YHR001W-A / QCR10

Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR001W-A / QCR10

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.07|P-value:9.68E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.33|P-value:3.26E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-4.02|P-value:1.85E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.10|P-value:5.53E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.31|P-value:3.11E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.63|P-value:6.31E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.03|P-value:7.23E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.41|P-value:1.72E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.44|P-value:1.51E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.35|P-value:2.19E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.24|P-value:3.34E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.94|P-value:9.68E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.89|P-value:2.29E-5 ID:SGTC_1691|Compound:st019933|FD-Score:4.85|P-value:1.90E-7 ID:SGTC_1709|Compound:st033179|FD-Score:3.66|P-value:6.09E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-4.65|P-value:9.20E-7 ID:SGTC_1715|Compound:st032160|FD-Score:3.12|P-value:5.20E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.17|P-value:4.28E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.02|P-value:7.28E-4 ID:SGTC_1885|Compound:st057546|FD-Score:7.03|P-value:1.13E-13 ID:SGTC_2001|Compound:4023502|FD-Score:-4.18|P-value:9.00E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-4.30|P-value:5.15E-6 ID:SGTC_2117|Compound:5521686|FD-Score:2.95|P-value:9.38E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.20|P-value:3.85E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.32|P-value:2.43E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.22|P-value:3.50E-4 ID:SGTC_2462|Compound:5162487|FD-Score:4.59|P-value:7.82E-7 ID:SGTC_2471|Compound:5466956|FD-Score:4.22|P-value:4.79E-6 ID:SGTC_2472|Compound:5377652|FD-Score:5.11|P-value:4.51E-8 ID:SGTC_2475|Compound:5812728|FD-Score:-3.10|P-value:7.61E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.20|P-value:1.84E-26 ID:SGTC_2606|Compound:farnesol|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.48|P-value:1.85E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.14|P-value:6.68E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.28|P-value:3.96E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.59|P-value:8.13E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.62|P-value:1.04E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.51|P-value:1.61E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.08|P-value:9.28E-6 ID:SGTC_3008|Compound:9078912|FD-Score:3.37|P-value:1.96E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.46|P-value:1.38E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.42|P-value:1.63E-4 ID:SGTC_3144|Compound:9087057|FD-Score:5.91|P-value:3.36E-10 ID:SGTC_3145|Compound:9085516|FD-Score:5.93|P-value:2.81E-10 ID:SGTC_3224|Compound:9130643|FD-Score:3.65|P-value:6.33E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.07|P-value:9.68E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.33|P-value:3.26E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-4.02|P-value:1.85E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.10|P-value:5.53E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.31|P-value:3.11E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.63|P-value:6.31E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.03|P-value:7.23E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.41|P-value:1.72E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.44|P-value:1.51E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.35|P-value:2.19E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.24|P-value:3.34E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.94|P-value:9.68E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.89|P-value:2.29E-5 ID:SGTC_1691|Compound:st019933|FD-Score:4.85|P-value:1.90E-7 ID:SGTC_1709|Compound:st033179|FD-Score:3.66|P-value:6.09E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-4.65|P-value:9.20E-7 ID:SGTC_1715|Compound:st032160|FD-Score:3.12|P-value:5.20E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.17|P-value:4.28E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.02|P-value:7.28E-4 ID:SGTC_1885|Compound:st057546|FD-Score:7.03|P-value:1.13E-13 ID:SGTC_2001|Compound:4023502|FD-Score:-4.18|P-value:9.00E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-4.30|P-value:5.15E-6 ID:SGTC_2117|Compound:5521686|FD-Score:2.95|P-value:9.38E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.20|P-value:3.85E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.32|P-value:2.43E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.22|P-value:3.50E-4 ID:SGTC_2462|Compound:5162487|FD-Score:4.59|P-value:7.82E-7 ID:SGTC_2471|Compound:5466956|FD-Score:4.22|P-value:4.79E-6 ID:SGTC_2472|Compound:5377652|FD-Score:5.11|P-value:4.51E-8 ID:SGTC_2475|Compound:5812728|FD-Score:-3.10|P-value:7.61E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.20|P-value:1.84E-26 ID:SGTC_2606|Compound:farnesol|FD-Score:3.18|P-value:4.11E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.48|P-value:1.85E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.14|P-value:6.68E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.28|P-value:3.96E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.59|P-value:8.13E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.62|P-value:1.04E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.51|P-value:1.61E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.08|P-value:9.28E-6 ID:SGTC_3008|Compound:9078912|FD-Score:3.37|P-value:1.96E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.46|P-value:1.38E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.42|P-value:1.63E-4 ID:SGTC_3144|Compound:9087057|FD-Score:5.91|P-value:3.36E-10 ID:SGTC_3145|Compound:9085516|FD-Score:5.93|P-value:2.81E-10 ID:SGTC_3224|Compound:9130643|FD-Score:3.65|P-value:6.33E-5

Top fitness defect scores for YHR001W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 10.20 100.0 µM 1.84E-26 redox potentiating 60 1.54E-24
2 SGTC_1885 st057546 7.03 99.9 µM 1.13E-13 1 1.07E-12
3 SGTC_3145 9085516 5.93 49.5 µM 2.81E-10 fatty acid desaturase (OLE1) 6 1.48E-9
4 SGTC_3144 9087057 5.91 49.5 µM 3.36E-10 3 1.75E-9
5 SGTC_2472 5377652 5.11 49.4 µM 4.51E-8 TRP & mitochondrial translation 27 1.62E-7
6 SGTC_1691 st019933 4.85 84.6 µM 1.90E-7 5 6.10E-7
7 SGTC_514 4466-0038 4.63 2.6 nM 6.31E-7 cell wall 124 1.85E-6
8 SGTC_2462 5162487 4.59 171.8 µM 7.82E-7 11 2.26E-6
9 SGTC_343 4130-2827 4.31 29.8 µM 3.11E-6 24 8.08E-6
10 SGTC_2471 5466956 4.22 24.8 µM 4.79E-6 mitochondrial processes 9 1.21E-5
11 SGTC_2943 9068529 4.08 45.3 µM 9.28E-6 19 2.22E-5
12 SGTC_39 0986-0283 4.07 58.4 µM 9.68E-6 calcium & mitochondrial duress 33 2.31E-5
13 SGTC_1644 st010134 3.89 20.9 µM 2.29E-5 mitochondrial processes 13 5.11E-5
14 SGTC_1709 st033179 3.66 39.1 µM 6.09E-5 20 1.26E-4
15 SGTC_3224 9130643 3.65 49.5 µM 6.33E-5 RPP1 & pyrimidine depletion 34 1.31E-4
16 SGTC_2834 9001755 3.59 58.4 µM 8.13E-5 47 1.65E-4
17 SGTC_3081 9117243 3.46 49.5 µM 1.38E-4 fatty acid desaturase (OLE1) 37 2.69E-4
18 SGTC_1149 3909-7961 3.44 23.3 µM 1.51E-4 40 2.92E-4
19 SGTC_3141 9094609 3.42 49.5 µM 1.63E-4 iron homeostasis 54 3.13E-4
20 SGTC_1023 4482-3888 3.41 16.0 µM 1.72E-4 TSC3-RPN4 35 3.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.264 1.86E-54 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.230 1.55E-41 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.223 5.73E-39 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.222 1.03E-38 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.214 3.19E-36 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.213 1.31E-35 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.204 8.26E-33 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.202 3.28E-32 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.194 9.27E-30 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.190 1.18E-28 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.187 9.59E-28 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.181 5.43E-26 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.170 3.54E-23 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.167 1.75E-22 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.166 4.55E-22 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription