YHL041W_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL041W / YHL041W

Click on Significant Values for Screen Details ID:SGTC_130|Compound:0136-0219|FD-Score:2.93|P-value:5.55E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.13|P-value:2.53E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.28|P-value:1.96E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.37|P-value:8.91E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.60|P-value:3.25E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.42|P-value:7.12E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.10|P-value:2.81E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.33|P-value:1.09E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.04|P-value:5.06E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.15|P-value:2.27E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:2.97|P-value:4.78E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.91|P-value:1.13E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.46|P-value:8.89E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:3.68|P-value:2.19E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.34|P-value:1.04E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.19|P-value:1.95E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.87|P-value:8.77E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.20|P-value:2.75E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:2.99|P-value:4.43E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.08|P-value:3.01E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.99|P-value:4.80E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.15|P-value:2.31E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.09|P-value:4.24E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.30|P-value:1.24E-4 ID:SGTC_1701|Compound:st028638|FD-Score:2.80|P-value:8.94E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.33|P-value:1.56E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.38|P-value:8.57E-5 ID:SGTC_1721|Compound:st082152|FD-Score:6.51|P-value:3.33E-13 ID:SGTC_1771|Compound:st048882|FD-Score:2.82|P-value:8.28E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-2.99|P-value:6.24E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.10|P-value:2.87E-4 ID:SGTC_2015|Compound:5119600|FD-Score:2.97|P-value:4.79E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.98|P-value:1.82E-8 ID:SGTC_2369|Compound:9071472|FD-Score:2.81|P-value:8.64E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:2.12E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.63|P-value:2.74E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.16|P-value:2.24E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.04|P-value:3.60E-4 ID:SGTC_3303|Compound:9125618|FD-Score:2.91|P-value:5.99E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.93|P-value:5.55E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.13|P-value:2.53E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.28|P-value:1.96E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.37|P-value:8.91E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.60|P-value:3.25E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.42|P-value:7.12E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.10|P-value:2.81E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.33|P-value:1.09E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.04|P-value:5.06E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.15|P-value:2.27E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:2.97|P-value:4.78E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.91|P-value:1.13E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.46|P-value:8.89E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:3.68|P-value:2.19E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.34|P-value:1.04E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.19|P-value:1.95E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.87|P-value:8.77E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.20|P-value:2.75E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:2.99|P-value:4.43E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.08|P-value:3.01E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.99|P-value:4.80E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.15|P-value:2.31E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.09|P-value:4.24E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.30|P-value:1.24E-4 ID:SGTC_1701|Compound:st028638|FD-Score:2.80|P-value:8.94E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.33|P-value:1.56E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.38|P-value:8.57E-5 ID:SGTC_1721|Compound:st082152|FD-Score:6.51|P-value:3.33E-13 ID:SGTC_1771|Compound:st048882|FD-Score:2.82|P-value:8.28E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-2.99|P-value:6.24E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.10|P-value:2.87E-4 ID:SGTC_2015|Compound:5119600|FD-Score:2.97|P-value:4.79E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.98|P-value:1.82E-8 ID:SGTC_2369|Compound:9071472|FD-Score:2.81|P-value:8.64E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:2.12E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.63|P-value:2.74E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.16|P-value:2.24E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.04|P-value:3.60E-4 ID:SGTC_3303|Compound:9125618|FD-Score:2.91|P-value:5.99E-4

Top fitness defect scores for YHL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1721 st082152 6.51 9.3 µM 3.33E-13 60S ribosome export 6 3.83E-11
2 SGTC_2082 5219693 4.98 150.0 µM 1.82E-8 RNA processing & uracil transport 7 3.23E-7
3 SGTC_1424 4048-1941 3.99 275.0 µM 4.80E-6 23 3.30E-5
4 SGTC_1368 1852-0141 3.87 284.0 µM 8.77E-6 ERG2 37 5.43E-5
5 SGTC_1101 ebselen 3.68 5.3 µM 2.19E-5 33 1.16E-4
6 SGTC_2474 5321570 3.63 43.3 µM 2.74E-5 22 1.40E-4
7 SGTC_635 k038-0028 3.60 24.7 µM 3.25E-5 ubiquinone biosynthesis & proteasome 56 1.61E-4
8 SGTC_803 4488-1585 3.42 147.0 µM 7.12E-5 25 3.09E-4
9 SGTC_1717 st033143 3.38 58.0 µM 8.57E-5 71 3.61E-4
10 SGTC_520 3584-0023 3.37 682.0 µM 8.91E-5 44 3.72E-4
11 SGTC_1229 0139-0193 3.34 12.2 µM 1.04E-4 RSC complex & mRNA processing 27 4.24E-4
12 SGTC_893 0958-0369 3.33 48.9 µM 1.09E-4 49 4.42E-4
13 SGTC_1636 st007707 3.30 68.9 µM 1.24E-4 76 4.89E-4
14 SGTC_1292 0kpi-0043 3.19 232.0 µM 1.95E-4 38 7.15E-4
15 SGTC_2375 9072683 3.17 200.0 µM 2.12E-4 mitochondrial processes 51 7.65E-4
16 SGTC_2807 7945238 3.16 52.0 µM 2.24E-4 74 8.00E-4
17 SGTC_937 3122-0005 3.15 46.7 µM 2.27E-4 54 8.11E-4
18 SGTC_1479 0549-0158 3.15 134.0 µM 2.31E-4 68 8.21E-4
19 SGTC_142 0335-0849 3.13 62.7 µM 2.53E-4 ubiquinone biosynthesis & proteasome 188 8.86E-4
20 SGTC_822 1487-0950 3.10 154.0 µM 2.81E-4 45 9.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.44E-15 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.127 1.77E-13 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.113 6.05E-11 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.112 7.29E-11 YML023C NSE5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.102 2.89E-9 YKL095W YJU2 het Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
0.098 1.24E-8 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.098 1.29E-8 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.097 1.57E-8 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.089 2.16E-7 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.088 2.90E-7 YPL138C SPP1 hom Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
0.087 5.02E-7 YGR277C CAB4 het Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
0.084 1.01E-6 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.083 1.61E-6 YGL044C RNA15 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.082 1.76E-6 YPL181W CTI6 hom Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
0.082 1.95E-6 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER