YHL006C / SHU1

Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL006C / SHU1

Click on Significant Values for Screen Details ID:SGTC_231|Compound:b-estradiol|FD-Score:-2.85|P-value:4.40E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.82|P-value:3.33E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.69|P-value:5.92E-4 ID:SGTC_417|Compound:st075190|FD-Score:2.57|P-value:9.45E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.29|P-value:3.74E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.28|P-value:4.07E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:2.61|P-value:8.19E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:2.57|P-value:9.67E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.23|P-value:5.14E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-2.84|P-value:4.56E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.48|P-value:1.41E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.88|P-value:2.71E-6 ID:SGTC_803|Compound:4488-1585|FD-Score:3.20|P-value:5.88E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:2.56|P-value:9.97E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.58|P-value:1.40E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.94|P-value:2.03E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.56|P-value:9.97E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.02|P-value:1.41E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.70|P-value:5.63E-4 ID:SGTC_1672|Compound:st016598|FD-Score:2.70|P-value:5.54E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.85|P-value:4.38E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-9.89|P-value:9.21E-32 ID:SGTC_1734|Compound:st037168|FD-Score:-2.93|P-value:3.07E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-9.01|P-value:1.04E-26 ID:SGTC_2031|Compound:5180455|FD-Score:-3.31|P-value:5.34E-5 ID:SGTC_2033|Compound:5192550|FD-Score:-3.45|P-value:2.78E-5 ID:SGTC_2040|Compound:5100729|FD-Score:2.63|P-value:7.40E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.51|P-value:1.21E-5 ID:SGTC_2051|Compound:5263410|FD-Score:-2.98|P-value:2.50E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.03|P-value:6.76E-7 ID:SGTC_2135|Compound:5326629|FD-Score:-2.79|P-value:5.58E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-2.80|P-value:5.54E-4 ID:SGTC_2306|Compound:7482397|FD-Score:2.57|P-value:9.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.99|P-value:1.58E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.17|P-value:1.06E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.85|P-value:2.94E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.19|P-value:9.68E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-2.65|P-value:9.94E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-2.90|P-value:3.50E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.84|P-value:3.14E-4 ID:SGTC_2840|Compound:9008771|FD-Score:2.89|P-value:2.47E-4 ID:SGTC_2847|Compound:9005661|FD-Score:5.49|P-value:2.64E-11 ID:SGTC_2868|Compound:9035608|FD-Score:-4.42|P-value:1.04E-7 ID:SGTC_2869|Compound:9037858|FD-Score:-3.77|P-value:5.00E-6 ID:SGTC_2875|Compound:9039966|FD-Score:3.00|P-value:1.49E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.98|P-value:9.10E-7 ID:SGTC_2954|Compound:9074818|FD-Score:2.93|P-value:2.06E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.79|P-value:3.84E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.93|P-value:2.10E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.17|P-value:6.93E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-4.00|P-value:1.40E-6 ID:SGTC_3162|Compound:9099653|FD-Score:2.86|P-value:2.90E-4 ID:SGTC_3230|Compound:9131665|FD-Score:2.97|P-value:1.70E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.91|P-value:2.29E-6 ID:SGTC_3242|Compound:9133940|FD-Score:3.76|P-value:3.24E-6 ID:SGTC_3249|Compound:9135183|FD-Score:-2.84|P-value:4.64E-4 ID:SGTC_3252|Compound:9135871|FD-Score:-3.58|P-value:1.37E-5 ID:SGTC_3262|Compound:9137218|FD-Score:3.06|P-value:1.15E-4 ID:SGTC_3265|Compound:9137266|FD-Score:2.74|P-value:4.85E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.70|P-value:5.63E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:-2.85|P-value:4.40E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.82|P-value:3.33E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.69|P-value:5.92E-4 ID:SGTC_417|Compound:st075190|FD-Score:2.57|P-value:9.45E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.29|P-value:3.74E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.28|P-value:4.07E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:2.61|P-value:8.19E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:2.57|P-value:9.67E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.23|P-value:5.14E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-2.84|P-value:4.56E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.48|P-value:1.41E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.88|P-value:2.71E-6 ID:SGTC_803|Compound:4488-1585|FD-Score:3.20|P-value:5.88E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:2.56|P-value:9.97E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.58|P-value:1.40E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.94|P-value:2.03E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.56|P-value:9.97E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.02|P-value:1.41E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.70|P-value:5.63E-4 ID:SGTC_1672|Compound:st016598|FD-Score:2.70|P-value:5.54E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.85|P-value:4.38E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-9.89|P-value:9.21E-32 ID:SGTC_1734|Compound:st037168|FD-Score:-2.93|P-value:3.07E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-9.01|P-value:1.04E-26 ID:SGTC_2031|Compound:5180455|FD-Score:-3.31|P-value:5.34E-5 ID:SGTC_2033|Compound:5192550|FD-Score:-3.45|P-value:2.78E-5 ID:SGTC_2040|Compound:5100729|FD-Score:2.63|P-value:7.40E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.51|P-value:1.21E-5 ID:SGTC_2051|Compound:5263410|FD-Score:-2.98|P-value:2.50E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.03|P-value:6.76E-7 ID:SGTC_2135|Compound:5326629|FD-Score:-2.79|P-value:5.58E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-2.80|P-value:5.54E-4 ID:SGTC_2306|Compound:7482397|FD-Score:2.57|P-value:9.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.99|P-value:1.58E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.17|P-value:1.06E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.85|P-value:2.94E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.19|P-value:9.68E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-2.65|P-value:9.94E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-2.90|P-value:3.50E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.84|P-value:3.14E-4 ID:SGTC_2840|Compound:9008771|FD-Score:2.89|P-value:2.47E-4 ID:SGTC_2847|Compound:9005661|FD-Score:5.49|P-value:2.64E-11 ID:SGTC_2868|Compound:9035608|FD-Score:-4.42|P-value:1.04E-7 ID:SGTC_2869|Compound:9037858|FD-Score:-3.77|P-value:5.00E-6 ID:SGTC_2875|Compound:9039966|FD-Score:3.00|P-value:1.49E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.98|P-value:9.10E-7 ID:SGTC_2954|Compound:9074818|FD-Score:2.93|P-value:2.06E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.79|P-value:3.84E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.93|P-value:2.10E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.17|P-value:6.93E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-4.00|P-value:1.40E-6 ID:SGTC_3162|Compound:9099653|FD-Score:2.86|P-value:2.90E-4 ID:SGTC_3230|Compound:9131665|FD-Score:2.97|P-value:1.70E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.91|P-value:2.29E-6 ID:SGTC_3242|Compound:9133940|FD-Score:3.76|P-value:3.24E-6 ID:SGTC_3249|Compound:9135183|FD-Score:-2.84|P-value:4.64E-4 ID:SGTC_3252|Compound:9135871|FD-Score:-3.58|P-value:1.37E-5 ID:SGTC_3262|Compound:9137218|FD-Score:3.06|P-value:1.15E-4 ID:SGTC_3265|Compound:9137266|FD-Score:2.74|P-value:4.85E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.70|P-value:5.63E-4

Top fitness defect scores for YHL006C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2847 9005661 5.49 71.4 µM 2.64E-11 4 2.04E-8
2 SGTC_2130 NSC 7 4.03 2.5 µM 6.76E-7 copper-dependent oxidative stress 22 2.81E-5
3 SGTC_2876 9059903 3.98 26.0 µM 9.10E-7 12 3.48E-5
4 SGTC_3242 9133940 3.76 49.5 µM 3.24E-6 14 8.62E-5
5 SGTC_2048 5246248 3.51 200.0 µM 1.21E-5 13 2.21E-4
6 SGTC_553 k007-0256 3.48 45.7 µM 1.41E-5 heme biosynthesis & mitochondrial translocase 36 2.47E-4
7 SGTC_427 1354-0053 3.29 47.3 µM 3.74E-5 45 4.95E-4
8 SGTC_474 dl-dihydrosphingosine 3.28 5.0 µM 4.07E-5 62 5.27E-4
9 SGTC_479 n-linoleoylglycine 3.23 10.0 µM 5.14E-5 24 6.22E-4
10 SGTC_803 4488-1585 3.20 147.0 µM 5.88E-5 36 6.84E-4
11 SGTC_2973 9094665 3.17 18.0 µM 6.93E-5 NEO1 67 7.71E-4
12 SGTC_3262 9137218 3.06 49.5 µM 1.15E-4 14 0.00111
13 SGTC_1402 3909-7673 3.02 35.9 µM 1.41E-4 46 0.00128
14 SGTC_2875 9039966 3.00 71.4 µM 1.49E-4 35 0.00134
15 SGTC_2582 agaric acid 2.99 100.0 µM 1.58E-4 redox potentiating 432 0.00139
16 SGTC_3230 9131665 2.97 49.5 µM 1.70E-4 9 0.00147
17 SGTC_1309 pyrazolanthrone 2.94 13.4 µM 2.03E-4 63 0.00167
18 SGTC_2954 9074818 2.93 52.7 µM 2.06E-4 79 0.00168
19 SGTC_2970 9090938 2.93 41.9 µM 2.10E-4 RNA processing & uracil transport 115 0.00171
20 SGTC_2840 9008771 2.89 71.4 µM 2.47E-4 44 0.00192

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.46E-20 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.149 4.92E-18 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.148 6.95E-18 YDR036C EHD3 hom 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
0.142 1.24E-16 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.141 1.78E-16 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.139 6.58E-16 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.139 6.93E-16 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.139 7.05E-16 YOR032C HMS1 hom Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
0.138 1.19E-15 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.134 6.05E-15 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.131 3.11E-14 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.129 9.09E-14 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.118 5.92E-12 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.117 9.33E-12 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.117 1.14E-11 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1