YHL027W / RIM101

Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL027W / RIM101

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:6.25|P-value:2.59E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:7.02|P-value:8.61E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.55|P-value:8.81E-8 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.69|P-value:9.50E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:7.18|P-value:4.20E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:8.07|P-value:4.63E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:8.30|P-value:1.34E-11 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.73|P-value:2.55E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:6.55|P-value:7.34E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:5.60|P-value:3.45E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:9.02|P-value:2.39E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:5.46|P-value:5.74E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.55|P-value:5.01E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:5.53|P-value:4.48E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:7.11|P-value:5.71E-9 ID:SGTC_200|Compound:k038-0079|FD-Score:6.31|P-value:2.01E-7 ID:SGTC_201|Compound:4262-0159|FD-Score:4.56|P-value:1.22E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.62|P-value:1.01E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:5.49|P-value:5.21E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.47|P-value:1.63E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.18|P-value:3.83E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:12.40|P-value:1.89E-23 ID:SGTC_278|Compound:4092-0821|FD-Score:3.95|P-value:7.30E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:8.21|P-value:2.21E-11 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.04|P-value:6.53E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.72|P-value:2.15E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:3.95|P-value:7.46E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:5.40|P-value:7.22E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:6.05|P-value:5.84E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:4.09|P-value:4.97E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.21|P-value:4.11E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.97|P-value:6.89E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.89|P-value:8.61E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.98|P-value:6.70E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.93|P-value:1.27E-10 ID:SGTC_525|Compound:k781-2675|FD-Score:7.43|P-value:1.23E-9 ID:SGTC_526|Compound:4469-0568|FD-Score:5.03|P-value:2.65E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:6.66|P-value:4.43E-8 ID:SGTC_547|Compound:1120-0019|FD-Score:6.32|P-value:1.93E-7 ID:SGTC_548|Compound:1436-0017|FD-Score:5.68|P-value:2.51E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:9.13|P-value:1.19E-13 ID:SGTC_577|Compound:r071-0003|FD-Score:3.92|P-value:8.06E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.43|P-value:1.82E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:5.36|P-value:8.18E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:5.82|P-value:1.48E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.60|P-value:4.17E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:4.10|P-value:4.86E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.88|P-value:4.41E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:6.83|P-value:2.08E-8 ID:SGTC_794|Compound:k038-0031|FD-Score:4.36|P-value:2.23E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:6.59|P-value:6.11E-8 ID:SGTC_902|Compound:1120-0002|FD-Score:9.17|P-value:9.71E-14 ID:SGTC_916|Compound:4466-0038|FD-Score:6.71|P-value:3.59E-8 ID:SGTC_917|Compound:harmaline|FD-Score:4.36|P-value:2.25E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:7.96|P-value:8.65E-11 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.63|P-value:3.08E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.76|P-value:2.82E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.45|P-value:6.05E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:9.06|P-value:1.83E-13 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.11|P-value:4.76E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.62|P-value:3.14E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-5.59|P-value:4.28E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.93|P-value:8.89E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:11.50|P-value:1.26E-20 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.15|P-value:4.20E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:6.08|P-value:5.23E-7 ID:SGTC_1317|Compound:1273-0028|FD-Score:14.40|P-value:3.60E-31 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.06|P-value:5.41E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-5.19|P-value:1.78E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.88|P-value:4.40E-5 ID:SGTC_1591|Compound:genipin|FD-Score:4.22|P-value:3.43E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-6.69|P-value:4.82E-8 ID:SGTC_1667|Compound:st014849|FD-Score:3.87|P-value:9.10E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.50|P-value:1.47E-4 ID:SGTC_1687|Compound:st020778|FD-Score:11.50|P-value:1.80E-20 ID:SGTC_1712|Compound:st032288|FD-Score:4.90|P-value:4.14E-5 ID:SGTC_1754|Compound:st042065|FD-Score:13.30|P-value:8.78E-27 ID:SGTC_1757|Compound:st041620|FD-Score:4.74|P-value:6.89E-5 ID:SGTC_1760|Compound:st045453|FD-Score:8.03|P-value:5.72E-11 ID:SGTC_1788|Compound:fluconazole|FD-Score:9.33|P-value:3.54E-14 ID:SGTC_1800|Compound:st050079|FD-Score:4.07|P-value:5.31E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.43|P-value:6.42E-6 ID:SGTC_1803|Compound:st050068|FD-Score:6.81|P-value:2.26E-8 ID:SGTC_1827|Compound:berberine|FD-Score:4.37|P-value:2.19E-4 ID:SGTC_1829|Compound:berberine|FD-Score:5.26|P-value:1.18E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.53|P-value:9.59E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.89|P-value:8.70E-4 ID:SGTC_1884|Compound:5633444|FD-Score:20.00|P-value:4.09E-58 ID:SGTC_1886|Compound:st057356|FD-Score:3.97|P-value:6.88E-4 ID:SGTC_1917|Compound:st066507|FD-Score:5.79|P-value:1.65E-6 ID:SGTC_2016|Compound:5121758|FD-Score:4.31|P-value:2.62E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.45|P-value:5.98E-6 ID:SGTC_2183|Compound:6420625|FD-Score:6.95|P-value:1.20E-8 ID:SGTC_2210|Compound:7115885|FD-Score:4.65|P-value:9.32E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.13|P-value:1.19E-13 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.05|P-value:7.75E-9 ID:SGTC_2289|Compound:7946404|FD-Score:6.26|P-value:2.48E-7 ID:SGTC_2328|Compound:6201408|FD-Score:-4.29|P-value:3.21E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.65|P-value:9.10E-5 ID:SGTC_2485|Compound:5633444|FD-Score:8.34|P-value:1.09E-11 ID:SGTC_2511|Compound:berberine|FD-Score:4.44|P-value:1.79E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.89|P-value:8.67E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.50|P-value:1.74E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:8.58|P-value:2.86E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.59|P-value:7.45E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.70|P-value:4.68E-18 ID:SGTC_2736|Compound:butenafine|FD-Score:5.32|P-value:9.70E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:9.43|P-value:1.97E-14 ID:SGTC_2756|Compound:carbadox|FD-Score:5.48|P-value:5.27E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.14|P-value:1.81E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.43|P-value:1.85E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.40|P-value:2.03E-4 ID:SGTC_2925|Compound:9010536|FD-Score:8.48|P-value:4.98E-12 ID:SGTC_2928|Compound:9011484|FD-Score:5.62|P-value:3.14E-6 ID:SGTC_2973|Compound:9094665|FD-Score:4.04|P-value:5.77E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.53|P-value:1.33E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.86|P-value:9.34E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.10|P-value:2.06E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.21|P-value:4.03E-4 ID:SGTC_3152|Compound:9099253|FD-Score:8.39|P-value:8.46E-12 ID:SGTC_3204|Compound:9114183|FD-Score:3.95|P-value:7.35E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.18|P-value:3.80E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.25|P-value:2.59E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:7.02|P-value:8.61E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.55|P-value:8.81E-8 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.69|P-value:9.50E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:7.18|P-value:4.20E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:8.07|P-value:4.63E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:8.30|P-value:1.34E-11 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.73|P-value:2.55E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:6.55|P-value:7.34E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:5.60|P-value:3.45E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:9.02|P-value:2.39E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:5.46|P-value:5.74E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.55|P-value:5.01E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:5.53|P-value:4.48E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:7.11|P-value:5.71E-9 ID:SGTC_200|Compound:k038-0079|FD-Score:6.31|P-value:2.01E-7 ID:SGTC_201|Compound:4262-0159|FD-Score:4.56|P-value:1.22E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.62|P-value:1.01E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:5.49|P-value:5.21E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.47|P-value:1.63E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.18|P-value:3.83E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:12.40|P-value:1.89E-23 ID:SGTC_278|Compound:4092-0821|FD-Score:3.95|P-value:7.30E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:8.21|P-value:2.21E-11 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.04|P-value:6.53E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.72|P-value:2.15E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:3.95|P-value:7.46E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:5.40|P-value:7.22E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:6.05|P-value:5.84E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:4.09|P-value:4.97E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.21|P-value:4.11E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.97|P-value:6.89E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.89|P-value:8.61E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.98|P-value:6.70E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.93|P-value:1.27E-10 ID:SGTC_525|Compound:k781-2675|FD-Score:7.43|P-value:1.23E-9 ID:SGTC_526|Compound:4469-0568|FD-Score:5.03|P-value:2.65E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:6.66|P-value:4.43E-8 ID:SGTC_547|Compound:1120-0019|FD-Score:6.32|P-value:1.93E-7 ID:SGTC_548|Compound:1436-0017|FD-Score:5.68|P-value:2.51E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:9.13|P-value:1.19E-13 ID:SGTC_577|Compound:r071-0003|FD-Score:3.92|P-value:8.06E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.43|P-value:1.82E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:5.36|P-value:8.18E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:5.82|P-value:1.48E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.60|P-value:4.17E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:4.10|P-value:4.86E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.88|P-value:4.41E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:6.83|P-value:2.08E-8 ID:SGTC_794|Compound:k038-0031|FD-Score:4.36|P-value:2.23E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:6.59|P-value:6.11E-8 ID:SGTC_902|Compound:1120-0002|FD-Score:9.17|P-value:9.71E-14 ID:SGTC_916|Compound:4466-0038|FD-Score:6.71|P-value:3.59E-8 ID:SGTC_917|Compound:harmaline|FD-Score:4.36|P-value:2.25E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:7.96|P-value:8.65E-11 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.63|P-value:3.08E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.76|P-value:2.82E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.45|P-value:6.05E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:9.06|P-value:1.83E-13 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.11|P-value:4.76E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.62|P-value:3.14E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-5.59|P-value:4.28E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.93|P-value:8.89E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:11.50|P-value:1.26E-20 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.15|P-value:4.20E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:6.08|P-value:5.23E-7 ID:SGTC_1317|Compound:1273-0028|FD-Score:14.40|P-value:3.60E-31 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.06|P-value:5.41E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-5.19|P-value:1.78E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.88|P-value:4.40E-5 ID:SGTC_1591|Compound:genipin|FD-Score:4.22|P-value:3.43E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-6.69|P-value:4.82E-8 ID:SGTC_1667|Compound:st014849|FD-Score:3.87|P-value:9.10E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.50|P-value:1.47E-4 ID:SGTC_1687|Compound:st020778|FD-Score:11.50|P-value:1.80E-20 ID:SGTC_1712|Compound:st032288|FD-Score:4.90|P-value:4.14E-5 ID:SGTC_1754|Compound:st042065|FD-Score:13.30|P-value:8.78E-27 ID:SGTC_1757|Compound:st041620|FD-Score:4.74|P-value:6.89E-5 ID:SGTC_1760|Compound:st045453|FD-Score:8.03|P-value:5.72E-11 ID:SGTC_1788|Compound:fluconazole|FD-Score:9.33|P-value:3.54E-14 ID:SGTC_1800|Compound:st050079|FD-Score:4.07|P-value:5.31E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.43|P-value:6.42E-6 ID:SGTC_1803|Compound:st050068|FD-Score:6.81|P-value:2.26E-8 ID:SGTC_1827|Compound:berberine|FD-Score:4.37|P-value:2.19E-4 ID:SGTC_1829|Compound:berberine|FD-Score:5.26|P-value:1.18E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.53|P-value:9.59E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.89|P-value:8.70E-4 ID:SGTC_1884|Compound:5633444|FD-Score:20.00|P-value:4.09E-58 ID:SGTC_1886|Compound:st057356|FD-Score:3.97|P-value:6.88E-4 ID:SGTC_1917|Compound:st066507|FD-Score:5.79|P-value:1.65E-6 ID:SGTC_2016|Compound:5121758|FD-Score:4.31|P-value:2.62E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.45|P-value:5.98E-6 ID:SGTC_2183|Compound:6420625|FD-Score:6.95|P-value:1.20E-8 ID:SGTC_2210|Compound:7115885|FD-Score:4.65|P-value:9.32E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.13|P-value:1.19E-13 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.05|P-value:7.75E-9 ID:SGTC_2289|Compound:7946404|FD-Score:6.26|P-value:2.48E-7 ID:SGTC_2328|Compound:6201408|FD-Score:-4.29|P-value:3.21E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.65|P-value:9.10E-5 ID:SGTC_2485|Compound:5633444|FD-Score:8.34|P-value:1.09E-11 ID:SGTC_2511|Compound:berberine|FD-Score:4.44|P-value:1.79E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.89|P-value:8.67E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.50|P-value:1.74E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:8.58|P-value:2.86E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.59|P-value:7.45E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.70|P-value:4.68E-18 ID:SGTC_2736|Compound:butenafine|FD-Score:5.32|P-value:9.70E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:9.43|P-value:1.97E-14 ID:SGTC_2756|Compound:carbadox|FD-Score:5.48|P-value:5.27E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.14|P-value:1.81E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.43|P-value:1.85E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.40|P-value:2.03E-4 ID:SGTC_2925|Compound:9010536|FD-Score:8.48|P-value:4.98E-12 ID:SGTC_2928|Compound:9011484|FD-Score:5.62|P-value:3.14E-6 ID:SGTC_2973|Compound:9094665|FD-Score:4.04|P-value:5.77E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.53|P-value:1.33E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.86|P-value:9.34E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.10|P-value:2.06E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.21|P-value:4.03E-4 ID:SGTC_3152|Compound:9099253|FD-Score:8.39|P-value:8.46E-12 ID:SGTC_3204|Compound:9114183|FD-Score:3.95|P-value:7.35E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.18|P-value:3.80E-4

Top fitness defect scores for YHL027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1884 5633444 20.00 25.0 µM 4.09E-58 redox potentiating 2 2.14E-89
2 SGTC_1317 1273-0028 14.40 910.0 nM 3.60E-31 azole & statin 5 2.01E-47
3 SGTC_1754 st042065 13.30 16.1 µM 8.78E-27 NEO1-PIK1 12 1.35E-40
4 SGTC_227 fluconazole 12.40 33.5 µM 1.89E-23 azole & statin 10 2.06E-35
5 SGTC_1191 1487-1166 11.50 10.6 µM 1.26E-20 azole & statin 2 5.03E-31
6 SGTC_1687 st020778 11.50 55.4 µM 1.80E-20 40 8.72E-31
7 SGTC_2688 kanamycin b 10.70 96.7 µM 4.68E-18 calcium & mitochondrial duress 21 4.91E-27
8 SGTC_2752 diclazuril 9.43 33.1 µM 1.97E-14 26 2.06E-21
9 SGTC_1788 fluconazole 9.33 20.0 µM 3.54E-14 azole & statin 13 5.09E-21
10 SGTC_902 1120-0002 9.17 2.1 µM 9.71E-14 azole & statin 5 2.43E-20
11 SGTC_576 1073-0113 9.13 22.7 µM 1.19E-13 redox potentiating 3 3.35E-20
12 SGTC_2249 haloperidol 9.13 116.4 µM 1.19E-13 ergosterol depletion effects on membrane 20 3.35E-20
13 SGTC_1044 1222-0021 9.06 1.8 µM 1.83E-13 heme biosynthesis & mitochondrial translocase 5 6.50E-20
14 SGTC_156 3474-0145 9.02 5.6 µM 2.39E-13 endomembrane recycling 8 9.82E-20
15 SGTC_2619 obliquin 8.58 87.9 µM 2.86E-12 cell wall 38 4.57E-18
16 SGTC_2925 9010536 8.48 32.5 µM 4.98E-12 azole & statin 6 1.08E-17
17 SGTC_3152 9099253 8.39 49.5 µM 8.46E-12 NEO1-PIK1 31 2.45E-17
18 SGTC_2485 5633444 8.34 17.8 µM 1.09E-11 redox potentiating 5 3.65E-17
19 SGTC_86 0417-1630 8.30 471.9 µM 1.34E-11 ubiquinone biosynthesis & proteasome 57 5.00E-17
20 SGTC_279 1273-0055 8.21 2.9 µM 2.21E-11 azole & statin 2 1.08E-16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.580 1.67E-299 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.565 5.20E-282 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.554 1.27E-268 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.553 3.27E-268 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.542 4.10E-255 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.496 9.23E-208 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.451 6.88E-167 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.383 1.10E-117 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.379 7.42E-115 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.374 1.59E-111 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.350 1.96E-97 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.344 4.59E-94 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.341 4.55E-92 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.315 3.52E-78 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.292 6.22E-67 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression