YHL015W / RPS20

Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHL015W / RPS20

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:-4.20|P-value:1.13E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.49|P-value:5.36E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-4.49|P-value:4.00E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:4.10|P-value:2.03E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.94|P-value:2.70E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.21|P-value:2.43E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.57|P-value:8.56E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.78|P-value:5.67E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:4.57|P-value:3.97E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.97|P-value:2.41E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.95|P-value:6.98E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:3.84|P-value:4.70E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.60|P-value:9.57E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.53|P-value:8.49E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:-4.10|P-value:1.59E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:13.50|P-value:3.16E-32 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.87|P-value:3.31E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.00|P-value:2.79E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.74|P-value:6.26E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.60|P-value:7.79E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.47|P-value:5.73E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:-4.16|P-value:1.29E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.64|P-value:8.61E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:7.18|P-value:2.55E-10 ID:SGTC_1143|Compound:3454-2408|FD-Score:-4.26|P-value:9.30E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.63|P-value:7.09E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.04|P-value:1.93E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.80|P-value:4.20E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.96|P-value:2.53E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-4.54|P-value:3.32E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:7.35|P-value:9.51E-11 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.65|P-value:6.64E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.33|P-value:9.17E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:6.09|P-value:6.73E-8 ID:SGTC_1522|Compound:st012842|FD-Score:-4.22|P-value:1.05E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.59|P-value:9.95E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.77|P-value:1.43E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.75|P-value:6.13E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.92|P-value:8.01E-6 ID:SGTC_1775|Compound:st081588|FD-Score:-4.21|P-value:1.09E-4 ID:SGTC_1804|Compound:st050076|FD-Score:4.13|P-value:1.84E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-6.25|P-value:2.16E-8 ID:SGTC_1829|Compound:berberine|FD-Score:-5.49|P-value:7.36E-7 ID:SGTC_1831|Compound:st055328|FD-Score:-3.81|P-value:4.07E-4 ID:SGTC_1900|Compound:st060200|FD-Score:6.25|P-value:3.13E-8 ID:SGTC_1901|Compound:st060216|FD-Score:4.43|P-value:6.55E-5 ID:SGTC_1902|Compound:st060212|FD-Score:5.92|P-value:1.48E-7 ID:SGTC_1904|Compound:st060225|FD-Score:4.16|P-value:1.68E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.55|P-value:8.85E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.77|P-value:5.70E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.74|P-value:5.07E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.74|P-value:5.09E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.53|P-value:6.19E-7 ID:SGTC_2352|Compound:9027995|FD-Score:3.68|P-value:7.68E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.86|P-value:3.41E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.67|P-value:7.85E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.93|P-value:2.79E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.84|P-value:3.64E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.82|P-value:1.16E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.69|P-value:5.91E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.43|P-value:6.48E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.33|P-value:7.17E-11 ID:SGTC_2766|Compound:oltipraz|FD-Score:-6.84|P-value:1.07E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.62|P-value:2.51E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.76|P-value:5.95E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.66|P-value:6.45E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.95|P-value:3.24E-4 ID:SGTC_2817|Compound:7995342|FD-Score:4.31|P-value:9.85E-5 ID:SGTC_2873|Compound:9040596|FD-Score:5.85|P-value:2.08E-7 ID:SGTC_2947|Compound:9072639|FD-Score:5.61|P-value:6.11E-7 ID:SGTC_2964|Compound:9083345|FD-Score:6.31|P-value:2.41E-8 ID:SGTC_2965|Compound:9082772|FD-Score:-4.02|P-value:2.08E-4 ID:SGTC_2977|Compound:9011197|FD-Score:5.61|P-value:6.01E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.59|P-value:2.83E-5 ID:SGTC_3032|Compound:9089427|FD-Score:-3.74|P-value:5.10E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.23|P-value:1.32E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.29|P-value:8.25E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.80|P-value:1.68E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-4.16|P-value:1.28E-4 ID:SGTC_3178|Compound:9107506|FD-Score:4.23|P-value:1.29E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.71|P-value:5.51E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.70|P-value:2.45E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.30|P-value:1.02E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.10|P-value:1.59E-4 ID:SGTC_3343|Compound:9148379|FD-Score:-3.69|P-value:5.94E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.68|P-value:6.03E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.20|P-value:1.13E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.49|P-value:5.36E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-4.49|P-value:4.00E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:4.10|P-value:2.03E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.94|P-value:2.70E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.21|P-value:2.43E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.57|P-value:8.56E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.78|P-value:5.67E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:4.57|P-value:3.97E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.97|P-value:2.41E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-4.95|P-value:6.98E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:3.84|P-value:4.70E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.60|P-value:9.57E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.53|P-value:8.49E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:-4.10|P-value:1.59E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:13.50|P-value:3.16E-32 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.87|P-value:3.31E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.00|P-value:2.79E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.74|P-value:6.26E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.60|P-value:7.79E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.47|P-value:5.73E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:-4.16|P-value:1.29E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.64|P-value:8.61E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:7.18|P-value:2.55E-10 ID:SGTC_1143|Compound:3454-2408|FD-Score:-4.26|P-value:9.30E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.63|P-value:7.09E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.04|P-value:1.93E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.80|P-value:4.20E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.96|P-value:2.53E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-4.54|P-value:3.32E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:7.35|P-value:9.51E-11 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.65|P-value:6.64E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.33|P-value:9.17E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:6.09|P-value:6.73E-8 ID:SGTC_1522|Compound:st012842|FD-Score:-4.22|P-value:1.05E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.59|P-value:9.95E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.77|P-value:1.43E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.75|P-value:6.13E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.92|P-value:8.01E-6 ID:SGTC_1775|Compound:st081588|FD-Score:-4.21|P-value:1.09E-4 ID:SGTC_1804|Compound:st050076|FD-Score:4.13|P-value:1.84E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-6.25|P-value:2.16E-8 ID:SGTC_1829|Compound:berberine|FD-Score:-5.49|P-value:7.36E-7 ID:SGTC_1831|Compound:st055328|FD-Score:-3.81|P-value:4.07E-4 ID:SGTC_1900|Compound:st060200|FD-Score:6.25|P-value:3.13E-8 ID:SGTC_1901|Compound:st060216|FD-Score:4.43|P-value:6.55E-5 ID:SGTC_1902|Compound:st060212|FD-Score:5.92|P-value:1.48E-7 ID:SGTC_1904|Compound:st060225|FD-Score:4.16|P-value:1.68E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.55|P-value:8.85E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.77|P-value:5.70E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.74|P-value:5.07E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.74|P-value:5.09E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.53|P-value:6.19E-7 ID:SGTC_2352|Compound:9027995|FD-Score:3.68|P-value:7.68E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.86|P-value:3.41E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.67|P-value:7.85E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.93|P-value:2.79E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.84|P-value:3.64E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.82|P-value:1.16E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.69|P-value:5.91E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.43|P-value:6.48E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.33|P-value:7.17E-11 ID:SGTC_2766|Compound:oltipraz|FD-Score:-6.84|P-value:1.07E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.62|P-value:2.51E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.76|P-value:5.95E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.66|P-value:6.45E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.95|P-value:3.24E-4 ID:SGTC_2817|Compound:7995342|FD-Score:4.31|P-value:9.85E-5 ID:SGTC_2873|Compound:9040596|FD-Score:5.85|P-value:2.08E-7 ID:SGTC_2947|Compound:9072639|FD-Score:5.61|P-value:6.11E-7 ID:SGTC_2964|Compound:9083345|FD-Score:6.31|P-value:2.41E-8 ID:SGTC_2965|Compound:9082772|FD-Score:-4.02|P-value:2.08E-4 ID:SGTC_2977|Compound:9011197|FD-Score:5.61|P-value:6.01E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.59|P-value:2.83E-5 ID:SGTC_3032|Compound:9089427|FD-Score:-3.74|P-value:5.10E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.23|P-value:1.32E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.29|P-value:8.25E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.80|P-value:1.68E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-4.16|P-value:1.28E-4 ID:SGTC_3178|Compound:9107506|FD-Score:4.23|P-value:1.29E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.71|P-value:5.51E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.70|P-value:2.45E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.30|P-value:1.02E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.10|P-value:1.59E-4 ID:SGTC_3343|Compound:9148379|FD-Score:-3.69|P-value:5.94E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.68|P-value:6.03E-4

Top fitness defect scores for YHL015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_800 3448-7362 13.50 155.0 µM 3.16E-32 translation 1 4.30E-42 2.06
2 SGTC_1339 1486-1321 7.35 22.7 µM 9.51E-11 ERG2 1 9.75E-14 2.68
3 SGTC_1119 parthenolide 7.18 318.5 nM 2.55E-10 TSC3-RPN4 1 3.58E-13 1.14
4 SGTC_2964 9083345 6.31 53.4 µM 2.41E-8 3 1.43E-10 0.38
5 SGTC_1900 st060200 6.25 72.8 µM 3.13E-8 2 2.02E-10 1.71
6 SGTC_1513 0337-0559 6.09 19.0 µM 6.73E-8 2 5.55E-10 0.97
7 SGTC_1902 st060212 5.92 70.5 µM 1.48E-7 2 1.57E-9 0.98
8 SGTC_2873 9040596 5.85 71.4 µM 2.08E-7 2 2.45E-9 1.35
9 SGTC_2977 9011197 5.61 71.4 µM 6.01E-7 2 9.91E-9 0.65
10 SGTC_2947 9072639 5.61 7.7 µM 6.11E-7 tubulin folding & SWR complex 4 1.01E-8 0.25
11 SGTC_708 3448-5400 5.53 146.0 µM 8.49E-7 6 1.56E-8 0.54
12 SGTC_3076 9116187 4.80 49.5 µM 1.68E-5 3 7.92E-7 0.00
13 SGTC_3238 9133470 4.70 49.5 µM 2.45E-5 2 1.30E-6 0.43
14 SGTC_583 1488-1091 4.57 88.9 µM 3.97E-5 4 2.45E-6 0.28
15 SGTC_241 5hr heat shock (37°C) + cantharidin 4.49 155.4 µM 5.36E-5 cell wall signaling 12 3.63E-6 0.11
16 SGTC_1052 3253-3998 4.47 198.0 µM 5.73E-5 3 3.96E-6 0.10
17 SGTC_2689 tacrolimus 4.43 100.0 µM 6.48E-5 9 4.65E-6 0.13
18 SGTC_1901 st060216 4.43 58.6 µM 6.55E-5 2 4.72E-6 0.32
19 SGTC_1465 k213-0056 4.33 144.0 µM 9.17E-5 DNA intercalators 7 7.34E-6 0.04
20 SGTC_2817 7995342 4.31 71.4 µM 9.85E-5 5 8.07E-6 0.45

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.334 5.21E-88 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.306 1.39E-73 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.302 8.54E-72 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.252 1.38E-49 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.251 1.99E-49 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.250 3.65E-49 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.234 4.30E-43 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.216 1.27E-36 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.201 8.90E-32 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.200 1.58E-31 YJR123W RPS5 het Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
0.196 3.11E-30 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.195 3.44E-30 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.182 2.78E-26 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.180 7.10E-26 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.173 5.96E-24 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript