YGR277C / CAB4

Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR277C / CAB4

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:2.96|P-value:5.20E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:4.95|P-value:2.10E-8 ID:SGTC_90|Compound:0870-0863|FD-Score:7.50|P-value:4.54E-17 ID:SGTC_91|Compound:0417-1751|FD-Score:4.44|P-value:4.25E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.29|P-value:1.26E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-2.89|P-value:6.66E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.74|P-value:1.61E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:2.81|P-value:9.10E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.25|P-value:1.53E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.05|P-value:3.59E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:2.90|P-value:6.67E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.79|P-value:1.32E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.11|P-value:2.87E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.95|P-value:6.15E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:-2.98|P-value:4.57E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.07|P-value:3.32E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.37|P-value:9.02E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:-2.84|P-value:7.87E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.93|P-value:6.38E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:4.96|P-value:1.86E-8 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.09|P-value:2.99E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:2.90|P-value:6.63E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.71|P-value:1.89E-5 ID:SGTC_1660|Compound:st012960|FD-Score:-2.81|P-value:8.74E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.12|P-value:2.75E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.40|P-value:8.08E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.32|P-value:1.10E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-2.94|P-value:5.48E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.08|P-value:3.21E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.34|P-value:1.09E-4 ID:SGTC_2308|Compound:7584454|FD-Score:2.93|P-value:5.91E-4 ID:SGTC_2373|Compound:9071805|FD-Score:2.79|P-value:9.83E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.27|P-value:1.46E-4 ID:SGTC_2400|Compound:5203494|FD-Score:2.91|P-value:6.38E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:2.89|P-value:6.73E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.15|P-value:2.38E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.85|P-value:7.93E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.19|P-value:2.05E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.07|P-value:3.17E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.49|P-value:5.29E-5 ID:SGTC_2850|Compound:9015429|FD-Score:-3.18|P-value:2.06E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.32|P-value:1.11E-4 ID:SGTC_3044|Compound:9093193|FD-Score:2.83|P-value:8.70E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.40|P-value:7.77E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.05|P-value:3.62E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:2.96|P-value:5.20E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:4.95|P-value:2.10E-8 ID:SGTC_90|Compound:0870-0863|FD-Score:7.50|P-value:4.54E-17 ID:SGTC_91|Compound:0417-1751|FD-Score:4.44|P-value:4.25E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.29|P-value:1.26E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-2.89|P-value:6.66E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.74|P-value:1.61E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:2.81|P-value:9.10E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.25|P-value:1.53E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.05|P-value:3.59E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:2.90|P-value:6.67E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.79|P-value:1.32E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.11|P-value:2.87E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.95|P-value:6.15E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:-2.98|P-value:4.57E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.07|P-value:3.32E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.37|P-value:9.02E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:-2.84|P-value:7.87E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.93|P-value:6.38E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:4.96|P-value:1.86E-8 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.09|P-value:2.99E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:2.90|P-value:6.63E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.71|P-value:1.89E-5 ID:SGTC_1660|Compound:st012960|FD-Score:-2.81|P-value:8.74E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.12|P-value:2.75E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.40|P-value:8.08E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.32|P-value:1.10E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-2.94|P-value:5.48E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.08|P-value:3.21E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.34|P-value:1.09E-4 ID:SGTC_2308|Compound:7584454|FD-Score:2.93|P-value:5.91E-4 ID:SGTC_2373|Compound:9071805|FD-Score:2.79|P-value:9.83E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.27|P-value:1.46E-4 ID:SGTC_2400|Compound:5203494|FD-Score:2.91|P-value:6.38E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:2.89|P-value:6.73E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.15|P-value:2.38E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.85|P-value:7.93E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.19|P-value:2.05E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.07|P-value:3.17E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.49|P-value:5.29E-5 ID:SGTC_2850|Compound:9015429|FD-Score:-3.18|P-value:2.06E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.32|P-value:1.11E-4 ID:SGTC_3044|Compound:9093193|FD-Score:2.83|P-value:8.70E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.40|P-value:7.77E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.05|P-value:3.62E-4

Top fitness defect scores for YGR277C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_90 0870-0863 7.50 4.6 µM 4.54E-17 1 3.22E-14 2.31
2 SGTC_988 1497-1057 4.96 103.0 µM 1.86E-8 3 3.45E-7 0.77
3 SGTC_89 0302-0250 4.95 142.1 µM 2.10E-8 3 3.80E-7 0.20
4 SGTC_91 0417-1751 4.44 58.4 µM 4.25E-7 Golgi 9 4.47E-6 0.24
5 SGTC_795 0685-0265 3.95 78.0 µM 6.15E-6 excess fatty acid 18 3.99E-5 0.05
6 SGTC_628 1636-0253 3.79 16.0 µM 1.32E-5 sphingolipid biosynthesis & PDR1 11 7.48E-5 0.14
7 SGTC_1742 st038235 3.40 28.9 µM 8.08E-5 mitochondrial stress 14 3.31E-4 0.01
8 SGTC_2119 5528445 3.34 120.6 µM 1.09E-4 7 4.25E-4 0.05
9 SGTC_2375 9072683 3.27 200.0 µM 1.46E-4 mitochondrial processes 8 5.38E-4 0.03
10 SGTC_2780 5215298 3.19 71.4 µM 2.05E-4 24 7.14E-4 0.05
11 SGTC_2541 muurolladie-3-one 3.15 83.1 µM 2.38E-4 excess fatty acid 31 8.08E-4 0.10
12 SGTC_1721 st082152 3.12 9.3 µM 2.75E-4 60S ribosome export 19 9.08E-4 0.05
13 SGTC_665 3914-0008 3.11 307.0 µM 2.87E-4 9 9.41E-4 0.08
14 SGTC_2065 5221596 3.08 34.3 µM 3.21E-4 12 0.00103 0.03
15 SGTC_969 1313-0238 3.07 134.0 µM 3.32E-4 mitochondrial processes 39 0.00106 0.02
16 SGTC_479 n-linoleoylglycine 3.05 10.0 µM 3.59E-4 7 0.00113 0.06
17 SGTC_3308 9128332 3.05 17.6 µM 3.62E-4 plasma membrane duress 19 0.00114 0.03
18 SGTC_86 0417-1630 2.96 471.9 µM 5.20E-4 ubiquinone biosynthesis & proteasome 48 0.00154 1.52E-4
19 SGTC_2308 7584454 2.93 197.6 µM 5.91E-4 31 0.00171 0.02
20 SGTC_2400 5203494 2.91 178.7 µM 6.38E-4 RSC complex & mRNA processing 33 0.00182 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.18E-16 YIL002W-A_p YIL002W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.113 5.37E-11 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.111 9.91E-11 YGL032C AGA2 hom Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
0.100 7.12E-9 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.099 9.29E-9 YLR336C SGD1 het Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
0.099 1.04E-8 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.096 2.56E-8 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.094 4.21E-8 YDL109C_p YDL109C_p hom Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication
0.093 7.69E-8 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.091 1.34E-7 YBR072C-A_p YBR072C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.089 2.43E-7 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.087 4.10E-7 YCR073C SSK22 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
0.087 5.02E-7 YHL041W_d YHL041W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.084 1.26E-6 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.083 1.54E-6 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS