YGR281W / YOR1

Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR281W / YOR1

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:6.29|P-value:2.70E-9 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.91|P-value:1.52E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.70|P-value:2.93E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.55|P-value:5.19E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.42|P-value:2.06E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.58|P-value:1.14E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.69|P-value:3.02E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.09|P-value:1.26E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.37|P-value:8.76E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.07|P-value:7.76E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.37|P-value:8.76E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.66|P-value:3.39E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.44|P-value:6.98E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.50|P-value:5.70E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.33|P-value:9.72E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:6.65|P-value:3.37E-10 ID:SGTC_984|Compound:1492-0255|FD-Score:4.05|P-value:8.56E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.66|P-value:3.40E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.12|P-value:6.44E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.61|P-value:4.03E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:5.67|P-value:7.26E-8 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.44|P-value:7.00E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.86|P-value:1.68E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.36|P-value:8.85E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.34|P-value:9.60E-4 ID:SGTC_1970|Compound:st070122|FD-Score:4.18|P-value:5.12E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.72|P-value:2.73E-4 ID:SGTC_1988|Compound:st071872|FD-Score:-4.32|P-value:3.27E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.60|P-value:4.18E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.66|P-value:3.37E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.10|P-value:1.12E-6 ID:SGTC_2306|Compound:7482397|FD-Score:-4.35|P-value:2.96E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.41|P-value:7.75E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.56|P-value:4.71E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.93|P-value:1.31E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.26|P-value:4.10E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.99|P-value:1.06E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.59|P-value:4.58E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:6.06|P-value:9.56E-9 ID:SGTC_2645|Compound:abamectin|FD-Score:4.25|P-value:3.91E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.55|P-value:4.93E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.02|P-value:9.41E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.68|P-value:3.14E-4 ID:SGTC_2864|Compound:9034755|FD-Score:4.74|P-value:5.33E-6 ID:SGTC_2870|Compound:9038528|FD-Score:3.51|P-value:5.60E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.60|P-value:4.43E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.88|P-value:1.57E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.89|P-value:1.53E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.40|P-value:7.90E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.57|P-value:4.57E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.40|P-value:8.60E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:6.29|P-value:2.70E-9 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.91|P-value:1.52E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.70|P-value:2.93E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.55|P-value:5.19E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.42|P-value:2.06E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.58|P-value:1.14E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.69|P-value:3.02E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.09|P-value:1.26E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.37|P-value:8.76E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.07|P-value:7.76E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.37|P-value:8.76E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.66|P-value:3.39E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.44|P-value:6.98E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.50|P-value:5.70E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.33|P-value:9.72E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:6.65|P-value:3.37E-10 ID:SGTC_984|Compound:1492-0255|FD-Score:4.05|P-value:8.56E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.66|P-value:3.40E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.12|P-value:6.44E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.61|P-value:4.03E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:5.67|P-value:7.26E-8 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.44|P-value:7.00E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.86|P-value:1.68E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.36|P-value:8.85E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.34|P-value:9.60E-4 ID:SGTC_1970|Compound:st070122|FD-Score:4.18|P-value:5.12E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.72|P-value:2.73E-4 ID:SGTC_1988|Compound:st071872|FD-Score:-4.32|P-value:3.27E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.60|P-value:4.18E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.66|P-value:3.37E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.10|P-value:1.12E-6 ID:SGTC_2306|Compound:7482397|FD-Score:-4.35|P-value:2.96E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.41|P-value:7.75E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.56|P-value:4.71E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.93|P-value:1.31E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-4.26|P-value:4.10E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.99|P-value:1.06E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.59|P-value:4.58E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:6.06|P-value:9.56E-9 ID:SGTC_2645|Compound:abamectin|FD-Score:4.25|P-value:3.91E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.55|P-value:4.93E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.02|P-value:9.41E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.68|P-value:3.14E-4 ID:SGTC_2864|Compound:9034755|FD-Score:4.74|P-value:5.33E-6 ID:SGTC_2870|Compound:9038528|FD-Score:3.51|P-value:5.60E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.60|P-value:4.43E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.88|P-value:1.57E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.89|P-value:1.53E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.40|P-value:7.90E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.57|P-value:4.57E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.40|P-value:8.60E-4

Top fitness defect scores for YGR281W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_956 1185-0240 6.65 191.0 µM 3.37E-10 6 1.44E-11
2 SGTC_42 0133-0086 6.29 60.6 µM 2.70E-9 2 1.61E-10
3 SGTC_2628 lathosterol 6.06 100.0 µM 9.56E-9 6 6.96E-10
4 SGTC_1397 3532-0190 5.67 20.1 µM 7.26E-8 1 7.29E-9
5 SGTC_2232 chlorophetanol 5.10 41.5 µM 1.12E-6 TRP & mitochondrial translation 75 1.74E-7
6 SGTC_2864 9034755 4.74 47.6 µM 5.33E-6 3 1.05E-6
7 SGTC_91 0417-1751 4.42 58.4 µM 2.06E-5 Golgi 39 5.03E-6
8 SGTC_2645 abamectin 4.25 100.0 µM 3.91E-5 heme requiring 23 1.05E-5
9 SGTC_1970 st070122 4.18 35.8 µM 5.12E-5 TSC3-RPN4 22 1.43E-5
10 SGTC_1255 0566-0045 4.12 221.0 µM 6.44E-5 excess fatty acid 26 1.87E-5
11 SGTC_451 chloral hydrate 4.07 100.0 µM 7.76E-5 46 2.32E-5
12 SGTC_984 1492-0255 4.05 2.9 µM 8.56E-5 SWF1 & branched chain AA biosynthesis 25 2.60E-5
13 SGTC_2679 rapamycin 4.02 1.0 nM 9.41E-5 140 2.90E-5
14 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.99 66.7 µM 1.06E-4 22 3.31E-5
15 SGTC_2434 5670830 3.93 169.9 µM 1.31E-4 26 4.25E-5
16 SGTC_2993 9054257 3.89 71.4 µM 1.53E-4 fatty acid desaturase (OLE1) 45 5.07E-5
17 SGTC_2951 9072950 3.88 58.1 µM 1.57E-4 ERG2 24 5.23E-5
18 SGTC_1637 st007924 3.86 17.4 µM 1.68E-4 21 5.66E-5
19 SGTC_1979 st071809 3.72 45.3 µM 2.73E-4 RPP1 & pyrimidine depletion 20 9.89E-5
20 SGTC_54 0159-0055 3.70 9.0 µM 2.93E-4 ERG2 51 1.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 7.73E-9 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.088 3.01E-7 YJL199C_d MBB1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
0.086 5.82E-7 YHR018C ARG4 hom Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
0.081 2.90E-6 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.080 3.52E-6 YPR067W ISA2 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
0.079 5.04E-6 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.078 6.12E-6 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.077 8.28E-6 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.077 8.97E-6 YFR034C PHO4 hom Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability
0.076 9.94E-6 YOR069W VPS5 hom Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes
0.075 1.29E-5 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.072 2.89E-5 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.071 3.95E-5 YBR238C YBR238C hom Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
0.070 4.50E-5 YOR136W IDH2 hom Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
0.070 4.69E-5 YOR367W SCP1 hom Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin