YGR284C / ERV29

Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR284C / ERV29

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:4.63|P-value:2.98E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:5.94|P-value:3.18E-9 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.70|P-value:2.17E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:3.32|P-value:5.99E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.59|P-value:2.28E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.45|P-value:3.78E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.57|P-value:2.42E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.59|P-value:2.21E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.36|P-value:5.10E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.76|P-value:1.63E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.18|P-value:9.27E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.29|P-value:6.62E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:-3.19|P-value:8.96E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.23|P-value:8.14E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.60|P-value:2.23E-4 ID:SGTC_2050|Compound:5263056|FD-Score:6.74|P-value:2.24E-11 ID:SGTC_2058|Compound:5236698|FD-Score:-3.59|P-value:2.17E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.41|P-value:4.34E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.02|P-value:4.27E-5 ID:SGTC_2152|Compound:5568786|FD-Score:3.84|P-value:8.88E-5 ID:SGTC_2179|Compound:6298986|FD-Score:4.16|P-value:2.38E-5 ID:SGTC_2194|Compound:5927483|FD-Score:3.36|P-value:5.12E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.27|P-value:7.10E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.85|P-value:8.41E-5 ID:SGTC_2302|Compound:7771753|FD-Score:5.35|P-value:8.73E-8 ID:SGTC_2342|Compound:7990637|FD-Score:3.36|P-value:5.09E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.37|P-value:5.05E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.45|P-value:3.81E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-4.19|P-value:2.04E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.40|P-value:4.36E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.79|P-value:1.08E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.37|P-value:4.93E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.49|P-value:3.22E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.63|P-value:1.90E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.43|P-value:7.51E-6 ID:SGTC_3296|Compound:9122258|FD-Score:-4.03|P-value:4.03E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.50|P-value:3.12E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.68|P-value:1.61E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.63|P-value:2.98E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:5.94|P-value:3.18E-9 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.70|P-value:2.17E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:3.32|P-value:5.99E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.59|P-value:2.28E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.45|P-value:3.78E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.57|P-value:2.42E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.59|P-value:2.21E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.36|P-value:5.10E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.76|P-value:1.63E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.18|P-value:9.27E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.29|P-value:6.62E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:-3.19|P-value:8.96E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.23|P-value:8.14E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.60|P-value:2.23E-4 ID:SGTC_2050|Compound:5263056|FD-Score:6.74|P-value:2.24E-11 ID:SGTC_2058|Compound:5236698|FD-Score:-3.59|P-value:2.17E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.41|P-value:4.34E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.02|P-value:4.27E-5 ID:SGTC_2152|Compound:5568786|FD-Score:3.84|P-value:8.88E-5 ID:SGTC_2179|Compound:6298986|FD-Score:4.16|P-value:2.38E-5 ID:SGTC_2194|Compound:5927483|FD-Score:3.36|P-value:5.12E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.27|P-value:7.10E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.85|P-value:8.41E-5 ID:SGTC_2302|Compound:7771753|FD-Score:5.35|P-value:8.73E-8 ID:SGTC_2342|Compound:7990637|FD-Score:3.36|P-value:5.09E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.37|P-value:5.05E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.45|P-value:3.81E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-4.19|P-value:2.04E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.40|P-value:4.36E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.79|P-value:1.08E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.37|P-value:4.93E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.49|P-value:3.22E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.63|P-value:1.90E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.43|P-value:7.51E-6 ID:SGTC_3296|Compound:9122258|FD-Score:-4.03|P-value:4.03E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.50|P-value:3.12E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.68|P-value:1.61E-4

Top fitness defect scores for YGR284C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2050 5263056 6.74 171.0 µM 2.24E-11 fatty acid desaturase (OLE1) 8 7.91E-12
2 SGTC_173 1273-0061 5.94 2.7 µM 3.18E-9 mitochondrial stress 110 1.41E-9
3 SGTC_2302 7771753 5.35 200.0 µM 8.73E-8 18 4.48E-8
4 SGTC_1121 fusaric acid 4.76 630.5 nM 1.63E-6 21 9.54E-7
5 SGTC_265 mycophenolic acid 4.70 32.9 µM 2.17E-6 RPP1 & pyrimidine depletion 6 1.29E-6
6 SGTC_103 0844-0104 4.63 51.8 µM 2.98E-6 ERAD & cell cycle 113 1.79E-6
7 SGTC_3217 9129673 4.43 49.5 µM 7.51E-6 22 4.70E-6
8 SGTC_2179 6298986 4.16 200.0 µM 2.38E-5 heme requiring 18 1.57E-5
9 SGTC_2070 5230947 4.02 200.0 µM 4.27E-5 8 2.89E-5
10 SGTC_2290 7904846 3.85 200.0 µM 8.41E-5 24 5.86E-5
11 SGTC_2152 5568786 3.84 200.0 µM 8.88E-5 13 6.21E-5
12 SGTC_2561 acetosyringone 3.79 100.0 µM 1.08E-4 31 7.62E-5
13 SGTC_1097 itavastatin 3.75 7.2 µM 1.26E-4 azole & statin 27 8.98E-5
14 SGTC_3326 9140064 3.68 16.4 µM 1.61E-4 27 1.16E-4
15 SGTC_1523 st012844 3.67 44.7 µM 1.69E-4 60S ribosome export 30 1.22E-4
16 SGTC_1613 st002381 3.60 52.1 µM 2.23E-4 31 1.62E-4
17 SGTC_598 3937-0236 3.59 20.2 µM 2.28E-4 ERG2 39 1.66E-4
18 SGTC_1016 4226-1401 3.57 38.0 µM 2.42E-4 RNA pol III & RNase P/MRP 28 1.77E-4
19 SGTC_1146 3579-1023 3.53 7.0 µM 2.84E-4 29 2.09E-4
20 SGTC_3302 9125395 3.50 16.4 µM 3.12E-4 25 2.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.71E-14 YBR063C_p YBR063C_p hom Putative protein of unknown function; YBR063C is not an essential gene
0.125 3.23E-13 YOR232W MGE1 het Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
0.117 9.57E-12 YOL069W NUF2 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.117 1.28E-11 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.114 3.63E-11 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
0.111 1.13E-10 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.111 1.33E-10 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.109 2.28E-10 YPL204W HRR25 het Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.108 2.92E-10 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.101 4.21E-9 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.100 5.70E-9 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.100 7.32E-9 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.099 7.99E-9 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.096 2.63E-8 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.095 3.94E-8 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog