YHL031C / GOS1

v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL031C / GOS1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:5.02|P-value:2.15E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.48|P-value:4.52E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:6.00|P-value:4.42E-7 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:6.26|P-value:1.42E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:3.89|P-value:8.45E-4 ID:SGTC_389|Compound:tpck|FD-Score:5.25|P-value:9.27E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.98|P-value:2.50E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.39|P-value:1.88E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.70|P-value:6.76E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.88|P-value:3.22E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:4.10|P-value:4.66E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.93|P-value:7.65E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.95|P-value:7.18E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.47|P-value:1.43E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:6.37|P-value:8.50E-8 ID:SGTC_893|Compound:0958-0369|FD-Score:7.84|P-value:4.98E-11 ID:SGTC_938|Compound:3126-1755|FD-Score:4.12|P-value:4.36E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-4.02|P-value:2.09E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.79|P-value:4.96E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.69|P-value:6.82E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.96|P-value:6.91E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.28|P-value:2.64E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.51|P-value:1.27E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.94|P-value:2.70E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.84|P-value:9.82E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.77|P-value:5.22E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.90|P-value:3.30E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.97|P-value:6.69E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:5.40|P-value:5.24E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.13|P-value:4.26E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.96|P-value:2.72E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.62|P-value:8.68E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:5.94|P-value:5.78E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.36|P-value:6.73E-10 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:5.40|P-value:5.16E-6 ID:SGTC_1687|Compound:st020778|FD-Score:4.28|P-value:2.69E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.90|P-value:3.02E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.35|P-value:6.97E-5 ID:SGTC_1790|Compound:st045711|FD-Score:5.09|P-value:1.68E-5 ID:SGTC_1826|Compound:st055655|FD-Score:-5.71|P-value:3.59E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.09|P-value:1.66E-5 ID:SGTC_1846|Compound:st056244|FD-Score:6.12|P-value:2.65E-7 ID:SGTC_1849|Compound:st056239|FD-Score:4.48|P-value:1.41E-4 ID:SGTC_1850|Compound:st056238|FD-Score:7.42|P-value:5.01E-10 ID:SGTC_1910|Compound:st062352|FD-Score:4.34|P-value:2.20E-4 ID:SGTC_1981|Compound:st071826|FD-Score:4.41|P-value:1.78E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-5.65|P-value:4.73E-7 ID:SGTC_2077|Compound:5212015|FD-Score:4.58|P-value:1.02E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.90|P-value:9.65E-6 ID:SGTC_2132|Compound:5317594|FD-Score:-3.54|P-value:8.83E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.26|P-value:2.84E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.43|P-value:1.67E-4 ID:SGTC_2433|Compound:5607874|FD-Score:5.52|P-value:3.22E-6 ID:SGTC_2461|Compound:5755302|FD-Score:5.41|P-value:5.09E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.08|P-value:4.89E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.96|P-value:5.30E-7 ID:SGTC_2544|Compound:sphondin|FD-Score:6.22|P-value:1.67E-7 ID:SGTC_2799|Compound:7812892|FD-Score:5.03|P-value:2.07E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.00|P-value:6.14E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.88|P-value:1.04E-5 ID:SGTC_2856|Compound:9022925|FD-Score:4.28|P-value:2.68E-4 ID:SGTC_2921|Compound:7974240|FD-Score:7.61|P-value:1.75E-10 ID:SGTC_3000|Compound:9075062|FD-Score:4.06|P-value:5.16E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.93|P-value:7.55E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.91|P-value:8.04E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.44|P-value:1.60E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.97|P-value:6.74E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:5.02|P-value:2.15E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.48|P-value:4.52E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:6.00|P-value:4.42E-7 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:6.26|P-value:1.42E-7 ID:SGTC_253|Compound:dyclonine|FD-Score:3.89|P-value:8.45E-4 ID:SGTC_389|Compound:tpck|FD-Score:5.25|P-value:9.27E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.98|P-value:2.50E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.39|P-value:1.88E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.70|P-value:6.76E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.88|P-value:3.22E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:4.10|P-value:4.66E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.93|P-value:7.65E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.95|P-value:7.18E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.47|P-value:1.43E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:6.37|P-value:8.50E-8 ID:SGTC_893|Compound:0958-0369|FD-Score:7.84|P-value:4.98E-11 ID:SGTC_938|Compound:3126-1755|FD-Score:4.12|P-value:4.36E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-4.02|P-value:2.09E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.79|P-value:4.96E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.69|P-value:6.82E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.96|P-value:6.91E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.28|P-value:2.64E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.51|P-value:1.27E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.94|P-value:2.70E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.84|P-value:9.82E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.77|P-value:5.22E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.90|P-value:3.30E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.97|P-value:6.69E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:5.40|P-value:5.24E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.13|P-value:4.26E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.96|P-value:2.72E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.62|P-value:8.68E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:5.94|P-value:5.78E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.36|P-value:6.73E-10 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:5.40|P-value:5.16E-6 ID:SGTC_1687|Compound:st020778|FD-Score:4.28|P-value:2.69E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.90|P-value:3.02E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.35|P-value:6.97E-5 ID:SGTC_1790|Compound:st045711|FD-Score:5.09|P-value:1.68E-5 ID:SGTC_1826|Compound:st055655|FD-Score:-5.71|P-value:3.59E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.09|P-value:1.66E-5 ID:SGTC_1846|Compound:st056244|FD-Score:6.12|P-value:2.65E-7 ID:SGTC_1849|Compound:st056239|FD-Score:4.48|P-value:1.41E-4 ID:SGTC_1850|Compound:st056238|FD-Score:7.42|P-value:5.01E-10 ID:SGTC_1910|Compound:st062352|FD-Score:4.34|P-value:2.20E-4 ID:SGTC_1981|Compound:st071826|FD-Score:4.41|P-value:1.78E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-5.65|P-value:4.73E-7 ID:SGTC_2077|Compound:5212015|FD-Score:4.58|P-value:1.02E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.90|P-value:9.65E-6 ID:SGTC_2132|Compound:5317594|FD-Score:-3.54|P-value:8.83E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.26|P-value:2.84E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.43|P-value:1.67E-4 ID:SGTC_2433|Compound:5607874|FD-Score:5.52|P-value:3.22E-6 ID:SGTC_2461|Compound:5755302|FD-Score:5.41|P-value:5.09E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.08|P-value:4.89E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.96|P-value:5.30E-7 ID:SGTC_2544|Compound:sphondin|FD-Score:6.22|P-value:1.67E-7 ID:SGTC_2799|Compound:7812892|FD-Score:5.03|P-value:2.07E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.00|P-value:6.14E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.88|P-value:1.04E-5 ID:SGTC_2856|Compound:9022925|FD-Score:4.28|P-value:2.68E-4 ID:SGTC_2921|Compound:7974240|FD-Score:7.61|P-value:1.75E-10 ID:SGTC_3000|Compound:9075062|FD-Score:4.06|P-value:5.16E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.93|P-value:7.55E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.91|P-value:8.04E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.44|P-value:1.60E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.97|P-value:6.74E-4

Top fitness defect scores for YHL031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_893 0958-0369 7.84 48.9 µM 4.98E-11 3 2.20E-15
2 SGTC_2921 7974240 7.61 10.7 µM 1.75E-10 8 1.32E-14
3 SGTC_1850 st056238 7.42 17.0 µM 5.01E-10 RPP1 & pyrimidine depletion 2 5.96E-14
4 SGTC_1525 8-methoxypsoralen 7.36 92.5 µM 6.73E-10 DNA damage response 3 9.09E-14
5 SGTC_878 0828-0289 6.37 13.7 µM 8.50E-8 12 9.22E-11
6 SGTC_240 5hr heat shock (37°C) + Streptovitacin 6.26 300.0 µM 1.42E-7 heat shock/prefoldin 15 1.93E-10
7 SGTC_2544 sphondin 6.22 68.5 µM 1.67E-7 RNA pol III & RNase P/MRP 5 2.44E-10
8 SGTC_1846 st056244 6.12 14.8 µM 2.65E-7 3 4.71E-10
9 SGTC_124 0136-0217 6.00 7.1 µM 4.42E-7 mitochondrial stress 24 9.77E-10
10 SGTC_2475 5812728 5.96 15.0 µM 5.30E-7 mitochondrial processes 7 1.27E-9
11 SGTC_1416 3966-0321 5.94 25.3 µM 5.78E-7 3 1.44E-9
12 SGTC_2433 5607874 5.52 27.8 µM 3.22E-6 4 1.68E-8
13 SGTC_2461 5755302 5.41 26.1 µM 5.09E-6 15 3.24E-8
14 SGTC_1538 2',3',6-trimethoxyflavanone 5.40 63.6 µM 5.16E-6 4 3.31E-8
15 SGTC_1307 1187-1599 5.40 12.2 µM 5.24E-6 PDR1 6 3.37E-8
16 SGTC_389 tpck 5.25 16.7 µM 9.27E-6 16 7.64E-8
17 SGTC_1844 rapamycin 5.09 4.0 nM 1.66E-5 113 1.76E-7
18 SGTC_1790 st045711 5.09 43.5 µM 1.68E-5 5 1.80E-7
19 SGTC_2799 7812892 5.03 81.8 µM 2.07E-5 superoxide 15 2.42E-7
20 SGTC_18 0111-0177 5.02 500.0 nM 2.15E-5 35 2.55E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.43E-18 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.149 4.45E-18 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.142 1.51E-16 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.141 2.54E-16 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.127 1.66E-13 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.124 7.20E-13 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.120 2.80E-12 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.115 2.23E-11 YPL102C_d YPL102C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4
0.114 4.52E-11 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.112 7.46E-11 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.112 8.77E-11 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.111 1.16E-10 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.110 1.44E-10 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.109 2.28E-10 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.109 2.51E-10 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation