YHL019C / APM2

Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL019C / APM2

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:7.04|P-value:5.14E-14 ID:SGTC_146|Compound:3448-8650|FD-Score:3.28|P-value:2.75E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:2.95|P-value:9.57E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.34|P-value:8.82E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:4.66|P-value:4.30E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:3.01|P-value:7.57E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.25|P-value:3.73E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:27.30|P-value:6.48E-184 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.08|P-value:5.91E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.80|P-value:3.06E-30 ID:SGTC_254|Compound:nsc-64875|FD-Score:8.07|P-value:8.18E-18 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.48|P-value:1.16E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:3.35|P-value:2.11E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:7.62|P-value:4.17E-16 ID:SGTC_312|Compound:4092-0653|FD-Score:8.86|P-value:3.97E-21 ID:SGTC_320|Compound:4092-0846|FD-Score:4.62|P-value:5.58E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:3.38|P-value:1.86E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.03|P-value:7.04E-4 ID:SGTC_447|Compound:ml7|FD-Score:3.98|P-value:1.34E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.36|P-value:2.09E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.77|P-value:3.58E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.25|P-value:3.13E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.18|P-value:4.01E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.04|P-value:6.73E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.07|P-value:5.56E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:8.81|P-value:6.75E-21 ID:SGTC_741|Compound:4582-0002|FD-Score:3.30|P-value:2.53E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.98|P-value:1.40E-10 ID:SGTC_995|Compound:3931-2021|FD-Score:2.99|P-value:8.28E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:5.26|P-value:1.42E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:2.97|P-value:8.70E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.00|P-value:1.22E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.02|P-value:7.25E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.03|P-value:6.43E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.19|P-value:3.85E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-4.16|P-value:5.11E-6 ID:SGTC_1672|Compound:st016598|FD-Score:8.72|P-value:1.59E-20 ID:SGTC_1712|Compound:st032288|FD-Score:5.17|P-value:2.40E-8 ID:SGTC_1750|Compound:st081859|FD-Score:20.80|P-value:4.61E-107 ID:SGTC_1754|Compound:st042065|FD-Score:5.21|P-value:1.93E-8 ID:SGTC_1760|Compound:st045453|FD-Score:3.60|P-value:7.40E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.55|P-value:9.16E-5 ID:SGTC_1795|Compound:st049545|FD-Score:3.22|P-value:3.45E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.30|P-value:2.86E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.48|P-value:3.71E-9 ID:SGTC_1801|Compound:st050089|FD-Score:3.72|P-value:4.30E-5 ID:SGTC_1803|Compound:st050068|FD-Score:7.67|P-value:2.80E-16 ID:SGTC_1818|Compound:st052136|FD-Score:4.54|P-value:8.37E-7 ID:SGTC_2006|Compound:4011487|FD-Score:11.50|P-value:2.87E-34 ID:SGTC_2021|Compound:4019055|FD-Score:4.08|P-value:8.44E-6 ID:SGTC_2167|Compound:5876490|FD-Score:4.48|P-value:1.16E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:12.60|P-value:8.42E-41 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.40|P-value:1.32E-28 ID:SGTC_2257|Compound:7960413|FD-Score:6.01|P-value:1.09E-10 ID:SGTC_2329|Compound:6138490|FD-Score:4.94|P-value:9.13E-8 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.78|P-value:3.35E-5 ID:SGTC_2523|Compound:spermine|FD-Score:3.11|P-value:5.31E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.09|P-value:8.21E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_2602|Compound:kawain|FD-Score:5.59|P-value:1.78E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.16|P-value:4.33E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.59|P-value:7.82E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.40|P-value:6.14E-9 ID:SGTC_2828|Compound:7998861|FD-Score:3.52|P-value:1.04E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.32|P-value:1.27E-11 ID:SGTC_2931|Compound:9014674|FD-Score:-5.31|P-value:9.44E-9 ID:SGTC_2955|Compound:9076254|FD-Score:3.48|P-value:1.20E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.66|P-value:5.29E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.75|P-value:3.92E-5 ID:SGTC_3018|Compound:9082602|FD-Score:11.80|P-value:4.35E-36 ID:SGTC_3037|Compound:9091026|FD-Score:4.06|P-value:9.43E-6 ID:SGTC_3152|Compound:9099253|FD-Score:2.98|P-value:8.39E-4 ID:SGTC_3308|Compound:9128332|FD-Score:9.51|P-value:4.71E-24 ID:SGTC_57|Compound:miconazole|FD-Score:7.04|P-value:5.14E-14 ID:SGTC_146|Compound:3448-8650|FD-Score:3.28|P-value:2.75E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:2.95|P-value:9.57E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.34|P-value:8.82E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:4.66|P-value:4.30E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:3.01|P-value:7.57E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.25|P-value:3.73E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:27.30|P-value:6.48E-184 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.08|P-value:5.91E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.80|P-value:3.06E-30 ID:SGTC_254|Compound:nsc-64875|FD-Score:8.07|P-value:8.18E-18 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.48|P-value:1.16E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:3.35|P-value:2.11E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:7.62|P-value:4.17E-16 ID:SGTC_312|Compound:4092-0653|FD-Score:8.86|P-value:3.97E-21 ID:SGTC_320|Compound:4092-0846|FD-Score:4.62|P-value:5.58E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:3.38|P-value:1.86E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.03|P-value:7.04E-4 ID:SGTC_447|Compound:ml7|FD-Score:3.98|P-value:1.34E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.36|P-value:2.09E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.77|P-value:3.58E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.25|P-value:3.13E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.18|P-value:4.01E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.04|P-value:6.73E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.07|P-value:5.56E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:8.81|P-value:6.75E-21 ID:SGTC_741|Compound:4582-0002|FD-Score:3.30|P-value:2.53E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.98|P-value:1.40E-10 ID:SGTC_995|Compound:3931-2021|FD-Score:2.99|P-value:8.28E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:5.26|P-value:1.42E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:2.97|P-value:8.70E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.00|P-value:1.22E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.02|P-value:7.25E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.03|P-value:6.43E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.19|P-value:3.85E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-4.16|P-value:5.11E-6 ID:SGTC_1672|Compound:st016598|FD-Score:8.72|P-value:1.59E-20 ID:SGTC_1712|Compound:st032288|FD-Score:5.17|P-value:2.40E-8 ID:SGTC_1750|Compound:st081859|FD-Score:20.80|P-value:4.61E-107 ID:SGTC_1754|Compound:st042065|FD-Score:5.21|P-value:1.93E-8 ID:SGTC_1760|Compound:st045453|FD-Score:3.60|P-value:7.40E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.55|P-value:9.16E-5 ID:SGTC_1795|Compound:st049545|FD-Score:3.22|P-value:3.45E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.30|P-value:2.86E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.48|P-value:3.71E-9 ID:SGTC_1801|Compound:st050089|FD-Score:3.72|P-value:4.30E-5 ID:SGTC_1803|Compound:st050068|FD-Score:7.67|P-value:2.80E-16 ID:SGTC_1818|Compound:st052136|FD-Score:4.54|P-value:8.37E-7 ID:SGTC_2006|Compound:4011487|FD-Score:11.50|P-value:2.87E-34 ID:SGTC_2021|Compound:4019055|FD-Score:4.08|P-value:8.44E-6 ID:SGTC_2167|Compound:5876490|FD-Score:4.48|P-value:1.16E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:12.60|P-value:8.42E-41 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.40|P-value:1.32E-28 ID:SGTC_2257|Compound:7960413|FD-Score:6.01|P-value:1.09E-10 ID:SGTC_2329|Compound:6138490|FD-Score:4.94|P-value:9.13E-8 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.78|P-value:3.35E-5 ID:SGTC_2523|Compound:spermine|FD-Score:3.11|P-value:5.31E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.09|P-value:8.21E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_2602|Compound:kawain|FD-Score:5.59|P-value:1.78E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.16|P-value:4.33E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.59|P-value:7.82E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.40|P-value:6.14E-9 ID:SGTC_2828|Compound:7998861|FD-Score:3.52|P-value:1.04E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.32|P-value:1.27E-11 ID:SGTC_2931|Compound:9014674|FD-Score:-5.31|P-value:9.44E-9 ID:SGTC_2955|Compound:9076254|FD-Score:3.48|P-value:1.20E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.66|P-value:5.29E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.75|P-value:3.92E-5 ID:SGTC_3018|Compound:9082602|FD-Score:11.80|P-value:4.35E-36 ID:SGTC_3037|Compound:9091026|FD-Score:4.06|P-value:9.43E-6 ID:SGTC_3152|Compound:9099253|FD-Score:2.98|P-value:8.39E-4 ID:SGTC_3308|Compound:9128332|FD-Score:9.51|P-value:4.71E-24

Top fitness defect scores for YHL019C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_207 4185-0010 27.30 4.5 µM 6.48E-184 endomembrane recycling 2 7.66E-165
2 SGTC_1750 st081859 20.80 2.4 µM 4.61E-107 endomembrane recycling 12 4.48E-96
3 SGTC_2249 haloperidol 12.60 116.4 µM 8.42E-41 ergosterol depletion effects on membrane 5 9.25E-37
4 SGTC_3018 9082602 11.80 49.5 µM 4.35E-36 9 1.54E-32
5 SGTC_2006 4011487 11.50 200.0 µM 2.87E-34 endomembrane recycling 9 6.56E-31
6 SGTC_221 trifluoperazine 10.80 10.3 µM 3.06E-30 NEO1-PIK1 49 2.67E-27
7 SGTC_2250 alverine citrate 10.40 130.0 µM 1.32E-28 7 7.76E-26
8 SGTC_3308 9128332 9.51 17.6 µM 4.71E-24 plasma membrane duress 22 9.33E-22
9 SGTC_312 4092-0653 8.86 6.8 µM 3.97E-21 ergosterol depletion effects on membrane 17 3.91E-19
10 SGTC_649 1123-0311 8.81 367.0 µM 6.75E-21 endomembrane recycling 13 6.30E-19
11 SGTC_1672 st016598 8.72 6.5 µM 1.59E-20 endomembrane recycling 14 1.36E-18
12 SGTC_254 nsc-64875 8.07 3.8 µM 8.18E-18 ergosterol depletion effects on membrane 10 3.66E-16
13 SGTC_1803 st050068 7.67 52.4 µM 2.80E-16 NEO1-PIK1 45 8.69E-15
14 SGTC_308 4092-1169 7.62 104.0 µM 4.17E-16 plasma membrane duress 9 1.24E-14
15 SGTC_57 miconazole 7.04 162.5 nM 5.14E-14 ergosterol depletion effects on membrane 7 9.35E-13
16 SGTC_2896 9052656 6.32 71.4 µM 1.27E-11 endomembrane recycling 35 1.32E-10
17 SGTC_2257 7960413 6.01 200.0 µM 1.09E-10 NEO1-PIK1 13 9.02E-10
18 SGTC_788 1182-0090 5.98 188.0 µM 1.40E-10 endomembrane recycling 35 1.13E-9
19 SGTC_2602 kawain 5.59 100.0 µM 1.78E-9 4 1.11E-8
20 SGTC_1800 st050079 5.48 29.1 µM 3.71E-9 NEO1-PIK1 58 2.15E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.773 0 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.630 0 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.593 7.09E-318 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.583 1.04E-304 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.528 1.18E-240 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.523 1.45E-235 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.512 9.35E-224 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.506 1.95E-217 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.484 7.68E-197 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.475 8.15E-188 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.471 6.66E-185 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.459 3.46E-174 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.416 1.02E-140 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.393 4.52E-124 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.354 1.33E-99 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity