HIPHOP chemogenomics database
YGR288W / MAL13 
MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YGR288W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.088 | 3.75E-7 | YNL258C | DSL1 | het | Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene |
| 0.082 | 1.85E-6 | YKL202W_d | YKL202W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.081 | 2.82E-6 | YCR048W | ARE1 | hom | Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication |
| 0.078 | 6.03E-6 | YML020W_p | YML020W_p | hom | Putative protein of unknown function |
| 0.078 | 6.33E-6 | YMR053C | STB2 | hom | Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p |
| 0.075 | 1.55E-5 | YNR072W | HXT17 | hom | Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose |
| 0.071 | 3.93E-5 | YCR047C | BUD23 | hom | Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern |
| 0.067 | 1.03E-4 | YER168C | CCA1 | het | ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites |
| 0.067 | 1.07E-4 | YBR224W_d | YBR224W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 |
| 0.067 | 1.13E-4 | YGR010W | NMA2 | hom | Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication |
| 0.066 | 1.20E-4 | YKL129C | MYO3 | hom | One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization |
| 0.065 | 1.57E-4 | YOR188W | MSB1 | hom | Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| 0.065 | 1.80E-4 | YOR111W_p | YOR111W_p | hom | Putative protein of unknown function |
| 0.064 | 1.98E-4 | YKL014C | URB1 | het | Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit |
| 0.064 | 2.05E-4 | YHL042W_p | YHL042W_p | hom | Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |