YHL020C / OPI1

Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL020C / OPI1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:7.65|P-value:2.20E-13 ID:SGTC_16|Compound:erodoxin|FD-Score:11.10|P-value:3.33E-26 ID:SGTC_17|Compound:0960-0276|FD-Score:3.86|P-value:1.31E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.29|P-value:2.51E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.83|P-value:1.34E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.38|P-value:7.13E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:10.70|P-value:1.68E-24 ID:SGTC_174|Compound:3553-0389|FD-Score:4.63|P-value:6.08E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.48|P-value:4.59E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.45|P-value:5.59E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.31|P-value:8.83E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.56|P-value:3.84E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.65|P-value:2.82E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:4.63|P-value:6.08E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:3.63|P-value:3.09E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.02|P-value:7.23E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.54|P-value:4.16E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.12|P-value:6.43E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.56|P-value:3.87E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-3.42|P-value:5.65E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.31|P-value:8.88E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.32|P-value:8.51E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.74|P-value:6.34E-17 ID:SGTC_1755|Compound:st041960|FD-Score:-3.40|P-value:6.01E-4 ID:SGTC_1782|Compound:st039423|FD-Score:5.08|P-value:7.70E-7 ID:SGTC_1818|Compound:st052136|FD-Score:3.64|P-value:2.97E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.40|P-value:6.62E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.57|P-value:3.31E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.35|P-value:1.99E-5 ID:SGTC_2144|Compound:5628481|FD-Score:4.40|P-value:1.61E-5 ID:SGTC_2517|Compound:totarol|FD-Score:3.55|P-value:4.02E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.60|P-value:2.06E-10 ID:SGTC_2789|Compound:5281112|FD-Score:4.42|P-value:1.47E-5 ID:SGTC_2925|Compound:9010536|FD-Score:3.79|P-value:1.71E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.32|P-value:8.51E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.85|P-value:1.38E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.31|P-value:8.82E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.47|P-value:4.77E-4 ID:SGTC_3087|Compound:9117406|FD-Score:7.18|P-value:5.40E-12 ID:SGTC_3088|Compound:9117578|FD-Score:5.93|P-value:1.01E-8 ID:SGTC_3091|Compound:9116372|FD-Score:4.04|P-value:6.76E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.65|P-value:2.80E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.75|P-value:3.57E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:7.65|P-value:2.20E-13 ID:SGTC_16|Compound:erodoxin|FD-Score:11.10|P-value:3.33E-26 ID:SGTC_17|Compound:0960-0276|FD-Score:3.86|P-value:1.31E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.29|P-value:2.51E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.83|P-value:1.34E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.38|P-value:7.13E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:10.70|P-value:1.68E-24 ID:SGTC_174|Compound:3553-0389|FD-Score:4.63|P-value:6.08E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.48|P-value:4.59E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.45|P-value:5.59E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.31|P-value:8.83E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.56|P-value:3.84E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.65|P-value:2.82E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:4.63|P-value:6.08E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:3.63|P-value:3.09E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.02|P-value:7.23E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.54|P-value:4.16E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.12|P-value:6.43E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.56|P-value:3.87E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-3.42|P-value:5.65E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.31|P-value:8.88E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.32|P-value:8.51E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.74|P-value:6.34E-17 ID:SGTC_1755|Compound:st041960|FD-Score:-3.40|P-value:6.01E-4 ID:SGTC_1782|Compound:st039423|FD-Score:5.08|P-value:7.70E-7 ID:SGTC_1818|Compound:st052136|FD-Score:3.64|P-value:2.97E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.40|P-value:6.62E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.57|P-value:3.31E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.35|P-value:1.99E-5 ID:SGTC_2144|Compound:5628481|FD-Score:4.40|P-value:1.61E-5 ID:SGTC_2517|Compound:totarol|FD-Score:3.55|P-value:4.02E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.60|P-value:2.06E-10 ID:SGTC_2789|Compound:5281112|FD-Score:4.42|P-value:1.47E-5 ID:SGTC_2925|Compound:9010536|FD-Score:3.79|P-value:1.71E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.32|P-value:8.51E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.85|P-value:1.38E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.31|P-value:8.82E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.47|P-value:4.77E-4 ID:SGTC_3087|Compound:9117406|FD-Score:7.18|P-value:5.40E-12 ID:SGTC_3088|Compound:9117578|FD-Score:5.93|P-value:1.01E-8 ID:SGTC_3091|Compound:9116372|FD-Score:4.04|P-value:6.76E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.65|P-value:2.80E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.75|P-value:3.57E-6

Top fitness defect scores for YHL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_16 erodoxin 11.10 22.8 µM 3.33E-26 unfolded protein response 9 5.46E-29
2 SGTC_146 3448-8650 10.70 53.1 µM 1.68E-24 NEO1-PIK1 15 4.28E-27
3 SGTC_1754 st042065 8.74 16.1 µM 6.34E-17 NEO1-PIK1 42 1.14E-18
4 SGTC_15 0266-0086 7.65 27.1 µM 2.20E-13 endomembrane recycling 9 9.87E-15
5 SGTC_3087 9117406 7.18 49.5 µM 5.40E-12 2 3.47E-13
6 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 6.60 70.0 µM 2.06E-10 redox potentiating 19 1.99E-11
7 SGTC_3088 9117578 5.93 49.5 µM 1.01E-8 amide catabolism 2 1.51E-9
8 SGTC_1155 4088-0394 5.12 48.2 µM 6.43E-7 5 1.52E-7
9 SGTC_1782 st039423 5.08 80.6 µM 7.70E-7 4 1.86E-7
10 SGTC_3351 9150312 4.75 21.6 µM 3.57E-6 cell wall 22 1.02E-6
11 SGTC_979 1426-2828 4.63 121.0 µM 6.08E-6 13 1.84E-6
12 SGTC_174 3553-0389 4.63 74.3 µM 6.08E-6 11 1.84E-6
13 SGTC_2789 5281112 4.42 71.4 µM 1.47E-5 23 4.91E-6
14 SGTC_2144 5628481 4.40 200.0 µM 1.61E-5 ERG2 16 5.44E-6
15 SGTC_2098 5376439 4.35 882.5 nM 1.99E-5 9 6.88E-6
16 SGTC_56 0957-0365 4.29 83.2 µM 2.51E-5 Golgi 36 8.90E-6
17 SGTC_3091 9116372 4.04 49.5 µM 6.76E-5 14 2.67E-5
18 SGTC_1091 telmisartan 4.02 47.6 µM 7.23E-5 10 2.88E-5
19 SGTC_17 0960-0276 3.86 49.8 µM 1.31E-4 36 5.58E-5
20 SGTC_3049 9092223 3.85 49.5 µM 1.38E-4 25 5.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.219 1.14E-37 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.213 1.44E-35 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.207 9.87E-34 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.190 1.55E-28 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.186 1.63E-27 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.182 1.65E-26 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.168 1.43E-22 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.166 3.49E-22 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.150 1.84E-18 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.145 2.63E-17 YIL149C MLP2 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
0.143 6.80E-17 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.139 6.99E-16 YDL070W BDF2 hom Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress
0.135 3.89E-15 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.133 1.12E-14 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.132 1.72E-14 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC