YHR009C_p / TDA3

Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR009C / TDA3

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.62|P-value:2.55E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.34|P-value:6.84E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.94|P-value:7.77E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.08|P-value:4.65E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.92|P-value:8.44E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.08|P-value:4.57E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.29|P-value:1.97E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:3.34|P-value:6.72E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.69|P-value:3.51E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-5.75|P-value:1.87E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:9.13|P-value:1.12E-18 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.04|P-value:5.70E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.63|P-value:2.52E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.88|P-value:1.01E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.39|P-value:5.71E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.56|P-value:2.14E-13 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.08|P-value:3.02E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.55|P-value:6.70E-6 ID:SGTC_671|Compound:0560-0003|FD-Score:5.05|P-value:6.44E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:5.00|P-value:8.17E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:10.20|P-value:4.93E-23 ID:SGTC_794|Compound:k038-0031|FD-Score:12.50|P-value:2.34E-33 ID:SGTC_837|Compound:0091-0265|FD-Score:3.86|P-value:1.05E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.17|P-value:1.69E-9 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.64|P-value:2.52E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.52|P-value:3.63E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.51|P-value:3.84E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.73|P-value:2.96E-6 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.50|P-value:8.17E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.30|P-value:1.86E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.70|P-value:1.95E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.55|P-value:6.46E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.69|P-value:2.05E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:6.30|P-value:7.68E-10 ID:SGTC_1570|Compound:verbenone|FD-Score:3.64|P-value:2.38E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.06|P-value:6.32E-7 ID:SGTC_1690|Compound:st023502|FD-Score:3.30|P-value:7.84E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.75|P-value:1.70E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.32|P-value:7.20E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.27|P-value:2.20E-5 ID:SGTC_1836|Compound:st055642|FD-Score:5.00|P-value:8.37E-7 ID:SGTC_1851|Compound:st056236|FD-Score:-3.36|P-value:6.52E-4 ID:SGTC_1853|Compound:st056710|FD-Score:6.04|P-value:3.50E-9 ID:SGTC_1855|Compound:st056195|FD-Score:-4.45|P-value:1.03E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.81|P-value:1.30E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.26|P-value:8.95E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.59|P-value:3.05E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.93|P-value:8.18E-5 ID:SGTC_2318|Compound:6029776|FD-Score:6.50|P-value:2.31E-10 ID:SGTC_2320|Compound:7373003|FD-Score:6.01|P-value:4.21E-9 ID:SGTC_2322|Compound:7413319|FD-Score:-8.08|P-value:5.39E-15 ID:SGTC_2327|Compound:6189656|FD-Score:5.30|P-value:1.89E-7 ID:SGTC_2349|Compound:9023730|FD-Score:4.64|P-value:4.26E-6 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.84|P-value:1.22E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.84|P-value:1.76E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.47|P-value:9.09E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.34|P-value:6.70E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.26|P-value:2.24E-5 ID:SGTC_2788|Compound:5282734|FD-Score:-4.86|P-value:1.70E-6 ID:SGTC_2823|Compound:7987624|FD-Score:6.14|P-value:2.05E-9 ID:SGTC_2824|Compound:7998404|FD-Score:4.26|P-value:2.23E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.56|P-value:3.17E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.71|P-value:1.87E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.44|P-value:5.05E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.30|P-value:7.99E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.85|P-value:1.75E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-4.02|P-value:6.03E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:3.62|P-value:2.55E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.34|P-value:6.84E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.94|P-value:7.77E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.08|P-value:4.65E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.92|P-value:8.44E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.08|P-value:4.57E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.29|P-value:1.97E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:3.34|P-value:6.72E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.69|P-value:3.51E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-5.75|P-value:1.87E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:9.13|P-value:1.12E-18 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.04|P-value:5.70E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.63|P-value:2.52E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.88|P-value:1.01E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.39|P-value:5.71E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.56|P-value:2.14E-13 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.08|P-value:3.02E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.55|P-value:6.70E-6 ID:SGTC_671|Compound:0560-0003|FD-Score:5.05|P-value:6.44E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:5.00|P-value:8.17E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:10.20|P-value:4.93E-23 ID:SGTC_794|Compound:k038-0031|FD-Score:12.50|P-value:2.34E-33 ID:SGTC_837|Compound:0091-0265|FD-Score:3.86|P-value:1.05E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.17|P-value:1.69E-9 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.64|P-value:2.52E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.52|P-value:3.63E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.51|P-value:3.84E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.73|P-value:2.96E-6 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.50|P-value:8.17E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.30|P-value:1.86E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.70|P-value:1.95E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.55|P-value:6.46E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.69|P-value:2.05E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:6.30|P-value:7.68E-10 ID:SGTC_1570|Compound:verbenone|FD-Score:3.64|P-value:2.38E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.06|P-value:6.32E-7 ID:SGTC_1690|Compound:st023502|FD-Score:3.30|P-value:7.84E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.75|P-value:1.70E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.32|P-value:7.20E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.27|P-value:2.20E-5 ID:SGTC_1836|Compound:st055642|FD-Score:5.00|P-value:8.37E-7 ID:SGTC_1851|Compound:st056236|FD-Score:-3.36|P-value:6.52E-4 ID:SGTC_1853|Compound:st056710|FD-Score:6.04|P-value:3.50E-9 ID:SGTC_1855|Compound:st056195|FD-Score:-4.45|P-value:1.03E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.81|P-value:1.30E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.26|P-value:8.95E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.59|P-value:3.05E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.93|P-value:8.18E-5 ID:SGTC_2318|Compound:6029776|FD-Score:6.50|P-value:2.31E-10 ID:SGTC_2320|Compound:7373003|FD-Score:6.01|P-value:4.21E-9 ID:SGTC_2322|Compound:7413319|FD-Score:-8.08|P-value:5.39E-15 ID:SGTC_2327|Compound:6189656|FD-Score:5.30|P-value:1.89E-7 ID:SGTC_2349|Compound:9023730|FD-Score:4.64|P-value:4.26E-6 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.84|P-value:1.22E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.84|P-value:1.76E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.47|P-value:9.09E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.34|P-value:6.70E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.26|P-value:2.24E-5 ID:SGTC_2788|Compound:5282734|FD-Score:-4.86|P-value:1.70E-6 ID:SGTC_2823|Compound:7987624|FD-Score:6.14|P-value:2.05E-9 ID:SGTC_2824|Compound:7998404|FD-Score:4.26|P-value:2.23E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.56|P-value:3.17E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.71|P-value:1.87E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.44|P-value:5.05E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.30|P-value:7.99E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.85|P-value:1.75E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-4.02|P-value:6.03E-5

Top fitness defect scores for YHR009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_794 k038-0031 12.50 316.0 µM 2.34E-33 ubiquinone biosynthesis & proteasome 8 3.51E-36
2 SGTC_690 glyoxal 10.20 20.3 µM 4.93E-23 17 6.25E-25
3 SGTC_236 1509-0011 9.13 5.3 µM 1.12E-18 214 3.46E-20
4 SGTC_453 enantio-paf c16 7.56 10.0 µM 2.14E-13 16 1.96E-14
5 SGTC_2318 6029776 6.50 164.0 µM 2.31E-10 2 3.94E-11
6 SGTC_1564 D-Arginine 6.30 115.0 µM 7.68E-10 7 1.45E-10
7 SGTC_852 0418-0143 6.17 439.0 µM 1.69E-9 calcium & mitochondrial duress 24 3.43E-10
8 SGTC_2823 7987624 6.14 58.4 µM 2.05E-9 3 4.23E-10
9 SGTC_1853 st056710 6.04 91.2 µM 3.50E-9 amide catabolism 4 7.56E-10
10 SGTC_2320 7373003 6.01 200.0 µM 4.21E-9 5 9.24E-10
11 SGTC_2327 6189656 5.30 200.0 µM 1.89E-7 5 5.79E-8
12 SGTC_137 0438-0332 5.29 85.4 µM 1.97E-7 ubiquinone biosynthesis & proteasome 71 6.06E-8
13 SGTC_1635 st007035 5.06 42.4 µM 6.32E-7 164 2.15E-7
14 SGTC_671 0560-0003 5.05 407.0 µM 6.44E-7 4 2.19E-7
15 SGTC_676 falcarinol 5.00 140.0 µM 8.17E-7 30 2.84E-7
16 SGTC_1836 st055642 5.00 81.0 µM 8.37E-7 6 2.92E-7
17 SGTC_2561 acetosyringone 4.84 100.0 µM 1.76E-6 8 6.55E-7
18 SGTC_1144 3486-0183 4.73 12.5 µM 2.96E-6 14 1.15E-6
19 SGTC_212 3807-4682 4.69 38.8 µM 3.51E-6 tubulin folding & SWR complex 42 1.38E-6
20 SGTC_2349 9023730 4.64 187.1 µM 4.26E-6 11 1.71E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 9.63E-61 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.252 9.62E-50 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.251 1.47E-49 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.249 1.69E-48 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.249 1.88E-48 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.248 3.06E-48 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.239 8.55E-45 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.233 1.54E-42 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.229 3.27E-41 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.224 2.03E-39 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.220 6.43E-38 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.213 9.05E-36 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.208 3.52E-34 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.207 8.21E-34 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.205 2.79E-33 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry