HIPHOP chemogenomics database

YHR011W / DIA4

Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR011W / DIA4

Click on Significant Values for Screen Details

Top fitness defect scores for YHR011W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_310	1273-0058	12.00	1.1 µM	3.61E-28	mitochondrial stress	21	1.63E-33
2	SGTC_2823	7987624	9.64	58.4 µM	7.52E-19		1	2.70E-22
3	SGTC_173	1273-0061	8.84	2.7 µM	3.89E-16	mitochondrial stress	52	4.97E-19
4	SGTC_351	caspofungin	8.03	25.0 nM	1.18E-13	cell wall	17	4.76E-16
5	SGTC_214	4373-3496	6.84	70.0 µM	2.10E-10		11	3.82E-12
6	SGTC_778	3456-2434	6.69	196.0 µM	4.99E-10	mitochondrial response to ROS	20	1.08E-11
7	SGTC_720	r052-1644	6.59	49.9 µM	9.12E-10	TSC3-RPN4	5	2.23E-11
8	SGTC_159	3970-0959	6.21	50.0 µM	7.14E-9		23	2.63E-10
9	SGTC_236	1509-0011	6.11	5.3 µM	1.24E-8		289	5.09E-10
10	SGTC_2113	5491891	5.82	107.0 µM	5.43E-8	TSC3-RPN4	4	2.99E-9
11	SGTC_1022	4477-0945	5.62	21.3 µM	1.45E-7		5	9.68E-9
12	SGTC_2818	7996756	5.51	13.0 µM	2.39E-7		5	1.76E-8
13	SGTC_596	1155-0152	5.48	116.0 µM	2.78E-7	TRP & mitochondrial translation	12	2.11E-8
14	SGTC_2124	5246320	5.43	200.0 µM	3.54E-7	heme biosynthesis & mitochondrial translocase	5	2.82E-8
15	SGTC_871	0574-0004	5.30	149.0 µM	6.34E-7		17	5.67E-8
16	SGTC_58	0957-0393	5.16	9.0 µM	1.19E-6	cell wall	266	1.21E-7
17	SGTC_2139	5578692	5.14	56.5 µM	1.35E-6	superoxide	9	1.40E-7
18	SGTC_212	3807-4682	5.01	38.8 µM	2.39E-6	tubulin folding & SWR complex	36	2.77E-7
19	SGTC_10	0279-0212	5.00	42.6 µM	2.50E-6	TRP & mitochondrial translation	62	2.91E-7
20	SGTC_195	4234-0266	4.83	16.6 µM	5.08E-6		16	6.82E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.371	4.07E-110	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit
0.355	2.83E-100	YMR072W	ABF2	hom	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.355	3.84E-100	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.351	1.49E-97	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.347	1.18E-95	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.342	1.79E-92	YDR337W	MRPS28	hom	Mitochondrial ribosomal protein of the small subunit
0.340	2.72E-91	YDR268W	MSW1	hom	Mitochondrial tryptophanyl-tRNA synthetase
0.340	3.15E-91	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.336	4.28E-89	YER077C_p	YER077C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.335	1.43E-88	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.333	3.68E-87	YMR293C	HER2	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.332	4.94E-87	YPL183W-A	RTC6	hom	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.328	6.07E-85	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.326	1.46E-83	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.326	1.60E-83	YDR298C	ATP5	hom	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated