HIPHOP chemogenomics database

YHL005C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W

Zygosity: Homozygous strain

fixedexpanded
Profile for YHL005C / YHL005C

Click on Significant Values for Screen Details

Top fitness defect scores for YHL005C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	11.80	5.3 µM	1.60E-37		156	2.40E-32
2	SGTC_2834	9001755	6.37	58.4 µM	2.76E-12		9	9.59E-11
3	SGTC_1935	st074532	6.04	41.6 µM	3.23E-11		2	7.90E-10
4	SGTC_1635	st007035	5.61	42.4 µM	6.20E-10		142	9.94E-9
5	SGTC_1767	st044992	5.16	70.3 µM	1.18E-8		7	1.25E-7
6	SGTC_2926	9010726	4.33	65.2 µM	1.38E-6		24	7.41E-6
7	SGTC_2909	7941780	4.27	10.5 µM	1.92E-6		15	9.86E-6
8	SGTC_35	0133-0054	4.14	64.1 µM	3.66E-6		29	1.72E-5
9	SGTC_3132	9126706	3.85	49.5 µM	1.57E-5		24	6.01E-5
10	SGTC_1341	1486-1360	3.83	280.0 µM	1.67E-5		28	6.35E-5
11	SGTC_2931	9014674	3.82	55.7 µM	1.80E-5		24	6.78E-5
12	SGTC_1802	st050112	3.78	57.9 µM	2.09E-5		13	7.69E-5
13	SGTC_3137	9097352	3.77	49.5 µM	2.21E-5		46	8.09E-5
14	SGTC_641	4092-0595	3.76	30.0 µM	2.35E-5		15	8.53E-5
15	SGTC_1806	st050005	3.68	60.3 µM	3.44E-5		18	1.18E-4
16	SGTC_1064	honokiol	3.50	6.8 µM	7.42E-5		35	2.29E-4
17	SGTC_2055	5235184	3.30	200.0 µM	1.79E-4	ERG2	63	4.91E-4
18	SGTC_3054	9094397	3.29	49.5 µM	1.83E-4	fatty acid desaturase (OLE1)	61	5.00E-4
19	SGTC_658	3253-0951	3.27	102.0 µM	2.03E-4	calcium & mitochondrial duress	94	5.47E-4
20	SGTC_1934	st074720	3.24	32.6 µM	2.25E-4		92	5.97E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.454	3.36E-170	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.452	3.85E-168	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.450	5.79E-167	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.428	7.96E-150	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.406	4.53E-133	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.399	2.01E-128	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.398	1.43E-127	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.397	4.14E-127	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.396	3.31E-126	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.383	1.60E-117	YKL087C	CYT2	hom	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.382	3.98E-117	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.381	1.61E-116	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.377	6.34E-114	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.376	3.06E-113	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.369	5.92E-109	YHR116W	COX23	hom	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs