Correlation | pval | ORF | Gene | Zygosity | Description |
---|
0.091 |
1.49E-7 |
YOR173W |
DCS2 |
hom |
Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance |
0.083 |
1.61E-6 |
YPR035W |
GLN1 |
het |
Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
0.081 |
2.89E-6 |
YER153C |
PET122 |
hom |
Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane |
0.079 |
5.22E-6 |
YKL137W |
CMC1 |
hom |
Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif |
0.076 |
1.14E-5 |
YDL058W |
USO1 |
het |
Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex |
0.074 |
1.72E-5 |
YJR103W |
URA8 |
hom |
Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication |
0.072 |
2.94E-5 |
YMR245W_d |
YMR245W_d |
hom |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.071 |
3.50E-5 |
YBR079C |
RPG1 |
het |
eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation |
0.071 |
3.54E-5 |
YDR442W_d |
YDR442W_d |
hom |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.071 |
4.00E-5 |
YNR055C |
HOL1 |
hom |
Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake |
0.069 |
5.82E-5 |
YDR479C |
PEX29 |
hom |
Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress |
0.067 |
9.68E-5 |
YMR092C |
AIP1 |
hom |
Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress |
0.067 |
9.76E-5 |
YML009W-B_d |
YML009W-B_d |
hom |
Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition |
0.063 |
2.70E-4 |
YEL065W |
SIT1 |
hom |
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p |
0.063 |
2.92E-4 |
YKL019W |
RAM2 |
het |
Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor |