YHL047C / ARN2

Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL047C / ARN2

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:-3.36|P-value:2.16E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-4.20|P-value:5.31E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:3.09|P-value:6.65E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.15|P-value:5.30E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.39|P-value:2.09E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.69|P-value:6.21E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.10|P-value:6.45E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.94|P-value:1.33E-7 ID:SGTC_592|Compound:k241-0073|FD-Score:3.27|P-value:3.32E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.90|P-value:2.45E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:4.71|P-value:4.67E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:3.05|P-value:7.68E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.77|P-value:4.34E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:4.51|P-value:1.32E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.09|P-value:6.68E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.03|P-value:7.42E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.96|P-value:1.66E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.98|P-value:9.46E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:5.46|P-value:6.48E-9 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.97|P-value:9.26E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.79|P-value:4.12E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.60|P-value:8.90E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.17|P-value:3.65E-8 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.34|P-value:2.30E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.76|P-value:4.64E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.04|P-value:7.27E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.98|P-value:9.77E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-5.86|P-value:4.32E-10 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.51|P-value:1.15E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.05|P-value:7.51E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.12|P-value:5.39E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-5.30|P-value:1.42E-8 ID:SGTC_1762|Compound:st045503|FD-Score:-2.98|P-value:8.76E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.54|P-value:1.14E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.01|P-value:1.52E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.26|P-value:3.56E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.08|P-value:6.80E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.17|P-value:4.94E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.11|P-value:6.19E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.26|P-value:3.47E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.62|P-value:2.43E-9 ID:SGTC_2416|Compound:tofa|FD-Score:-3.15|P-value:4.77E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-2.99|P-value:8.49E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.20|P-value:4.45E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.01|P-value:8.91E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.52|P-value:1.24E-4 ID:SGTC_2624|Compound:nerol|FD-Score:5.64|P-value:2.10E-9 ID:SGTC_2625|Compound:euphol|FD-Score:6.25|P-value:3.70E-11 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.58|P-value:8.90E-5 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.68|P-value:6.44E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.18|P-value:4.74E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.45|P-value:1.78E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.13|P-value:5.69E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.03|P-value:7.54E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.99|P-value:1.63E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.08|P-value:6.88E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.49|P-value:1.41E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.00|P-value:9.01E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.45|P-value:1.68E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.09|P-value:6.55E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-10.80|P-value:7.44E-30 ID:SGTC_3223|Compound:9129970|FD-Score:-3.23|P-value:3.55E-4 ID:SGTC_3224|Compound:9130643|FD-Score:8.62|P-value:1.24E-19 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.36|P-value:2.16E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-4.20|P-value:5.31E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:3.09|P-value:6.65E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.15|P-value:5.30E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.39|P-value:2.09E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.69|P-value:6.21E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.10|P-value:6.45E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.94|P-value:1.33E-7 ID:SGTC_592|Compound:k241-0073|FD-Score:3.27|P-value:3.32E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.90|P-value:2.45E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:4.71|P-value:4.67E-7 ID:SGTC_620|Compound:0109-0052|FD-Score:3.05|P-value:7.68E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.77|P-value:4.34E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:4.51|P-value:1.32E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.09|P-value:6.68E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.03|P-value:7.42E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.96|P-value:1.66E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.98|P-value:9.46E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:5.46|P-value:6.48E-9 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.97|P-value:9.26E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.79|P-value:4.12E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.60|P-value:8.90E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.17|P-value:3.65E-8 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.34|P-value:2.30E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.76|P-value:4.64E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.04|P-value:7.27E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.98|P-value:9.77E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-5.86|P-value:4.32E-10 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.51|P-value:1.15E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.05|P-value:7.51E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.12|P-value:5.39E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-5.30|P-value:1.42E-8 ID:SGTC_1762|Compound:st045503|FD-Score:-2.98|P-value:8.76E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.54|P-value:1.14E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.01|P-value:1.52E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.26|P-value:3.56E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.08|P-value:6.80E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.17|P-value:4.94E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.11|P-value:6.19E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.26|P-value:3.47E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.62|P-value:2.43E-9 ID:SGTC_2416|Compound:tofa|FD-Score:-3.15|P-value:4.77E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-2.99|P-value:8.49E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.20|P-value:4.45E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.01|P-value:8.91E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.52|P-value:1.24E-4 ID:SGTC_2624|Compound:nerol|FD-Score:5.64|P-value:2.10E-9 ID:SGTC_2625|Compound:euphol|FD-Score:6.25|P-value:3.70E-11 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.58|P-value:8.90E-5 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.68|P-value:6.44E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.18|P-value:4.74E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.45|P-value:1.78E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.13|P-value:5.69E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.03|P-value:7.54E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.99|P-value:1.63E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.08|P-value:6.88E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.49|P-value:1.41E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.00|P-value:9.01E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.45|P-value:1.68E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.09|P-value:6.55E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-10.80|P-value:7.44E-30 ID:SGTC_3223|Compound:9129970|FD-Score:-3.23|P-value:3.55E-4 ID:SGTC_3224|Compound:9130643|FD-Score:8.62|P-value:1.24E-19

Top fitness defect scores for YHL047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3224 9130643 8.62 49.5 µM 1.24E-19 RPP1 & pyrimidine depletion 3 3.21E-18
2 SGTC_2625 euphol 6.25 100.0 µM 3.70E-11 5 2.03E-10
3 SGTC_2624 nerol 5.64 100.0 µM 2.10E-9 2 8.37E-9
4 SGTC_2282 7944268 5.62 200.0 µM 2.43E-9 RPP1 & pyrimidine depletion 6 9.61E-9
5 SGTC_912 3474-0017 5.46 2.2 µM 6.48E-9 6 2.37E-8
6 SGTC_1257 0669-0121 5.17 16.0 µM 3.65E-8 11 1.17E-7
7 SGTC_473 2-arachidonoylglycerol 4.94 10.0 µM 1.33E-7 7 3.85E-7
8 SGTC_619 1652-1634 4.71 108.0 µM 4.67E-7 PDR1 10 1.23E-6
9 SGTC_711 k292-0785 4.51 179.0 µM 1.32E-6 DNA intercalators 12 3.20E-6
10 SGTC_2791 5663188 4.45 71.4 µM 1.78E-6 RPP1 & pyrimidine depletion 15 4.20E-6
11 SGTC_1849 st056239 4.01 19.2 µM 1.52E-5 RPP1 & pyrimidine depletion 25 3.05E-5
12 SGTC_2910 7948405 3.99 26.0 µM 1.63E-5 plasma membrane duress 25 3.25E-5
13 SGTC_612 0302-0167 3.90 22.4 µM 2.45E-5 copper-dependent oxidative stress 34 4.75E-5
14 SGTC_1107 amlodipine 3.79 47.0 µM 4.12E-5 42 7.67E-5
15 SGTC_622 1348-1566 3.77 26.3 µM 4.34E-5 23 8.06E-5
16 SGTC_1280 0880-0253 3.76 10.1 µM 4.64E-5 24 8.57E-5
17 SGTC_276 colchicine 3.69 750.0 µM 6.21E-5 21 1.12E-4
18 SGTC_2747 doxorubicin 3.68 7.6 µM 6.44E-5 anthracycline transcription coupled DNA repair 8 1.16E-4
19 SGTC_1222 0366-0074 3.60 1.2 µM 8.90E-5 TSC3-RPN4 25 1.57E-4
20 SGTC_2281 7943571 3.56 200.0 µM 1.05E-4 18 1.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 3.41E-13 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 4.30E-8 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.090 1.51E-7 YER007C-A TMA20 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress
0.087 3.85E-7 YHR085W IPI1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene
0.085 7.31E-7 YOR261C RPN8 het Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
0.085 7.89E-7 YBR092C PHO3 hom Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
0.078 5.39E-6 YLR059C REX2 hom 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease
0.076 1.26E-5 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.076 1.16E-5 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
0.075 1.52E-5 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.072 2.85E-5 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
0.072 3.15E-5 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.070 5.40E-5 YOR075W UFE1 het t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
0.069 6.06E-5 YGL190C CDC55 hom Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion
0.068 7.25E-5 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress