YHL043W / ECM34

Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL043W / ECM34

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.36|P-value:4.63E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:5.87|P-value:6.80E-10 ID:SGTC_84|Compound:0443-0269|FD-Score:3.01|P-value:8.06E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.28|P-value:4.42E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.42|P-value:1.79E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.60|P-value:8.96E-7 ID:SGTC_604|Compound:1000-0114|FD-Score:3.74|P-value:4.92E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.13|P-value:5.18E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.23|P-value:3.59E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.01|P-value:7.93E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.94|P-value:2.09E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:-3.45|P-value:3.42E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.09|P-value:6.00E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.73|P-value:4.95E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.18|P-value:4.33E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.53|P-value:2.53E-4 ID:SGTC_1691|Compound:st019933|FD-Score:4.33|P-value:3.52E-6 ID:SGTC_1708|Compound:st033234|FD-Score:5.58|P-value:4.16E-9 ID:SGTC_1714|Compound:st033236|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-4.01|P-value:3.70E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.56|P-value:1.01E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.18|P-value:8.77E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.98|P-value:8.95E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.47|P-value:1.43E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-3.28|P-value:6.20E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.47|P-value:3.09E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-4.49|P-value:4.14E-6 ID:SGTC_2144|Compound:5628481|FD-Score:-4.13|P-value:2.22E-5 ID:SGTC_2145|Compound:5634607|FD-Score:-3.50|P-value:2.85E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.83|P-value:3.33E-5 ID:SGTC_2318|Compound:6029776|FD-Score:2.95|P-value:9.78E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.87|P-value:2.78E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.43|P-value:3.64E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.02|P-value:3.50E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.24|P-value:7.21E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.04|P-value:7.20E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.60|P-value:8.50E-5 ID:SGTC_3098|Compound:9119039|FD-Score:-3.35|P-value:4.91E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.20|P-value:4.08E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.54|P-value:2.40E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-5.61|P-value:1.10E-8 ID:SGTC_3159|Compound:9100096|FD-Score:-3.25|P-value:6.94E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.00|P-value:8.36E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.36|P-value:4.63E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:5.87|P-value:6.80E-10 ID:SGTC_84|Compound:0443-0269|FD-Score:3.01|P-value:8.06E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.28|P-value:4.42E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.42|P-value:1.79E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.60|P-value:8.96E-7 ID:SGTC_604|Compound:1000-0114|FD-Score:3.74|P-value:4.92E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.13|P-value:5.18E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.23|P-value:3.59E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.01|P-value:7.93E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.94|P-value:2.09E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:-3.45|P-value:3.42E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.09|P-value:6.00E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.73|P-value:4.95E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.18|P-value:4.33E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.53|P-value:2.53E-4 ID:SGTC_1691|Compound:st019933|FD-Score:4.33|P-value:3.52E-6 ID:SGTC_1708|Compound:st033234|FD-Score:5.58|P-value:4.16E-9 ID:SGTC_1714|Compound:st033236|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-4.01|P-value:3.70E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.56|P-value:1.01E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.18|P-value:8.77E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.98|P-value:8.95E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.47|P-value:1.43E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-3.28|P-value:6.20E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.47|P-value:3.09E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-4.49|P-value:4.14E-6 ID:SGTC_2144|Compound:5628481|FD-Score:-4.13|P-value:2.22E-5 ID:SGTC_2145|Compound:5634607|FD-Score:-3.50|P-value:2.85E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.83|P-value:3.33E-5 ID:SGTC_2318|Compound:6029776|FD-Score:2.95|P-value:9.78E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.87|P-value:2.78E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.43|P-value:3.64E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.02|P-value:3.50E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.24|P-value:7.21E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.04|P-value:7.20E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.60|P-value:8.50E-5 ID:SGTC_3098|Compound:9119039|FD-Score:-3.35|P-value:4.91E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.20|P-value:4.08E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.54|P-value:2.40E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-5.61|P-value:1.10E-8 ID:SGTC_3159|Compound:9100096|FD-Score:-3.25|P-value:6.94E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.00|P-value:8.36E-4

Top fitness defect scores for YHL043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_51 1013-0126 5.87 23.4 µM 6.80E-10 14 2.18E-9
2 SGTC_1708 st033234 5.58 31.8 µM 4.16E-9 3 1.23E-8
3 SGTC_366 0181-0206 4.60 4.3 µM 8.96E-7 Golgi 21 2.07E-6
4 SGTC_1691 st019933 4.33 84.6 µM 3.52E-6 8 7.61E-6
5 SGTC_176 1486-1328 4.28 72.8 µM 4.42E-6 45 9.45E-6
6 SGTC_1408 3909-7976 3.94 48.8 µM 2.09E-5 Golgi 20 4.14E-5
7 SGTC_2536 dehydroabietamide 3.87 32.0 µM 2.78E-5 38 5.44E-5
8 SGTC_2160 5660466 3.83 132.9 µM 3.33E-5 60S ribosome export 21 6.44E-5
9 SGTC_604 1000-0114 3.74 314.0 µM 4.92E-5 29 9.34E-5
10 SGTC_1629 st005085 3.73 44.9 µM 4.95E-5 RPP1 & pyrimidine depletion 42 9.39E-5
11 SGTC_2989 9073649 3.60 71.4 µM 8.50E-5 55 1.57E-4
12 SGTC_1814 st052110 3.56 31.5 µM 1.01E-4 RNA processing & uracil transport 19 1.84E-4
13 SGTC_1714 st033236 3.54 13.6 µM 1.11E-4 37 2.02E-4
14 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.47 14.9 µM 1.43E-4 24 2.57E-4
15 SGTC_182 3448-4371 3.42 550.5 µM 1.79E-4 40 3.18E-4
16 SGTC_822 1487-0950 3.23 154.0 µM 3.59E-4 38 6.15E-4
17 SGTC_3149 9097855 3.20 49.5 µM 4.08E-4 Golgi 57 6.95E-4
18 SGTC_1636 st007707 3.18 68.9 µM 4.33E-4 82 7.35E-4
19 SGTC_911 3456-4043 3.14 236.0 µM 5.10E-4 mitochondrial processes 63 8.58E-4
20 SGTC_718 1130-0073 3.13 349.0 µM 5.18E-4 53 8.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.54E-10 YBR301W PAU24 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.107 5.90E-10 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking
0.100 5.71E-9 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.097 1.70E-8 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.086 5.54E-7 YMR128W ECM16 het Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
0.074 2.00E-5 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.072 2.64E-5 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.070 5.21E-5 YGL208W SIP2 hom One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
0.070 5.41E-5 YHR098C SFB3 hom Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p
0.070 5.46E-5 YFR033C QCR6 hom Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space
0.068 7.57E-5 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.068 7.90E-5 YGR130C YGR130C hom Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
0.067 9.33E-5 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.067 1.01E-4 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.067 1.05E-4 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)