YHL009C / YAP3

Basic leucine zipper (bZIP) transcription factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL009C / YAP3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.44|P-value:2.79E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:5.58|P-value:1.23E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:3.29|P-value:5.47E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.28|P-value:6.83E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:3.92|P-value:4.74E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.97|P-value:3.55E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:4.11|P-value:2.12E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.41|P-value:3.54E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.66|P-value:1.34E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.72|P-value:1.21E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.12|P-value:9.87E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.30|P-value:5.10E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.12|P-value:9.59E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.49|P-value:4.15E-11 ID:SGTC_880|Compound:0833-0487|FD-Score:3.75|P-value:9.53E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.86|P-value:4.15E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.23|P-value:6.54E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.13|P-value:1.93E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:5.78|P-value:3.71E-9 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.92|P-value:4.81E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.08|P-value:8.20E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.21|P-value:1.39E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.26|P-value:5.99E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:6.15|P-value:3.95E-10 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.20|P-value:5.47E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.42|P-value:3.35E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.40|P-value:3.34E-8 ID:SGTC_1320|Compound:1313-0481|FD-Score:6.46|P-value:5.04E-11 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.41|P-value:5.46E-6 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.08|P-value:8.33E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.19|P-value:7.64E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.43|P-value:3.22E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.95|P-value:3.78E-7 ID:SGTC_1714|Compound:st033236|FD-Score:6.50|P-value:3.99E-11 ID:SGTC_1715|Compound:st032160|FD-Score:-3.54|P-value:1.55E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.49|P-value:2.62E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.61|P-value:1.40E-6 ID:SGTC_1746|Compound:st038117|FD-Score:3.48|P-value:2.74E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.95|P-value:4.19E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.38|P-value:2.80E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.51|P-value:1.89E-8 ID:SGTC_1801|Compound:st050089|FD-Score:6.79|P-value:5.55E-12 ID:SGTC_1803|Compound:st050068|FD-Score:10.70|P-value:3.42E-27 ID:SGTC_2291|Compound:7917025|FD-Score:-3.13|P-value:7.08E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.18|P-value:7.96E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.21|P-value:7.18E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.72|P-value:7.44E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.75|P-value:1.08E-6 ID:SGTC_2694|Compound:st077685|FD-Score:3.19|P-value:7.68E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.42|P-value:3.33E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.26|P-value:5.98E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.34|P-value:4.52E-4 ID:SGTC_2828|Compound:7998861|FD-Score:5.99|P-value:1.07E-9 ID:SGTC_2957|Compound:9076800|FD-Score:-4.61|P-value:1.37E-6 ID:SGTC_3008|Compound:9078912|FD-Score:4.09|P-value:2.33E-5 ID:SGTC_3036|Compound:9090181|FD-Score:-4.18|P-value:1.08E-5 ID:SGTC_3159|Compound:9100096|FD-Score:4.78|P-value:9.38E-7 ID:SGTC_3179|Compound:9107801|FD-Score:3.47|P-value:2.84E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.74|P-value:9.80E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.69|P-value:1.21E-4 ID:SGTC_3335|Compound:9143315|FD-Score:5.12|P-value:1.57E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:5.44|P-value:2.79E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:5.58|P-value:1.23E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:3.29|P-value:5.47E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.28|P-value:6.83E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:3.92|P-value:4.74E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.97|P-value:3.55E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:4.11|P-value:2.12E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.41|P-value:3.54E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.66|P-value:1.34E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.72|P-value:1.21E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.12|P-value:9.87E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.30|P-value:5.10E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.12|P-value:9.59E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.49|P-value:4.15E-11 ID:SGTC_880|Compound:0833-0487|FD-Score:3.75|P-value:9.53E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.86|P-value:4.15E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.23|P-value:6.54E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.13|P-value:1.93E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:5.78|P-value:3.71E-9 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.92|P-value:4.81E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.08|P-value:8.20E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.21|P-value:1.39E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.26|P-value:5.99E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:6.15|P-value:3.95E-10 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.20|P-value:5.47E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.42|P-value:3.35E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.40|P-value:3.34E-8 ID:SGTC_1320|Compound:1313-0481|FD-Score:6.46|P-value:5.04E-11 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.41|P-value:5.46E-6 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.08|P-value:8.33E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.19|P-value:7.64E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.43|P-value:3.22E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.95|P-value:3.78E-7 ID:SGTC_1714|Compound:st033236|FD-Score:6.50|P-value:3.99E-11 ID:SGTC_1715|Compound:st032160|FD-Score:-3.54|P-value:1.55E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.49|P-value:2.62E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-4.61|P-value:1.40E-6 ID:SGTC_1746|Compound:st038117|FD-Score:3.48|P-value:2.74E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.95|P-value:4.19E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.38|P-value:2.80E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.51|P-value:1.89E-8 ID:SGTC_1801|Compound:st050089|FD-Score:6.79|P-value:5.55E-12 ID:SGTC_1803|Compound:st050068|FD-Score:10.70|P-value:3.42E-27 ID:SGTC_2291|Compound:7917025|FD-Score:-3.13|P-value:7.08E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.18|P-value:7.96E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.21|P-value:7.18E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.72|P-value:7.44E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.75|P-value:1.08E-6 ID:SGTC_2694|Compound:st077685|FD-Score:3.19|P-value:7.68E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.42|P-value:3.33E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.26|P-value:5.98E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.34|P-value:4.52E-4 ID:SGTC_2828|Compound:7998861|FD-Score:5.99|P-value:1.07E-9 ID:SGTC_2957|Compound:9076800|FD-Score:-4.61|P-value:1.37E-6 ID:SGTC_3008|Compound:9078912|FD-Score:4.09|P-value:2.33E-5 ID:SGTC_3036|Compound:9090181|FD-Score:-4.18|P-value:1.08E-5 ID:SGTC_3159|Compound:9100096|FD-Score:4.78|P-value:9.38E-7 ID:SGTC_3179|Compound:9107801|FD-Score:3.47|P-value:2.84E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.74|P-value:9.80E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.69|P-value:1.21E-4 ID:SGTC_3335|Compound:9143315|FD-Score:5.12|P-value:1.57E-7

Top fitness defect scores for YHL009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1803 st050068 10.70 52.4 µM 3.42E-27 NEO1-PIK1 21 4.86E-27
2 SGTC_1801 st050089 6.79 28.4 µM 5.55E-12 NEO1-PIK1 38 5.74E-12
3 SGTC_1714 st033236 6.50 13.6 µM 3.99E-11 3 4.06E-11
4 SGTC_794 k038-0031 6.49 316.0 µM 4.15E-11 ubiquinone biosynthesis & proteasome 47 4.22E-11
5 SGTC_1320 1313-0481 6.46 95.3 µM 5.04E-11 2 5.12E-11
6 SGTC_1081 sertraline 6.15 6.0 µM 3.95E-10 60S ribosome export 9 3.96E-10
7 SGTC_2828 7998861 5.99 71.4 µM 1.07E-9 2 1.06E-9
8 SGTC_994 3910-0338 5.78 138.0 µM 3.71E-9 calcium & mitochondrial duress 16 3.66E-9
9 SGTC_64 000l-0018 5.58 272.1 µM 1.23E-8 ubiquinone biosynthesis & proteasome 90 1.20E-8
10 SGTC_1800 st050079 5.51 29.1 µM 1.89E-8 NEO1-PIK1 56 1.85E-8
11 SGTC_58 0957-0393 5.44 9.0 µM 2.79E-8 cell wall 245 2.72E-8
12 SGTC_1247 0448-0043 5.40 5.8 µM 3.34E-8 ERG2 16 3.25E-8
13 SGTC_184 1494-0393 5.28 24.7 µM 6.83E-8 24 6.61E-8
14 SGTC_3335 9143315 5.12 29.6 µM 1.57E-7 fatty acid desaturase (OLE1) 2 1.51E-7
15 SGTC_221 trifluoperazine 4.97 10.3 µM 3.55E-7 NEO1-PIK1 163 3.40E-7
16 SGTC_1712 st032288 4.95 53.4 µM 3.78E-7 calcium & mitochondrial duress 122 3.62E-7
17 SGTC_3159 9100096 4.78 49.5 µM 9.38E-7 9 8.95E-7
18 SGTC_2584 androsterone 4.75 48.7 µM 1.08E-6 cell wall 87 1.03E-6
19 SGTC_528 3492-0019 4.72 172.0 µM 1.21E-6 calcium & mitochondrial duress 168 1.15E-6
20 SGTC_1383 3049-0032 4.41 20.7 µM 5.46E-6 60S ribosome export 15 5.16E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.257 1.49E-51 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.244 8.24E-47 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.239 6.52E-45 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.239 1.13E-44 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.232 2.62E-42 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.229 2.45E-41 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.225 7.84E-40 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.223 5.36E-39 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.221 3.20E-38 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.220 3.52E-38 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.220 6.13E-38 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.218 1.71E-37 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.215 2.17E-36 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.213 1.18E-35 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.211 3.01E-35 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction