YHR004C / NEM1

Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR004C / NEM1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.51|P-value:4.64E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.43|P-value:7.79E-10 ID:SGTC_16|Compound:erodoxin|FD-Score:3.28|P-value:9.74E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.41|P-value:8.21E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-4.40|P-value:2.33E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.08|P-value:8.05E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.29|P-value:2.61E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.94|P-value:1.34E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:8.31|P-value:3.01E-15 ID:SGTC_108|Compound:0509-0257|FD-Score:6.46|P-value:6.39E-10 ID:SGTC_114|Compound:0364-0001|FD-Score:3.40|P-value:6.60E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:7.96|P-value:4.09E-14 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.62|P-value:4.15E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.42|P-value:6.15E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.27|P-value:2.90E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.70|P-value:6.07E-33 ID:SGTC_232|Compound:clozapine|FD-Score:12.80|P-value:1.87E-33 ID:SGTC_288|Compound:1315-0019|FD-Score:5.86|P-value:1.80E-8 ID:SGTC_301|Compound:4119-0100|FD-Score:9.16|P-value:4.11E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.33|P-value:3.02E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.68|P-value:2.58E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.67|P-value:1.83E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.50|P-value:1.51E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:6.04|P-value:6.77E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:4.19|P-value:3.91E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:7.72|P-value:2.14E-13 ID:SGTC_637|Compound:1181-0519|FD-Score:3.94|P-value:1.00E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:7.22|P-value:5.88E-12 ID:SGTC_660|Compound:4031-1742|FD-Score:9.17|P-value:4.07E-18 ID:SGTC_733|Compound:4069-0007|FD-Score:9.70|P-value:4.66E-20 ID:SGTC_743|Compound:1275-0778|FD-Score:6.65|P-value:2.02E-10 ID:SGTC_788|Compound:1182-0090|FD-Score:6.76|P-value:1.09E-10 ID:SGTC_842|Compound:0271-0008|FD-Score:4.50|P-value:1.11E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:4.89|P-value:2.09E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:4.51|P-value:1.07E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:3.85|P-value:1.38E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:5.31|P-value:2.91E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.04|P-value:6.94E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.91|P-value:5.61E-14 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.87|P-value:1.33E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.89|P-value:1.23E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:10.80|P-value:1.85E-24 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.18|P-value:8.05E-15 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.58|P-value:3.65E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.34|P-value:2.18E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.66|P-value:5.66E-6 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.06|P-value:9.43E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_1547|Compound:harmine|FD-Score:12.80|P-value:3.14E-33 ID:SGTC_1581|Compound:himbacine|FD-Score:5.33|P-value:2.71E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.73|P-value:2.18E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.27|P-value:2.87E-5 ID:SGTC_1658|Compound:st012944|FD-Score:6.72|P-value:1.40E-10 ID:SGTC_1717|Compound:st033143|FD-Score:3.30|P-value:8.95E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.42|P-value:6.18E-4 ID:SGTC_1760|Compound:st045453|FD-Score:7.60|P-value:4.88E-13 ID:SGTC_1781|Compound:st038725|FD-Score:9.03|P-value:1.24E-17 ID:SGTC_1797|Compound:st048695|FD-Score:6.79|P-value:9.07E-11 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.35|P-value:2.30E-15 ID:SGTC_1854|Compound:st056233|FD-Score:3.42|P-value:6.25E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.54|P-value:9.51E-6 ID:SGTC_1884|Compound:5633444|FD-Score:3.43|P-value:5.95E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.14|P-value:4.72E-5 ID:SGTC_1991|Compound:st073000|FD-Score:10.40|P-value:6.21E-23 ID:SGTC_2006|Compound:4011487|FD-Score:9.13|P-value:5.40E-18 ID:SGTC_2036|Compound:5160441|FD-Score:4.92|P-value:1.81E-6 ID:SGTC_2147|Compound:5545932|FD-Score:3.58|P-value:3.65E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.65|P-value:2.85E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.96|P-value:9.37E-5 ID:SGTC_2257|Compound:7960413|FD-Score:3.57|P-value:3.70E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.83|P-value:2.00E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-4.18|P-value:5.43E-5 ID:SGTC_2322|Compound:7413319|FD-Score:5.34|P-value:2.53E-7 ID:SGTC_2385|Compound:9074692|FD-Score:6.27|P-value:1.94E-9 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.91|P-value:1.12E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.22|P-value:4.44E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.89|P-value:2.06E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.04|P-value:6.83E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.35|P-value:2.39E-7 ID:SGTC_2691|Compound:st077356|FD-Score:3.52|P-value:4.44E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.84|P-value:6.51E-11 ID:SGTC_2699|Compound:st077704|FD-Score:3.50|P-value:4.74E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:7.33|P-value:2.98E-12 ID:SGTC_2809|Compound:7964133|FD-Score:4.34|P-value:2.17E-5 ID:SGTC_2818|Compound:7996756|FD-Score:-3.38|P-value:9.05E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.30|P-value:8.99E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.74|P-value:2.05E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.70|P-value:4.07E-8 ID:SGTC_3142|Compound:9086498|FD-Score:3.85|P-value:1.42E-4 ID:SGTC_3152|Compound:9099253|FD-Score:10.30|P-value:3.56E-22 ID:SGTC_3333|Compound:9141820|FD-Score:-3.79|P-value:2.29E-4 ID:SGTC_3334|Compound:9142812|FD-Score:6.02|P-value:7.58E-9 ID:SGTC_3341|Compound:9147222|FD-Score:8.50|P-value:7.77E-16 ID:SGTC_3342|Compound:9147791|FD-Score:4.16|P-value:4.44E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.51|P-value:4.64E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.43|P-value:7.79E-10 ID:SGTC_16|Compound:erodoxin|FD-Score:3.28|P-value:9.74E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.41|P-value:8.21E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-4.40|P-value:2.33E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.08|P-value:8.05E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.29|P-value:2.61E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.94|P-value:1.34E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:8.31|P-value:3.01E-15 ID:SGTC_108|Compound:0509-0257|FD-Score:6.46|P-value:6.39E-10 ID:SGTC_114|Compound:0364-0001|FD-Score:3.40|P-value:6.60E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:7.96|P-value:4.09E-14 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.62|P-value:4.15E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.42|P-value:6.15E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.27|P-value:2.90E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.70|P-value:6.07E-33 ID:SGTC_232|Compound:clozapine|FD-Score:12.80|P-value:1.87E-33 ID:SGTC_288|Compound:1315-0019|FD-Score:5.86|P-value:1.80E-8 ID:SGTC_301|Compound:4119-0100|FD-Score:9.16|P-value:4.11E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.33|P-value:3.02E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.68|P-value:2.58E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.67|P-value:1.83E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.50|P-value:1.51E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:6.04|P-value:6.77E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:4.19|P-value:3.91E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:7.72|P-value:2.14E-13 ID:SGTC_637|Compound:1181-0519|FD-Score:3.94|P-value:1.00E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:7.22|P-value:5.88E-12 ID:SGTC_660|Compound:4031-1742|FD-Score:9.17|P-value:4.07E-18 ID:SGTC_733|Compound:4069-0007|FD-Score:9.70|P-value:4.66E-20 ID:SGTC_743|Compound:1275-0778|FD-Score:6.65|P-value:2.02E-10 ID:SGTC_788|Compound:1182-0090|FD-Score:6.76|P-value:1.09E-10 ID:SGTC_842|Compound:0271-0008|FD-Score:4.50|P-value:1.11E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:4.89|P-value:2.09E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:4.51|P-value:1.07E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:3.85|P-value:1.38E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:5.31|P-value:2.91E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.04|P-value:6.94E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.91|P-value:5.61E-14 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.87|P-value:1.33E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.89|P-value:1.23E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:10.80|P-value:1.85E-24 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.18|P-value:8.05E-15 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.58|P-value:3.65E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.34|P-value:2.18E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.66|P-value:5.66E-6 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.06|P-value:9.43E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_1547|Compound:harmine|FD-Score:12.80|P-value:3.14E-33 ID:SGTC_1581|Compound:himbacine|FD-Score:5.33|P-value:2.71E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.73|P-value:2.18E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.27|P-value:2.87E-5 ID:SGTC_1658|Compound:st012944|FD-Score:6.72|P-value:1.40E-10 ID:SGTC_1717|Compound:st033143|FD-Score:3.30|P-value:8.95E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.42|P-value:6.18E-4 ID:SGTC_1760|Compound:st045453|FD-Score:7.60|P-value:4.88E-13 ID:SGTC_1781|Compound:st038725|FD-Score:9.03|P-value:1.24E-17 ID:SGTC_1797|Compound:st048695|FD-Score:6.79|P-value:9.07E-11 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.35|P-value:2.30E-15 ID:SGTC_1854|Compound:st056233|FD-Score:3.42|P-value:6.25E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.54|P-value:9.51E-6 ID:SGTC_1884|Compound:5633444|FD-Score:3.43|P-value:5.95E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.14|P-value:4.72E-5 ID:SGTC_1991|Compound:st073000|FD-Score:10.40|P-value:6.21E-23 ID:SGTC_2006|Compound:4011487|FD-Score:9.13|P-value:5.40E-18 ID:SGTC_2036|Compound:5160441|FD-Score:4.92|P-value:1.81E-6 ID:SGTC_2147|Compound:5545932|FD-Score:3.58|P-value:3.65E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.65|P-value:2.85E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.96|P-value:9.37E-5 ID:SGTC_2257|Compound:7960413|FD-Score:3.57|P-value:3.70E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.83|P-value:2.00E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-4.18|P-value:5.43E-5 ID:SGTC_2322|Compound:7413319|FD-Score:5.34|P-value:2.53E-7 ID:SGTC_2385|Compound:9074692|FD-Score:6.27|P-value:1.94E-9 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.91|P-value:1.12E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.22|P-value:4.44E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.89|P-value:2.06E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.04|P-value:6.83E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.35|P-value:2.39E-7 ID:SGTC_2691|Compound:st077356|FD-Score:3.52|P-value:4.44E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.84|P-value:6.51E-11 ID:SGTC_2699|Compound:st077704|FD-Score:3.50|P-value:4.74E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:7.33|P-value:2.98E-12 ID:SGTC_2809|Compound:7964133|FD-Score:4.34|P-value:2.17E-5 ID:SGTC_2818|Compound:7996756|FD-Score:-3.38|P-value:9.05E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.30|P-value:8.99E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.74|P-value:2.05E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.70|P-value:4.07E-8 ID:SGTC_3142|Compound:9086498|FD-Score:3.85|P-value:1.42E-4 ID:SGTC_3152|Compound:9099253|FD-Score:10.30|P-value:3.56E-22 ID:SGTC_3333|Compound:9141820|FD-Score:-3.79|P-value:2.29E-4 ID:SGTC_3334|Compound:9142812|FD-Score:6.02|P-value:7.58E-9 ID:SGTC_3341|Compound:9147222|FD-Score:8.50|P-value:7.77E-16 ID:SGTC_3342|Compound:9147791|FD-Score:4.16|P-value:4.44E-5

Top fitness defect scores for YHR004C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_232 clozapine 12.80 119.0 µM 1.87E-33 NEO1 13 7.97E-38
2 SGTC_1547 harmine 12.80 94.2 µM 3.14E-33 ergosterol biosynthesis 2 1.44E-37
3 SGTC_221 trifluoperazine 12.70 10.3 µM 6.07E-33 NEO1-PIK1 33 3.05E-37
4 SGTC_1130 3454-2858 10.80 15.9 µM 1.85E-24 NEO1 11 1.46E-27
5 SGTC_1991 st073000 10.40 8.9 µM 6.21E-23 NEO1 8 8.03E-26
6 SGTC_3152 9099253 10.30 49.5 µM 3.56E-22 NEO1-PIK1 21 5.86E-25
7 SGTC_733 4069-0007 9.70 56.1 µM 4.66E-20 ERAD & cell cycle 15 1.52E-22
8 SGTC_660 4031-1742 9.17 102.0 µM 4.07E-18 redox potentiating 5 2.48E-20
9 SGTC_301 4119-0100 9.16 24.5 µM 4.11E-18 NEO1 16 2.51E-20
10 SGTC_2006 4011487 9.13 200.0 µM 5.40E-18 endomembrane recycling 23 3.42E-20
11 SGTC_1781 st038725 9.03 66.3 µM 1.24E-17 NEO1 23 8.85E-20
12 SGTC_3341 9147222 8.50 25.9 µM 7.77E-16 RNA processing & uracil transport 1 9.82E-18
13 SGTC_1844 rapamycin 8.35 4.0 nM 2.30E-15 52 3.38E-17
14 SGTC_64 000l-0018 8.31 272.1 µM 3.01E-15 ubiquinone biosynthesis & proteasome 46 4.59E-17
15 SGTC_1161 k007-0610 8.18 110.0 µM 8.05E-15 ERAD & cell cycle 22 1.41E-16
16 SGTC_115 0527-0192 7.96 112.0 µM 4.09E-14 9 8.94E-16
17 SGTC_1026 k007-1105 7.91 30.6 µM 5.61E-14 ERAD & cell cycle 19 1.28E-15
18 SGTC_535 2293-4129 7.72 48.2 µM 2.14E-13 NEO1 14 5.88E-15
19 SGTC_1760 st045453 7.60 10.4 µM 4.88E-13 NEO1-PIK1 60 1.50E-14
20 SGTC_2776 terbinafine 7.33 19.9 µM 2.98E-12 cell wall signaling 17 1.17E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.606 0 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.498 4.26E-209 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.497 5.17E-208 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.491 2.06E-202 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.477 1.36E-189 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.476 4.62E-189 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.470 1.67E-183 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.456 6.89E-172 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.440 3.77E-158 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.431 9.36E-152 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.420 7.53E-143 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.415 1.07E-139 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.375 2.04E-112 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.361 1.66E-103 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.329 5.10E-85 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton