YGR291C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR291C / YGR291C

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.54|P-value:4.17E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:6.75|P-value:8.97E-11 ID:SGTC_64|Compound:000l-0018|FD-Score:3.89|P-value:1.17E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.04|P-value:7.15E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.88|P-value:1.27E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.45|P-value:5.49E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.66|P-value:2.72E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.42|P-value:6.33E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.34|P-value:8.34E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-4.35|P-value:2.13E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.14|P-value:4.91E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.33|P-value:8.71E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-5.75|P-value:3.02E-8 ID:SGTC_706|Compound:4262-0057|FD-Score:3.36|P-value:7.41E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.35|P-value:8.15E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.64|P-value:2.86E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:4.06|P-value:6.29E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:-4.97|P-value:1.43E-6 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.55|P-value:4.20E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-4.26|P-value:3.01E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.47|P-value:5.20E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.00|P-value:7.75E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:-4.04|P-value:7.02E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.66|P-value:2.68E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.13|P-value:4.68E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.40|P-value:6.55E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.80|P-value:1.66E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:6.32|P-value:1.17E-9 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.13|P-value:4.74E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.45|P-value:5.89E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.75|P-value:2.05E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-4.94|P-value:1.62E-6 ID:SGTC_1744|Compound:st037937|FD-Score:4.50|P-value:1.06E-5 ID:SGTC_1784|Compound:st039334|FD-Score:-3.92|P-value:1.12E-4 ID:SGTC_1806|Compound:st050005|FD-Score:-4.44|P-value:1.42E-5 ID:SGTC_1807|Compound:st050092|FD-Score:-4.00|P-value:8.14E-5 ID:SGTC_1822|Compound:st052468|FD-Score:-3.53|P-value:4.38E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.21|P-value:3.44E-5 ID:SGTC_2062|Compound:5245942|FD-Score:4.03|P-value:7.01E-5 ID:SGTC_2074|Compound:5212007|FD-Score:3.71|P-value:2.24E-4 ID:SGTC_2196|Compound:6573537|FD-Score:-3.32|P-value:9.01E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.96|P-value:1.39E-6 ID:SGTC_2381|Compound:9035592|FD-Score:3.85|P-value:1.39E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.62|P-value:3.14E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.53|P-value:8.92E-8 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.32|P-value:2.49E-7 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.54|P-value:4.34E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.81|P-value:1.59E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-3.40|P-value:6.87E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.57|P-value:3.68E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.12|P-value:4.99E-5 ID:SGTC_3182|Compound:9108849|FD-Score:4.11|P-value:5.07E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.40|P-value:6.60E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.54|P-value:4.17E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:6.75|P-value:8.97E-11 ID:SGTC_64|Compound:000l-0018|FD-Score:3.89|P-value:1.17E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.04|P-value:7.15E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.88|P-value:1.27E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.45|P-value:5.49E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.66|P-value:2.72E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.42|P-value:6.33E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.34|P-value:8.34E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-4.35|P-value:2.13E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.14|P-value:4.91E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.33|P-value:8.71E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-5.75|P-value:3.02E-8 ID:SGTC_706|Compound:4262-0057|FD-Score:3.36|P-value:7.41E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.35|P-value:8.15E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.64|P-value:2.86E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:4.06|P-value:6.29E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:-4.97|P-value:1.43E-6 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.55|P-value:4.20E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-4.26|P-value:3.01E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.47|P-value:5.20E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.00|P-value:7.75E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:-4.04|P-value:7.02E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.66|P-value:2.68E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.13|P-value:4.68E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.40|P-value:6.55E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.80|P-value:1.66E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:6.32|P-value:1.17E-9 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.13|P-value:4.74E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.45|P-value:5.89E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.75|P-value:2.05E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-4.94|P-value:1.62E-6 ID:SGTC_1744|Compound:st037937|FD-Score:4.50|P-value:1.06E-5 ID:SGTC_1784|Compound:st039334|FD-Score:-3.92|P-value:1.12E-4 ID:SGTC_1806|Compound:st050005|FD-Score:-4.44|P-value:1.42E-5 ID:SGTC_1807|Compound:st050092|FD-Score:-4.00|P-value:8.14E-5 ID:SGTC_1822|Compound:st052468|FD-Score:-3.53|P-value:4.38E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.21|P-value:3.44E-5 ID:SGTC_2062|Compound:5245942|FD-Score:4.03|P-value:7.01E-5 ID:SGTC_2074|Compound:5212007|FD-Score:3.71|P-value:2.24E-4 ID:SGTC_2196|Compound:6573537|FD-Score:-3.32|P-value:9.01E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.96|P-value:1.39E-6 ID:SGTC_2381|Compound:9035592|FD-Score:3.85|P-value:1.39E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.62|P-value:3.14E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.53|P-value:8.92E-8 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.32|P-value:2.49E-7 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.54|P-value:4.34E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.81|P-value:1.59E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-3.40|P-value:6.87E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.57|P-value:3.68E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.12|P-value:4.99E-5 ID:SGTC_3182|Compound:9108849|FD-Score:4.11|P-value:5.07E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.40|P-value:6.60E-4

Top fitness defect scores for YGR291C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_20 0481-0013 6.75 4.9 µM 8.97E-11 2 7.18E-12
2 SGTC_1351 1496-0003 6.32 46.5 µM 1.17E-9 2 1.28E-10
3 SGTC_2496 diffractaic acid 5.53 79.8 µM 8.92E-8 6 1.63E-8
4 SGTC_2500 5-alpha-androstan-3,17-dione 5.32 61.4 µM 2.49E-7 16 5.13E-8
5 SGTC_2331 7980721 4.96 200.0 µM 1.39E-6 5 3.52E-7
6 SGTC_1744 st037937 4.50 38.9 µM 1.06E-5 13 3.39E-6
7 SGTC_1893 st059353 4.21 36.1 µM 3.44E-5 17 1.26E-5
8 SGTC_1063 disulfiram 4.13 1.8 µM 4.68E-5 16 1.78E-5
9 SGTC_1354 1498-1681 4.13 81.0 µM 4.74E-5 16 1.80E-5
10 SGTC_3058 9093861 4.12 49.5 µM 4.99E-5 11 1.91E-5
11 SGTC_3182 9108849 4.11 49.5 µM 5.07E-5 RPP1 & pyrimidine depletion 10 1.94E-5
12 SGTC_898 1000-0849 4.06 28.3 µM 6.29E-5 4 2.48E-5
13 SGTC_2062 5245942 4.03 200.0 µM 7.01E-5 15 2.79E-5
14 SGTC_976 1348-1067 4.00 47.6 µM 7.75E-5 60S ribosome export 28 3.13E-5
15 SGTC_64 000l-0018 3.89 272.1 µM 1.17E-4 ubiquinone biosynthesis & proteasome 153 4.95E-5
16 SGTC_2381 9035592 3.85 200.0 µM 1.39E-4 19 5.98E-5
17 SGTC_2544 sphondin 3.81 68.5 µM 1.59E-4 RNA pol III & RNase P/MRP 28 6.97E-5
18 SGTC_1273 0849-0096 3.80 14.1 µM 1.66E-4 RPP1 & pyrimidine depletion 23 7.32E-5
19 SGTC_2074 5212007 3.71 75.4 µM 2.24E-4 17 1.02E-4
20 SGTC_1020 4335-0961 3.66 93.3 µM 2.68E-4 24 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.47E-24 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.084 1.13E-6 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.083 1.70E-6 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.082 2.07E-6 YDR327W_d YDR327W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
0.081 2.34E-6 YEL013W VAC8 hom Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
0.080 3.16E-6 YOL070C NBA1 hom Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
0.076 1.15E-5 YDR276C PMP3 hom Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.071 4.34E-5 YDL150W RPC53 het RNA polymerase III subunit C53
0.070 5.32E-5 YLL041C SDH2 hom Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
0.070 5.31E-5 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.069 6.63E-5 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.068 7.21E-5 YDR350C ATP22 hom Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane
0.068 7.91E-5 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.068 8.48E-5 YEL015W EDC3 hom Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress
0.067 9.17E-5 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)