YHR006W / STP2

Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR006W / STP2

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.19|P-value:3.44E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.42|P-value:1.48E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.13|P-value:9.71E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:5.46|P-value:4.16E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:3.70|P-value:4.45E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.42|P-value:1.43E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:2.94|P-value:8.89E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.06|P-value:8.08E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.50|P-value:1.60E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.13|P-value:6.39E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.94|P-value:2.31E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.06|P-value:8.14E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.84|P-value:3.60E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.10|P-value:7.12E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.25|P-value:4.04E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:2.93|P-value:9.05E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.10|P-value:7.10E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:2.95|P-value:8.43E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.17|P-value:5.50E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.18|P-value:7.65E-6 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.33|P-value:2.96E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.07|P-value:7.98E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.13|P-value:4.41E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.83|P-value:1.67E-7 ID:SGTC_1678|Compound:st019265|FD-Score:3.34|P-value:1.94E-4 ID:SGTC_1906|Compound:st060206|FD-Score:4.15|P-value:5.44E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.52|P-value:1.44E-4 ID:SGTC_2076|Compound:5212012|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.13|P-value:4.37E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.70|P-value:4.38E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.46|P-value:1.80E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.77|P-value:3.18E-5 ID:SGTC_2425|Compound:5628681|FD-Score:4.66|P-value:4.15E-7 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.98|P-value:1.23E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.20|P-value:4.31E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.42|P-value:2.35E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.68|P-value:1.95E-9 ID:SGTC_2804|Compound:7954240|FD-Score:3.43|P-value:1.35E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.92|P-value:1.68E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.32|P-value:3.05E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-4.23|P-value:5.97E-6 ID:SGTC_2873|Compound:9040596|FD-Score:3.63|P-value:5.92E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.85|P-value:2.26E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.11|P-value:4.73E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.24|P-value:4.22E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.56|P-value:1.21E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.07|P-value:5.45E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-3.74|P-value:5.63E-5 ID:SGTC_3167|Compound:9103034|FD-Score:3.21|P-value:3.28E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.55|P-value:1.24E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.63|P-value:8.96E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-4.21|P-value:6.66E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.08|P-value:5.36E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.19|P-value:3.44E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.42|P-value:1.48E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.13|P-value:9.71E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:5.46|P-value:4.16E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:3.70|P-value:4.45E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.42|P-value:1.43E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:2.94|P-value:8.89E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.06|P-value:8.08E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.50|P-value:1.60E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.13|P-value:6.39E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.94|P-value:2.31E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.06|P-value:8.14E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.84|P-value:3.60E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.10|P-value:7.12E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.25|P-value:4.04E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:2.93|P-value:9.05E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.10|P-value:7.10E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:2.95|P-value:8.43E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.17|P-value:5.50E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.18|P-value:7.65E-6 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.33|P-value:2.96E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.07|P-value:7.98E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.13|P-value:4.41E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.83|P-value:1.67E-7 ID:SGTC_1678|Compound:st019265|FD-Score:3.34|P-value:1.94E-4 ID:SGTC_1906|Compound:st060206|FD-Score:4.15|P-value:5.44E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.52|P-value:1.44E-4 ID:SGTC_2076|Compound:5212012|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.13|P-value:4.37E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.70|P-value:4.38E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.46|P-value:1.80E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.77|P-value:3.18E-5 ID:SGTC_2425|Compound:5628681|FD-Score:4.66|P-value:4.15E-7 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.98|P-value:1.23E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.20|P-value:4.31E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.42|P-value:2.35E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.68|P-value:1.95E-9 ID:SGTC_2804|Compound:7954240|FD-Score:3.43|P-value:1.35E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.92|P-value:1.68E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.32|P-value:3.05E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-4.23|P-value:5.97E-6 ID:SGTC_2873|Compound:9040596|FD-Score:3.63|P-value:5.92E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.85|P-value:2.26E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.11|P-value:4.73E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.24|P-value:4.22E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.56|P-value:1.21E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.07|P-value:5.45E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-3.74|P-value:5.63E-5 ID:SGTC_3167|Compound:9103034|FD-Score:3.21|P-value:3.28E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.55|P-value:1.24E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.63|P-value:8.96E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-4.21|P-value:6.66E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.08|P-value:5.36E-4

Top fitness defect scores for YHR006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_180 1486-1293 5.46 102.8 µM 4.16E-9 19 2.42E-8
2 SGTC_1382 3002-2117 4.83 298.0 µM 1.67E-7 5 6.92E-7
3 SGTC_2425 5628681 4.66 7.8 µM 4.15E-7 8 1.58E-6
4 SGTC_163 1327-0036 4.42 7.5 µM 1.48E-6 85 4.99E-6
5 SGTC_2522 biochanin a 4.20 4.9 µM 4.31E-6 RNA pol III & RNase P/MRP 8 1.32E-5
6 SGTC_1906 st060206 4.15 94.7 µM 5.44E-6 17 1.63E-5
7 SGTC_1370 2001-0092 4.07 44.6 µM 7.98E-6 27 2.31E-5
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.98 3.7 µM 1.23E-5 82 3.40E-5
9 SGTC_2812 7970281 3.92 58.4 µM 1.68E-5 31 4.52E-5
10 SGTC_2916 7875993 3.85 68.8 µM 2.26E-5 32 5.92E-5
11 SGTC_2415 st077333 3.77 57.7 µM 3.18E-5 49 8.07E-5
12 SGTC_2103 5378138 3.70 10.0 µM 4.38E-5 23 1.08E-4
13 SGTC_181 1447-1644 3.70 8.1 µM 4.45E-5 endomembrane recycling 38 1.09E-4
14 SGTC_2873 9040596 3.63 71.4 µM 5.92E-5 60 1.42E-4
15 SGTC_2804 7954240 3.43 19.5 µM 1.35E-4 53 2.99E-4
16 SGTC_517 1365-0151 3.42 113.0 µM 1.43E-4 48 3.15E-4
17 SGTC_1678 st019265 3.34 80.2 µM 1.94E-4 60S ribosome export 42 4.17E-4
18 SGTC_3167 9103034 3.21 49.5 µM 3.28E-4 RPP1 & pyrimidine depletion 16 6.71E-4
19 SGTC_14 0354-0009 3.19 295.0 µM 3.44E-4 52 6.99E-4
20 SGTC_2097 5376186 3.13 200.0 µM 4.37E-4 60 8.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 5.05E-43 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.213 1.09E-35 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.188 4.68E-28 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.174 3.73E-24 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.162 4.55E-21 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.159 2.63E-20 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.150 2.05E-18 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.145 2.87E-17 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.144 4.50E-17 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.142 1.12E-16 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.142 1.56E-16 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.141 1.99E-16 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.139 7.01E-16 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.128 9.81E-14 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.127 1.92E-13 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants