YGR290W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR290W / YGR290W

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.17|P-value:9.38E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.28|P-value:6.50E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.36|P-value:4.88E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:5.28|P-value:1.05E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.72|P-value:1.01E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.18|P-value:1.99E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:4.49|P-value:5.24E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:3.21|P-value:8.25E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.46|P-value:3.50E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.25|P-value:5.90E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.67|P-value:1.58E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.88|P-value:6.89E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.16|P-value:9.74E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.22|P-value:8.04E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.61|P-value:2.01E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.16|P-value:2.22E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.45|P-value:3.58E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:5.92|P-value:2.81E-9 ID:SGTC_1250|Compound:0485-0349|FD-Score:7.13|P-value:1.08E-12 ID:SGTC_1251|Compound:0490-5699|FD-Score:8.69|P-value:5.18E-18 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.34|P-value:9.98E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.23|P-value:7.82E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.17|P-value:6.19E-10 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.88|P-value:6.99E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.81|P-value:1.11E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.53|P-value:2.14E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.73|P-value:1.70E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.70|P-value:1.44E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.81|P-value:1.14E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.17|P-value:9.53E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:6.25|P-value:3.80E-10 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.33|P-value:1.03E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.48|P-value:5.48E-6 ID:SGTC_1558|Compound:st069300|FD-Score:5.70|P-value:1.01E-8 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.33|P-value:1.04E-5 ID:SGTC_1590|Compound:st077108|FD-Score:-4.23|P-value:1.23E-5 ID:SGTC_1661|Compound:st013063|FD-Score:3.63|P-value:1.84E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.47|P-value:3.35E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.50|P-value:2.95E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.44|P-value:2.98E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.67|P-value:2.18E-6 ID:SGTC_1824|Compound:st053723|FD-Score:3.79|P-value:9.98E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.75|P-value:1.54E-6 ID:SGTC_1871|Compound:st057448|FD-Score:3.41|P-value:4.18E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.24|P-value:6.02E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:5.41|P-value:5.02E-8 ID:SGTC_2083|Compound:5306046|FD-Score:3.22|P-value:8.00E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.31|P-value:5.95E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.19|P-value:8.77E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.26|P-value:7.00E-4 ID:SGTC_2199|Compound:6590217|FD-Score:4.03|P-value:3.86E-5 ID:SGTC_2211|Compound:7117706|FD-Score:4.30|P-value:1.23E-5 ID:SGTC_2241|Compound:6772625|FD-Score:5.17|P-value:1.86E-7 ID:SGTC_2292|Compound:7671323|FD-Score:4.21|P-value:1.81E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.58|P-value:2.25E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.45|P-value:3.58E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-7.45|P-value:6.62E-14 ID:SGTC_2756|Compound:carbadox|FD-Score:3.49|P-value:3.07E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:5.26|P-value:1.15E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:4.14|P-value:2.39E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.18|P-value:1.52E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.37|P-value:8.66E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-3.52|P-value:2.17E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.57|P-value:2.28E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.72|P-value:1.01E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.50|P-value:2.96E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.61|P-value:3.00E-6 ID:SGTC_2973|Compound:9094665|FD-Score:4.99|P-value:4.55E-7 ID:SGTC_3204|Compound:9114183|FD-Score:4.44|P-value:6.31E-6 ID:SGTC_3296|Compound:9122258|FD-Score:3.19|P-value:8.90E-4 ID:SGTC_3305|Compound:9127027|FD-Score:5.08|P-value:2.92E-7 ID:SGTC_3307|Compound:9126885|FD-Score:-3.51|P-value:2.29E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.17|P-value:9.38E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.28|P-value:6.50E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.36|P-value:4.88E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:5.28|P-value:1.05E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.72|P-value:1.01E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.18|P-value:1.99E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:4.49|P-value:5.24E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:3.21|P-value:8.25E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.46|P-value:3.50E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.25|P-value:5.90E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.67|P-value:1.58E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.88|P-value:6.89E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.16|P-value:9.74E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.22|P-value:8.04E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.61|P-value:2.01E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.16|P-value:2.22E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.45|P-value:3.58E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:5.92|P-value:2.81E-9 ID:SGTC_1250|Compound:0485-0349|FD-Score:7.13|P-value:1.08E-12 ID:SGTC_1251|Compound:0490-5699|FD-Score:8.69|P-value:5.18E-18 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.34|P-value:9.98E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.23|P-value:7.82E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.17|P-value:6.19E-10 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.88|P-value:6.99E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.81|P-value:1.11E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.53|P-value:2.14E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.73|P-value:1.70E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.70|P-value:1.44E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.81|P-value:1.14E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.17|P-value:9.53E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:6.25|P-value:3.80E-10 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.33|P-value:1.03E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.48|P-value:5.48E-6 ID:SGTC_1558|Compound:st069300|FD-Score:5.70|P-value:1.01E-8 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.33|P-value:1.04E-5 ID:SGTC_1590|Compound:st077108|FD-Score:-4.23|P-value:1.23E-5 ID:SGTC_1661|Compound:st013063|FD-Score:3.63|P-value:1.84E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.47|P-value:3.35E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.50|P-value:2.95E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.44|P-value:2.98E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.67|P-value:2.18E-6 ID:SGTC_1824|Compound:st053723|FD-Score:3.79|P-value:9.98E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.75|P-value:1.54E-6 ID:SGTC_1871|Compound:st057448|FD-Score:3.41|P-value:4.18E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.24|P-value:6.02E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:5.41|P-value:5.02E-8 ID:SGTC_2083|Compound:5306046|FD-Score:3.22|P-value:8.00E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.31|P-value:5.95E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.19|P-value:8.77E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.26|P-value:7.00E-4 ID:SGTC_2199|Compound:6590217|FD-Score:4.03|P-value:3.86E-5 ID:SGTC_2211|Compound:7117706|FD-Score:4.30|P-value:1.23E-5 ID:SGTC_2241|Compound:6772625|FD-Score:5.17|P-value:1.86E-7 ID:SGTC_2292|Compound:7671323|FD-Score:4.21|P-value:1.81E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.58|P-value:2.25E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.45|P-value:3.58E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-7.45|P-value:6.62E-14 ID:SGTC_2756|Compound:carbadox|FD-Score:3.49|P-value:3.07E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:5.26|P-value:1.15E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:4.14|P-value:2.39E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.18|P-value:1.52E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.37|P-value:8.66E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-3.52|P-value:2.17E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.57|P-value:2.28E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.72|P-value:1.01E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.50|P-value:2.96E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.61|P-value:3.00E-6 ID:SGTC_2973|Compound:9094665|FD-Score:4.99|P-value:4.55E-7 ID:SGTC_3204|Compound:9114183|FD-Score:4.44|P-value:6.31E-6 ID:SGTC_3296|Compound:9122258|FD-Score:3.19|P-value:8.90E-4 ID:SGTC_3305|Compound:9127027|FD-Score:5.08|P-value:2.92E-7 ID:SGTC_3307|Compound:9126885|FD-Score:-3.51|P-value:2.29E-4

Top fitness defect scores for YGR290W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1251 0490-5699 8.69 265.0 µM 5.18E-18 2 1.80E-18
2 SGTC_1250 0485-0349 7.13 40.2 µM 1.08E-12 4 5.06E-13
3 SGTC_1534 6-azauridine 6.25 81.6 µM 3.80E-10 RNA pol III & RNase P/MRP 7 2.06E-10
4 SGTC_1371 2421-0008 6.17 32.7 µM 6.19E-10 mitochondrial processes 6 3.41E-10
5 SGTC_1243 0416-0003 5.92 5.7 µM 2.81E-9 PDR1 7 1.61E-9
6 SGTC_1558 st069300 5.70 45.6 µM 1.01E-8 2 6.00E-9
7 SGTC_1955 wogonin 5.41 32.4 µM 5.02E-8 6 3.09E-8
8 SGTC_566 0958-0068 5.28 16.5 µM 1.05E-7 RSC & ERG11 8 6.59E-8
9 SGTC_2761 levamisole 5.26 97.9 µM 1.15E-7 2 7.23E-8
10 SGTC_2241 6772625 5.17 37.8 µM 1.86E-7 7 1.19E-7
11 SGTC_3305 9127027 5.08 53.8 µM 2.92E-7 8 1.88E-7
12 SGTC_2973 9094665 4.99 18.0 µM 4.55E-7 NEO1 12 2.97E-7
13 SGTC_1387 3342-1166 4.81 1.8 µM 1.11E-6 mitochondrial processes 6 7.38E-7
14 SGTC_1414 3917-0015 4.81 5.4 µM 1.14E-6 2 7.65E-7
15 SGTC_1869 3',7'-dimethoxyflavone 4.75 40.3 µM 1.54E-6 11 1.04E-6
16 SGTC_1405 3909-7894 4.73 12.0 µM 1.70E-6 60S ribosome export 3 1.15E-6
17 SGTC_1769 st044406 4.67 64.4 µM 2.18E-6 1 1.48E-6
18 SGTC_2968 9090663 4.61 33.4 µM 3.00E-6 17 2.06E-6
19 SGTC_583 1488-1091 4.49 88.9 µM 5.24E-6 11 3.65E-6
20 SGTC_1557 sumaresinolic acid 4.48 42.3 µM 5.48E-6 9 3.82E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.75E-10 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.096 2.94E-8 YML079W_p YML079W_p hom Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
0.095 3.79E-8 YOR381W FRE3 hom Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
0.090 1.79E-7 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.087 4.79E-7 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.082 1.95E-6 YDR421W ARO80 hom Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
0.081 2.95E-6 YOR015W_d YOR015W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.50E-6 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.079 4.36E-6 YKR068C BET3 het Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
0.078 6.25E-6 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.076 9.94E-6 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.075 1.20E-5 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.074 1.87E-5 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.073 2.33E-5 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.072 2.63E-5 YDL115C IWR1 hom RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress