YGR275W / RTT102

Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR275W / RTT102

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:-3.80|P-value:1.42E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.90|P-value:1.13E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.50|P-value:4.74E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.79|P-value:2.84E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:3.47|P-value:5.24E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.39|P-value:6.72E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.44|P-value:5.20E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:5.29|P-value:2.68E-7 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.91|P-value:9.45E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.46|P-value:5.35E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.17|P-value:3.93E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.28|P-value:9.64E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.48|P-value:4.96E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.87|P-value:1.23E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.64|P-value:2.89E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.44|P-value:5.15E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.94|P-value:9.75E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.34|P-value:8.04E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.47|P-value:5.11E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.43|P-value:5.86E-4 ID:SGTC_2281|Compound:7943571|FD-Score:4.74|P-value:3.53E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.25|P-value:2.82E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:4.68|P-value:4.71E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.73|P-value:1.83E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.37|P-value:1.74E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.29|P-value:8.41E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.31|P-value:8.70E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.73|P-value:2.07E-4 ID:SGTC_2949|Compound:9072542|FD-Score:5.05|P-value:8.66E-7 ID:SGTC_2950|Compound:9072895|FD-Score:-3.42|P-value:5.38E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.81|P-value:1.41E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.80|P-value:1.42E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.90|P-value:1.13E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.50|P-value:4.74E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.79|P-value:2.84E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:3.47|P-value:5.24E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.39|P-value:6.72E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.44|P-value:5.20E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:5.29|P-value:2.68E-7 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.91|P-value:9.45E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.46|P-value:5.35E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.17|P-value:3.93E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.28|P-value:9.64E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.48|P-value:4.96E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.87|P-value:1.23E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.64|P-value:2.89E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.44|P-value:5.15E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.94|P-value:9.75E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.34|P-value:8.04E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.47|P-value:5.11E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.43|P-value:5.86E-4 ID:SGTC_2281|Compound:7943571|FD-Score:4.74|P-value:3.53E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.25|P-value:2.82E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:4.68|P-value:4.71E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.73|P-value:1.83E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.37|P-value:1.74E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.29|P-value:8.41E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.31|P-value:8.70E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.73|P-value:2.07E-4 ID:SGTC_2949|Compound:9072542|FD-Score:5.05|P-value:8.66E-7 ID:SGTC_2950|Compound:9072895|FD-Score:-3.42|P-value:5.38E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.81|P-value:1.41E-4

Top fitness defect scores for YGR275W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_966 1300-0360 5.29 30.2 µM 2.68E-7 heme requiring 5 6.06E-8
2 SGTC_2949 9072542 5.05 2.2 µM 8.66E-7 TSC3-RPN4 12 2.22E-7
3 SGTC_300 r073-0011 4.79 5.0 µM 2.84E-6 8 8.25E-7
4 SGTC_2281 7943571 4.74 200.0 µM 3.53E-6 3 1.05E-6
5 SGTC_2495 cafestol 4.68 54.5 µM 4.71E-6 Golgi 16 1.45E-6
6 SGTC_2580 diallyl disulphide 4.37 81.4 µM 1.74E-5 13 6.15E-6
7 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.25 3.7 µM 2.82E-5 65 1.05E-5
8 SGTC_1163 k060-0048 4.17 49.9 µM 3.93E-5 18 1.51E-5
9 SGTC_1953 st076800 3.94 12.1 µM 9.75E-5 49 4.13E-5
10 SGTC_151 3013-0144 3.90 2.3 µM 1.13E-4 iron homeostasis 29 4.84E-5
11 SGTC_1510 1123-0200 3.87 71.5 µM 1.23E-4 45 5.34E-5
12 SGTC_2942 9052777 3.73 62.2 µM 2.07E-4 42 9.50E-5
13 SGTC_1715 st032160 3.64 10.2 µM 2.89E-4 52 1.37E-4
14 SGTC_153 4077-0274 3.50 519.7 µM 4.74E-4 30 2.37E-4
15 SGTC_1501 4491-0275 3.48 38.4 µM 4.96E-4 21 2.49E-4
16 SGTC_2112 5488546 3.47 200.0 µM 5.11E-4 TSC3-RPN4 32 2.58E-4
17 SGTC_366 0181-0206 3.47 4.3 µM 5.24E-4 Golgi 61 2.65E-4
18 SGTC_1070 indatraline 3.46 8.8 µM 5.35E-4 60S ribosome export 43 2.71E-4
19 SGTC_2280 7785178 3.43 200.0 µM 5.86E-4 19 2.99E-4
20 SGTC_369 0957-0393 3.39 4.5 µM 6.72E-4 cell wall signaling 45 3.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.10E-10 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.109 2.60E-10 YAR035C-A_p YAR035C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis
0.108 3.97E-10 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.097 1.54E-8 YLR334C_d YLR334C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
0.094 5.01E-8 YGL101W_p YGL101W_p hom Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
0.088 3.46E-7 YHR107C CDC12 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.086 5.63E-7 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.085 9.15E-7 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.084 1.00E-6 YBL052C SAS3 hom Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal
0.081 2.49E-6 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.080 3.46E-6 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.079 5.17E-6 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.079 5.22E-6 YHR139C SPS100 hom Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin
0.076 1.03E-5 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.074 1.74E-5 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing