YHL004W / MRP4

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL004W / MRP4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.97|P-value:4.75E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.69|P-value:1.04E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:3.83|P-value:8.10E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.44|P-value:3.55E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.24|P-value:1.25E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:3.27|P-value:6.47E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.02|P-value:3.73E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.48|P-value:3.45E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:7.21|P-value:5.87E-13 ID:SGTC_127|Compound:0180-0333|FD-Score:4.26|P-value:1.40E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:6.00|P-value:1.68E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:15.40|P-value:3.28E-52 ID:SGTC_141|Compound:0443-0274|FD-Score:4.18|P-value:1.93E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.32|P-value:5.43E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.95|P-value:5.59E-19 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.61|P-value:1.89E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.54|P-value:2.52E-21 ID:SGTC_251|Compound:melphalan|FD-Score:4.86|P-value:8.43E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.11|P-value:1.36E-19 ID:SGTC_310|Compound:1273-0058|FD-Score:4.51|P-value:4.41E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.36|P-value:4.35E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.38|P-value:8.15E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.18|P-value:8.31E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.06|P-value:3.25E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.43|P-value:3.63E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.72|P-value:1.26E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.14|P-value:9.89E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.60|P-value:1.85E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.23|P-value:7.02E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.01|P-value:3.92E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:4.10|P-value:2.71E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.37|P-value:4.58E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.61|P-value:1.76E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.17|P-value:8.45E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.80|P-value:9.04E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.55|P-value:2.34E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.25|P-value:6.88E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.28|P-value:6.36E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.55|P-value:2.35E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.86|P-value:7.33E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.49|P-value:3.00E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:5.86|P-value:3.80E-9 ID:SGTC_1627|Compound:st003713|FD-Score:5.25|P-value:1.19E-7 ID:SGTC_1635|Compound:st007035|FD-Score:5.21|P-value:1.43E-7 ID:SGTC_1678|Compound:st019265|FD-Score:-3.35|P-value:4.53E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.12|P-value:2.33E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.47|P-value:3.17E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.27|P-value:1.33E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.40|P-value:4.17E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.18|P-value:8.29E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.43|P-value:1.15E-10 ID:SGTC_1964|Compound:st076914|FD-Score:3.86|P-value:7.23E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.33|P-value:5.34E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.21|P-value:7.96E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.15|P-value:9.06E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.31|P-value:1.08E-5 ID:SGTC_2486|Compound:5283202|FD-Score:4.37|P-value:8.28E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.29|P-value:6.06E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.80|P-value:9.25E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:5.34|P-value:7.23E-8 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.26|P-value:1.35E-5 ID:SGTC_2863|Compound:9028737|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.24|P-value:7.11E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.34|P-value:4.75E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.99|P-value:4.27E-5 ID:SGTC_3128|Compound:9127691|FD-Score:4.14|P-value:2.34E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.84|P-value:7.94E-5 ID:SGTC_3206|Compound:9114350|FD-Score:4.03|P-value:3.71E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.97|P-value:4.75E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.69|P-value:1.04E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:3.83|P-value:8.10E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.44|P-value:3.55E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.24|P-value:1.25E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:3.27|P-value:6.47E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.02|P-value:3.73E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.48|P-value:3.45E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:7.21|P-value:5.87E-13 ID:SGTC_127|Compound:0180-0333|FD-Score:4.26|P-value:1.40E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:6.00|P-value:1.68E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:15.40|P-value:3.28E-52 ID:SGTC_141|Compound:0443-0274|FD-Score:4.18|P-value:1.93E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.32|P-value:5.43E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.95|P-value:5.59E-19 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.61|P-value:1.89E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.54|P-value:2.52E-21 ID:SGTC_251|Compound:melphalan|FD-Score:4.86|P-value:8.43E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.11|P-value:1.36E-19 ID:SGTC_310|Compound:1273-0058|FD-Score:4.51|P-value:4.41E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.36|P-value:4.35E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.38|P-value:8.15E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.18|P-value:8.31E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.06|P-value:3.25E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.43|P-value:3.63E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.72|P-value:1.26E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.14|P-value:9.89E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.60|P-value:1.85E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.23|P-value:7.02E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.01|P-value:3.92E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:4.10|P-value:2.71E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.37|P-value:4.58E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.61|P-value:1.76E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.17|P-value:8.45E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.80|P-value:9.04E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.55|P-value:2.34E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.25|P-value:6.88E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.28|P-value:6.36E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.55|P-value:2.35E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.86|P-value:7.33E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.49|P-value:3.00E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:5.86|P-value:3.80E-9 ID:SGTC_1627|Compound:st003713|FD-Score:5.25|P-value:1.19E-7 ID:SGTC_1635|Compound:st007035|FD-Score:5.21|P-value:1.43E-7 ID:SGTC_1678|Compound:st019265|FD-Score:-3.35|P-value:4.53E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.12|P-value:2.33E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.47|P-value:3.17E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.27|P-value:1.33E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.40|P-value:4.17E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.18|P-value:8.29E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.43|P-value:1.15E-10 ID:SGTC_1964|Compound:st076914|FD-Score:3.86|P-value:7.23E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.33|P-value:5.34E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.21|P-value:7.96E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.15|P-value:9.06E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.31|P-value:1.08E-5 ID:SGTC_2486|Compound:5283202|FD-Score:4.37|P-value:8.28E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.29|P-value:6.06E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.80|P-value:9.25E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:5.34|P-value:7.23E-8 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.26|P-value:1.35E-5 ID:SGTC_2863|Compound:9028737|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.24|P-value:7.11E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.34|P-value:4.75E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.99|P-value:4.27E-5 ID:SGTC_3128|Compound:9127691|FD-Score:4.14|P-value:2.34E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.84|P-value:7.94E-5 ID:SGTC_3206|Compound:9114350|FD-Score:4.03|P-value:3.71E-5

Top fitness defect scores for YHL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 15.40 6.9 µM 3.28E-52 14 1.30E-53
2 SGTC_236 1509-0011 9.54 5.3 µM 2.52E-21 205 6.92E-22
3 SGTC_275 trichlorophene 9.11 5.7 µM 1.36E-19 mitochondrial stress 56 4.17E-20
4 SGTC_173 1273-0061 8.95 2.7 µM 5.59E-19 mitochondrial stress 50 1.78E-19
5 SGTC_119 0121-0043 7.21 24.8 µM 5.87E-13 mitochondrial stress 14 2.74E-13
6 SGTC_1921 5740136 6.43 50.0 µM 1.15E-10 TRP & mitochondrial translation 11 6.19E-11
7 SGTC_131 0141-0277 6.00 33.9 µM 1.68E-9 6 9.78E-10
8 SGTC_1568 digitonin 5.86 820.0 nM 3.80E-9 sphingolipid biosynthesis & PDR1 11 2.26E-9
9 SGTC_59 0330-0160 5.69 1.3 µM 1.04E-8 44 6.34E-9
10 SGTC_118 0083-0097 5.48 135.3 µM 3.45E-8 translation 39 2.18E-8
11 SGTC_2610 ononetin 5.34 44.2 µM 7.23E-8 11 4.66E-8
12 SGTC_1627 st003713 5.25 25.6 µM 1.19E-7 calcium & mitochondrial duress 37 7.75E-8
13 SGTC_108 0509-0257 5.24 621.1 µM 1.25E-7 21 8.18E-8
14 SGTC_1635 st007035 5.21 42.4 µM 1.43E-7 160 9.41E-8
15 SGTC_251 melphalan 4.86 456.5 µM 8.43E-7 DNA damage response 9 5.82E-7
16 SGTC_310 1273-0058 4.51 1.1 µM 4.41E-6 mitochondrial stress 208 3.19E-6
17 SGTC_386 1509-0011 4.38 3.1 µM 8.15E-6 125 5.99E-6
18 SGTC_2486 5283202 4.37 22.4 µM 8.28E-6 28 6.09E-6
19 SGTC_2368 9071271 4.31 200.0 µM 1.08E-5 25 8.01E-6
20 SGTC_1823 3-hydroxy-2-naphthoic acid 4.27 106.0 µM 1.33E-5 9 9.92E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.491 1.91E-203 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.475 3.35E-188 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.442 1.10E-160 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.439 9.38E-158 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.436 5.93E-156 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.435 4.82E-155 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.423 1.77E-145 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.420 9.27E-144 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.414 2.64E-139 YBL080C PET112 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog
0.413 1.94E-138 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.412 1.36E-137 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.410 1.34E-136 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.410 5.88E-136 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.404 1.60E-131 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.401 3.79E-130 YDL032W_d YDL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene