YHR005C-A / TIM10

Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR005C-A / TIM10

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.81|P-value:6.07E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.81|P-value:6.21E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.96|P-value:3.27E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.49|P-value:3.01E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:3.75|P-value:8.38E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.81|P-value:6.10E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.07|P-value:2.03E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.82|P-value:6.44E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:4.00|P-value:3.03E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.22|P-value:5.96E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.31|P-value:4.32E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.51|P-value:2.14E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.19|P-value:6.94E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.30|P-value:4.69E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:4.28|P-value:8.60E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:3.60|P-value:1.53E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.21|P-value:6.38E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.39|P-value:3.42E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.49|P-value:1.64E-8 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.12|P-value:1.66E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.07|P-value:9.98E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.84|P-value:5.94E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.63|P-value:7.33E-9 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.37|P-value:3.48E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.35|P-value:3.68E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.21|P-value:6.45E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.39|P-value:3.14E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.23|P-value:5.92E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.75|P-value:7.79E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.70|P-value:1.13E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.92|P-value:3.94E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.07|P-value:2.05E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.25|P-value:9.99E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.60|P-value:1.80E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.20|P-value:6.75E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.35|P-value:3.74E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.35|P-value:3.93E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.83|P-value:5.74E-7 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.11|P-value:8.55E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.95|P-value:1.15E-9 ID:SGTC_1604|Compound:st002052|FD-Score:3.99|P-value:3.12E-5 ID:SGTC_1609|Compound:st001574|FD-Score:3.45|P-value:2.69E-4 ID:SGTC_1734|Compound:st037168|FD-Score:5.15|P-value:1.17E-7 ID:SGTC_1797|Compound:st048695|FD-Score:-3.19|P-value:6.58E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.95|P-value:3.43E-5 ID:SGTC_1831|Compound:st055328|FD-Score:-3.71|P-value:9.13E-5 ID:SGTC_1850|Compound:st056238|FD-Score:3.95|P-value:3.68E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.40|P-value:3.28E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.29|P-value:7.65E-6 ID:SGTC_2068|Compound:5226020|FD-Score:4.55|P-value:2.54E-6 ID:SGTC_2114|Compound:5491910|FD-Score:4.04|P-value:2.55E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.10|P-value:9.51E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-4.63|P-value:1.55E-6 ID:SGTC_2155|Compound:5570423|FD-Score:-3.44|P-value:2.63E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.70|P-value:9.59E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.09|P-value:1.89E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.37|P-value:3.59E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.88|P-value:5.02E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-4.70|P-value:1.11E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-3.13|P-value:7.92E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.52|P-value:2.60E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.21|P-value:6.17E-4 ID:SGTC_2472|Compound:5377652|FD-Score:7.04|P-value:7.61E-13 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.71|P-value:9.25E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.51|P-value:2.04E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.30|P-value:4.45E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.13|P-value:8.15E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.35|P-value:3.70E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.54|P-value:1.80E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.42|P-value:4.60E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.57|P-value:1.74E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.11|P-value:8.60E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.20|P-value:1.16E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.29|P-value:8.28E-6 ID:SGTC_2799|Compound:7812892|FD-Score:-3.18|P-value:6.81E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.30|P-value:7.31E-6 ID:SGTC_2927|Compound:9011802|FD-Score:5.11|P-value:1.47E-7 ID:SGTC_2928|Compound:9011484|FD-Score:-8.16|P-value:1.12E-16 ID:SGTC_2980|Compound:9014342|FD-Score:-3.19|P-value:6.49E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.14|P-value:8.35E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.20|P-value:6.60E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.81|P-value:6.07E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.81|P-value:6.21E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.96|P-value:3.27E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.49|P-value:3.01E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:3.75|P-value:8.38E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.81|P-value:6.10E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.07|P-value:2.03E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.82|P-value:6.44E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:4.00|P-value:3.03E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.22|P-value:5.96E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.31|P-value:4.32E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.51|P-value:2.14E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.19|P-value:6.94E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.30|P-value:4.69E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:4.28|P-value:8.60E-6 ID:SGTC_680|Compound:0417-1641|FD-Score:3.60|P-value:1.53E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.21|P-value:6.38E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.39|P-value:3.42E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.49|P-value:1.64E-8 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.12|P-value:1.66E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.07|P-value:9.98E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.84|P-value:5.94E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.63|P-value:7.33E-9 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.37|P-value:3.48E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.35|P-value:3.68E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.21|P-value:6.45E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.39|P-value:3.14E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.23|P-value:5.92E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.75|P-value:7.79E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.70|P-value:1.13E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.92|P-value:3.94E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.07|P-value:2.05E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.25|P-value:9.99E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.60|P-value:1.80E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.20|P-value:6.75E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.35|P-value:3.74E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.35|P-value:3.93E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.83|P-value:5.74E-7 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.11|P-value:8.55E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.95|P-value:1.15E-9 ID:SGTC_1604|Compound:st002052|FD-Score:3.99|P-value:3.12E-5 ID:SGTC_1609|Compound:st001574|FD-Score:3.45|P-value:2.69E-4 ID:SGTC_1734|Compound:st037168|FD-Score:5.15|P-value:1.17E-7 ID:SGTC_1797|Compound:st048695|FD-Score:-3.19|P-value:6.58E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.95|P-value:3.43E-5 ID:SGTC_1831|Compound:st055328|FD-Score:-3.71|P-value:9.13E-5 ID:SGTC_1850|Compound:st056238|FD-Score:3.95|P-value:3.68E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.40|P-value:3.28E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.29|P-value:7.65E-6 ID:SGTC_2068|Compound:5226020|FD-Score:4.55|P-value:2.54E-6 ID:SGTC_2114|Compound:5491910|FD-Score:4.04|P-value:2.55E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.10|P-value:9.51E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-4.63|P-value:1.55E-6 ID:SGTC_2155|Compound:5570423|FD-Score:-3.44|P-value:2.63E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.70|P-value:9.59E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.09|P-value:1.89E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.37|P-value:3.59E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.88|P-value:5.02E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-4.70|P-value:1.11E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-3.13|P-value:7.92E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.52|P-value:2.60E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.21|P-value:6.17E-4 ID:SGTC_2472|Compound:5377652|FD-Score:7.04|P-value:7.61E-13 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.71|P-value:9.25E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.51|P-value:2.04E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.30|P-value:4.45E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.13|P-value:8.15E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.35|P-value:3.70E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.54|P-value:1.80E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.42|P-value:4.60E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.57|P-value:1.74E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.11|P-value:8.60E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.20|P-value:1.16E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.29|P-value:8.28E-6 ID:SGTC_2799|Compound:7812892|FD-Score:-3.18|P-value:6.81E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.30|P-value:7.31E-6 ID:SGTC_2927|Compound:9011802|FD-Score:5.11|P-value:1.47E-7 ID:SGTC_2928|Compound:9011484|FD-Score:-8.16|P-value:1.12E-16 ID:SGTC_2980|Compound:9014342|FD-Score:-3.19|P-value:6.49E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.14|P-value:8.35E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.20|P-value:6.60E-4

Top fitness defect scores for YHR005C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2472 5377652 7.04 49.4 µM 7.61E-13 TRP & mitochondrial translation 3 9.33E-13 2.45
2 SGTC_1599 8-chlro-1-tetrahydronorharmanone 5.95 90.6 µM 1.15E-9 2 1.33E-9 0.41
3 SGTC_1734 st037168 5.15 69.4 µM 1.17E-7 3 1.29E-7 0.80
4 SGTC_2927 9011802 5.11 47.9 µM 1.47E-7 4 1.62E-7 0.41
5 SGTC_2068 5226020 4.55 147.0 µM 2.54E-6 3 2.73E-6 0.34
6 SGTC_2682 pyrogallin 4.42 40.0 µM 4.60E-6 copper-dependent oxidative stress 2 4.92E-6 0.39
7 SGTC_2781 5567276 4.29 71.4 µM 8.28E-6 6 8.82E-6 0.29
8 SGTC_618 k072-0232 4.28 33.2 µM 8.60E-6 60S ribosome export 3 9.15E-6 0.34
9 SGTC_1361 1608-0041 4.25 5.6 µM 9.99E-6 RPP1 & pyrimidine depletion 4 1.06E-5 0.02
10 SGTC_2114 5491910 4.04 81.2 µM 2.55E-5 4 2.69E-5 0.17
11 SGTC_533 1222-0222 4.00 6.7 µM 3.03E-5 PDR1 12 3.19E-5 0.02
12 SGTC_1604 st002052 3.99 72.4 µM 3.12E-5 TSC3-RPN4 8 3.29E-5 0.15
13 SGTC_1850 st056238 3.95 17.0 µM 3.68E-5 RPP1 & pyrimidine depletion 3 3.87E-5 0.02
14 SGTC_2320 7373003 3.88 200.0 µM 5.02E-5 9 5.27E-5 0.01
15 SGTC_965 1291-5240 3.84 308.0 µM 5.94E-5 4 6.23E-5 0.12
16 SGTC_454 lyso-paf C-16 3.82 6.7 µM 6.44E-5 5 6.75E-5 0.33
17 SGTC_286 k060-0067 3.75 22.9 µM 8.38E-5 tubulin folding & SWR complex 7 8.76E-5 0.06
18 SGTC_959 1222-0044 3.70 107.0 µM 1.03E-4 6 1.08E-4 0.21
19 SGTC_680 0417-1641 3.60 114.0 µM 1.53E-4 RPP1 & pyrimidine depletion 9 1.59E-4 0.06
20 SGTC_803 4488-1585 3.58 147.0 µM 1.64E-4 6 1.70E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.75E-18 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.148 6.38E-18 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.147 1.15E-17 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.139 6.03E-16 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
0.139 7.13E-16 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.135 4.75E-15 YML092C PRE8 het Alpha 2 subunit of the 20S proteasome
0.132 2.03E-14 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.124 5.81E-13 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.123 7.26E-13 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.122 1.23E-12 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.113 6.00E-11 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.111 1.11E-10 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.104 1.38E-9 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.103 1.92E-9 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.103 2.13E-9 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein