YGR279C / SCW4

Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR279C / SCW4

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.01|P-value:3.64E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:3.15|P-value:9.19E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.68|P-value:1.20E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:6.94|P-value:2.91E-12 ID:SGTC_349|Compound:k015-0014|FD-Score:3.40|P-value:3.85E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.27|P-value:1.19E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.22|P-value:1.50E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.77|P-value:9.49E-5 ID:SGTC_442|Compound:cape|FD-Score:-3.52|P-value:2.21E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:-4.25|P-value:1.13E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:3.39|P-value:3.97E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.69|P-value:1.33E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.79|P-value:8.83E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.49|P-value:2.77E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.66|P-value:1.47E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.28|P-value:6.01E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.23|P-value:6.26E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.22|P-value:1.47E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.43|P-value:5.90E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.73|P-value:9.76E-5 ID:SGTC_3082|Compound:9117008|FD-Score:6.15|P-value:5.52E-10 ID:SGTC_3087|Compound:9117406|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.32|P-value:9.49E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:4.01|P-value:3.64E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:3.15|P-value:9.19E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.68|P-value:1.20E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:6.94|P-value:2.91E-12 ID:SGTC_349|Compound:k015-0014|FD-Score:3.40|P-value:3.85E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.27|P-value:1.19E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.22|P-value:1.50E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.77|P-value:9.49E-5 ID:SGTC_442|Compound:cape|FD-Score:-3.52|P-value:2.21E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:-4.25|P-value:1.13E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:3.39|P-value:3.97E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.69|P-value:1.33E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.79|P-value:8.83E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.49|P-value:2.77E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.66|P-value:1.47E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.28|P-value:6.01E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.23|P-value:6.26E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.22|P-value:1.47E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.43|P-value:5.90E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.73|P-value:9.76E-5 ID:SGTC_3082|Compound:9117008|FD-Score:6.15|P-value:5.52E-10 ID:SGTC_3087|Compound:9117406|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.32|P-value:9.49E-6

Top fitness defect scores for YGR279C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_348 k064-0012 6.94 10.7 µM 2.91E-12 60S ribosome export 3 1.91E-12
2 SGTC_3082 9117008 6.15 49.5 µM 5.52E-10 4 3.92E-10
3 SGTC_2800 7887935 4.43 81.8 µM 5.90E-6 RPP1 & pyrimidine depletion 15 4.81E-6
4 SGTC_3286 9117135 4.32 37.2 µM 9.49E-6 7 7.81E-6
5 SGTC_401 neomycin 4.27 50.0 µM 1.19E-5 6 9.86E-6
6 SGTC_2776 terbinafine 4.22 19.9 µM 1.47E-5 cell wall signaling 49 1.22E-5
7 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 4.22 8.0 µM 1.50E-5 22 1.24E-5
8 SGTC_6 0844-0013 4.01 19.8 µM 3.64E-5 82 3.06E-5
9 SGTC_916 4466-0038 3.79 42.0 nM 8.83E-5 cell wall 75 7.52E-5
10 SGTC_437 s-farnesyl-l-cysteine methyl ester 3.77 6.7 µM 9.49E-5 15 8.09E-5
11 SGTC_3087 9117406 3.72 49.5 µM 1.14E-4 24 9.78E-5
12 SGTC_706 4262-0057 3.69 46.9 µM 1.33E-4 fatty acid desaturase (OLE1) 45 1.14E-4
13 SGTC_3113 9123498 3.67 49.5 µM 1.40E-4 15 1.20E-4
14 SGTC_1676 st018489 3.66 23.4 µM 1.47E-4 60S ribosome export 47 1.26E-4
15 SGTC_2168 5727979 3.57 200.0 µM 2.03E-4 28 1.76E-4
16 SGTC_1197 1601-0112 3.49 267.0 µM 2.77E-4 31 2.41E-4
17 SGTC_349 k015-0014 3.40 24.0 µM 3.85E-4 41 3.36E-4
18 SGTC_681 1642-0006 3.39 26.6 µM 3.97E-4 7 3.46E-4
19 SGTC_2017 5132927 3.28 60.6 µM 6.01E-4 59 5.28E-4
20 SGTC_98 0074-0023 3.15 107.7 µM 9.19E-4 Golgi 76 8.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.78E-18 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.129 6.98E-14 YLL058W_p YLL058W_p hom Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
0.118 6.30E-12 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.110 1.94E-10 YJR154W_p YJR154W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.105 1.01E-9 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.101 5.65E-9 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.100 6.26E-9 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.100 7.33E-9 YLR303W MET17 hom Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
0.099 1.07E-8 YDR053W_d YDR053W_d het Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
0.098 1.13E-8 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.093 6.58E-8 YGR176W_d YGR176W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.34E-8 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.091 1.20E-7 YPR196W_p YPR196W_p hom Putative maltose-responsive transcription factor
0.091 1.38E-7 YOL107W_p YOL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.088 3.21E-7 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis