YHR011W / DIA4

Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR011W / DIA4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.00|P-value:2.50E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.16|P-value:1.19E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.59|P-value:5.03E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.49|P-value:2.02E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.99|P-value:1.30E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:6.21|P-value:7.14E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:4.30|P-value:4.29E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:8.84|P-value:3.89E-16 ID:SGTC_195|Compound:4234-0266|FD-Score:4.83|P-value:5.08E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:5.01|P-value:2.39E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:6.84|P-value:2.10E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:6.11|P-value:1.24E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.59|P-value:1.38E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:12.00|P-value:3.61E-28 ID:SGTC_351|Compound:caspofungin|FD-Score:8.03|P-value:1.18E-13 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.96|P-value:3.51E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:3.72|P-value:3.34E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.19|P-value:6.39E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:5.48|P-value:2.78E-7 ID:SGTC_599|Compound:1935-0052|FD-Score:4.46|P-value:2.28E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.57|P-value:5.36E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-4.04|P-value:1.30E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.45|P-value:7.83E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.24|P-value:5.21E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:6.59|P-value:9.12E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:6.69|P-value:4.99E-10 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.44|P-value:9.30E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.30|P-value:6.34E-7 ID:SGTC_884|Compound:0851-0618|FD-Score:4.33|P-value:3.78E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.79|P-value:2.60E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.84|P-value:2.18E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.86|P-value:2.06E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.99|P-value:1.54E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:5.62|P-value:1.45E-7 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.77|P-value:6.55E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.88|P-value:1.94E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.14|P-value:7.58E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.08|P-value:9.46E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.68|P-value:9.38E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.45|P-value:7.99E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.72|P-value:3.85E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.14|P-value:7.79E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.35|P-value:3.48E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.97|P-value:1.61E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.68|P-value:3.84E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.16|P-value:7.23E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.41|P-value:9.11E-4 ID:SGTC_2113|Compound:5491891|FD-Score:5.82|P-value:5.43E-8 ID:SGTC_2124|Compound:5246320|FD-Score:5.43|P-value:3.54E-7 ID:SGTC_2139|Compound:5578692|FD-Score:5.14|P-value:1.35E-6 ID:SGTC_2156|Compound:5649887|FD-Score:4.05|P-value:1.07E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.13|P-value:7.93E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.95|P-value:1.51E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.35|P-value:3.51E-5 ID:SGTC_2254|Compound:7938975|FD-Score:4.05|P-value:1.07E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.52|P-value:6.41E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.81|P-value:2.48E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-4.02|P-value:1.38E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-4.50|P-value:2.30E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.81|P-value:2.44E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.38|P-value:9.83E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.62|P-value:4.56E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.55|P-value:5.87E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.66|P-value:4.07E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.06|P-value:2.24E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.08|P-value:9.70E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.69|P-value:4.21E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.44|P-value:8.17E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.47|P-value:2.21E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.64|P-value:5.03E-4 ID:SGTC_2818|Compound:7996756|FD-Score:5.51|P-value:2.39E-7 ID:SGTC_2823|Compound:7987624|FD-Score:9.64|P-value:7.52E-19 ID:SGTC_2841|Compound:9004761|FD-Score:3.73|P-value:3.17E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.63|P-value:5.16E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.40|P-value:9.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-9.51|P-value:3.02E-18 ID:SGTC_2928|Compound:9011484|FD-Score:3.60|P-value:4.88E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.19|P-value:6.40E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.86|P-value:2.06E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.62|P-value:5.28E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.55|P-value:5.74E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.92|P-value:4.10E-6 ID:SGTC_3278|Compound:9139605|FD-Score:3.59|P-value:5.05E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.00|P-value:2.50E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.16|P-value:1.19E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.59|P-value:5.03E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.49|P-value:2.02E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.99|P-value:1.30E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:6.21|P-value:7.14E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:4.30|P-value:4.29E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:8.84|P-value:3.89E-16 ID:SGTC_195|Compound:4234-0266|FD-Score:4.83|P-value:5.08E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:5.01|P-value:2.39E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:6.84|P-value:2.10E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:6.11|P-value:1.24E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.59|P-value:1.38E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:12.00|P-value:3.61E-28 ID:SGTC_351|Compound:caspofungin|FD-Score:8.03|P-value:1.18E-13 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.96|P-value:3.51E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:3.72|P-value:3.34E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.19|P-value:6.39E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:5.48|P-value:2.78E-7 ID:SGTC_599|Compound:1935-0052|FD-Score:4.46|P-value:2.28E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.57|P-value:5.36E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-4.04|P-value:1.30E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.45|P-value:7.83E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.24|P-value:5.21E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:6.59|P-value:9.12E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:6.69|P-value:4.99E-10 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.44|P-value:9.30E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.30|P-value:6.34E-7 ID:SGTC_884|Compound:0851-0618|FD-Score:4.33|P-value:3.78E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.79|P-value:2.60E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.84|P-value:2.18E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.86|P-value:2.06E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.99|P-value:1.54E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:5.62|P-value:1.45E-7 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.77|P-value:6.55E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.88|P-value:1.94E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.14|P-value:7.58E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.08|P-value:9.46E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.68|P-value:9.38E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.45|P-value:7.99E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.72|P-value:3.85E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.14|P-value:7.79E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.35|P-value:3.48E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.97|P-value:1.61E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.68|P-value:3.84E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.16|P-value:7.23E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.41|P-value:9.11E-4 ID:SGTC_2113|Compound:5491891|FD-Score:5.82|P-value:5.43E-8 ID:SGTC_2124|Compound:5246320|FD-Score:5.43|P-value:3.54E-7 ID:SGTC_2139|Compound:5578692|FD-Score:5.14|P-value:1.35E-6 ID:SGTC_2156|Compound:5649887|FD-Score:4.05|P-value:1.07E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.13|P-value:7.93E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.95|P-value:1.51E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.35|P-value:3.51E-5 ID:SGTC_2254|Compound:7938975|FD-Score:4.05|P-value:1.07E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.52|P-value:6.41E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.81|P-value:2.48E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-4.02|P-value:1.38E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-4.50|P-value:2.30E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.81|P-value:2.44E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.38|P-value:9.83E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.62|P-value:4.56E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.55|P-value:5.87E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.66|P-value:4.07E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.06|P-value:2.24E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.08|P-value:9.70E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.69|P-value:4.21E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.44|P-value:8.17E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.47|P-value:2.21E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.64|P-value:5.03E-4 ID:SGTC_2818|Compound:7996756|FD-Score:5.51|P-value:2.39E-7 ID:SGTC_2823|Compound:7987624|FD-Score:9.64|P-value:7.52E-19 ID:SGTC_2841|Compound:9004761|FD-Score:3.73|P-value:3.17E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.63|P-value:5.16E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.40|P-value:9.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-9.51|P-value:3.02E-18 ID:SGTC_2928|Compound:9011484|FD-Score:3.60|P-value:4.88E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.19|P-value:6.40E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.86|P-value:2.06E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.62|P-value:5.28E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.55|P-value:5.74E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.92|P-value:4.10E-6 ID:SGTC_3278|Compound:9139605|FD-Score:3.59|P-value:5.05E-4

Top fitness defect scores for YHR011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 12.00 1.1 µM 3.61E-28 mitochondrial stress 21 1.63E-33
2 SGTC_2823 7987624 9.64 58.4 µM 7.52E-19 1 2.70E-22
3 SGTC_173 1273-0061 8.84 2.7 µM 3.89E-16 mitochondrial stress 52 4.97E-19
4 SGTC_351 caspofungin 8.03 25.0 nM 1.18E-13 cell wall 17 4.76E-16
5 SGTC_214 4373-3496 6.84 70.0 µM 2.10E-10 11 3.82E-12
6 SGTC_778 3456-2434 6.69 196.0 µM 4.99E-10 mitochondrial response to ROS 20 1.08E-11
7 SGTC_720 r052-1644 6.59 49.9 µM 9.12E-10 TSC3-RPN4 5 2.23E-11
8 SGTC_159 3970-0959 6.21 50.0 µM 7.14E-9 23 2.63E-10
9 SGTC_236 1509-0011 6.11 5.3 µM 1.24E-8 289 5.09E-10
10 SGTC_2113 5491891 5.82 107.0 µM 5.43E-8 TSC3-RPN4 4 2.99E-9
11 SGTC_1022 4477-0945 5.62 21.3 µM 1.45E-7 5 9.68E-9
12 SGTC_2818 7996756 5.51 13.0 µM 2.39E-7 5 1.76E-8
13 SGTC_596 1155-0152 5.48 116.0 µM 2.78E-7 TRP & mitochondrial translation 12 2.11E-8
14 SGTC_2124 5246320 5.43 200.0 µM 3.54E-7 heme biosynthesis & mitochondrial translocase 5 2.82E-8
15 SGTC_871 0574-0004 5.30 149.0 µM 6.34E-7 17 5.67E-8
16 SGTC_58 0957-0393 5.16 9.0 µM 1.19E-6 cell wall 266 1.21E-7
17 SGTC_2139 5578692 5.14 56.5 µM 1.35E-6 superoxide 9 1.40E-7
18 SGTC_212 3807-4682 5.01 38.8 µM 2.39E-6 tubulin folding & SWR complex 36 2.77E-7
19 SGTC_10 0279-0212 5.00 42.6 µM 2.50E-6 TRP & mitochondrial translation 62 2.91E-7
20 SGTC_195 4234-0266 4.83 16.6 µM 5.08E-6 16 6.82E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.371 4.07E-110 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.355 2.83E-100 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.355 3.84E-100 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.351 1.49E-97 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.347 1.18E-95 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.342 1.79E-92 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.340 2.72E-91 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.340 3.15E-91 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.336 4.28E-89 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.335 1.43E-88 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.333 3.68E-87 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.332 4.94E-87 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.328 6.07E-85 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.326 1.46E-83 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.326 1.60E-83 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated