YHL026C_p

Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL026C / YHL026C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.54|P-value:2.78E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.44|P-value:3.55E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.57|P-value:2.50E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.70|P-value:1.52E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:5.07|P-value:3.60E-7 ID:SGTC_427|Compound:1354-0053|FD-Score:3.67|P-value:1.68E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:4.16|P-value:2.44E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:3.28|P-value:6.87E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-3.31|P-value:5.48E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.23|P-value:7.37E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.21|P-value:8.64E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.69|P-value:1.59E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.65|P-value:1.82E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.61|P-value:3.29E-6 ID:SGTC_1594|Compound:piperine|FD-Score:3.99|P-value:4.93E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-5.08|P-value:2.84E-7 ID:SGTC_1930|Compound:st074634|FD-Score:3.24|P-value:7.95E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.93|P-value:6.25E-5 ID:SGTC_1991|Compound:st073000|FD-Score:4.79|P-value:1.41E-6 ID:SGTC_1999|Compound:st074831|FD-Score:5.64|P-value:1.74E-8 ID:SGTC_2141|Compound:5621638|FD-Score:-3.77|P-value:1.04E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.51|P-value:3.07E-4 ID:SGTC_2148|Compound:5546263|FD-Score:5.29|P-value:1.19E-7 ID:SGTC_2154|Compound:5570129|FD-Score:4.14|P-value:2.62E-5 ID:SGTC_2158|Compound:5657123|FD-Score:-3.63|P-value:1.77E-4 ID:SGTC_2431|Compound:5490079|FD-Score:5.00|P-value:5.19E-7 ID:SGTC_2441|Compound:5730946|FD-Score:-3.27|P-value:6.32E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.21|P-value:1.95E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.00|P-value:4.71E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.41|P-value:4.35E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.19|P-value:9.40E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.64|P-value:1.95E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.62|P-value:2.06E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.53|P-value:2.83E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.28|P-value:6.90E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.85|P-value:8.71E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.29|P-value:6.59E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.54|P-value:2.78E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.44|P-value:3.55E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.57|P-value:2.50E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.70|P-value:1.52E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:5.07|P-value:3.60E-7 ID:SGTC_427|Compound:1354-0053|FD-Score:3.67|P-value:1.68E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:4.16|P-value:2.44E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:3.28|P-value:6.87E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-3.31|P-value:5.48E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.23|P-value:7.37E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.21|P-value:8.64E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.69|P-value:1.59E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.65|P-value:1.82E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.61|P-value:3.29E-6 ID:SGTC_1594|Compound:piperine|FD-Score:3.99|P-value:4.93E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-5.08|P-value:2.84E-7 ID:SGTC_1930|Compound:st074634|FD-Score:3.24|P-value:7.95E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.93|P-value:6.25E-5 ID:SGTC_1991|Compound:st073000|FD-Score:4.79|P-value:1.41E-6 ID:SGTC_1999|Compound:st074831|FD-Score:5.64|P-value:1.74E-8 ID:SGTC_2141|Compound:5621638|FD-Score:-3.77|P-value:1.04E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.51|P-value:3.07E-4 ID:SGTC_2148|Compound:5546263|FD-Score:5.29|P-value:1.19E-7 ID:SGTC_2154|Compound:5570129|FD-Score:4.14|P-value:2.62E-5 ID:SGTC_2158|Compound:5657123|FD-Score:-3.63|P-value:1.77E-4 ID:SGTC_2431|Compound:5490079|FD-Score:5.00|P-value:5.19E-7 ID:SGTC_2441|Compound:5730946|FD-Score:-3.27|P-value:6.32E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.21|P-value:1.95E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.00|P-value:4.71E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.41|P-value:4.35E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.19|P-value:9.40E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.64|P-value:1.95E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.62|P-value:2.06E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.53|P-value:2.83E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.28|P-value:6.90E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.85|P-value:8.71E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.29|P-value:6.59E-4

Top fitness defect scores for YHL026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1999 st074831 5.64 12.5 µM 1.74E-8 plasma membrane duress 15 8.36E-9
2 SGTC_2148 5546263 5.29 113.6 µM 1.19E-7 9 6.20E-8
3 SGTC_425 3825-7017 5.07 13.1 µM 3.60E-7 12 1.97E-7
4 SGTC_2431 5490079 5.00 200.0 µM 5.19E-7 13 2.89E-7
5 SGTC_1991 st073000 4.79 8.9 µM 1.41E-6 NEO1 55 8.16E-7
6 SGTC_1441 4106-0040 4.61 13.0 µM 3.29E-6 4 1.97E-6
7 SGTC_2451 5856223 4.21 45.7 µM 1.95E-5 18 1.26E-5
8 SGTC_554 4483-2211 4.16 187.0 µM 2.44E-5 15 1.60E-5
9 SGTC_2154 5570129 4.14 200.0 µM 2.62E-5 13 1.72E-5
10 SGTC_2621 lithochol-11-enic acid 4.00 100.0 µM 4.71E-5 23 3.16E-5
11 SGTC_1594 piperine 3.99 70.1 µM 4.93E-5 13 3.32E-5
12 SGTC_1977 st070720 3.93 65.3 µM 6.25E-5 9 4.25E-5
13 SGTC_3085 9117376 3.85 49.5 µM 8.71E-5 10 6.01E-5
14 SGTC_2499 avocadenofuran 3.79 51.5 µM 1.06E-4 42 7.39E-5
15 SGTC_3035 9091303 3.79 49.5 µM 1.09E-4 8 7.58E-5
16 SGTC_406 estrone 3.70 100.0 µM 1.52E-4 14 1.07E-4
17 SGTC_1301 naphtanilide LB 3.69 4.8 µM 1.59E-4 heme requiring 16 1.12E-4
18 SGTC_427 1354-0053 3.67 47.3 µM 1.68E-4 30 1.19E-4
19 SGTC_1438 4092-1045 3.65 4.0 µM 1.82E-4 12 1.29E-4
20 SGTC_2818 7996756 3.64 13.0 µM 1.95E-4 20 1.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 5.79E-23 YLR106C MDN1 het Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
0.099 9.72E-9 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.090 1.64E-7 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.090 1.68E-7 YLR187W SKG3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication
0.089 2.41E-7 YNL206C RTT106 hom Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition
0.089 2.78E-7 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.088 3.23E-7 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.087 4.47E-7 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.086 5.40E-7 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.086 5.92E-7 YMR220W ERG8 het Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.083 1.43E-6 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.082 1.80E-6 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.082 2.05E-6 YER186C_p YER186C_p hom Putative protein of unknown function
0.081 2.41E-6 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.080 3.08E-6 YKR013W PRY2 hom Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication