YHL037C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL037C / YHL037C

Click on Significant Values for Screen Details ID:SGTC_305|Compound:1682-2595|FD-Score:4.43|P-value:1.55E-6 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.44|P-value:1.63E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:2.97|P-value:8.83E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.94|P-value:9.86E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.32|P-value:2.68E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.43|P-value:1.52E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.15|P-value:5.13E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.48|P-value:1.37E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.03|P-value:7.03E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.24|P-value:3.98E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:4.20|P-value:5.05E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.41|P-value:1.86E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.15|P-value:4.47E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.21|P-value:3.60E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.39|P-value:1.80E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:2.96|P-value:8.98E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.06|P-value:6.29E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.20|P-value:3.79E-4 ID:SGTC_2067|Compound:5224629|FD-Score:5.48|P-value:4.27E-9 ID:SGTC_2069|Compound:5228469|FD-Score:3.34|P-value:2.20E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.65|P-value:6.17E-5 ID:SGTC_2104|Compound:5389443|FD-Score:-2.98|P-value:9.50E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.70|P-value:5.49E-5 ID:SGTC_2229|Compound:7354935|FD-Score:3.31|P-value:2.46E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.17|P-value:4.18E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.17|P-value:4.63E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.01|P-value:8.30E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.01|P-value:7.56E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.65|P-value:5.99E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.09|P-value:5.59E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.82|P-value:3.35E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.69|P-value:5.05E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.77|P-value:3.55E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.49|P-value:1.20E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.21|P-value:3.65E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-4.48|P-value:1.42E-6 ID:SGTC_3204|Compound:9114183|FD-Score:4.02|P-value:1.15E-5 ID:SGTC_3233|Compound:9132340|FD-Score:4.68|P-value:4.38E-7 ID:SGTC_305|Compound:1682-2595|FD-Score:4.43|P-value:1.55E-6 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.44|P-value:1.63E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:2.97|P-value:8.83E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.94|P-value:9.86E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.32|P-value:2.68E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.43|P-value:1.52E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.15|P-value:5.13E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.48|P-value:1.37E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.03|P-value:7.03E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.24|P-value:3.98E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:4.20|P-value:5.05E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.41|P-value:1.86E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.15|P-value:4.47E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.21|P-value:3.60E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.39|P-value:1.80E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:2.96|P-value:8.98E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.06|P-value:6.29E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.20|P-value:3.79E-4 ID:SGTC_2067|Compound:5224629|FD-Score:5.48|P-value:4.27E-9 ID:SGTC_2069|Compound:5228469|FD-Score:3.34|P-value:2.20E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.65|P-value:6.17E-5 ID:SGTC_2104|Compound:5389443|FD-Score:-2.98|P-value:9.50E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.70|P-value:5.49E-5 ID:SGTC_2229|Compound:7354935|FD-Score:3.31|P-value:2.46E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.17|P-value:4.18E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.17|P-value:4.63E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.01|P-value:8.30E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.01|P-value:7.56E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.65|P-value:5.99E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.09|P-value:5.59E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.82|P-value:3.35E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.69|P-value:5.05E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.77|P-value:3.55E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.49|P-value:1.20E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.21|P-value:3.65E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-4.48|P-value:1.42E-6 ID:SGTC_3204|Compound:9114183|FD-Score:4.02|P-value:1.15E-5 ID:SGTC_3233|Compound:9132340|FD-Score:4.68|P-value:4.38E-7

Top fitness defect scores for YHL037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2067 5224629 5.48 34.1 µM 4.27E-9 6 2.17E-8
2 SGTC_3233 9132340 4.68 49.5 µM 4.38E-7 10 1.47E-6
3 SGTC_305 1682-2595 4.43 20.8 µM 1.55E-6 RNA processing & uracil transport 16 4.63E-6
4 SGTC_789 1309-1135 4.24 70.6 µM 3.98E-6 ERG2 23 1.09E-5
5 SGTC_829 1635-0120 4.20 117.0 µM 5.05E-6 DNA damage response 36 1.36E-5
6 SGTC_3204 9114183 4.02 49.5 µM 1.15E-5 31 2.88E-5
7 SGTC_2993 9054257 3.77 71.4 µM 3.55E-5 fatty acid desaturase (OLE1) 51 8.01E-5
8 SGTC_2916 7875993 3.69 68.8 µM 5.05E-5 36 1.10E-4
9 SGTC_2585 alliin 3.65 100.0 µM 5.99E-5 37 1.29E-4
10 SGTC_2074 5212007 3.65 75.4 µM 6.17E-5 18 1.33E-4
11 SGTC_3082 9117008 3.49 49.5 µM 1.20E-4 29 2.42E-4
12 SGTC_622 1348-1566 3.43 26.3 µM 1.52E-4 34 3.02E-4
13 SGTC_1651 st011928 3.39 86.1 µM 1.80E-4 RSC complex & mRNA processing 26 3.52E-4
14 SGTC_1707 st032323 3.35 6.3 µM 2.08E-4 DNA damage response 86 4.01E-4
15 SGTC_2069 5228469 3.34 200.0 µM 2.20E-4 33 4.22E-4
16 SGTC_2229 7354935 3.31 190.0 µM 2.46E-4 RSC complex & mRNA processing 17 4.67E-4
17 SGTC_1429 4049-0205 3.21 9.5 µM 3.60E-4 31 6.61E-4
18 SGTC_3114 9122766 3.21 49.5 µM 3.65E-4 48 6.70E-4
19 SGTC_1939 st074455 3.20 53.6 µM 3.79E-4 60 6.94E-4
20 SGTC_2286 7945697 3.17 125.0 µM 4.18E-4 97 7.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.75E-13 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.126 2.18E-13 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.114 3.40E-11 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.098 1.27E-8 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.094 4.19E-8 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.091 1.40E-7 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.086 5.48E-7 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.086 5.96E-7 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.086 6.83E-7 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.084 1.09E-6 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
0.082 2.23E-6 YCL010C SGF29 hom Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation
0.081 2.37E-6 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.081 2.60E-6 YHR028C DAP2 hom Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
0.078 5.87E-6 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.078 5.90E-6 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data