HIPHOP chemogenomics database
YGR287C / IMA1 
Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGR287C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.127 | 1.26E-13 | YJR154W_p | YJR154W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
| 0.109 | 2.10E-10 | YER032W | FIR1 | hom | Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate |
| 0.091 | 1.26E-7 | YMR020W | FMS1 | hom | Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis |
| 0.088 | 3.81E-7 | YGL256W | ADH4 | hom | Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency |
| 0.086 | 5.23E-7 | YPR005C | HAL1 | hom | Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p |
| 0.084 | 1.01E-6 | YLR341W | SPO77 | hom | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis |
| 0.079 | 4.22E-6 | YOR077W | RTS2 | het | Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication |
| 0.078 | 6.78E-6 | YDL188C | PPH22 | hom | Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication |
| 0.077 | 8.47E-6 | YNL179C_d | YNL179C_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance |
| 0.074 | 1.89E-5 | YER118C | SHO1 | hom | Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p |
| 0.073 | 2.17E-5 | YDR105C | TMS1 | hom | Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance |
| 0.073 | 2.56E-5 | YKR105C_p | VBA5_p | hom | Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p |
| 0.070 | 5.42E-5 | YER085C_p | YER085C_p | hom | Putative protein of unknown function |
| 0.068 | 8.46E-5 | YNR062C_p | YNR062C_p | hom | Putative membrane protein of unknown function |
| 0.067 | 9.42E-5 | YAL031C | GIP4 | hom | Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate |