YGR288W / MAL13

MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR288W / MAL13

Click on Significant Values for Screen Details ID:SGTC_117|Compound:lucigenin|FD-Score:4.03|P-value:1.72E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.28|P-value:3.18E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.22|P-value:4.72E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.20|P-value:7.88E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:3.19|P-value:5.25E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.76|P-value:5.59E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.32|P-value:2.74E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:5.73|P-value:1.81E-9 ID:SGTC_336|Compound:4111-0029|FD-Score:3.04|P-value:9.14E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:5.16|P-value:5.56E-8 ID:SGTC_555|Compound:4296-0685|FD-Score:3.03|P-value:9.36E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.17|P-value:5.78E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.63|P-value:9.60E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.05|P-value:8.68E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.75|P-value:5.19E-7 ID:SGTC_856|Compound:0433-0016|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:4.05|P-value:1.54E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.36|P-value:2.79E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.49|P-value:1.65E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.93|P-value:2.72E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.51|P-value:1.73E-6 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.40|P-value:2.41E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.96|P-value:1.66E-7 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.55|P-value:1.34E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.06|P-value:8.31E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.55|P-value:1.33E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.91|P-value:2.87E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.94|P-value:2.59E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.18|P-value:4.61E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.32|P-value:3.29E-4 ID:SGTC_1716|Compound:st033144|FD-Score:6.90|P-value:5.79E-13 ID:SGTC_1717|Compound:st033143|FD-Score:-3.83|P-value:3.42E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.36|P-value:2.36E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.05|P-value:8.79E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.03|P-value:9.28E-4 ID:SGTC_1904|Compound:st060225|FD-Score:6.67|P-value:3.02E-12 ID:SGTC_2132|Compound:5317594|FD-Score:3.17|P-value:5.75E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.99|P-value:2.01E-5 ID:SGTC_2229|Compound:7354935|FD-Score:4.31|P-value:4.69E-6 ID:SGTC_2371|Compound:9071574|FD-Score:5.04|P-value:1.04E-7 ID:SGTC_2385|Compound:9074692|FD-Score:-4.28|P-value:4.20E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-2.99|P-value:9.12E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.55|P-value:1.39E-6 ID:SGTC_2709|Compound:st078560|FD-Score:3.80|P-value:4.66E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.21|P-value:4.96E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.13|P-value:5.61E-4 ID:SGTC_2882|Compound:9058044|FD-Score:4.55|P-value:1.46E-6 ID:SGTC_2911|Compound:7942208|FD-Score:5.52|P-value:6.65E-9 ID:SGTC_2923|Compound:7992654|FD-Score:5.83|P-value:9.77E-10 ID:SGTC_2927|Compound:9011802|FD-Score:3.13|P-value:6.49E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.09|P-value:7.53E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.12|P-value:6.72E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-4.61|P-value:8.43E-7 ID:SGTC_3070|Compound:9117005|FD-Score:5.57|P-value:4.86E-9 ID:SGTC_3102|Compound:9121669|FD-Score:6.48|P-value:1.22E-11 ID:SGTC_3105|Compound:9121040|FD-Score:3.24|P-value:4.48E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.23|P-value:3.79E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.14|P-value:6.43E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.50|P-value:1.61E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.03|P-value:1.72E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.28|P-value:3.18E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.22|P-value:4.72E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.20|P-value:7.88E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:3.19|P-value:5.25E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.76|P-value:5.59E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.32|P-value:2.74E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:5.73|P-value:1.81E-9 ID:SGTC_336|Compound:4111-0029|FD-Score:3.04|P-value:9.14E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:5.16|P-value:5.56E-8 ID:SGTC_555|Compound:4296-0685|FD-Score:3.03|P-value:9.36E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.17|P-value:5.78E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.63|P-value:9.60E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.05|P-value:8.68E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.75|P-value:5.19E-7 ID:SGTC_856|Compound:0433-0016|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:4.05|P-value:1.54E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.36|P-value:2.79E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.49|P-value:1.65E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.93|P-value:2.72E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.51|P-value:1.73E-6 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.40|P-value:2.41E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.96|P-value:1.66E-7 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.55|P-value:1.34E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.06|P-value:8.31E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.55|P-value:1.33E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.91|P-value:2.87E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.94|P-value:2.59E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.18|P-value:4.61E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.32|P-value:3.29E-4 ID:SGTC_1716|Compound:st033144|FD-Score:6.90|P-value:5.79E-13 ID:SGTC_1717|Compound:st033143|FD-Score:-3.83|P-value:3.42E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.36|P-value:2.36E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.05|P-value:8.79E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.03|P-value:9.28E-4 ID:SGTC_1904|Compound:st060225|FD-Score:6.67|P-value:3.02E-12 ID:SGTC_2132|Compound:5317594|FD-Score:3.17|P-value:5.75E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.99|P-value:2.01E-5 ID:SGTC_2229|Compound:7354935|FD-Score:4.31|P-value:4.69E-6 ID:SGTC_2371|Compound:9071574|FD-Score:5.04|P-value:1.04E-7 ID:SGTC_2385|Compound:9074692|FD-Score:-4.28|P-value:4.20E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-2.99|P-value:9.12E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.55|P-value:1.39E-6 ID:SGTC_2709|Compound:st078560|FD-Score:3.80|P-value:4.66E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.21|P-value:4.96E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.13|P-value:5.61E-4 ID:SGTC_2882|Compound:9058044|FD-Score:4.55|P-value:1.46E-6 ID:SGTC_2911|Compound:7942208|FD-Score:5.52|P-value:6.65E-9 ID:SGTC_2923|Compound:7992654|FD-Score:5.83|P-value:9.77E-10 ID:SGTC_2927|Compound:9011802|FD-Score:3.13|P-value:6.49E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.09|P-value:7.53E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.12|P-value:6.72E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-4.61|P-value:8.43E-7 ID:SGTC_3070|Compound:9117005|FD-Score:5.57|P-value:4.86E-9 ID:SGTC_3102|Compound:9121669|FD-Score:6.48|P-value:1.22E-11 ID:SGTC_3105|Compound:9121040|FD-Score:3.24|P-value:4.48E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.23|P-value:3.79E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.14|P-value:6.43E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.50|P-value:1.61E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.27|P-value:3.94E-4

Top fitness defect scores for YGR288W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1716 st033144 6.90 30.6 µM 5.79E-13 2 2.63E-12
2 SGTC_1904 st060225 6.67 78.0 µM 3.02E-12 2 1.24E-11
3 SGTC_3102 9121669 6.48 49.5 µM 1.22E-11 1 4.59E-11
4 SGTC_2923 7992654 5.83 58.1 µM 9.77E-10 Golgi 5 2.83E-9
5 SGTC_314 1671-0008 5.73 2.7 µM 1.81E-9 7 5.06E-9
6 SGTC_3070 9117005 5.57 49.5 µM 4.86E-9 1 1.28E-8
7 SGTC_2911 7942208 5.52 15.6 µM 6.65E-9 mitochondrial response to ROS 2 1.72E-8
8 SGTC_552 k242-0005 5.16 476.0 µM 5.56E-8 4 1.27E-7
9 SGTC_2371 9071574 5.04 200.0 µM 1.04E-7 3 2.28E-7
10 SGTC_1363 1636-0063 4.96 10.4 µM 1.66E-7 Golgi 12 3.54E-7
11 SGTC_785 1270-0111 4.75 65.3 µM 5.19E-7 12 1.04E-6
12 SGTC_2410 aloe-emodin-8-o-glycoside 4.55 46.3 µM 1.39E-6 mitochondrial processes 12 2.62E-6
13 SGTC_2882 9058044 4.55 58.4 µM 1.46E-6 9 2.74E-6
14 SGTC_1325 1431-0015 4.51 227.0 µM 1.73E-6 Golgi 9 3.22E-6
15 SGTC_2229 7354935 4.31 190.0 µM 4.69E-6 RSC complex & mRNA processing 5 8.24E-6
16 SGTC_165 k038-0023 4.20 64.4 µM 7.88E-6 ubiquinone biosynthesis & proteasome 68 1.34E-5
17 SGTC_901 1112-0062 4.05 60.1 µM 1.54E-5 9 2.53E-5
18 SGTC_117 lucigenin 4.03 22.1 µM 1.72E-5 redox potentiating 80 2.80E-5
19 SGTC_2166 5933061 3.99 31.5 µM 2.01E-5 tubulin folding & SWR complex 44 3.24E-5
20 SGTC_1547 harmine 3.94 94.2 µM 2.59E-5 ergosterol biosynthesis 41 4.12E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.75E-7 YNL258C DSL1 het Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene
0.082 1.85E-6 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.82E-6 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.078 6.03E-6 YML020W_p YML020W_p hom Putative protein of unknown function
0.078 6.33E-6 YMR053C STB2 hom Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
0.075 1.55E-5 YNR072W HXT17 hom Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
0.071 3.93E-5 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.067 1.03E-4 YER168C CCA1 het ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
0.067 1.07E-4 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.067 1.13E-4 YGR010W NMA2 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication
0.066 1.20E-4 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.065 1.57E-4 YOR188W MSB1 hom Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.065 1.80E-4 YOR111W_p YOR111W_p hom Putative protein of unknown function
0.064 1.98E-4 YKL014C URB1 het Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
0.064 2.05E-4 YHL042W_p YHL042W_p hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins