HIPHOP chemogenomics database

YGR291C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR291C / YGR291C

Click on Significant Values for Screen Details

Top fitness defect scores for YGR291C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_20	0481-0013	6.75	4.9 µM	8.97E-11		2	7.18E-12
2	SGTC_1351	1496-0003	6.32	46.5 µM	1.17E-9		2	1.28E-10
3	SGTC_2496	diffractaic acid	5.53	79.8 µM	8.92E-8		6	1.63E-8
4	SGTC_2500	5-alpha-androstan-3,17-dione	5.32	61.4 µM	2.49E-7		16	5.13E-8
5	SGTC_2331	7980721	4.96	200.0 µM	1.39E-6		5	3.52E-7
6	SGTC_1744	st037937	4.50	38.9 µM	1.06E-5		13	3.39E-6
7	SGTC_1893	st059353	4.21	36.1 µM	3.44E-5		17	1.26E-5
8	SGTC_1063	disulfiram	4.13	1.8 µM	4.68E-5		16	1.78E-5
9	SGTC_1354	1498-1681	4.13	81.0 µM	4.74E-5		16	1.80E-5
10	SGTC_3058	9093861	4.12	49.5 µM	4.99E-5		11	1.91E-5
11	SGTC_3182	9108849	4.11	49.5 µM	5.07E-5	RPP1 & pyrimidine depletion	10	1.94E-5
12	SGTC_898	1000-0849	4.06	28.3 µM	6.29E-5		4	2.48E-5
13	SGTC_2062	5245942	4.03	200.0 µM	7.01E-5		15	2.79E-5
14	SGTC_976	1348-1067	4.00	47.6 µM	7.75E-5	60S ribosome export	28	3.13E-5
15	SGTC_64	000l-0018	3.89	272.1 µM	1.17E-4	ubiquinone biosynthesis & proteasome	153	4.95E-5
16	SGTC_2381	9035592	3.85	200.0 µM	1.39E-4		19	5.98E-5
17	SGTC_2544	sphondin	3.81	68.5 µM	1.59E-4	RNA pol III & RNase P/MRP	28	6.97E-5
18	SGTC_1273	0849-0096	3.80	14.1 µM	1.66E-4	RPP1 & pyrimidine depletion	23	7.32E-5
19	SGTC_2074	5212007	3.71	75.4 µM	2.24E-4		17	1.02E-4
20	SGTC_1020	4335-0961	3.66	93.3 µM	2.68E-4		24	1.24E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.175	1.47E-24	YDR032C	PST2	hom	Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.084	1.13E-6	YPL144W	POC4	hom	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.083	1.70E-6	YJL072C	PSF2	het	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.082	2.07E-6	YDR327W_d	YDR327W_d	het	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
0.081	2.34E-6	YEL013W	VAC8	hom	Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
0.080	3.16E-6	YOL070C	NBA1	hom	Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
0.076	1.15E-5	YDR276C	PMP3	hom	Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.071	4.34E-5	YDL150W	RPC53	het	RNA polymerase III subunit C53
0.070	5.32E-5	YLL041C	SDH2	hom	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
0.070	5.31E-5	YML014W	TRM9	hom	tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.069	6.63E-5	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.068	7.21E-5	YDR350C	ATP22	hom	Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane
0.068	7.91E-5	YER094C	PUP3	het	Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.068	8.48E-5	YEL015W	EDC3	hom	Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress
0.067	9.17E-5	YGR255C	COQ6	hom	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)