YGR276C / RNH70

3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR276C / RNH70

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.25|P-value:8.59E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.23|P-value:5.48E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.19|P-value:6.46E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.13|P-value:7.73E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.48|P-value:2.18E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.10|P-value:8.69E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:5.05|P-value:1.62E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.21|P-value:5.73E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.65|P-value:5.46E-9 ID:SGTC_508|Compound:roscovitine|FD-Score:-3.62|P-value:1.30E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.10|P-value:8.58E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.17|P-value:1.21E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.23|P-value:5.49E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.33|P-value:3.86E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.67|P-value:1.01E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.21|P-value:6.03E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.07|P-value:9.36E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.75|P-value:7.44E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.46|P-value:3.19E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.14|P-value:7.59E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.11|P-value:1.62E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.18|P-value:6.50E-4 ID:SGTC_1637|Compound:st007924|FD-Score:4.27|P-value:7.77E-6 ID:SGTC_1641|Compound:st009299|FD-Score:3.09|P-value:8.87E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.48|P-value:2.15E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.62|P-value:1.24E-4 ID:SGTC_1661|Compound:st013063|FD-Score:-3.23|P-value:5.51E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-3.88|P-value:4.42E-5 ID:SGTC_1807|Compound:st050092|FD-Score:-3.57|P-value:1.56E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.75|P-value:7.49E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.57|P-value:1.54E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.34|P-value:3.77E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.69|P-value:9.42E-5 ID:SGTC_2008|Compound:4012253|FD-Score:3.38|P-value:3.09E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.90|P-value:4.03E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-4.85|P-value:4.90E-7 ID:SGTC_2070|Compound:5230947|FD-Score:3.47|P-value:2.20E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.91|P-value:3.79E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.20|P-value:6.13E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.56|P-value:1.57E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.10|P-value:8.64E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.22|P-value:5.52E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.13|P-value:7.89E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.01|P-value:2.51E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.04|P-value:1.72E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.23|P-value:5.35E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.06|P-value:9.83E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.51|P-value:1.96E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.73|P-value:8.68E-7 ID:SGTC_3087|Compound:9117406|FD-Score:-4.42|P-value:4.07E-6 ID:SGTC_3178|Compound:9107506|FD-Score:-3.14|P-value:7.56E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.29|P-value:4.33E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.21|P-value:5.77E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.25|P-value:8.59E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.23|P-value:5.48E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.19|P-value:6.46E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.13|P-value:7.73E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.48|P-value:2.18E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.10|P-value:8.69E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:5.05|P-value:1.62E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.21|P-value:5.73E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.65|P-value:5.46E-9 ID:SGTC_508|Compound:roscovitine|FD-Score:-3.62|P-value:1.30E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.10|P-value:8.58E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.17|P-value:1.21E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.23|P-value:5.49E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.33|P-value:3.86E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.67|P-value:1.01E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.21|P-value:6.03E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.07|P-value:9.36E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.75|P-value:7.44E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.46|P-value:3.19E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.14|P-value:7.59E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.11|P-value:1.62E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.18|P-value:6.50E-4 ID:SGTC_1637|Compound:st007924|FD-Score:4.27|P-value:7.77E-6 ID:SGTC_1641|Compound:st009299|FD-Score:3.09|P-value:8.87E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.48|P-value:2.15E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.62|P-value:1.24E-4 ID:SGTC_1661|Compound:st013063|FD-Score:-3.23|P-value:5.51E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-3.88|P-value:4.42E-5 ID:SGTC_1807|Compound:st050092|FD-Score:-3.57|P-value:1.56E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.75|P-value:7.49E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.57|P-value:1.54E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.34|P-value:3.77E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.69|P-value:9.42E-5 ID:SGTC_2008|Compound:4012253|FD-Score:3.38|P-value:3.09E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.90|P-value:4.03E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-4.85|P-value:4.90E-7 ID:SGTC_2070|Compound:5230947|FD-Score:3.47|P-value:2.20E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.91|P-value:3.79E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.20|P-value:6.13E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.56|P-value:1.57E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.10|P-value:8.64E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.22|P-value:5.52E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.13|P-value:7.89E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.01|P-value:2.51E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.04|P-value:1.72E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.23|P-value:5.35E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.06|P-value:9.83E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.51|P-value:1.96E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.73|P-value:8.68E-7 ID:SGTC_3087|Compound:9117406|FD-Score:-4.42|P-value:4.07E-6 ID:SGTC_3178|Compound:9107506|FD-Score:-3.14|P-value:7.56E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.29|P-value:4.33E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.21|P-value:5.77E-4

Top fitness defect scores for YGR276C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_503 tyrphostin 8 5.65 294.0 µM 5.46E-9 TSC3-RPN4 5 7.94E-9
2 SGTC_496 calpeptin 5.05 138.0 µM 1.62E-7 5 2.20E-7
3 SGTC_2684 capsaicin 5.04 100.0 µM 1.72E-7 10 2.32E-7
4 SGTC_3065 9113888 4.73 49.5 µM 8.68E-7 13 1.13E-6
5 SGTC_1051 3253-3903 4.46 78.0 µM 3.19E-6 14 4.06E-6
6 SGTC_1637 st007924 4.27 17.4 µM 7.77E-6 15 9.69E-6
7 SGTC_163 1327-0036 4.25 7.5 µM 8.59E-6 92 1.07E-5
8 SGTC_588 3970-1144 4.17 52.9 µM 1.21E-5 23 1.49E-5
9 SGTC_1602 st001878 4.11 87.6 µM 1.62E-5 18 1.99E-5
10 SGTC_2633 5,7-dihydroxyisoflavone 4.01 100.0 µM 2.51E-5 31 3.05E-5
11 SGTC_2125 5246583 3.91 200.0 µM 3.79E-5 tubulin folding & SWR complex 43 4.57E-5
12 SGTC_2055 5235184 3.90 200.0 µM 4.03E-5 ERG2 33 4.86E-5
13 SGTC_970 1315-0089 3.75 19.5 µM 7.44E-5 RSC & ERG11 28 8.85E-5
14 SGTC_1835 st008666 3.75 49.2 µM 7.49E-5 27 8.91E-5
15 SGTC_2001 4023502 3.69 57.7 µM 9.42E-5 mitochondrial processes 26 1.11E-4
16 SGTC_769 0302-0231 3.67 76.0 µM 1.01E-4 51 1.20E-4
17 SGTC_1817 st052116 3.63 64.4 µM 1.20E-4 RNA processing & uracil transport 19 1.41E-4
18 SGTC_1656 st012921 3.62 11.0 µM 1.24E-4 38 1.46E-4
19 SGTC_2411 st077133 3.56 39.9 µM 1.57E-4 RNA pol III & RNase P/MRP 44 1.83E-4
20 SGTC_87 0100-0052 3.55 35.5 µM 1.66E-4 145 1.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.90E-12 YGR142W BTN2 hom v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication
0.115 2.75E-11 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.097 1.64E-8 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.095 3.99E-8 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.092 1.01E-7 YBR223C TDP1 hom Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI
0.091 1.27E-7 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.089 2.26E-7 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.089 2.45E-7 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.089 2.83E-7 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.089 2.84E-7 YKL123W_d YKL123W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4
0.088 3.69E-7 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.086 6.13E-7 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.085 7.97E-7 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.084 1.05E-6 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.083 1.69E-6 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M