SGTC_2373|Compound:9071805|FD-Score:-5.11|P-value:3.09E-7 ID:SGTC_2381|Compound:9035592|FD-Score:-4.70|P-value:2.26E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-3.27|P-value:7.04E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.46|P-value:3.86E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.35|P-value:5.67E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.80|P-value:1.04E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.20|P-value:8.79E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.31|P-value:6.45E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.35|P-value:5.64E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.81|P-value:1.41E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.40|P-value:4.53E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.90|P-value:4.54E-9 ID:SGTC_2761|Compound:levamisole|FD-Score:4.11|P-value:3.17E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.62|P-value:3.38E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.28|P-value:1.56E-5 ID:SGTC_3035|Compound:9091303|FD-Score:-3.49|P-value:3.26E-4 ID:SGTC_3181|Compound:9108277|FD-Score:5.06|P-value:4.27E-7 ID:SGTC_3202|Compound:9113761|FD-Score:3.34|P-value:5.81E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.35|P-value:5.59E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.23|P-value:8.38E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.61|P-value:2.21E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.71|P-value:1.46E-4

Top fitness defect scores for YGR273C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1908 st060353 6.38 56.5 µM 2.63E-10 RPP1 & pyrimidine depletion 6 8.97E-11
2 SGTC_2757 clomiphene 5.90 4.2 µM 4.54E-9 fatty acid desaturase (OLE1) 8 1.79E-9
3 SGTC_2017 5132927 5.07 60.6 µM 4.04E-7 10 2.02E-7
4 SGTC_3181 9108277 5.06 49.5 µM 4.27E-7 iron homeostasis 4 2.14E-7
5 SGTC_1919 st067113 4.88 52.3 µM 1.01E-6 TSC3-RPN4 17 5.27E-7
6 SGTC_710 3448-4187 4.86 58.0 µM 1.11E-6 fatty acid desaturase (OLE1) 29 5.86E-7
7 SGTC_2749 bexarotene 4.81 57.4 µM 1.41E-6 10 7.48E-7
8 SGTC_2324 6149169 4.70 200.0 µM 2.33E-6 12 1.27E-6
9 SGTC_2768 sulfasalazine 4.62 50.2 µM 3.38E-6 6 1.88E-6
10 SGTC_1959 st077091 4.46 55.8 µM 7.04E-6 RPP1 & pyrimidine depletion 34 4.07E-6
11 SGTC_2770 toltrazuril 4.28 17.5 µM 1.56E-5 17 9.41E-6
12 SGTC_2761 levamisole 4.11 97.9 µM 3.17E-5 14 1.98E-5
13 SGTC_175 3793-3120 3.88 23.7 µM 8.02E-5 16 5.26E-5
14 SGTC_2050 5263056 3.74 171.0 µM 1.35E-4 fatty acid desaturase (OLE1) 51 9.07E-5
15 SGTC_123 0083-0120 3.71 66.7 µM 1.54E-4 56 1.05E-4
16 SGTC_2012 4023501 3.64 200.0 µM 2.00E-4 40 1.37E-4
17 SGTC_93 0109-0045 3.62 59.2 µM 2.18E-4 DNA damage response 63 1.50E-4
18 SGTC_3339 9145883 3.61 14.9 µM 2.21E-4 19 1.53E-4
19 SGTC_1035 k081-0041 3.56 55.2 µM 2.65E-4 Golgi 33 1.85E-4
20 SGTC_2021 4019055 3.48 173.0 µM 3.50E-4 endomembrane recycling 159 2.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.32E-12 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.105 1.12E-9 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.105 1.17E-9 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.103 2.58E-9 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.102 3.13E-9 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.102 3.62E-9 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.100 7.33E-9 YMR300C ADE4 hom Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
0.094 4.40E-8 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.093 7.42E-8 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.090 1.92E-7 YDR408C ADE8 hom Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.089 2.07E-7 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.086 6.80E-7 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.084 1.20E-6 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.083 1.67E-6 YMR085W_p YMR085W_p hom Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.081 2.87E-6 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria