YGR287C / IMA1

Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR287C / IMA1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.50|P-value:1.97E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.26|P-value:4.39E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.81|P-value:5.26E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.63|P-value:1.07E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.40|P-value:3.66E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.14|P-value:7.54E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-3.23|P-value:4.88E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.43|P-value:2.56E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.18|P-value:5.81E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.30|P-value:4.23E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.18|P-value:6.41E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.44|P-value:2.45E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.40|P-value:2.88E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.56|P-value:1.88E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.25|P-value:4.96E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.05|P-value:9.39E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:6.77|P-value:3.35E-12 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.12|P-value:7.86E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.36|P-value:3.32E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.80|P-value:5.96E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.91|P-value:3.82E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.14|P-value:7.54E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.16|P-value:6.85E-4 ID:SGTC_1761|Compound:st044296|FD-Score:4.42|P-value:3.85E-6 ID:SGTC_1827|Compound:berberine|FD-Score:3.20|P-value:6.06E-4 ID:SGTC_1847|Compound:st056231|FD-Score:7.29|P-value:7.39E-14 ID:SGTC_1853|Compound:st056710|FD-Score:3.11|P-value:8.37E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.07|P-value:1.87E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.91|P-value:3.75E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-5.70|P-value:3.29E-9 ID:SGTC_2022|Compound:5136654|FD-Score:3.96|P-value:3.01E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.07|P-value:9.52E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.08|P-value:9.13E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.28|P-value:4.46E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.33|P-value:3.71E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.21|P-value:5.71E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.39|P-value:3.88E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.18|P-value:1.03E-5 ID:SGTC_2421|Compound:5690543|FD-Score:4.56|P-value:1.89E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:3.51|P-value:1.93E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.34|P-value:3.59E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.33|P-value:3.82E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.07|P-value:9.33E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.07|P-value:1.92E-5 ID:SGTC_2797|Compound:7859098|FD-Score:3.34|P-value:3.62E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.57|P-value:1.49E-4 ID:SGTC_2826|Compound:7992541|FD-Score:5.61|P-value:6.57E-9 ID:SGTC_2841|Compound:9004761|FD-Score:4.42|P-value:3.74E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.37|P-value:4.78E-6 ID:SGTC_2950|Compound:9072895|FD-Score:4.60|P-value:1.57E-6 ID:SGTC_3048|Compound:9093155|FD-Score:-3.50|P-value:1.79E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.10|P-value:1.66E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.67|P-value:1.01E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.24|P-value:5.22E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.39|P-value:4.29E-6 ID:SGTC_3200|Compound:9114385|FD-Score:-4.83|P-value:4.40E-7 ID:SGTC_3213|Compound:9129884|FD-Score:4.24|P-value:8.58E-6 ID:SGTC_3249|Compound:9135183|FD-Score:3.08|P-value:9.16E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.50|P-value:1.97E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.26|P-value:4.39E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.81|P-value:5.26E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.63|P-value:1.07E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.40|P-value:3.66E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.14|P-value:7.54E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-3.23|P-value:4.88E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.43|P-value:2.56E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.18|P-value:5.81E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.30|P-value:4.23E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.18|P-value:6.41E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.44|P-value:2.45E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.40|P-value:2.88E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.56|P-value:1.88E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.25|P-value:4.96E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.05|P-value:9.39E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:6.77|P-value:3.35E-12 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.12|P-value:7.86E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.36|P-value:3.32E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.80|P-value:5.96E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.91|P-value:3.82E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.14|P-value:7.54E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.16|P-value:6.85E-4 ID:SGTC_1761|Compound:st044296|FD-Score:4.42|P-value:3.85E-6 ID:SGTC_1827|Compound:berberine|FD-Score:3.20|P-value:6.06E-4 ID:SGTC_1847|Compound:st056231|FD-Score:7.29|P-value:7.39E-14 ID:SGTC_1853|Compound:st056710|FD-Score:3.11|P-value:8.37E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.07|P-value:1.87E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.91|P-value:3.75E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-5.70|P-value:3.29E-9 ID:SGTC_2022|Compound:5136654|FD-Score:3.96|P-value:3.01E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.07|P-value:9.52E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.08|P-value:9.13E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.28|P-value:4.46E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.33|P-value:3.71E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.21|P-value:5.71E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.39|P-value:3.88E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.18|P-value:1.03E-5 ID:SGTC_2421|Compound:5690543|FD-Score:4.56|P-value:1.89E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:3.51|P-value:1.93E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.34|P-value:3.59E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.33|P-value:3.82E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.07|P-value:9.33E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.07|P-value:1.92E-5 ID:SGTC_2797|Compound:7859098|FD-Score:3.34|P-value:3.62E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.57|P-value:1.49E-4 ID:SGTC_2826|Compound:7992541|FD-Score:5.61|P-value:6.57E-9 ID:SGTC_2841|Compound:9004761|FD-Score:4.42|P-value:3.74E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.37|P-value:4.78E-6 ID:SGTC_2950|Compound:9072895|FD-Score:4.60|P-value:1.57E-6 ID:SGTC_3048|Compound:9093155|FD-Score:-3.50|P-value:1.79E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.10|P-value:1.66E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.67|P-value:1.01E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.24|P-value:5.22E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.39|P-value:4.29E-6 ID:SGTC_3200|Compound:9114385|FD-Score:-4.83|P-value:4.40E-7 ID:SGTC_3213|Compound:9129884|FD-Score:4.24|P-value:8.58E-6 ID:SGTC_3249|Compound:9135183|FD-Score:3.08|P-value:9.16E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.63|P-value:1.20E-4

Top fitness defect scores for YGR287C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1847 st056231 7.29 15.0 µM 7.39E-14 4 1.59E-13
2 SGTC_1335 1486-0900 6.77 202.0 µM 3.35E-12 7 6.46E-12
3 SGTC_2826 7992541 5.61 19.5 µM 6.57E-9 4 1.02E-8
4 SGTC_2950 9072895 4.60 21.5 µM 1.57E-6 21 2.10E-6
5 SGTC_1158 4092-0494 4.56 91.8 µM 1.88E-6 10 2.50E-6
6 SGTC_2421 5690543 4.56 90.7 µM 1.89E-6 9 2.51E-6
7 SGTC_2841 9004761 4.42 39.0 µM 3.74E-6 amide catabolism 14 4.89E-6
8 SGTC_1761 st044296 4.42 37.0 µM 3.85E-6 7 5.02E-6
9 SGTC_3159 9100096 4.39 49.5 µM 4.29E-6 13 5.59E-6
10 SGTC_2920 7982904 4.37 15.8 µM 4.78E-6 12 6.20E-6
11 SGTC_3213 9129884 4.24 49.5 µM 8.58E-6 17 1.10E-5
12 SGTC_3050 9093513 4.10 49.5 µM 1.66E-5 15 2.09E-5
13 SGTC_1921 5740136 4.07 50.0 µM 1.87E-5 TRP & mitochondrial translation 52 2.34E-5
14 SGTC_2789 5281112 4.07 71.4 µM 1.92E-5 34 2.39E-5
15 SGTC_2022 5136654 3.96 200.0 µM 3.01E-5 22 3.72E-5
16 SGTC_1934 st074720 3.91 32.6 µM 3.75E-5 59 4.61E-5
17 SGTC_1576 erythromycin ethylsuccinate 3.91 23.2 µM 3.82E-5 20 4.69E-5
18 SGTC_1495 4469-0029 3.80 237.0 µM 5.96E-5 116 7.22E-5
19 SGTC_3082 9117008 3.67 49.5 µM 1.01E-4 20 1.20E-4
20 SGTC_3260 9137109 3.63 49.5 µM 1.20E-4 60S ribosome export 14 1.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.26E-13 YJR154W_p YJR154W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.109 2.10E-10 YER032W FIR1 hom Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
0.091 1.26E-7 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.088 3.81E-7 YGL256W ADH4 hom Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
0.086 5.23E-7 YPR005C HAL1 hom Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
0.084 1.01E-6 YLR341W SPO77 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.079 4.22E-6 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.078 6.78E-6 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.077 8.47E-6 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.074 1.89E-5 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.073 2.17E-5 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.073 2.56E-5 YKR105C_p VBA5_p hom Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p
0.070 5.42E-5 YER085C_p YER085C_p hom Putative protein of unknown function
0.068 8.46E-5 YNR062C_p YNR062C_p hom Putative membrane protein of unknown function
0.067 9.42E-5 YAL031C GIP4 hom Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate