YHL039W / EFM1

Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL039W / EFM1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:6.05|P-value:1.15E-9 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.79|P-value:1.10E-6 ID:SGTC_96|Compound:0929-0093|FD-Score:3.24|P-value:6.77E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:5.13|P-value:2.00E-7 ID:SGTC_125|Compound:0133-0007|FD-Score:4.22|P-value:1.51E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:4.95|P-value:4.96E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:10.40|P-value:4.23E-25 ID:SGTC_144|Compound:4161-2749|FD-Score:10.20|P-value:3.94E-24 ID:SGTC_145|Compound:3737-0113|FD-Score:16.10|P-value:2.70E-57 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.98|P-value:4.30E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.49|P-value:2.83E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:20.10|P-value:2.39E-88 ID:SGTC_230|Compound:MPP+|FD-Score:5.02|P-value:3.59E-7 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:5.74|P-value:6.95E-9 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.34|P-value:1.86E-10 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.43|P-value:3.57E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:13.10|P-value:1.62E-38 ID:SGTC_264|Compound:promethazine|FD-Score:24.40|P-value:8.29E-129 ID:SGTC_266|Compound:formosanin C|FD-Score:5.53|P-value:2.37E-8 ID:SGTC_318|Compound:1488-0629|FD-Score:3.15|P-value:9.30E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.87|P-value:6.58E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.06|P-value:2.93E-7 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.99|P-value:4.09E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.33|P-value:5.11E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.62|P-value:1.76E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.31|P-value:1.03E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.67|P-value:1.44E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.65|P-value:1.54E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:5.59|P-value:1.68E-8 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.11|P-value:2.26E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.20|P-value:7.86E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.27|P-value:6.21E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.34|P-value:4.85E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.65|P-value:1.57E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.40|P-value:3.87E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.60|P-value:2.81E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.50|P-value:2.75E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.22|P-value:7.25E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.23|P-value:7.21E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.44|P-value:3.36E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.48|P-value:4.72E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:7.22|P-value:4.87E-13 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.31|P-value:1.02E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.84|P-value:7.33E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.80|P-value:1.07E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.22|P-value:1.51E-5 ID:SGTC_1519|Compound:esterone|FD-Score:5.33|P-value:6.96E-8 ID:SGTC_1529|Compound:apigenin|FD-Score:3.25|P-value:6.66E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.25|P-value:6.70E-4 ID:SGTC_1701|Compound:st028638|FD-Score:5.92|P-value:2.43E-9 ID:SGTC_1717|Compound:st033143|FD-Score:3.18|P-value:8.47E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.65|P-value:2.14E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.60|P-value:1.62E-8 ID:SGTC_2062|Compound:5245942|FD-Score:-3.38|P-value:4.18E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-4.00|P-value:3.86E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.25|P-value:6.51E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.15|P-value:9.26E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.65|P-value:2.19E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.80|P-value:8.84E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.15|P-value:9.27E-4 ID:SGTC_2848|Compound:9016370|FD-Score:5.19|P-value:1.45E-7 ID:SGTC_2894|Compound:9048625|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.96|P-value:1.99E-9 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.83|P-value:7.70E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.38|P-value:4.14E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.91|P-value:5.57E-5 ID:SGTC_3294|Compound:9122953|FD-Score:3.67|P-value:1.47E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.05|P-value:1.15E-9 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.79|P-value:1.10E-6 ID:SGTC_96|Compound:0929-0093|FD-Score:3.24|P-value:6.77E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:5.13|P-value:2.00E-7 ID:SGTC_125|Compound:0133-0007|FD-Score:4.22|P-value:1.51E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:4.95|P-value:4.96E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:10.40|P-value:4.23E-25 ID:SGTC_144|Compound:4161-2749|FD-Score:10.20|P-value:3.94E-24 ID:SGTC_145|Compound:3737-0113|FD-Score:16.10|P-value:2.70E-57 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.98|P-value:4.30E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.49|P-value:2.83E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:20.10|P-value:2.39E-88 ID:SGTC_230|Compound:MPP+|FD-Score:5.02|P-value:3.59E-7 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:5.74|P-value:6.95E-9 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.34|P-value:1.86E-10 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.43|P-value:3.57E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:13.10|P-value:1.62E-38 ID:SGTC_264|Compound:promethazine|FD-Score:24.40|P-value:8.29E-129 ID:SGTC_266|Compound:formosanin C|FD-Score:5.53|P-value:2.37E-8 ID:SGTC_318|Compound:1488-0629|FD-Score:3.15|P-value:9.30E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.87|P-value:6.58E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.06|P-value:2.93E-7 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.99|P-value:4.09E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.33|P-value:5.11E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.62|P-value:1.76E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.31|P-value:1.03E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.67|P-value:1.44E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.65|P-value:1.54E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:5.59|P-value:1.68E-8 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.11|P-value:2.26E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.20|P-value:7.86E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.27|P-value:6.21E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.34|P-value:4.85E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.65|P-value:1.57E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.40|P-value:3.87E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.60|P-value:2.81E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.50|P-value:2.75E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.22|P-value:7.25E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.23|P-value:7.21E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.44|P-value:3.36E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.48|P-value:4.72E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:7.22|P-value:4.87E-13 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.31|P-value:1.02E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.84|P-value:7.33E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.80|P-value:1.07E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.22|P-value:1.51E-5 ID:SGTC_1519|Compound:esterone|FD-Score:5.33|P-value:6.96E-8 ID:SGTC_1529|Compound:apigenin|FD-Score:3.25|P-value:6.66E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.25|P-value:6.70E-4 ID:SGTC_1701|Compound:st028638|FD-Score:5.92|P-value:2.43E-9 ID:SGTC_1717|Compound:st033143|FD-Score:3.18|P-value:8.47E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.65|P-value:2.14E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.60|P-value:1.62E-8 ID:SGTC_2062|Compound:5245942|FD-Score:-3.38|P-value:4.18E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-4.00|P-value:3.86E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.25|P-value:6.51E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.15|P-value:9.26E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.65|P-value:2.19E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.80|P-value:8.84E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.15|P-value:9.27E-4 ID:SGTC_2848|Compound:9016370|FD-Score:5.19|P-value:1.45E-7 ID:SGTC_2894|Compound:9048625|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.96|P-value:1.99E-9 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.83|P-value:7.70E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.38|P-value:4.14E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.91|P-value:5.57E-5 ID:SGTC_3294|Compound:9122953|FD-Score:3.67|P-value:1.47E-4

Top fitness defect scores for YHL039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 24.40 12.5 mM 8.29E-129 DNA intercalators 1 5.61E-132
2 SGTC_219 mitoxanthrone 20.10 164.4 µM 2.39E-88 DNA intercalators 1 1.67E-90
3 SGTC_145 3737-0113 16.10 38.4 µM 2.70E-57 DNA intercalators 1 1.12E-58
4 SGTC_257 daunorubicin 13.10 18.5 µM 1.62E-38 anthracycline transcription coupled DNA repair 1 1.98E-39
5 SGTC_143 4032-1194 10.40 15.7 µM 4.23E-25 4 1.11E-25
6 SGTC_144 4161-2749 10.20 112.4 µM 3.94E-24 DNA intercalators 3 1.10E-24
7 SGTC_1468 k284-1086 7.22 134.0 µM 4.87E-13 DNA intercalators 2 2.55E-13
8 SGTC_255 tunicamycin 6.34 200.5 nM 1.86E-10 unfolded protein response 27 1.13E-10
9 SGTC_43 0570-0105 6.05 72.5 µM 1.15E-9 ERG2 37 7.26E-10
10 SGTC_3040 9091894 5.96 49.5 µM 1.99E-9 DNA intercalators 8 1.28E-9
11 SGTC_1701 st028638 5.92 40.4 µM 2.43E-9 1 1.57E-9
12 SGTC_238 5hr heat shock (37°C) + nsc-638432 5.74 8.9 µM 6.95E-9 heat shock/prefoldin 18 4.60E-9
13 SGTC_1926 methyl fluorone black 5.60 53.6 µM 1.62E-8 DNA intercalators 23 1.10E-8
14 SGTC_867 0518-0118 5.59 155.0 µM 1.68E-8 DNA intercalators 5 1.13E-8
15 SGTC_266 formosanin C 5.53 406.0 nM 2.37E-8 sphingolipid biosynthesis & PDR1 35 1.61E-8
16 SGTC_1519 esterone 5.33 74.0 µM 6.96E-8 DNA intercalators 7 4.87E-8
17 SGTC_2848 9016370 5.19 26.0 µM 1.45E-7 9 1.04E-7
18 SGTC_112 phenothiazine 5.13 287.2 µM 2.00E-7 unfolded protein response 7 1.44E-7
19 SGTC_905 2-aminofluorene 5.11 215.0 µM 2.26E-7 cell wall signaling 9 1.63E-7
20 SGTC_471 1-acyl-paf 5.06 4.0 µM 2.93E-7 DNA intercalators 12 2.13E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.719 0 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.709 0 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.619 0 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.545 2.81E-258 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.525 8.85E-237 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.509 1.43E-220 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.430 1.18E-150 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.413 3.29E-138 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.412 1.88E-137 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.410 4.04E-136 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.376 6.93E-113 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.375 2.69E-112 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.365 2.06E-106 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.363 5.83E-105 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.333 1.27E-87 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data