YGR282C / BGL2

Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR282C / BGL2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.33|P-value:8.45E-11 ID:SGTC_79|Compound:0052-0007|FD-Score:4.09|P-value:1.88E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:3.14|P-value:7.84E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.20|P-value:6.43E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.27|P-value:4.88E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.22|P-value:5.82E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:4.23|P-value:1.00E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.61|P-value:1.37E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.32|P-value:6.62E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:3.20|P-value:6.46E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.39|P-value:2.80E-8 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:4.37|P-value:5.38E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.20|P-value:6.31E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.49|P-value:2.17E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.14|P-value:1.49E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.09|P-value:9.42E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.29|P-value:4.67E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.65|P-value:1.40E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:5.44|P-value:2.02E-8 ID:SGTC_858|Compound:0438-0351|FD-Score:3.18|P-value:6.71E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.12|P-value:1.65E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:4.56|P-value:2.15E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.13|P-value:8.17E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.28|P-value:4.76E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.73|P-value:7.92E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.16|P-value:1.36E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.07|P-value:9.28E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.16|P-value:7.19E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.31|P-value:4.31E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_1776|Compound:st049249|FD-Score:6.55|P-value:1.92E-11 ID:SGTC_1782|Compound:st039423|FD-Score:3.11|P-value:8.67E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-4.23|P-value:9.16E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.12|P-value:1.66E-5 ID:SGTC_1791|Compound:st048313|FD-Score:-3.25|P-value:4.89E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.22|P-value:5.91E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.13|P-value:8.18E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-3.15|P-value:7.13E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.07|P-value:9.23E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.73|P-value:8.42E-5 ID:SGTC_2363|Compound:9053361|FD-Score:4.00|P-value:2.79E-5 ID:SGTC_2382|Compound:9035899|FD-Score:5.04|P-value:1.86E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.91|P-value:3.63E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.43|P-value:2.72E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.26|P-value:4.83E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.46|P-value:2.45E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.20|P-value:5.90E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.46|P-value:3.49E-6 ID:SGTC_2825|Compound:7998094|FD-Score:6.90|P-value:1.68E-12 ID:SGTC_2831|Compound:7999036|FD-Score:-3.07|P-value:9.21E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.30|P-value:4.19E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.90|P-value:4.30E-5 ID:SGTC_2961|Compound:9083290|FD-Score:3.10|P-value:9.11E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.12|P-value:7.76E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.78|P-value:6.42E-5 ID:SGTC_3081|Compound:9117243|FD-Score:-3.12|P-value:7.84E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-4.36|P-value:5.12E-6 ID:SGTC_3085|Compound:9117376|FD-Score:3.43|P-value:2.76E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.10|P-value:1.33E-7 ID:SGTC_3150|Compound:9097574|FD-Score:3.10|P-value:8.96E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.04|P-value:2.32E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.89|P-value:4.46E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.33|P-value:8.45E-11 ID:SGTC_79|Compound:0052-0007|FD-Score:4.09|P-value:1.88E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:3.14|P-value:7.84E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.20|P-value:6.43E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.27|P-value:4.88E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.22|P-value:5.82E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:4.23|P-value:1.00E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.61|P-value:1.37E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.32|P-value:6.62E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:3.20|P-value:6.46E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.39|P-value:2.80E-8 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:4.37|P-value:5.38E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.20|P-value:6.31E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.49|P-value:2.17E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.14|P-value:1.49E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.09|P-value:9.42E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.29|P-value:4.67E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.65|P-value:1.40E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:5.44|P-value:2.02E-8 ID:SGTC_858|Compound:0438-0351|FD-Score:3.18|P-value:6.71E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.12|P-value:1.65E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:4.56|P-value:2.15E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.13|P-value:8.17E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.28|P-value:4.76E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.73|P-value:7.92E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.16|P-value:1.36E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.07|P-value:9.28E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.16|P-value:7.19E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.31|P-value:4.31E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_1776|Compound:st049249|FD-Score:6.55|P-value:1.92E-11 ID:SGTC_1782|Compound:st039423|FD-Score:3.11|P-value:8.67E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-4.23|P-value:9.16E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.12|P-value:1.66E-5 ID:SGTC_1791|Compound:st048313|FD-Score:-3.25|P-value:4.89E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.22|P-value:5.91E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.13|P-value:8.18E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-3.15|P-value:7.13E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.07|P-value:9.23E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.73|P-value:8.42E-5 ID:SGTC_2363|Compound:9053361|FD-Score:4.00|P-value:2.79E-5 ID:SGTC_2382|Compound:9035899|FD-Score:5.04|P-value:1.86E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.91|P-value:3.63E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.43|P-value:2.72E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.26|P-value:4.83E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.46|P-value:2.45E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.20|P-value:5.90E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.46|P-value:3.49E-6 ID:SGTC_2825|Compound:7998094|FD-Score:6.90|P-value:1.68E-12 ID:SGTC_2831|Compound:7999036|FD-Score:-3.07|P-value:9.21E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.30|P-value:4.19E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.90|P-value:4.30E-5 ID:SGTC_2961|Compound:9083290|FD-Score:3.10|P-value:9.11E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.12|P-value:7.76E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.78|P-value:6.42E-5 ID:SGTC_3081|Compound:9117243|FD-Score:-3.12|P-value:7.84E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-4.36|P-value:5.12E-6 ID:SGTC_3085|Compound:9117376|FD-Score:3.43|P-value:2.76E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.10|P-value:1.33E-7 ID:SGTC_3150|Compound:9097574|FD-Score:3.10|P-value:8.96E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.04|P-value:2.32E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.89|P-value:4.46E-5

Top fitness defect scores for YGR282C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2825 7998094 6.90 58.4 µM 1.68E-12 fatty acid desaturase (OLE1) 7 2.58E-12
2 SGTC_1776 st049249 6.55 45.9 µM 1.92E-11 2 2.82E-11
3 SGTC_58 0957-0393 6.33 9.0 µM 8.45E-11 cell wall 190 1.21E-10
4 SGTC_840 0245-0196 5.44 390.0 µM 2.02E-8 2 2.61E-8
5 SGTC_369 0957-0393 5.39 4.5 µM 2.80E-8 cell wall signaling 6 3.60E-8
6 SGTC_3098 9119039 5.10 49.5 µM 1.33E-7 Golgi 14 1.67E-7
7 SGTC_2382 9035899 5.04 200.0 µM 1.86E-7 60S ribosome export 7 2.32E-7
8 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 4.91 200.0 µM 3.63E-7 5 4.46E-7
9 SGTC_836 0330-0104 4.65 1.4 µM 1.40E-6 7 1.68E-6
10 SGTC_880 0833-0487 4.56 87.2 µM 2.15E-6 mitochondrial processes 10 2.56E-6
11 SGTC_2726 cimetidine 4.46 79.3 µM 3.49E-6 5 4.13E-6
12 SGTC_414 piperonyl butoxide 4.37 100.0 µM 5.38E-6 3 6.31E-6
13 SGTC_312 4092-0653 4.32 6.8 µM 6.62E-6 ergosterol depletion effects on membrane 75 7.74E-6
14 SGTC_233 rapamycin 4.23 362.0 pM 1.00E-5 7 1.17E-5
15 SGTC_1207 2099-0101 4.16 141.0 µM 1.36E-5 14 1.57E-5
16 SGTC_710 3448-4187 4.14 58.0 µM 1.49E-5 fatty acid desaturase (OLE1) 53 1.71E-5
17 SGTC_863 0466-0191 4.12 129.0 µM 1.65E-5 cell wall 66 1.90E-5
18 SGTC_1789 tunicamycin 4.12 25.0 nM 1.66E-5 unfolded protein response 42 1.91E-5
19 SGTC_79 0052-0007 4.09 94.1 µM 1.88E-5 38 2.16E-5
20 SGTC_3152 9099253 4.04 49.5 µM 2.32E-5 NEO1-PIK1 123 2.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.91E-16 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.137 1.52E-15 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.129 5.62E-14 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.128 9.39E-14 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.125 3.22E-13 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.121 1.94E-12 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.120 2.72E-12 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.119 3.98E-12 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.119 4.09E-12 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.119 5.53E-12 YBR044C TCM62 hom Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
0.118 8.06E-12 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.116 1.87E-11 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.114 3.93E-11 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.113 5.51E-11 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.109 2.44E-10 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1