YHL021C / AIM17

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL021C / AIM17

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:-3.04|P-value:8.41E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-3.64|P-value:8.73E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.27|P-value:3.73E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.00|P-value:9.65E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.88|P-value:3.11E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.11|P-value:6.38E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.08|P-value:7.18E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.04|P-value:8.21E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.15|P-value:5.57E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.89|P-value:2.90E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.69|P-value:6.96E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:-4.02|P-value:1.66E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.04|P-value:8.38E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.02|P-value:8.77E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.64|P-value:8.39E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.82|P-value:3.95E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:4.10|P-value:1.09E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.20|P-value:6.95E-6 ID:SGTC_1896|Compound:st058441|FD-Score:3.12|P-value:6.32E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.07|P-value:7.35E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.63|P-value:9.02E-5 ID:SGTC_1967|Compound:st070177|FD-Score:4.71|P-value:5.66E-7 ID:SGTC_1968|Compound:st069590|FD-Score:3.14|P-value:5.79E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.21|P-value:4.54E-4 ID:SGTC_2065|Compound:5221596|FD-Score:5.14|P-value:5.42E-8 ID:SGTC_2066|Compound:5222451|FD-Score:-3.06|P-value:7.99E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.07|P-value:7.39E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-4.52|P-value:1.55E-6 ID:SGTC_2285|Compound:7945142|FD-Score:4.30|P-value:4.27E-6 ID:SGTC_2286|Compound:7945697|FD-Score:9.00|P-value:6.71E-21 ID:SGTC_2292|Compound:7671323|FD-Score:4.21|P-value:6.71E-6 ID:SGTC_2296|Compound:7971656|FD-Score:-3.82|P-value:4.01E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.61|P-value:9.40E-5 ID:SGTC_2353|Compound:9059630|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_2425|Compound:5628681|FD-Score:6.17|P-value:8.53E-11 ID:SGTC_2426|Compound:5582046|FD-Score:3.01|P-value:9.33E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.26|P-value:3.69E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.00|P-value:9.93E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.22|P-value:4.28E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.16|P-value:5.47E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.51|P-value:1.44E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.35|P-value:2.71E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.53|P-value:1.41E-6 ID:SGTC_2802|Compound:7925815|FD-Score:3.07|P-value:7.45E-4 ID:SGTC_2861|Compound:9024595|FD-Score:3.43|P-value:1.95E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-4.05|P-value:1.47E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.61|P-value:9.82E-5 ID:SGTC_2994|Compound:9053520|FD-Score:-4.08|P-value:1.26E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.16|P-value:5.34E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.04|P-value:8.53E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.70|P-value:6.66E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-3.48|P-value:1.62E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.00|P-value:9.64E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-4.57|P-value:1.18E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-3.28|P-value:3.57E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.36|P-value:2.58E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.01|P-value:9.09E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:-3.04|P-value:8.41E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-3.64|P-value:8.73E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.27|P-value:3.73E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.00|P-value:9.65E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.88|P-value:3.11E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.11|P-value:6.38E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.08|P-value:7.18E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.04|P-value:8.21E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.15|P-value:5.57E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.89|P-value:2.90E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.69|P-value:6.96E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:-4.02|P-value:1.66E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.04|P-value:8.38E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.02|P-value:8.77E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.64|P-value:8.39E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.82|P-value:3.95E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:4.10|P-value:1.09E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.20|P-value:6.95E-6 ID:SGTC_1896|Compound:st058441|FD-Score:3.12|P-value:6.32E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.07|P-value:7.35E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.63|P-value:9.02E-5 ID:SGTC_1967|Compound:st070177|FD-Score:4.71|P-value:5.66E-7 ID:SGTC_1968|Compound:st069590|FD-Score:3.14|P-value:5.79E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.21|P-value:4.54E-4 ID:SGTC_2065|Compound:5221596|FD-Score:5.14|P-value:5.42E-8 ID:SGTC_2066|Compound:5222451|FD-Score:-3.06|P-value:7.99E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.07|P-value:7.39E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-4.52|P-value:1.55E-6 ID:SGTC_2285|Compound:7945142|FD-Score:4.30|P-value:4.27E-6 ID:SGTC_2286|Compound:7945697|FD-Score:9.00|P-value:6.71E-21 ID:SGTC_2292|Compound:7671323|FD-Score:4.21|P-value:6.71E-6 ID:SGTC_2296|Compound:7971656|FD-Score:-3.82|P-value:4.01E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.61|P-value:9.40E-5 ID:SGTC_2353|Compound:9059630|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_2425|Compound:5628681|FD-Score:6.17|P-value:8.53E-11 ID:SGTC_2426|Compound:5582046|FD-Score:3.01|P-value:9.33E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.26|P-value:3.69E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.00|P-value:9.93E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.22|P-value:4.28E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.16|P-value:5.47E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.51|P-value:1.44E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.35|P-value:2.71E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.53|P-value:1.41E-6 ID:SGTC_2802|Compound:7925815|FD-Score:3.07|P-value:7.45E-4 ID:SGTC_2861|Compound:9024595|FD-Score:3.43|P-value:1.95E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-4.05|P-value:1.47E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.61|P-value:9.82E-5 ID:SGTC_2994|Compound:9053520|FD-Score:-4.08|P-value:1.26E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.16|P-value:5.34E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.04|P-value:8.53E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.70|P-value:6.66E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-3.48|P-value:1.62E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.00|P-value:9.64E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-4.57|P-value:1.18E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-3.28|P-value:3.57E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.36|P-value:2.58E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.01|P-value:9.09E-4

Top fitness defect scores for YHL021C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2286 7945697 9.00 125.0 µM 6.71E-21 5 1.13E-19
2 SGTC_2425 5628681 6.17 7.8 µM 8.53E-11 2 3.31E-10
3 SGTC_2065 5221596 5.14 34.3 µM 5.42E-8 4 1.40E-7
4 SGTC_1967 st070177 4.71 51.4 µM 5.66E-7 8 1.26E-6
5 SGTC_2790 5423970 4.53 71.4 µM 1.41E-6 endomembrane recycling 45 2.97E-6
6 SGTC_2285 7945142 4.30 200.0 µM 4.27E-6 13 8.43E-6
7 SGTC_2292 7671323 4.21 168.1 µM 6.71E-6 RNA processing & uracil transport 23 1.29E-5
8 SGTC_1893 st059353 4.20 36.1 µM 6.95E-6 18 1.33E-5
9 SGTC_1693 xanthone 4.10 101.9 µM 1.09E-5 DNA damage response 14 2.02E-5
10 SGTC_762 1165-0429 3.89 115.0 µM 2.90E-5 TSC3-RPN4 19 5.08E-5
11 SGTC_1309 pyrazolanthrone 3.82 13.4 µM 3.95E-5 23 6.79E-5
12 SGTC_1212 0520-0165 3.64 585.0 µM 8.39E-5 45 1.38E-4
13 SGTC_2314 7727897 3.61 200.0 µM 9.40E-5 34 1.53E-4
14 SGTC_2353 9059630 3.58 146.7 µM 1.07E-4 27 1.72E-4
15 SGTC_2570 licareol 3.55 100.0 µM 1.21E-4 45 1.94E-4
16 SGTC_2861 9024595 3.43 19.5 µM 1.95E-4 7 3.05E-4
17 SGTC_3292 9120825 3.36 59.8 µM 2.58E-4 28 3.95E-4
18 SGTC_2460 5552655 3.26 174.2 µM 3.69E-4 amide catabolism 59 5.54E-4
19 SGTC_2551 apiole 3.22 73.9 µM 4.28E-4 23 6.36E-4
20 SGTC_2063 5246145 3.21 200.0 µM 4.54E-4 51 6.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.44E-12 YHR015W MIP6 hom Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication
0.100 5.72E-9 YIL124W AYR1 hom NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
0.098 1.48E-8 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.088 3.23E-7 YMR315W YMR315W hom Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress
0.086 5.79E-7 YJR141W_p YJR141W_p het Essential protein of unknown function
0.085 9.04E-7 YNL289W PCL1 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
0.083 1.47E-6 YFR030W MET10 hom Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
0.080 3.59E-6 YPL087W YDC1 hom Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication
0.079 5.29E-6 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
0.078 5.38E-6 YNL050C_p YNL050C_p hom Putative protein of unknown function; YNL050c is not an essential gene
0.078 6.46E-6 YMR172W HOT1 hom Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
0.077 7.83E-6 YNL328C MDJ2 hom Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
0.077 8.77E-6 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.076 9.76E-6 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.076 1.21E-5 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data