YHR007C / ERG11

Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR007C / ERG11

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:7.67|P-value:1.53E-8 ID:SGTC_56|Compound:0957-0365|FD-Score:5.36|P-value:5.38E-5 ID:SGTC_57|Compound:miconazole|FD-Score:11.30|P-value:1.51E-16 ID:SGTC_103|Compound:0844-0104|FD-Score:5.93|P-value:9.15E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:6.86|P-value:3.65E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:16.10|P-value:1.58E-31 ID:SGTC_146|Compound:3448-8650|FD-Score:7.00|P-value:2.20E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:5.06|P-value:1.26E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.51|P-value:3.37E-5 ID:SGTC_185|Compound:k048-0037|FD-Score:9.05|P-value:3.44E-11 ID:SGTC_197|Compound:4544-0043|FD-Score:10.40|P-value:2.83E-14 ID:SGTC_203|Compound:k066-0004|FD-Score:10.40|P-value:2.89E-14 ID:SGTC_206|Compound:4546-0025|FD-Score:9.34|P-value:8.14E-12 ID:SGTC_207|Compound:4185-0010|FD-Score:11.40|P-value:9.56E-17 ID:SGTC_212|Compound:3807-4682|FD-Score:4.44|P-value:6.52E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:18.60|P-value:5.40E-41 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:6.79|P-value:4.65E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:12.90|P-value:1.01E-20 ID:SGTC_252|Compound:miconazole|FD-Score:10.30|P-value:4.56E-14 ID:SGTC_268|Compound:camptothecin|FD-Score:4.54|P-value:5.05E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:4.35|P-value:8.27E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:4.70|P-value:3.32E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.64|P-value:3.96E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:5.44|P-value:4.15E-5 ID:SGTC_324|Compound:1315-0088|FD-Score:4.44|P-value:6.59E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:6.60|P-value:9.54E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:4.43|P-value:6.76E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.25|P-value:3.87E-6 ID:SGTC_376|Compound:3970-0862|FD-Score:4.33|P-value:8.67E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.40|P-value:7.21E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.80|P-value:2.55E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.07|P-value:1.66E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.43|P-value:6.71E-4 ID:SGTC_459|Compound:nigericin|FD-Score:6.78|P-value:4.93E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.37|P-value:6.17E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:-4.61|P-value:5.01E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-8.37|P-value:1.05E-9 ID:SGTC_524|Compound:r073-0010|FD-Score:6.96|P-value:2.52E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:11.00|P-value:1.02E-15 ID:SGTC_566|Compound:0958-0068|FD-Score:5.88|P-value:1.07E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.45|P-value:6.47E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:8.58|P-value:3.03E-10 ID:SGTC_617|Compound:3770-0098|FD-Score:5.12|P-value:1.06E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:7.13|P-value:1.30E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:4.90|P-value:1.97E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:13.10|P-value:2.51E-21 ID:SGTC_637|Compound:1181-0519|FD-Score:11.80|P-value:8.86E-18 ID:SGTC_641|Compound:4092-0595|FD-Score:6.81|P-value:4.36E-7 ID:SGTC_643|Compound:k048-0106|FD-Score:15.40|P-value:6.34E-29 ID:SGTC_649|Compound:1123-0311|FD-Score:7.68|P-value:1.48E-8 ID:SGTC_658|Compound:3253-0951|FD-Score:5.74|P-value:1.67E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:19.10|P-value:3.57E-43 ID:SGTC_690|Compound:glyoxal|FD-Score:4.32|P-value:8.82E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.55|P-value:5.02E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:8.29|P-value:1.13E-9 ID:SGTC_746|Compound:1095-0025|FD-Score:7.70|P-value:1.37E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:6.22|P-value:3.54E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:10.40|P-value:3.82E-14 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.15|P-value:1.17E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:16.70|P-value:9.41E-34 ID:SGTC_788|Compound:1182-0090|FD-Score:5.20|P-value:8.54E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:10.10|P-value:2.08E-13 ID:SGTC_816|Compound:0325-0417|FD-Score:-10.10|P-value:1.85E-13 ID:SGTC_817|Compound:1391-0715|FD-Score:-9.03|P-value:5.03E-11 ID:SGTC_818|Compound:4072-2707|FD-Score:-8.61|P-value:3.55E-10 ID:SGTC_834|Compound:0312-0008|FD-Score:9.75|P-value:1.02E-12 ID:SGTC_852|Compound:0418-0143|FD-Score:4.45|P-value:6.33E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:10.20|P-value:8.14E-14 ID:SGTC_859|Compound:0439-0102|FD-Score:4.42|P-value:6.83E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:7.32|P-value:6.39E-8 ID:SGTC_868|Compound:0527-0199|FD-Score:12.70|P-value:2.93E-20 ID:SGTC_875|Compound:0709-0210|FD-Score:12.30|P-value:3.48E-19 ID:SGTC_878|Compound:0828-0289|FD-Score:6.35|P-value:2.25E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:5.40|P-value:4.77E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.28|P-value:9.63E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.32|P-value:8.89E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:6.85|P-value:3.80E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:4.36|P-value:7.91E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.31|P-value:6.22E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.47|P-value:7.15E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:8.38|P-value:7.36E-10 ID:SGTC_999|Compound:4022-0066|FD-Score:7.68|P-value:1.51E-8 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.96|P-value:8.19E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.76|P-value:1.10E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:14.30|P-value:4.40E-25 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.35|P-value:9.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:8.27|P-value:1.22E-9 ID:SGTC_1067|Compound:clotrimazole|FD-Score:8.17|P-value:1.91E-9 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.10|P-value:5.29E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:14.40|P-value:2.13E-25 ID:SGTC_1084|Compound:voriconazole|FD-Score:6.12|P-value:4.92E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:5.85|P-value:1.17E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.62|P-value:4.16E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.94|P-value:8.81E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.21|P-value:1.56E-9 ID:SGTC_1162|Compound:k048-0130|FD-Score:6.70|P-value:6.60E-7 ID:SGTC_1191|Compound:1487-1166|FD-Score:6.07|P-value:5.78E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.23|P-value:7.84E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:5.18|P-value:8.93E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.84|P-value:2.34E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.18|P-value:1.10E-7 ID:SGTC_1308|Compound:1187-1617|FD-Score:7.15|P-value:1.22E-7 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.29|P-value:9.38E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.42|P-value:6.97E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:6.51|P-value:1.27E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.28|P-value:9.80E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.63|P-value:4.01E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.85|P-value:2.28E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:4.40|P-value:7.17E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-6.32|P-value:3.10E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:5.11|P-value:1.11E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.65|P-value:3.83E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:7.41|P-value:4.49E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.64|P-value:3.91E-4 ID:SGTC_1731|Compound:st035964|FD-Score:13.30|P-value:3.37E-22 ID:SGTC_1750|Compound:st081859|FD-Score:6.21|P-value:3.69E-6 ID:SGTC_1752|Compound:st044819|FD-Score:6.29|P-value:2.77E-6 ID:SGTC_1754|Compound:st042065|FD-Score:6.88|P-value:3.37E-7 ID:SGTC_1764|Compound:st044502|FD-Score:4.85|P-value:2.26E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-4.66|P-value:4.42E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:22.20|P-value:1.35E-57 ID:SGTC_1800|Compound:st050079|FD-Score:10.00|P-value:2.77E-13 ID:SGTC_1801|Compound:st050089|FD-Score:10.50|P-value:1.85E-14 ID:SGTC_1803|Compound:st050068|FD-Score:10.50|P-value:2.25E-14 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.30|P-value:6.83E-8 ID:SGTC_1873|Compound:rapamycin|FD-Score:19.30|P-value:3.46E-44 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.29|P-value:9.58E-4 ID:SGTC_1882|Compound:5615643|FD-Score:4.76|P-value:2.89E-4 ID:SGTC_1949|Compound:st076024|FD-Score:6.17|P-value:4.19E-6 ID:SGTC_1991|Compound:st073000|FD-Score:10.10|P-value:1.54E-13 ID:SGTC_2006|Compound:4011487|FD-Score:5.31|P-value:6.17E-5 ID:SGTC_2021|Compound:4019055|FD-Score:7.79|P-value:9.53E-9 ID:SGTC_2036|Compound:5160441|FD-Score:7.01|P-value:2.09E-7 ID:SGTC_2050|Compound:5263056|FD-Score:8.88|P-value:7.49E-11 ID:SGTC_2066|Compound:5222451|FD-Score:-4.85|P-value:2.63E-4 ID:SGTC_2147|Compound:5545932|FD-Score:6.78|P-value:4.88E-7 ID:SGTC_2161|Compound:5662504|FD-Score:4.32|P-value:8.74E-4 ID:SGTC_2185|Compound:6113692|FD-Score:5.16|P-value:9.61E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-6.35|P-value:2.81E-6 ID:SGTC_2242|Compound:6630449|FD-Score:7.61|P-value:2.02E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.05|P-value:1.31E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.25|P-value:8.29E-8 ID:SGTC_2307|Compound:7538926|FD-Score:7.54|P-value:2.65E-8 ID:SGTC_2322|Compound:7413319|FD-Score:5.48|P-value:3.76E-5 ID:SGTC_2340|Compound:7987427|FD-Score:6.77|P-value:5.13E-7 ID:SGTC_2344|Compound:7990960|FD-Score:-4.37|P-value:9.03E-4 ID:SGTC_2350|Compound:9023895|FD-Score:5.06|P-value:1.27E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.60|P-value:4.33E-4 ID:SGTC_2398|Compound:5228213|FD-Score:11.80|P-value:9.73E-18 ID:SGTC_2416|Compound:tofa|FD-Score:6.22|P-value:3.48E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:6.80|P-value:4.65E-7 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:11.10|P-value:8.19E-16 ID:SGTC_2515|Compound:chrysin|FD-Score:4.27|P-value:9.91E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-5.65|P-value:2.72E-5 ID:SGTC_2525|Compound:harmine|FD-Score:5.26|P-value:7.17E-5 ID:SGTC_2526|Compound:patulin|FD-Score:8.25|P-value:1.32E-9 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.49|P-value:3.57E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.74|P-value:3.02E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:16.60|P-value:3.83E-33 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.82|P-value:2.45E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.65|P-value:4.54E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.24|P-value:9.01E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:15.00|P-value:1.20E-27 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.53|P-value:5.26E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.85|P-value:2.23E-4 ID:SGTC_2671|Compound:danthron|FD-Score:10.70|P-value:5.78E-15 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.94|P-value:4.99E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.33|P-value:7.05E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:9.02|P-value:3.80E-11 ID:SGTC_2765|Compound:myclobutanil|FD-Score:12.60|P-value:4.56E-20 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.35|P-value:8.42E-10 ID:SGTC_2783|Compound:7738165|FD-Score:-4.84|P-value:2.77E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-5.61|P-value:3.00E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.88|P-value:2.09E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.97|P-value:8.05E-6 ID:SGTC_2814|Compound:7977482|FD-Score:5.87|P-value:1.09E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.60|P-value:4.38E-4 ID:SGTC_2836|Compound:9010338|FD-Score:7.33|P-value:6.20E-8 ID:SGTC_2845|Compound:9003024|FD-Score:4.80|P-value:2.61E-4 ID:SGTC_2867|Compound:9039098|FD-Score:6.08|P-value:5.55E-6 ID:SGTC_2908|Compound:7930301|FD-Score:4.40|P-value:7.32E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-5.17|P-value:1.12E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.85|P-value:2.24E-4 ID:SGTC_2971|Compound:9092186|FD-Score:8.39|P-value:6.99E-10 ID:SGTC_2973|Compound:9094665|FD-Score:6.86|P-value:3.66E-7 ID:SGTC_2974|Compound:9094440|FD-Score:8.81|P-value:1.04E-10 ID:SGTC_2980|Compound:9014342|FD-Score:-5.37|P-value:6.19E-5 ID:SGTC_2991|Compound:9074669|FD-Score:19.80|P-value:1.40E-46 ID:SGTC_3018|Compound:9082602|FD-Score:8.85|P-value:8.51E-11 ID:SGTC_3062|Compound:9077494|FD-Score:-4.99|P-value:1.84E-4 ID:SGTC_3091|Compound:9116372|FD-Score:5.20|P-value:8.42E-5 ID:SGTC_3098|Compound:9119039|FD-Score:6.50|P-value:1.35E-6 ID:SGTC_3127|Compound:9126946|FD-Score:7.48|P-value:3.38E-8 ID:SGTC_3141|Compound:9094609|FD-Score:7.19|P-value:1.04E-7 ID:SGTC_3142|Compound:9086498|FD-Score:5.48|P-value:3.71E-5 ID:SGTC_3197|Compound:9113331|FD-Score:5.17|P-value:9.21E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-4.83|P-value:2.82E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.15|P-value:1.16E-4 ID:SGTC_3266|Compound:9136860|FD-Score:6.05|P-value:6.17E-6 ID:SGTC_3287|Compound:9117173|FD-Score:-4.33|P-value:9.89E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-4.91|P-value:2.28E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:7.67|P-value:1.53E-8 ID:SGTC_56|Compound:0957-0365|FD-Score:5.36|P-value:5.38E-5 ID:SGTC_57|Compound:miconazole|FD-Score:11.30|P-value:1.51E-16 ID:SGTC_103|Compound:0844-0104|FD-Score:5.93|P-value:9.15E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:6.86|P-value:3.65E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:16.10|P-value:1.58E-31 ID:SGTC_146|Compound:3448-8650|FD-Score:7.00|P-value:2.20E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:5.06|P-value:1.26E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.51|P-value:3.37E-5 ID:SGTC_185|Compound:k048-0037|FD-Score:9.05|P-value:3.44E-11 ID:SGTC_197|Compound:4544-0043|FD-Score:10.40|P-value:2.83E-14 ID:SGTC_203|Compound:k066-0004|FD-Score:10.40|P-value:2.89E-14 ID:SGTC_206|Compound:4546-0025|FD-Score:9.34|P-value:8.14E-12 ID:SGTC_207|Compound:4185-0010|FD-Score:11.40|P-value:9.56E-17 ID:SGTC_212|Compound:3807-4682|FD-Score:4.44|P-value:6.52E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:18.60|P-value:5.40E-41 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:6.79|P-value:4.65E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:12.90|P-value:1.01E-20 ID:SGTC_252|Compound:miconazole|FD-Score:10.30|P-value:4.56E-14 ID:SGTC_268|Compound:camptothecin|FD-Score:4.54|P-value:5.05E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:4.35|P-value:8.27E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:4.70|P-value:3.32E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.64|P-value:3.96E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:5.44|P-value:4.15E-5 ID:SGTC_324|Compound:1315-0088|FD-Score:4.44|P-value:6.59E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:6.60|P-value:9.54E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:4.43|P-value:6.76E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.25|P-value:3.87E-6 ID:SGTC_376|Compound:3970-0862|FD-Score:4.33|P-value:8.67E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.40|P-value:7.21E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.80|P-value:2.55E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.07|P-value:1.66E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.43|P-value:6.71E-4 ID:SGTC_459|Compound:nigericin|FD-Score:6.78|P-value:4.93E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.37|P-value:6.17E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:-4.61|P-value:5.01E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-8.37|P-value:1.05E-9 ID:SGTC_524|Compound:r073-0010|FD-Score:6.96|P-value:2.52E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:11.00|P-value:1.02E-15 ID:SGTC_566|Compound:0958-0068|FD-Score:5.88|P-value:1.07E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.45|P-value:6.47E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:8.58|P-value:3.03E-10 ID:SGTC_617|Compound:3770-0098|FD-Score:5.12|P-value:1.06E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:7.13|P-value:1.30E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:4.90|P-value:1.97E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:13.10|P-value:2.51E-21 ID:SGTC_637|Compound:1181-0519|FD-Score:11.80|P-value:8.86E-18 ID:SGTC_641|Compound:4092-0595|FD-Score:6.81|P-value:4.36E-7 ID:SGTC_643|Compound:k048-0106|FD-Score:15.40|P-value:6.34E-29 ID:SGTC_649|Compound:1123-0311|FD-Score:7.68|P-value:1.48E-8 ID:SGTC_658|Compound:3253-0951|FD-Score:5.74|P-value:1.67E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:19.10|P-value:3.57E-43 ID:SGTC_690|Compound:glyoxal|FD-Score:4.32|P-value:8.82E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.55|P-value:5.02E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:8.29|P-value:1.13E-9 ID:SGTC_746|Compound:1095-0025|FD-Score:7.70|P-value:1.37E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:6.22|P-value:3.54E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:10.40|P-value:3.82E-14 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.15|P-value:1.17E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:16.70|P-value:9.41E-34 ID:SGTC_788|Compound:1182-0090|FD-Score:5.20|P-value:8.54E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:10.10|P-value:2.08E-13 ID:SGTC_816|Compound:0325-0417|FD-Score:-10.10|P-value:1.85E-13 ID:SGTC_817|Compound:1391-0715|FD-Score:-9.03|P-value:5.03E-11 ID:SGTC_818|Compound:4072-2707|FD-Score:-8.61|P-value:3.55E-10 ID:SGTC_834|Compound:0312-0008|FD-Score:9.75|P-value:1.02E-12 ID:SGTC_852|Compound:0418-0143|FD-Score:4.45|P-value:6.33E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:10.20|P-value:8.14E-14 ID:SGTC_859|Compound:0439-0102|FD-Score:4.42|P-value:6.83E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:7.32|P-value:6.39E-8 ID:SGTC_868|Compound:0527-0199|FD-Score:12.70|P-value:2.93E-20 ID:SGTC_875|Compound:0709-0210|FD-Score:12.30|P-value:3.48E-19 ID:SGTC_878|Compound:0828-0289|FD-Score:6.35|P-value:2.25E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:5.40|P-value:4.77E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.28|P-value:9.63E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.32|P-value:8.89E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:6.85|P-value:3.80E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:4.36|P-value:7.91E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.31|P-value:6.22E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.47|P-value:7.15E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:8.38|P-value:7.36E-10 ID:SGTC_999|Compound:4022-0066|FD-Score:7.68|P-value:1.51E-8 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.96|P-value:8.19E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.76|P-value:1.10E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:14.30|P-value:4.40E-25 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.35|P-value:9.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:8.27|P-value:1.22E-9 ID:SGTC_1067|Compound:clotrimazole|FD-Score:8.17|P-value:1.91E-9 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.10|P-value:5.29E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:14.40|P-value:2.13E-25 ID:SGTC_1084|Compound:voriconazole|FD-Score:6.12|P-value:4.92E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:5.85|P-value:1.17E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.62|P-value:4.16E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.94|P-value:8.81E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.21|P-value:1.56E-9 ID:SGTC_1162|Compound:k048-0130|FD-Score:6.70|P-value:6.60E-7 ID:SGTC_1191|Compound:1487-1166|FD-Score:6.07|P-value:5.78E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.23|P-value:7.84E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:5.18|P-value:8.93E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.84|P-value:2.34E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.18|P-value:1.10E-7 ID:SGTC_1308|Compound:1187-1617|FD-Score:7.15|P-value:1.22E-7 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.29|P-value:9.38E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.42|P-value:6.97E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:6.51|P-value:1.27E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.28|P-value:9.80E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.63|P-value:4.01E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.85|P-value:2.28E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:4.40|P-value:7.17E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-6.32|P-value:3.10E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:5.11|P-value:1.11E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.65|P-value:3.83E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:7.41|P-value:4.49E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.64|P-value:3.91E-4 ID:SGTC_1731|Compound:st035964|FD-Score:13.30|P-value:3.37E-22 ID:SGTC_1750|Compound:st081859|FD-Score:6.21|P-value:3.69E-6 ID:SGTC_1752|Compound:st044819|FD-Score:6.29|P-value:2.77E-6 ID:SGTC_1754|Compound:st042065|FD-Score:6.88|P-value:3.37E-7 ID:SGTC_1764|Compound:st044502|FD-Score:4.85|P-value:2.26E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-4.66|P-value:4.42E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:22.20|P-value:1.35E-57 ID:SGTC_1800|Compound:st050079|FD-Score:10.00|P-value:2.77E-13 ID:SGTC_1801|Compound:st050089|FD-Score:10.50|P-value:1.85E-14 ID:SGTC_1803|Compound:st050068|FD-Score:10.50|P-value:2.25E-14 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.30|P-value:6.83E-8 ID:SGTC_1873|Compound:rapamycin|FD-Score:19.30|P-value:3.46E-44 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.29|P-value:9.58E-4 ID:SGTC_1882|Compound:5615643|FD-Score:4.76|P-value:2.89E-4 ID:SGTC_1949|Compound:st076024|FD-Score:6.17|P-value:4.19E-6 ID:SGTC_1991|Compound:st073000|FD-Score:10.10|P-value:1.54E-13 ID:SGTC_2006|Compound:4011487|FD-Score:5.31|P-value:6.17E-5 ID:SGTC_2021|Compound:4019055|FD-Score:7.79|P-value:9.53E-9 ID:SGTC_2036|Compound:5160441|FD-Score:7.01|P-value:2.09E-7 ID:SGTC_2050|Compound:5263056|FD-Score:8.88|P-value:7.49E-11 ID:SGTC_2066|Compound:5222451|FD-Score:-4.85|P-value:2.63E-4 ID:SGTC_2147|Compound:5545932|FD-Score:6.78|P-value:4.88E-7 ID:SGTC_2161|Compound:5662504|FD-Score:4.32|P-value:8.74E-4 ID:SGTC_2185|Compound:6113692|FD-Score:5.16|P-value:9.61E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-6.35|P-value:2.81E-6 ID:SGTC_2242|Compound:6630449|FD-Score:7.61|P-value:2.02E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.05|P-value:1.31E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.25|P-value:8.29E-8 ID:SGTC_2307|Compound:7538926|FD-Score:7.54|P-value:2.65E-8 ID:SGTC_2322|Compound:7413319|FD-Score:5.48|P-value:3.76E-5 ID:SGTC_2340|Compound:7987427|FD-Score:6.77|P-value:5.13E-7 ID:SGTC_2344|Compound:7990960|FD-Score:-4.37|P-value:9.03E-4 ID:SGTC_2350|Compound:9023895|FD-Score:5.06|P-value:1.27E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.60|P-value:4.33E-4 ID:SGTC_2398|Compound:5228213|FD-Score:11.80|P-value:9.73E-18 ID:SGTC_2416|Compound:tofa|FD-Score:6.22|P-value:3.48E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:6.80|P-value:4.65E-7 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:11.10|P-value:8.19E-16 ID:SGTC_2515|Compound:chrysin|FD-Score:4.27|P-value:9.91E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-5.65|P-value:2.72E-5 ID:SGTC_2525|Compound:harmine|FD-Score:5.26|P-value:7.17E-5 ID:SGTC_2526|Compound:patulin|FD-Score:8.25|P-value:1.32E-9 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.49|P-value:3.57E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.74|P-value:3.02E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:16.60|P-value:3.83E-33 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.82|P-value:2.45E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.65|P-value:4.54E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.24|P-value:9.01E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:15.00|P-value:1.20E-27 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.53|P-value:5.26E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.85|P-value:2.23E-4 ID:SGTC_2671|Compound:danthron|FD-Score:10.70|P-value:5.78E-15 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.94|P-value:4.99E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.33|P-value:7.05E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:9.02|P-value:3.80E-11 ID:SGTC_2765|Compound:myclobutanil|FD-Score:12.60|P-value:4.56E-20 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.35|P-value:8.42E-10 ID:SGTC_2783|Compound:7738165|FD-Score:-4.84|P-value:2.77E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-5.61|P-value:3.00E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.88|P-value:2.09E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.97|P-value:8.05E-6 ID:SGTC_2814|Compound:7977482|FD-Score:5.87|P-value:1.09E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.60|P-value:4.38E-4 ID:SGTC_2836|Compound:9010338|FD-Score:7.33|P-value:6.20E-8 ID:SGTC_2845|Compound:9003024|FD-Score:4.80|P-value:2.61E-4 ID:SGTC_2867|Compound:9039098|FD-Score:6.08|P-value:5.55E-6 ID:SGTC_2908|Compound:7930301|FD-Score:4.40|P-value:7.32E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-5.17|P-value:1.12E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.85|P-value:2.24E-4 ID:SGTC_2971|Compound:9092186|FD-Score:8.39|P-value:6.99E-10 ID:SGTC_2973|Compound:9094665|FD-Score:6.86|P-value:3.66E-7 ID:SGTC_2974|Compound:9094440|FD-Score:8.81|P-value:1.04E-10 ID:SGTC_2980|Compound:9014342|FD-Score:-5.37|P-value:6.19E-5 ID:SGTC_2991|Compound:9074669|FD-Score:19.80|P-value:1.40E-46 ID:SGTC_3018|Compound:9082602|FD-Score:8.85|P-value:8.51E-11 ID:SGTC_3062|Compound:9077494|FD-Score:-4.99|P-value:1.84E-4 ID:SGTC_3091|Compound:9116372|FD-Score:5.20|P-value:8.42E-5 ID:SGTC_3098|Compound:9119039|FD-Score:6.50|P-value:1.35E-6 ID:SGTC_3127|Compound:9126946|FD-Score:7.48|P-value:3.38E-8 ID:SGTC_3141|Compound:9094609|FD-Score:7.19|P-value:1.04E-7 ID:SGTC_3142|Compound:9086498|FD-Score:5.48|P-value:3.71E-5 ID:SGTC_3197|Compound:9113331|FD-Score:5.17|P-value:9.21E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-4.83|P-value:2.82E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.15|P-value:1.16E-4 ID:SGTC_3266|Compound:9136860|FD-Score:6.05|P-value:6.17E-6 ID:SGTC_3287|Compound:9117173|FD-Score:-4.33|P-value:9.89E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-4.91|P-value:2.28E-4

Top fitness defect scores for YHR007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1788 fluconazole 22.20 20.0 µM 1.35E-57 azole & statin 1 3.77E-109 15.40
2 SGTC_2991 9074669 19.80 71.4 µM 1.40E-46 azole & statin 1 6.65E-88 4.75
3 SGTC_1873 rapamycin 19.30 2.0 nM 3.46E-44 2 2.73E-83 6.77
4 SGTC_659 k018-0002 19.10 107.0 µM 3.57E-43 1 2.44E-81 12.20
5 SGTC_221 trifluoperazine 18.60 10.3 µM 5.40E-41 NEO1-PIK1 3 3.90E-77 2.33
6 SGTC_783 0848-0141 16.70 92.7 µM 9.41E-34 RSC & ERG11 2 3.48E-63 9.02
7 SGTC_2567 aureobasidin a 16.60 60.0 nM 3.83E-33 7 5.20E-62 3.52
8 SGTC_145 3737-0113 16.10 38.4 µM 1.58E-31 DNA intercalators 2 6.71E-59 4.52
9 SGTC_643 k048-0106 15.40 28.4 µM 6.34E-29 RSC & ERG11 3 6.88E-54 2.87
10 SGTC_2648 atorvastatin 15.00 78.7 µM 1.20E-27 azole & statin 1 1.96E-51 8.05
11 SGTC_1083 didemethylchlorpromazine sulfoxide 14.40 707.4 nM 2.13E-25 redox potentiating 4 4.20E-47 0.86
12 SGTC_1026 k007-1105 14.30 30.6 µM 4.40E-25 ERAD & cell cycle 4 1.69E-46 4.23
13 SGTC_1731 st035964 13.30 63.0 µM 3.37E-22 1 5.93E-41 4.14
14 SGTC_632 0781-2353 13.10 4.7 µM 2.51E-21 Golgi 1 2.81E-39 5.79
15 SGTC_227 fluconazole 12.90 33.5 µM 1.01E-20 azole & statin 9 4.07E-38 0.24
16 SGTC_868 0527-0199 12.70 213.0 µM 2.93E-20 fatty acid desaturase (OLE1) 1 3.15E-37 4.85
17 SGTC_2765 myclobutanil 12.60 7.7 µM 4.56E-20 azole & statin 1 7.37E-37 7.25
18 SGTC_875 0709-0210 12.30 25.7 µM 3.48E-19 fatty acid desaturase (OLE1) 1 3.65E-35 3.41
19 SGTC_637 1181-0519 11.80 7.3 µM 8.86E-18 fatty acid desaturase (OLE1) 3 1.81E-32 3.64
20 SGTC_2398 5228213 11.80 48.8 µM 9.73E-18 iron homeostasis 2 2.17E-32 2.59

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.375 1.29E-112 YOR319W HSH49 het U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
0.279 4.95E-61 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.258 4.71E-52 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.251 2.28E-49 YOR157C PUP1 het Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
0.249 1.56E-48 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.246 2.65E-47 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.228 6.80E-41 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.228 1.53E-40 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.227 1.53E-40 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.225 1.08E-39 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.225 8.66E-40 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.224 2.08E-39 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.219 7.82E-38 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.218 2.46E-37 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.217 3.41E-37 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport