YHL012W_p

Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL012W / YHL012W

Click on Significant Values for Screen Details ID:SGTC_158|Compound:k038-0087|FD-Score:2.81|P-value:8.20E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.94|P-value:4.98E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.11|P-value:2.54E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.02|P-value:3.63E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-2.99|P-value:5.03E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:2.88|P-value:6.22E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:2.81|P-value:8.08E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:2.88|P-value:6.25E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.94|P-value:5.32E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:-2.95|P-value:6.04E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.50|P-value:4.60E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.05|P-value:3.19E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.51|P-value:5.71E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-7.21|P-value:7.92E-16 ID:SGTC_1741|Compound:st038134|FD-Score:4.92|P-value:1.99E-8 ID:SGTC_1976|Compound:st070609|FD-Score:3.36|P-value:8.74E-5 ID:SGTC_2053|Compound:5265679|FD-Score:2.89|P-value:6.13E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-2.87|P-value:8.01E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.21|P-value:2.08E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.72|P-value:1.59E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.85|P-value:4.30E-8 ID:SGTC_2259|Compound:7964009|FD-Score:2.87|P-value:6.54E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.04|P-value:4.14E-4 ID:SGTC_2448|Compound:5185112|FD-Score:4.41|P-value:4.33E-7 ID:SGTC_2451|Compound:5856223|FD-Score:-5.07|P-value:1.13E-8 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.23|P-value:1.95E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.46|P-value:3.20E-7 ID:SGTC_2694|Compound:st077685|FD-Score:-3.82|P-value:1.30E-5 ID:SGTC_2710|Compound:st078562|FD-Score:-2.86|P-value:8.49E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.10|P-value:3.31E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.27|P-value:1.29E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.47|P-value:6.60E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.00|P-value:4.89E-4 ID:SGTC_3185|Compound:9108267|FD-Score:2.79|P-value:8.78E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.35|P-value:9.07E-5 ID:SGTC_3323|Compound:9138564|FD-Score:2.81|P-value:8.24E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:2.81|P-value:8.20E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.94|P-value:4.98E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.11|P-value:2.54E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.02|P-value:3.63E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-2.99|P-value:5.03E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:2.88|P-value:6.22E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:2.81|P-value:8.08E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:2.88|P-value:6.25E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.94|P-value:5.32E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:-2.95|P-value:6.04E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.50|P-value:4.60E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.05|P-value:3.19E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.51|P-value:5.71E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-7.21|P-value:7.92E-16 ID:SGTC_1741|Compound:st038134|FD-Score:4.92|P-value:1.99E-8 ID:SGTC_1976|Compound:st070609|FD-Score:3.36|P-value:8.74E-5 ID:SGTC_2053|Compound:5265679|FD-Score:2.89|P-value:6.13E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-2.87|P-value:8.01E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.21|P-value:2.08E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.72|P-value:1.59E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.85|P-value:4.30E-8 ID:SGTC_2259|Compound:7964009|FD-Score:2.87|P-value:6.54E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.04|P-value:4.14E-4 ID:SGTC_2448|Compound:5185112|FD-Score:4.41|P-value:4.33E-7 ID:SGTC_2451|Compound:5856223|FD-Score:-5.07|P-value:1.13E-8 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.23|P-value:1.95E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.46|P-value:3.20E-7 ID:SGTC_2694|Compound:st077685|FD-Score:-3.82|P-value:1.30E-5 ID:SGTC_2710|Compound:st078562|FD-Score:-2.86|P-value:8.49E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.10|P-value:3.31E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.27|P-value:1.29E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.47|P-value:6.60E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.00|P-value:4.89E-4 ID:SGTC_3185|Compound:9108267|FD-Score:2.79|P-value:8.78E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.35|P-value:9.07E-5 ID:SGTC_3323|Compound:9138564|FD-Score:2.81|P-value:8.24E-4

Top fitness defect scores for YHL012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1741 st038134 4.92 10.2 µM 1.99E-8 11 4.27E-7
2 SGTC_2582 agaric acid 4.46 100.0 µM 3.20E-7 redox potentiating 262 4.09E-6
3 SGTC_2448 5185112 4.41 27.2 µM 4.33E-7 8 5.23E-6
4 SGTC_786 4544-0069 3.94 423.0 µM 5.32E-6 27 4.04E-5
5 SGTC_2247 cerulenin 3.72 830.0 nM 1.59E-5 23 9.86E-5
6 SGTC_865 0488-0499 3.50 301.0 µM 4.60E-5 28 2.35E-4
7 SGTC_1976 st070609 3.36 63.5 µM 8.74E-5 27 3.96E-4
8 SGTC_3195 9113082 3.35 49.5 µM 9.07E-5 32 4.08E-4
9 SGTC_2851 9015922 3.27 71.4 µM 1.29E-4 73 5.45E-4
10 SGTC_283 0987-0079 3.11 11.7 µM 2.54E-4 66 9.48E-4
11 SGTC_948 3448-0295 3.05 75.3 µM 3.19E-4 81 0.00114
12 SGTC_294 k038-0071 3.02 157.0 µM 3.63E-4 ubiquinone biosynthesis & proteasome 111 0.00127
13 SGTC_182 3448-4371 2.94 550.5 µM 4.98E-4 60 0.00164
14 SGTC_2053 5265679 2.89 138.0 µM 6.13E-4 88 0.00195
15 SGTC_418 lividomycin a 2.88 100.0 µM 6.22E-4 55 0.00197
16 SGTC_771 0250-0039 2.88 27.3 µM 6.25E-4 55 0.00198
17 SGTC_2259 7964009 2.87 200.0 µM 6.54E-4 superoxide 92 0.00206
18 SGTC_532 1548-0774 2.81 215.0 µM 8.08E-4 69 0.00244
19 SGTC_158 k038-0087 2.81 26.4 µM 8.20E-4 ubiquinone biosynthesis & proteasome 226 0.00247
20 SGTC_3323 9138564 2.81 53.9 µM 8.24E-4 85 0.00248

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.58E-25 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.167 2.33E-22 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.164 1.55E-21 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.161 4.97E-21 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.161 7.88E-21 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.155 2.10E-19 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.154 2.18E-19 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.151 1.31E-18 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.146 1.59E-17 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.141 2.29E-16 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.140 4.32E-16 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.132 1.64E-14 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.128 1.12E-13 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.127 1.37E-13 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.123 8.03E-13 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p