YHR008C / SOD2

Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR008C / SOD2

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:6.69|P-value:2.40E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:5.88|P-value:8.66E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:12.70|P-value:3.82E-26 ID:SGTC_117|Compound:lucigenin|FD-Score:4.16|P-value:4.12E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.07|P-value:5.51E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:5.78|P-value:1.33E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:5.00|P-value:2.60E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.39|P-value:2.05E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.70|P-value:1.45E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:7.19|P-value:2.10E-9 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.84|P-value:4.63E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:6.05|P-value:4.16E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:5.39|P-value:6.21E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.79|P-value:1.38E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.11|P-value:1.74E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.55|P-value:9.20E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.60|P-value:8.14E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:4.68|P-value:7.83E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:5.59|P-value:2.83E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:7.36|P-value:8.53E-10 ID:SGTC_979|Compound:1426-2828|FD-Score:9.17|P-value:2.36E-14 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.08|P-value:1.97E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:-5.85|P-value:2.37E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.65|P-value:6.96E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.16|P-value:1.47E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.38|P-value:2.12E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.95|P-value:7.69E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.31|P-value:8.41E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.17|P-value:3.97E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-4.26|P-value:1.06E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.80|P-value:4.44E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-3.86|P-value:3.74E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:5.44|P-value:5.15E-6 ID:SGTC_1739|Compound:st037196|FD-Score:-3.62|P-value:7.67E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.55|P-value:4.66E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-8.11|P-value:2.13E-12 ID:SGTC_2054|Compound:5233173|FD-Score:6.44|P-value:7.51E-8 ID:SGTC_2068|Compound:5226020|FD-Score:4.60|P-value:1.05E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.77|P-value:5.92E-5 ID:SGTC_2259|Compound:7964009|FD-Score:7.17|P-value:2.32E-9 ID:SGTC_2266|Compound:7929956|FD-Score:7.48|P-value:4.72E-10 ID:SGTC_2445|Compound:5742597|FD-Score:4.72|P-value:7.01E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.27|P-value:2.95E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.74|P-value:6.41E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.55|P-value:1.20E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.40|P-value:8.87E-8 ID:SGTC_2671|Compound:danthron|FD-Score:3.94|P-value:7.94E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.02|P-value:6.26E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.40|P-value:6.62E-5 ID:SGTC_2930|Compound:9013230|FD-Score:4.15|P-value:4.26E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.60|P-value:8.07E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.41|P-value:6.41E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-3.75|P-value:5.22E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:6.69|P-value:2.40E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:5.88|P-value:8.66E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:12.70|P-value:3.82E-26 ID:SGTC_117|Compound:lucigenin|FD-Score:4.16|P-value:4.12E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.07|P-value:5.51E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:5.78|P-value:1.33E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:5.00|P-value:2.60E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.39|P-value:2.05E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.70|P-value:1.45E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:7.19|P-value:2.10E-9 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.84|P-value:4.63E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:6.05|P-value:4.16E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:5.39|P-value:6.21E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.79|P-value:1.38E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.11|P-value:1.74E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.55|P-value:9.20E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.60|P-value:8.14E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:4.68|P-value:7.83E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:5.59|P-value:2.83E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:7.36|P-value:8.53E-10 ID:SGTC_979|Compound:1426-2828|FD-Score:9.17|P-value:2.36E-14 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.08|P-value:1.97E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:-5.85|P-value:2.37E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.65|P-value:6.96E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.16|P-value:1.47E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.38|P-value:2.12E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.95|P-value:7.69E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.31|P-value:8.41E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.17|P-value:3.97E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-4.26|P-value:1.06E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.80|P-value:4.44E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-3.86|P-value:3.74E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:5.44|P-value:5.15E-6 ID:SGTC_1739|Compound:st037196|FD-Score:-3.62|P-value:7.67E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.55|P-value:4.66E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-8.11|P-value:2.13E-12 ID:SGTC_2054|Compound:5233173|FD-Score:6.44|P-value:7.51E-8 ID:SGTC_2068|Compound:5226020|FD-Score:4.60|P-value:1.05E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.77|P-value:5.92E-5 ID:SGTC_2259|Compound:7964009|FD-Score:7.17|P-value:2.32E-9 ID:SGTC_2266|Compound:7929956|FD-Score:7.48|P-value:4.72E-10 ID:SGTC_2445|Compound:5742597|FD-Score:4.72|P-value:7.01E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.27|P-value:2.95E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.74|P-value:6.41E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.55|P-value:1.20E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.40|P-value:8.87E-8 ID:SGTC_2671|Compound:danthron|FD-Score:3.94|P-value:7.94E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.02|P-value:6.26E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.40|P-value:6.62E-5 ID:SGTC_2930|Compound:9013230|FD-Score:4.15|P-value:4.26E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.60|P-value:8.07E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.41|P-value:6.41E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-3.75|P-value:5.22E-4

Top fitness defect scores for YHR008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_100 0086-0128 12.70 49.6 µM 3.82E-26 copper-dependent oxidative stress 4 2.15E-37
2 SGTC_979 1426-2828 9.17 121.0 µM 2.36E-14 1 2.28E-20
3 SGTC_173 1273-0061 7.70 2.7 µM 1.45E-10 mitochondrial stress 74 6.90E-15
4 SGTC_2266 7929956 7.48 200.0 µM 4.72E-10 5 3.81E-14
5 SGTC_832 4083-0019 7.36 164.0 µM 8.53E-10 translation 11 8.99E-14
6 SGTC_236 1509-0011 7.19 5.3 µM 2.10E-9 266 3.32E-13
7 SGTC_2259 7964009 7.17 200.0 µM 2.32E-9 superoxide 9 3.84E-13
8 SGTC_55 0767-0285 6.69 6.6 µM 2.40E-8 15 1.13E-11
9 SGTC_1742 st038235 6.55 28.9 µM 4.66E-8 mitochondrial stress 33 2.96E-11
10 SGTC_2054 5233173 6.44 129.0 µM 7.51E-8 mitochondrial response to ROS 14 5.91E-11
11 SGTC_2615 purpurogallin-4-carboxylic acid 6.40 100.0 µM 8.87E-8 redox potentiating 25 7.52E-11
12 SGTC_310 1273-0058 6.05 1.1 µM 4.16E-7 mitochondrial stress 142 7.08E-10
13 SGTC_70 0141-0289 5.88 43.3 µM 8.66E-7 mitochondrial stress 84 2.05E-9
14 SGTC_123 0083-0120 5.78 66.7 µM 1.33E-6 19 3.83E-9
15 SGTC_778 3456-2434 5.59 196.0 µM 2.83E-6 mitochondrial response to ROS 28 1.14E-8
16 SGTC_1718 roemerine 5.44 11.9 µM 5.15E-6 redox potentiating 18 2.72E-8
17 SGTC_381 3461-2219 5.39 42.7 µM 6.21E-6 copper-dependent oxidative stress 7 3.57E-8
18 SGTC_1240 0356-0016 5.31 42.1 µM 8.41E-6 mitochondrial response to ROS 12 5.54E-8
19 SGTC_1001 4048-4355 5.08 44.4 µM 1.97E-5 copper-dependent oxidative stress 18 1.90E-7
20 SGTC_134 0269-0018 5.00 6.9 µM 2.60E-5 104 2.85E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.319 4.28E-80 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.287 1.47E-64 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.279 5.11E-61 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.279 8.60E-61 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.274 9.63E-59 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.272 4.84E-58 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.270 6.05E-57 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.269 1.14E-56 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.269 1.72E-56 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.266 1.57E-55 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.266 1.80E-55 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.263 4.05E-54 YCR028C-A RIM1 hom Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
0.258 2.78E-52 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.258 3.01E-52 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.256 3.65E-51 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs