YGR283C

Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR283C / YGR283C

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:3.08|P-value:8.67E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.34|P-value:3.33E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.55|P-value:1.79E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.13|P-value:7.14E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.18|P-value:6.19E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.96|P-value:6.57E-10 ID:SGTC_935|Compound:2996-0153|FD-Score:3.64|P-value:1.05E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.05|P-value:9.33E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.16|P-value:6.36E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.87|P-value:4.07E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.10|P-value:7.94E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.03|P-value:2.05E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.64|P-value:1.03E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.10|P-value:7.87E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.61|P-value:1.36E-6 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.05|P-value:9.69E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.80|P-value:5.46E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.27|P-value:4.44E-4 ID:SGTC_1702|Compound:st027038|FD-Score:-3.04|P-value:9.85E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.85|P-value:4.47E-5 ID:SGTC_1720|Compound:st037298|FD-Score:3.46|P-value:2.11E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.80|P-value:5.50E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.17|P-value:6.19E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.05|P-value:9.78E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-3.24|P-value:4.94E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.54|P-value:1.59E-4 ID:SGTC_1906|Compound:st060206|FD-Score:5.14|P-value:8.27E-8 ID:SGTC_1961|Compound:st076550|FD-Score:4.52|P-value:2.05E-6 ID:SGTC_2001|Compound:4023502|FD-Score:3.05|P-value:9.55E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.87|P-value:3.99E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.25|P-value:4.69E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.22|P-value:5.19E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-3.87|P-value:4.14E-5 ID:SGTC_2383|Compound:9036125|FD-Score:3.59|P-value:1.27E-4 ID:SGTC_2433|Compound:5607874|FD-Score:4.01|P-value:2.26E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-3.13|P-value:7.28E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.13|P-value:7.20E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-4.12|P-value:1.39E-5 ID:SGTC_2894|Compound:9048625|FD-Score:5.43|P-value:1.62E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.10|P-value:7.91E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.70|P-value:8.11E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.47|P-value:2.03E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.32|P-value:3.63E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.38|P-value:2.87E-4 ID:SGTC_3151|Compound:9099821|FD-Score:6.08|P-value:3.02E-10 ID:SGTC_3159|Compound:9100096|FD-Score:3.06|P-value:9.07E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.79|P-value:5.61E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.74|P-value:7.01E-5 ID:SGTC_3319|Compound:9138450|FD-Score:5.61|P-value:5.74E-9 ID:SGTC_3327|Compound:9140648|FD-Score:-3.91|P-value:3.42E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.08|P-value:8.67E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.34|P-value:3.33E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.55|P-value:1.79E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.13|P-value:7.14E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.18|P-value:6.19E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.96|P-value:6.57E-10 ID:SGTC_935|Compound:2996-0153|FD-Score:3.64|P-value:1.05E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.05|P-value:9.33E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.16|P-value:6.36E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.87|P-value:4.07E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.10|P-value:7.94E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.03|P-value:2.05E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.64|P-value:1.03E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.10|P-value:7.87E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.61|P-value:1.36E-6 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.05|P-value:9.69E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.80|P-value:5.46E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.27|P-value:4.44E-4 ID:SGTC_1702|Compound:st027038|FD-Score:-3.04|P-value:9.85E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.85|P-value:4.47E-5 ID:SGTC_1720|Compound:st037298|FD-Score:3.46|P-value:2.11E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.80|P-value:5.50E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.17|P-value:6.19E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.05|P-value:9.78E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-3.24|P-value:4.94E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.54|P-value:1.59E-4 ID:SGTC_1906|Compound:st060206|FD-Score:5.14|P-value:8.27E-8 ID:SGTC_1961|Compound:st076550|FD-Score:4.52|P-value:2.05E-6 ID:SGTC_2001|Compound:4023502|FD-Score:3.05|P-value:9.55E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.87|P-value:3.99E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.25|P-value:4.69E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.22|P-value:5.19E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-3.87|P-value:4.14E-5 ID:SGTC_2383|Compound:9036125|FD-Score:3.59|P-value:1.27E-4 ID:SGTC_2433|Compound:5607874|FD-Score:4.01|P-value:2.26E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-3.13|P-value:7.28E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.13|P-value:7.20E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-4.12|P-value:1.39E-5 ID:SGTC_2894|Compound:9048625|FD-Score:5.43|P-value:1.62E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.10|P-value:7.91E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.70|P-value:8.11E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.47|P-value:2.03E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.32|P-value:3.63E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.38|P-value:2.87E-4 ID:SGTC_3151|Compound:9099821|FD-Score:6.08|P-value:3.02E-10 ID:SGTC_3159|Compound:9100096|FD-Score:3.06|P-value:9.07E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.79|P-value:5.61E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.74|P-value:7.01E-5 ID:SGTC_3319|Compound:9138450|FD-Score:5.61|P-value:5.74E-9 ID:SGTC_3327|Compound:9140648|FD-Score:-3.91|P-value:3.42E-5

Top fitness defect scores for YGR283C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3151 9099821 6.08 49.5 µM 3.02E-10 3 6.06E-10
2 SGTC_792 4534-1957 5.96 155.0 µM 6.57E-10 11 1.28E-9
3 SGTC_3319 9138450 5.61 16.8 µM 5.74E-9 4 1.04E-8
4 SGTC_2894 9048625 5.43 32.5 µM 1.62E-8 2 2.84E-8
5 SGTC_1906 st060206 5.14 94.7 µM 8.27E-8 6 1.37E-7
6 SGTC_1494 4358-1428 4.61 177.0 µM 1.36E-6 13 2.05E-6
7 SGTC_580 1123-0028 4.55 41.0 µM 1.79E-6 DNA damage response 18 2.67E-6
8 SGTC_1961 st076550 4.52 68.7 µM 2.05E-6 8 3.04E-6
9 SGTC_1252 0493-0875 4.03 34.8 µM 2.05E-5 26 2.82E-5
10 SGTC_2433 5607874 4.01 27.8 µM 2.26E-5 18 3.10E-5
11 SGTC_2002 4023503 3.87 131.0 µM 3.99E-5 mitochondrial processes 32 5.37E-5
12 SGTC_1108 betulinic acid 3.87 729.1 nM 4.07E-5 15 5.47E-5
13 SGTC_1539 benzyladenosine 3.80 56.0 µM 5.46E-5 20 7.25E-5
14 SGTC_1769 st044406 3.80 64.4 µM 5.50E-5 20 7.31E-5
15 SGTC_3199 9111318 3.79 49.5 µM 5.61E-5 25 7.45E-5
16 SGTC_2980 9014342 3.70 25.3 µM 8.11E-5 44 1.06E-4
17 SGTC_1337 1486-1011 3.64 40.3 µM 1.03E-4 25 1.35E-4
18 SGTC_935 2996-0153 3.64 430.0 µM 1.05E-4 PDR1 29 1.37E-4
19 SGTC_2383 9036125 3.59 200.0 µM 1.27E-4 8 1.64E-4
20 SGTC_1707 st032323 3.57 6.3 µM 1.39E-4 DNA damage response 76 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.88E-8 YER149C PEA2 hom Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
0.094 4.29E-8 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.094 4.41E-8 YMR172C-A_d YMR172C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 1.71E-7 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.088 3.61E-7 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.079 4.16E-6 YNL088W TOP2 het Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.078 6.88E-6 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.077 8.06E-6 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.076 9.79E-6 YPL038W MET31 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication
0.076 9.95E-6 YDL221W_d YDL221W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
0.076 1.18E-5 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.074 1.96E-5 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.074 2.00E-5 YLR336C SGD1 het Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
0.069 7.16E-5 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.068 8.15E-5 YHR139C-A_d YHR139C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data