YGR280C / PXR1

Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR280C / PXR1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:4.53|P-value:1.21E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.54|P-value:1.12E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.29|P-value:2.64E-11 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.17|P-value:4.80E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.50|P-value:1.37E-6 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.13|P-value:5.66E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.13|P-value:5.69E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.37|P-value:2.28E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.00|P-value:8.99E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.01|P-value:8.51E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.25|P-value:3.57E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.74|P-value:5.00E-5 ID:SGTC_1667|Compound:st014849|FD-Score:3.20|P-value:4.40E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.09|P-value:6.47E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.64|P-value:7.47E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.48|P-value:1.43E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.38|P-value:2.20E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.62|P-value:7.94E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-3.22|P-value:3.96E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.16|P-value:5.06E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.91|P-value:2.29E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.37|P-value:2.24E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.43|P-value:1.72E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.31|P-value:2.87E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.82|P-value:3.39E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.02|P-value:8.47E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.09|P-value:6.47E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.15|P-value:5.14E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.53|P-value:1.21E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.54|P-value:1.12E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.29|P-value:2.64E-11 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.17|P-value:4.80E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.50|P-value:1.37E-6 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.13|P-value:5.66E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.13|P-value:5.69E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.37|P-value:2.28E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.00|P-value:8.99E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.01|P-value:8.51E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.25|P-value:3.57E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.74|P-value:5.00E-5 ID:SGTC_1667|Compound:st014849|FD-Score:3.20|P-value:4.40E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.09|P-value:6.47E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.64|P-value:7.47E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.48|P-value:1.43E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.38|P-value:2.20E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.62|P-value:7.94E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-3.22|P-value:3.96E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.16|P-value:5.06E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.91|P-value:2.29E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.37|P-value:2.24E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.43|P-value:1.72E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.31|P-value:2.87E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.82|P-value:3.39E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.02|P-value:8.47E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.09|P-value:6.47E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.15|P-value:5.14E-4

Top fitness defect scores for YGR280C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_21 0849-0113 4.53 23.0 µM 1.21E-6 7 2.99E-6 0.52
2 SGTC_258 haloperidol 4.50 50.8 µM 1.37E-6 fatty acid desaturase (OLE1) 13 3.35E-6 6.33E-5
3 SGTC_2501 sodium tetradecyl sulfate 3.91 13.4 µM 2.29E-5 6 4.53E-5 0.40
4 SGTC_1656 st012921 3.74 11.0 µM 5.00E-5 3 9.33E-5 0.00
5 SGTC_119 0121-0043 3.54 24.8 µM 1.12E-4 mitochondrial stress 31 1.97E-4 0.05
6 SGTC_2174 5790901 3.48 200.0 µM 1.43E-4 tubulin folding & SWR complex 12 2.47E-4 0.09
7 SGTC_2753 fluvastatin 3.47 17.1 µM 1.53E-4 azole & statin 11 2.63E-4 0.09
8 SGTC_2270 7924575 3.38 90.9 µM 2.20E-4 RPP1 & pyrimidine depletion 9 3.68E-4 0.04
9 SGTC_2506 ethyl hematommate 3.37 54.2 µM 2.24E-4 RPP1 & pyrimidine depletion 8 3.74E-4 0.08
10 SGTC_641 4092-0595 3.37 30.0 µM 2.28E-4 15 3.79E-4 0.03
11 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.31 70.0 µM 2.87E-4 redox potentiating 14 4.71E-4 0.02
12 SGTC_1011 4112-3381 3.25 17.4 µM 3.57E-4 6 5.76E-4 0.05
13 SGTC_1667 st014849 3.20 34.6 µM 4.40E-4 Golgi 6 6.99E-4 0.09
14 SGTC_2471 5466956 3.16 24.8 µM 5.06E-4 mitochondrial processes 29 7.95E-4 0.14
15 SGTC_261 5-fluorouridine 3.13 15.4 µM 5.66E-4 exosome 19 8.82E-4 0.00
16 SGTC_506 n9-isopropylolomoucine 3.13 153.0 µM 5.69E-4 7 8.88E-4 0.03
17 SGTC_2918 7977171 3.09 22.1 µM 6.47E-4 12 9.99E-4 0.10
18 SGTC_1669 st015249 3.09 58.4 µM 6.47E-4 Golgi 7 0.00100 0.03
19 SGTC_2761 levamisole 3.02 97.9 µM 8.47E-4 6 0.00128 0.05
20 SGTC_943 3253-1379 3.00 105.0 µM 8.99E-4 19 0.00136 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.02E-19 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.155 1.77E-19 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.153 4.37E-19 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.145 2.97E-17 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.143 9.97E-17 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.141 1.84E-16 YJR076C CDC11 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.124 4.84E-13 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.124 5.78E-13 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.113 4.79E-11 YMR292W GOT1 hom Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
0.112 8.19E-11 YJL173C RFA3 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.110 1.59E-10 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.110 1.93E-10 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.108 4.20E-10 YGR140W CBF2 het Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
0.105 9.56E-10 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.105 1.06E-9 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress