YHL005C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL005C / YHL005C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.14|P-value:3.66E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.13|P-value:3.64E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.80|P-value:1.60E-37 ID:SGTC_310|Compound:1273-0058|FD-Score:2.91|P-value:8.22E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.33|P-value:1.60E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-2.90|P-value:8.70E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.18|P-value:2.92E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.76|P-value:2.35E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.27|P-value:2.03E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.06|P-value:4.52E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.50|P-value:7.42E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:-3.03|P-value:5.26E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.07|P-value:4.55E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:-2.87|P-value:9.51E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.86|P-value:9.89E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.83|P-value:1.67E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.03|P-value:5.23E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.61|P-value:6.20E-10 ID:SGTC_1706|Compound:st031321|FD-Score:2.95|P-value:7.08E-4 ID:SGTC_1767|Compound:st044992|FD-Score:5.16|P-value:1.18E-8 ID:SGTC_1802|Compound:st050112|FD-Score:3.78|P-value:2.09E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.68|P-value:3.44E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.21|P-value:2.54E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.13|P-value:3.63E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.24|P-value:2.25E-4 ID:SGTC_1935|Compound:st074532|FD-Score:6.04|P-value:3.23E-11 ID:SGTC_1975|Compound:st070967|FD-Score:-3.28|P-value:1.95E-4 ID:SGTC_1976|Compound:st070609|FD-Score:-2.96|P-value:6.85E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.30|P-value:1.79E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_2248|Compound:tofa|FD-Score:-2.90|P-value:8.56E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-4.21|P-value:2.73E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.76|P-value:2.40E-5 ID:SGTC_2834|Compound:9001755|FD-Score:6.37|P-value:2.76E-12 ID:SGTC_2909|Compound:7941780|FD-Score:4.27|P-value:1.92E-6 ID:SGTC_2926|Compound:9010726|FD-Score:4.33|P-value:1.38E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.82|P-value:1.80E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.07|P-value:4.56E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.12|P-value:3.65E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.29|P-value:1.83E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.85|P-value:1.57E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.77|P-value:2.21E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:4.14|P-value:3.66E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.13|P-value:3.64E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.80|P-value:1.60E-37 ID:SGTC_310|Compound:1273-0058|FD-Score:2.91|P-value:8.22E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.33|P-value:1.60E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-2.90|P-value:8.70E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.18|P-value:2.92E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.76|P-value:2.35E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.27|P-value:2.03E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.06|P-value:4.52E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.50|P-value:7.42E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:-3.03|P-value:5.26E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.07|P-value:4.55E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:-2.87|P-value:9.51E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.86|P-value:9.89E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.83|P-value:1.67E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.03|P-value:5.23E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.61|P-value:6.20E-10 ID:SGTC_1706|Compound:st031321|FD-Score:2.95|P-value:7.08E-4 ID:SGTC_1767|Compound:st044992|FD-Score:5.16|P-value:1.18E-8 ID:SGTC_1802|Compound:st050112|FD-Score:3.78|P-value:2.09E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.68|P-value:3.44E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.21|P-value:2.54E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.13|P-value:3.63E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.24|P-value:2.25E-4 ID:SGTC_1935|Compound:st074532|FD-Score:6.04|P-value:3.23E-11 ID:SGTC_1975|Compound:st070967|FD-Score:-3.28|P-value:1.95E-4 ID:SGTC_1976|Compound:st070609|FD-Score:-2.96|P-value:6.85E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.30|P-value:1.79E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_2248|Compound:tofa|FD-Score:-2.90|P-value:8.56E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-4.21|P-value:2.73E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.76|P-value:2.40E-5 ID:SGTC_2834|Compound:9001755|FD-Score:6.37|P-value:2.76E-12 ID:SGTC_2909|Compound:7941780|FD-Score:4.27|P-value:1.92E-6 ID:SGTC_2926|Compound:9010726|FD-Score:4.33|P-value:1.38E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.82|P-value:1.80E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.07|P-value:4.56E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.12|P-value:3.65E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.29|P-value:1.83E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.85|P-value:1.57E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.77|P-value:2.21E-5

Top fitness defect scores for YHL005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 11.80 5.3 µM 1.60E-37 156 2.40E-32
2 SGTC_2834 9001755 6.37 58.4 µM 2.76E-12 9 9.59E-11
3 SGTC_1935 st074532 6.04 41.6 µM 3.23E-11 2 7.90E-10
4 SGTC_1635 st007035 5.61 42.4 µM 6.20E-10 142 9.94E-9
5 SGTC_1767 st044992 5.16 70.3 µM 1.18E-8 7 1.25E-7
6 SGTC_2926 9010726 4.33 65.2 µM 1.38E-6 24 7.41E-6
7 SGTC_2909 7941780 4.27 10.5 µM 1.92E-6 15 9.86E-6
8 SGTC_35 0133-0054 4.14 64.1 µM 3.66E-6 29 1.72E-5
9 SGTC_3132 9126706 3.85 49.5 µM 1.57E-5 24 6.01E-5
10 SGTC_1341 1486-1360 3.83 280.0 µM 1.67E-5 28 6.35E-5
11 SGTC_2931 9014674 3.82 55.7 µM 1.80E-5 24 6.78E-5
12 SGTC_1802 st050112 3.78 57.9 µM 2.09E-5 13 7.69E-5
13 SGTC_3137 9097352 3.77 49.5 µM 2.21E-5 46 8.09E-5
14 SGTC_641 4092-0595 3.76 30.0 µM 2.35E-5 15 8.53E-5
15 SGTC_1806 st050005 3.68 60.3 µM 3.44E-5 18 1.18E-4
16 SGTC_1064 honokiol 3.50 6.8 µM 7.42E-5 35 2.29E-4
17 SGTC_2055 5235184 3.30 200.0 µM 1.79E-4 ERG2 63 4.91E-4
18 SGTC_3054 9094397 3.29 49.5 µM 1.83E-4 fatty acid desaturase (OLE1) 61 5.00E-4
19 SGTC_658 3253-0951 3.27 102.0 µM 2.03E-4 calcium & mitochondrial duress 94 5.47E-4
20 SGTC_1934 st074720 3.24 32.6 µM 2.25E-4 92 5.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.454 3.36E-170 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.452 3.85E-168 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.450 5.79E-167 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.428 7.96E-150 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.406 4.53E-133 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.399 2.01E-128 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.398 1.43E-127 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.397 4.14E-127 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.396 3.31E-126 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.383 1.60E-117 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.382 3.98E-117 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.381 1.61E-116 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.377 6.34E-114 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.376 3.06E-113 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.369 5.92E-109 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs