Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR011W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.371 | 4.07E-110 | YPR100W | MRPL51 | hom | Mitochondrial ribosomal protein of the large subunit |
0.355 | 2.83E-100 | YMR072W | ABF2 | hom | Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation |
0.355 | 3.84E-100 | YMR193W | MRPL24 | hom | Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene |
0.351 | 1.49E-97 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.347 | 1.18E-95 | YNL184C_p | YNL184C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
0.342 | 1.79E-92 | YDR337W | MRPS28 | hom | Mitochondrial ribosomal protein of the small subunit |
0.340 | 2.72E-91 | YDR268W | MSW1 | hom | Mitochondrial tryptophanyl-tRNA synthetase |
0.340 | 3.15E-91 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
0.336 | 4.28E-89 | YER077C_p | YER077C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport |
0.335 | 1.43E-88 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
0.333 | 3.68E-87 | YMR293C | HER2 | hom | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase |
0.332 | 4.94E-87 | YPL183W-A | RTC6 | hom | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
0.328 | 6.07E-85 | YGL064C | MRH4 | hom | Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function |
0.326 | 1.46E-83 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
0.326 | 1.60E-83 | YDR298C | ATP5 | hom | Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated |