HIPHOP chemogenomics database

YHL036W / MUP3

Low affinity methionine permease, similar to Mup1p

Zygosity: Homozygous strain

fixedexpanded
Profile for YHL036W / MUP3

Click on Significant Values for Screen Details

Top fitness defect scores for YHL036W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1921	5740136	7.39	50.0 µM	2.43E-13	TRP & mitochondrial translation	8	7.15E-14
2	SGTC_1685	st024049	5.80	53.1 µM	7.52E-9	TSC3-RPN4	4	3.41E-9
3	SGTC_1925	st057770	4.41	10.1 µM	8.39E-6	TSC3-RPN4	15	5.11E-6
4	SGTC_154	3389-1638	4.37	511.1 µM	1.02E-5		16	6.25E-6
5	SGTC_1892	st058411	4.32	7.4 µM	1.27E-5		12	7.87E-6
6	SGTC_393	acivicin	4.23	6.2 µM	1.83E-5		16	1.15E-5
7	SGTC_765	1319-0117	4.23	244.0 µM	1.88E-5	60S ribosome export	7	1.19E-5
8	SGTC_3288	9119690	4.21	36.2 µM	2.01E-5		19	1.27E-5
9	SGTC_1818	st052136	4.03	56.3 µM	4.19E-5	NEO1-PIK1	49	2.73E-5
10	SGTC_3138	9097216	4.00	49.5 µM	4.75E-5		13	3.12E-5
11	SGTC_1567	st069303	4.00	68.4 µM	4.78E-5	mitochondrial processes	19	3.14E-5
12	SGTC_1904	st060225	4.00	78.0 µM	4.81E-5		18	3.16E-5
13	SGTC_1255	0566-0045	3.97	221.0 µM	5.55E-5	excess fatty acid	29	3.67E-5
14	SGTC_1593	justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one	3.95	54.9 µM	5.91E-5	redox potentiating	54	3.92E-5
15	SGTC_2391	6285546	3.93	200.0 µM	6.36E-5		19	4.23E-5
16	SGTC_604	1000-0114	3.80	314.0 µM	1.06E-4		24	7.22E-5
17	SGTC_1252	0493-0875	3.79	34.8 µM	1.09E-4		34	7.43E-5
18	SGTC_3133	9127736	3.77	49.5 µM	1.19E-4		25	8.15E-5
19	SGTC_2384	9036245	3.68	200.0 µM	1.70E-4		38	1.18E-4
20	SGTC_1926	methyl fluorone black	3.65	53.6 µM	1.89E-4	DNA intercalators	71	1.32E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.091	1.49E-7	YOR173W	DCS2	hom	Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance
0.083	1.61E-6	YPR035W	GLN1	het	Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.081	2.89E-6	YER153C	PET122	hom	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
0.079	5.22E-6	YKL137W	CMC1	hom	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.076	1.14E-5	YDL058W	USO1	het	Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.074	1.72E-5	YJR103W	URA8	hom	Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
0.072	2.94E-5	YMR245W_d	YMR245W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071	3.50E-5	YBR079C	RPG1	het	eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
0.071	3.54E-5	YDR442W_d	YDR442W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071	4.00E-5	YNR055C	HOL1	hom	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake
0.069	5.82E-5	YDR479C	PEX29	hom	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.067	9.68E-5	YMR092C	AIP1	hom	Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.067	9.76E-5	YML009W-B_d	YML009W-B_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.063	2.70E-4	YEL065W	SIT1	hom	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.063	2.92E-4	YKL019W	RAM2	het	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor