YHL046C / PAU13

Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL046C / PAU13

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-3.69|P-value:2.92E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:2.95|P-value:6.37E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.47|P-value:7.89E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.26|P-value:1.67E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.00|P-value:5.23E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.05|P-value:4.38E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.02|P-value:5.00E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.09|P-value:3.78E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:2.87|P-value:8.59E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:2.95|P-value:6.32E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.58|P-value:4.94E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.90|P-value:1.05E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.49|P-value:4.95E-7 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.16|P-value:2.93E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.99|P-value:5.48E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.00|P-value:5.38E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.13|P-value:3.17E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:2.91|P-value:7.42E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.95|P-value:8.20E-6 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.06|P-value:4.67E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.27|P-value:1.79E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.24|P-value:2.08E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.20|P-value:2.44E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.43|P-value:7.08E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.68|P-value:1.68E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.56|P-value:3.51E-7 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.44|P-value:9.14E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.70|P-value:1.57E-7 ID:SGTC_1344|Compound:1488-0097|FD-Score:-2.97|P-value:6.11E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.41|P-value:1.01E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.09|P-value:3.68E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:3.06|P-value:4.16E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-2.86|P-value:9.45E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-2.88|P-value:8.51E-4 ID:SGTC_1908|Compound:st060353|FD-Score:6.24|P-value:5.17E-12 ID:SGTC_1912|Compound:st060209|FD-Score:4.04|P-value:5.28E-6 ID:SGTC_1949|Compound:st076024|FD-Score:-4.04|P-value:5.41E-6 ID:SGTC_1950|Compound:st077106|FD-Score:-3.09|P-value:3.88E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.35|P-value:1.37E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.48|P-value:7.57E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.47|P-value:7.70E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.25|P-value:1.92E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-2.89|P-value:8.41E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-2.87|P-value:9.00E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.59|P-value:4.40E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-2.92|P-value:7.39E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.93|P-value:6.99E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.59|P-value:2.78E-7 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.48|P-value:7.42E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.69|P-value:1.56E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.10|P-value:3.53E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.10|P-value:3.60E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.98|P-value:5.84E-4 ID:SGTC_2713|Compound:st079149|FD-Score:2.99|P-value:5.55E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.16|P-value:2.78E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.69|P-value:2.98E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.91|P-value:1.06E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.69|P-value:2.92E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:2.95|P-value:6.37E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.47|P-value:7.89E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.26|P-value:1.67E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.00|P-value:5.23E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.05|P-value:4.38E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.02|P-value:5.00E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.09|P-value:3.78E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:2.87|P-value:8.59E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:2.95|P-value:6.32E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.58|P-value:4.94E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.90|P-value:1.05E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.49|P-value:4.95E-7 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.16|P-value:2.93E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.99|P-value:5.48E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.00|P-value:5.38E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.13|P-value:3.17E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:2.91|P-value:7.42E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.95|P-value:8.20E-6 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.06|P-value:4.67E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.27|P-value:1.79E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.24|P-value:2.08E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.20|P-value:2.44E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.43|P-value:7.08E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.68|P-value:1.68E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.56|P-value:3.51E-7 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.44|P-value:9.14E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.70|P-value:1.57E-7 ID:SGTC_1344|Compound:1488-0097|FD-Score:-2.97|P-value:6.11E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.41|P-value:1.01E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.09|P-value:3.68E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:3.06|P-value:4.16E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-2.86|P-value:9.45E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-2.88|P-value:8.51E-4 ID:SGTC_1908|Compound:st060353|FD-Score:6.24|P-value:5.17E-12 ID:SGTC_1912|Compound:st060209|FD-Score:4.04|P-value:5.28E-6 ID:SGTC_1949|Compound:st076024|FD-Score:-4.04|P-value:5.41E-6 ID:SGTC_1950|Compound:st077106|FD-Score:-3.09|P-value:3.88E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.35|P-value:1.37E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.48|P-value:7.57E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.47|P-value:7.70E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.25|P-value:1.92E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-2.89|P-value:8.41E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-2.87|P-value:9.00E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.59|P-value:4.40E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-2.92|P-value:7.39E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.93|P-value:6.99E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.59|P-value:2.78E-7 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.48|P-value:7.42E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.69|P-value:1.56E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.10|P-value:3.53E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.10|P-value:3.60E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.98|P-value:5.84E-4 ID:SGTC_2713|Compound:st079149|FD-Score:2.99|P-value:5.55E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.16|P-value:2.78E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.69|P-value:2.98E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.91|P-value:1.06E-5

Top fitness defect scores for YHL046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1908 st060353 6.24 56.5 µM 5.17E-12 RPP1 & pyrimidine depletion 7 2.22E-10
2 SGTC_2497 7-hydroxyflavone 4.69 100.0 µM 1.56E-7 9 1.36E-6
3 SGTC_1127 asiatic acid 4.68 681.4 nM 1.68E-7 10 1.45E-6
4 SGTC_2489 cantharidin 4.59 73.4 µM 2.78E-7 cell wall signaling 25 2.22E-6
5 SGTC_916 4466-0038 4.49 42.0 nM 4.95E-7 cell wall 51 3.62E-6
6 SGTC_420 mitomycin C 4.26 81.9 mM 1.67E-6 15 1.02E-5
7 SGTC_1097 itavastatin 4.06 7.2 µM 4.67E-6 azole & statin 20 2.42E-5
8 SGTC_1912 st060209 4.04 90.8 µM 5.28E-6 35 2.69E-5
9 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 3.95 15.5 µM 8.20E-6 26 3.91E-5
10 SGTC_912 3474-0017 3.90 2.2 µM 1.05E-5 23 4.83E-5
11 SGTC_2278 7948257 3.59 134.3 µM 4.40E-5 35 1.63E-4
12 SGTC_2493 resveratrol 3.48 26.1 µM 7.42E-5 16 2.53E-4
13 SGTC_2160 5660466 3.47 132.9 µM 7.70E-5 60S ribosome export 31 2.62E-4
14 SGTC_1354 1498-1681 3.41 81.0 µM 1.01E-4 39 3.31E-4
15 SGTC_1099 5-nonyloxytryptamine 3.27 2.9 µM 1.79E-4 46 5.36E-4
16 SGTC_2162 5663267 3.25 200.0 µM 1.92E-4 29 5.69E-4
17 SGTC_1106 tegaserod maleate 3.24 11.7 µM 2.08E-4 55 6.08E-4
18 SGTC_1119 parthenolide 3.20 318.5 nM 2.44E-4 TSC3-RPN4 81 6.97E-4
19 SGTC_2751 anetholtrithion 3.16 17.2 µM 2.78E-4 60 7.80E-4
20 SGTC_1065 prochlorperazine maleate 3.13 2.5 µM 3.17E-4 41 8.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 5.50E-12 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.112 8.23E-11 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.112 8.67E-11 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.104 1.78E-9 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.102 3.05E-9 YNL068C FKH2 hom Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication
0.096 2.32E-8 YIL116W HIS5 hom Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
0.095 3.31E-8 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.092 1.08E-7 YJL127C-B_p YJL127C-B_p hom Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
0.090 1.87E-7 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.090 1.85E-7 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.088 2.94E-7 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.087 3.90E-7 YNL240C NAR1 het Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf
0.085 7.60E-7 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.085 8.27E-7 YDR307W_p PMT7_p hom Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation
0.083 1.64E-6 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly