YHL024W / RIM4

Putative RNA-binding protein required for the expression of early and middle sporulation genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL024W / RIM4

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:4.73|P-value:5.52E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:3.38|P-value:8.50E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.31|P-value:2.70E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.72|P-value:2.45E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:4.12|P-value:6.48E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.64|P-value:3.67E-4 ID:SGTC_271|Compound:rotenone|FD-Score:5.37|P-value:2.98E-7 ID:SGTC_274|Compound:sirtinol|FD-Score:3.65|P-value:3.53E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.56|P-value:4.22E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:5.04|P-value:1.41E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:4.57|P-value:1.07E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:-6.45|P-value:8.25E-10 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.85|P-value:1.56E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.07|P-value:7.80E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.41|P-value:7.91E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.65|P-value:3.17E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.81|P-value:1.99E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.58|P-value:4.40E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.91|P-value:1.39E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.49|P-value:6.07E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.45|P-value:6.13E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.70|P-value:2.59E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.56|P-value:4.83E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.74|P-value:5.38E-6 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.60|P-value:4.13E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:3.58E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.84|P-value:1.62E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.39|P-value:7.46E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-4.41|P-value:1.80E-5 ID:SGTC_1710|Compound:st031758|FD-Score:4.64|P-value:8.18E-6 ID:SGTC_2143|Compound:5623677|FD-Score:-3.65|P-value:3.16E-4 ID:SGTC_2150|Compound:5556613|FD-Score:-3.81|P-value:1.76E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.69|P-value:3.04E-4 ID:SGTC_2343|Compound:7990716|FD-Score:5.08|P-value:1.16E-6 ID:SGTC_2350|Compound:9023895|FD-Score:-3.66|P-value:3.05E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.59|P-value:4.31E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.46|P-value:5.99E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.86|P-value:1.52E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.05|P-value:1.15E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.07|P-value:7.75E-5 ID:SGTC_3336|Compound:9143619|FD-Score:-3.36|P-value:8.16E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.73|P-value:5.52E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:3.38|P-value:8.50E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.31|P-value:2.70E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.72|P-value:2.45E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:4.12|P-value:6.48E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.64|P-value:3.67E-4 ID:SGTC_271|Compound:rotenone|FD-Score:5.37|P-value:2.98E-7 ID:SGTC_274|Compound:sirtinol|FD-Score:3.65|P-value:3.53E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.56|P-value:4.22E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:5.04|P-value:1.41E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:4.57|P-value:1.07E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:-6.45|P-value:8.25E-10 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.85|P-value:1.56E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.07|P-value:7.80E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.41|P-value:7.91E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.65|P-value:3.17E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.81|P-value:1.99E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.58|P-value:4.40E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.91|P-value:1.39E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.49|P-value:6.07E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.45|P-value:6.13E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.70|P-value:2.59E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.56|P-value:4.83E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.74|P-value:5.38E-6 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.60|P-value:4.13E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:3.58E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.84|P-value:1.62E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.39|P-value:7.46E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-4.41|P-value:1.80E-5 ID:SGTC_1710|Compound:st031758|FD-Score:4.64|P-value:8.18E-6 ID:SGTC_2143|Compound:5623677|FD-Score:-3.65|P-value:3.16E-4 ID:SGTC_2150|Compound:5556613|FD-Score:-3.81|P-value:1.76E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.69|P-value:3.04E-4 ID:SGTC_2343|Compound:7990716|FD-Score:5.08|P-value:1.16E-6 ID:SGTC_2350|Compound:9023895|FD-Score:-3.66|P-value:3.05E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.59|P-value:4.31E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.46|P-value:5.99E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.86|P-value:1.52E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.05|P-value:1.15E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.07|P-value:7.75E-5 ID:SGTC_3336|Compound:9143619|FD-Score:-3.36|P-value:8.16E-4

Top fitness defect scores for YHL024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_271 rotenone 5.37 740.0 µM 2.98E-7 6 3.91E-8
2 SGTC_2343 7990716 5.08 14.8 µM 1.16E-6 4 1.86E-7
3 SGTC_392 N-ethylmaleimide 5.04 8.3 µM 1.41E-6 RNA pol III & RNase P/MRP 4 2.34E-7
4 SGTC_982 1491-0518 4.74 27.5 µM 5.38E-6 4 1.08E-6
5 SGTC_76 0433-0009 4.73 400.3 µM 5.52E-6 5 1.12E-6
6 SGTC_1710 st031758 4.64 61.5 µM 8.18E-6 9 1.75E-6
7 SGTC_395 anisomycin 4.57 6.2 µM 1.07E-5 4 2.39E-6
8 SGTC_209 4077-0173 4.12 175.6 µM 6.48E-5 8 1.88E-5
9 SGTC_2757 clomiphene 4.07 4.2 µM 7.75E-5 fatty acid desaturase (OLE1) 36 2.31E-5
10 SGTC_432 NS 1619 4.07 61.3 µM 7.80E-5 25 2.33E-5
11 SGTC_610 4215-0184 3.91 155.0 µM 1.39E-4 exosome 13 4.53E-5
12 SGTC_440 fluspirilene 3.81 35.1 µM 1.99E-4 16 6.82E-5
13 SGTC_2280 7785178 3.69 200.0 µM 3.04E-4 14 1.11E-4
14 SGTC_274 sirtinol 3.65 40.1 µM 3.53E-4 26 1.31E-4
15 SGTC_1262 0737-0114 3.65 49.6 µM 3.58E-4 28 1.33E-4
16 SGTC_261 5-fluorouridine 3.64 15.4 µM 3.67E-4 exosome 20 1.37E-4
17 SGTC_1236 0330-0013 3.60 258.0 µM 4.13E-4 23 1.57E-4
18 SGTC_2364 9055074 3.59 200.0 µM 4.31E-4 28 1.65E-4
19 SGTC_574 1315-0397 3.58 40.0 µM 4.40E-4 54 1.69E-4
20 SGTC_847 0342-0274 3.56 5.5 µM 4.83E-4 29 1.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.09E-13 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.119 5.22E-12 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.115 2.12E-11 YDR223W CRF1 hom Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain
0.101 5.34E-9 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.094 4.80E-8 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.082 1.76E-6 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.082 2.11E-6 YDR489W SLD5 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.080 3.26E-6 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.078 6.22E-6 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.078 6.95E-6 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.074 1.96E-5 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.074 2.02E-5 YOL115W PAP2 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p
0.073 2.11E-5 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.072 2.64E-5 YLR017W MEU1 hom Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
0.072 2.99E-5 YHR163W SOL3 hom 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication