YHL036W / MUP3

Low affinity methionine permease, similar to Mup1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL036W / MUP3

Click on Significant Values for Screen Details ID:SGTC_154|Compound:3389-1638|FD-Score:4.37|P-value:1.02E-5 ID:SGTC_393|Compound:acivicin|FD-Score:4.23|P-value:1.83E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.80|P-value:1.06E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.27|P-value:6.19E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:4.23|P-value:1.88E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.48|P-value:2.87E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.56|P-value:2.66E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.97|P-value:5.55E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.53|P-value:3.91E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.34|P-value:5.67E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.62|P-value:2.12E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.63|P-value:2.03E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:-3.18|P-value:8.30E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.26|P-value:7.41E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.00|P-value:4.78E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.39|P-value:4.76E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.50|P-value:3.22E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.95|P-value:5.91E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.21|P-value:8.79E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.23|P-value:8.22E-4 ID:SGTC_1685|Compound:st024049|FD-Score:5.80|P-value:7.52E-9 ID:SGTC_1696|Compound:st025591|FD-Score:-3.23|P-value:7.08E-4 ID:SGTC_1703|Compound:st026983|FD-Score:-3.22|P-value:7.31E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.46|P-value:3.18E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.29|P-value:6.76E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.03|P-value:4.19E-5 ID:SGTC_1892|Compound:st058411|FD-Score:4.32|P-value:1.27E-5 ID:SGTC_1904|Compound:st060225|FD-Score:4.00|P-value:4.81E-5 ID:SGTC_1921|Compound:5740136|FD-Score:7.39|P-value:2.43E-13 ID:SGTC_1925|Compound:st057770|FD-Score:4.41|P-value:8.39E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.65|P-value:1.89E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.17|P-value:8.63E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.68|P-value:1.70E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.93|P-value:6.36E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.52|P-value:3.05E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.41|P-value:3.70E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.23|P-value:6.98E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.63|P-value:1.67E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.58|P-value:2.42E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.47|P-value:3.62E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.28|P-value:6.95E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.13|P-value:9.71E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.25|P-value:6.56E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-5.43|P-value:4.28E-8 ID:SGTC_3133|Compound:9127736|FD-Score:3.77|P-value:1.19E-4 ID:SGTC_3138|Compound:9097216|FD-Score:4.00|P-value:4.75E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-5.04|P-value:3.40E-7 ID:SGTC_3252|Compound:9135871|FD-Score:3.54|P-value:2.87E-4 ID:SGTC_3288|Compound:9119690|FD-Score:4.21|P-value:2.01E-5 ID:SGTC_3293|Compound:9120939|FD-Score:-5.11|P-value:2.39E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:4.37|P-value:1.02E-5 ID:SGTC_393|Compound:acivicin|FD-Score:4.23|P-value:1.83E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.80|P-value:1.06E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.27|P-value:6.19E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:4.23|P-value:1.88E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.48|P-value:2.87E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.56|P-value:2.66E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.97|P-value:5.55E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.53|P-value:3.91E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.34|P-value:5.67E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.62|P-value:2.12E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.63|P-value:2.03E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:-3.18|P-value:8.30E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.26|P-value:7.41E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.00|P-value:4.78E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.39|P-value:4.76E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.50|P-value:3.22E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.95|P-value:5.91E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.21|P-value:8.79E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.23|P-value:8.22E-4 ID:SGTC_1685|Compound:st024049|FD-Score:5.80|P-value:7.52E-9 ID:SGTC_1696|Compound:st025591|FD-Score:-3.23|P-value:7.08E-4 ID:SGTC_1703|Compound:st026983|FD-Score:-3.22|P-value:7.31E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.46|P-value:3.18E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.29|P-value:6.76E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.03|P-value:4.19E-5 ID:SGTC_1892|Compound:st058411|FD-Score:4.32|P-value:1.27E-5 ID:SGTC_1904|Compound:st060225|FD-Score:4.00|P-value:4.81E-5 ID:SGTC_1921|Compound:5740136|FD-Score:7.39|P-value:2.43E-13 ID:SGTC_1925|Compound:st057770|FD-Score:4.41|P-value:8.39E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.65|P-value:1.89E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.17|P-value:8.63E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.68|P-value:1.70E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.93|P-value:6.36E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.52|P-value:3.05E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.41|P-value:3.70E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.23|P-value:6.98E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.63|P-value:1.67E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.58|P-value:2.42E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.47|P-value:3.62E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.28|P-value:6.95E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.13|P-value:9.71E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.25|P-value:6.56E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-5.43|P-value:4.28E-8 ID:SGTC_3133|Compound:9127736|FD-Score:3.77|P-value:1.19E-4 ID:SGTC_3138|Compound:9097216|FD-Score:4.00|P-value:4.75E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-5.04|P-value:3.40E-7 ID:SGTC_3252|Compound:9135871|FD-Score:3.54|P-value:2.87E-4 ID:SGTC_3288|Compound:9119690|FD-Score:4.21|P-value:2.01E-5 ID:SGTC_3293|Compound:9120939|FD-Score:-5.11|P-value:2.39E-7

Top fitness defect scores for YHL036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1921 5740136 7.39 50.0 µM 2.43E-13 TRP & mitochondrial translation 8 7.15E-14
2 SGTC_1685 st024049 5.80 53.1 µM 7.52E-9 TSC3-RPN4 4 3.41E-9
3 SGTC_1925 st057770 4.41 10.1 µM 8.39E-6 TSC3-RPN4 15 5.11E-6
4 SGTC_154 3389-1638 4.37 511.1 µM 1.02E-5 16 6.25E-6
5 SGTC_1892 st058411 4.32 7.4 µM 1.27E-5 12 7.87E-6
6 SGTC_393 acivicin 4.23 6.2 µM 1.83E-5 16 1.15E-5
7 SGTC_765 1319-0117 4.23 244.0 µM 1.88E-5 60S ribosome export 7 1.19E-5
8 SGTC_3288 9119690 4.21 36.2 µM 2.01E-5 19 1.27E-5
9 SGTC_1818 st052136 4.03 56.3 µM 4.19E-5 NEO1-PIK1 49 2.73E-5
10 SGTC_3138 9097216 4.00 49.5 µM 4.75E-5 13 3.12E-5
11 SGTC_1567 st069303 4.00 68.4 µM 4.78E-5 mitochondrial processes 19 3.14E-5
12 SGTC_1904 st060225 4.00 78.0 µM 4.81E-5 18 3.16E-5
13 SGTC_1255 0566-0045 3.97 221.0 µM 5.55E-5 excess fatty acid 29 3.67E-5
14 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.95 54.9 µM 5.91E-5 redox potentiating 54 3.92E-5
15 SGTC_2391 6285546 3.93 200.0 µM 6.36E-5 19 4.23E-5
16 SGTC_604 1000-0114 3.80 314.0 µM 1.06E-4 24 7.22E-5
17 SGTC_1252 0493-0875 3.79 34.8 µM 1.09E-4 34 7.43E-5
18 SGTC_3133 9127736 3.77 49.5 µM 1.19E-4 25 8.15E-5
19 SGTC_2384 9036245 3.68 200.0 µM 1.70E-4 38 1.18E-4
20 SGTC_1926 methyl fluorone black 3.65 53.6 µM 1.89E-4 DNA intercalators 71 1.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.49E-7 YOR173W DCS2 hom Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance
0.083 1.61E-6 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.081 2.89E-6 YER153C PET122 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
0.079 5.22E-6 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.076 1.14E-5 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.074 1.72E-5 YJR103W URA8 hom Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
0.072 2.94E-5 YMR245W_d YMR245W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071 3.50E-5 YBR079C RPG1 het eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
0.071 3.54E-5 YDR442W_d YDR442W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071 4.00E-5 YNR055C HOL1 hom Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake
0.069 5.82E-5 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.067 9.68E-5 YMR092C AIP1 hom Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.067 9.76E-5 YML009W-B_d YML009W-B_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.063 2.70E-4 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.063 2.92E-4 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor