YHR012W / VPS29

Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR012W / VPS29

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.95|P-value:2.80E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:9.44|P-value:2.22E-18 ID:SGTC_58|Compound:0957-0393|FD-Score:-11.10|P-value:9.75E-25 ID:SGTC_61|Compound:0978-8327|FD-Score:4.25|P-value:4.75E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:5.30|P-value:5.73E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:6.03|P-value:1.55E-8 ID:SGTC_206|Compound:4546-0025|FD-Score:15.10|P-value:7.17E-44 ID:SGTC_221|Compound:trifluoperazine|FD-Score:21.00|P-value:1.98E-83 ID:SGTC_227|Compound:fluconazole|FD-Score:5.65|P-value:1.04E-7 ID:SGTC_232|Compound:clozapine|FD-Score:22.00|P-value:2.98E-91 ID:SGTC_264|Compound:promethazine|FD-Score:4.40|P-value:2.65E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:15.60|P-value:1.22E-46 ID:SGTC_308|Compound:4092-1169|FD-Score:4.43|P-value:2.39E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.37|P-value:2.94E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:6.29|P-value:3.86E-9 ID:SGTC_443|Compound:clozapine|FD-Score:3.88|P-value:1.87E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:8.21|P-value:2.40E-14 ID:SGTC_447|Compound:ml7|FD-Score:6.57|P-value:8.09E-10 ID:SGTC_449|Compound:xestospongin c|FD-Score:7.85|P-value:2.76E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-10.70|P-value:2.77E-23 ID:SGTC_528|Compound:3492-0019|FD-Score:7.45|P-value:3.88E-12 ID:SGTC_535|Compound:2293-4129|FD-Score:7.81|P-value:3.79E-13 ID:SGTC_562|Compound:3772-2733|FD-Score:5.50|P-value:2.21E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:4.09|P-value:8.88E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.74|P-value:2.95E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:5.15|P-value:1.12E-6 ID:SGTC_699|Compound:0375-0592|FD-Score:3.92|P-value:1.62E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.51|P-value:6.31E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:-3.62|P-value:4.39E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.90|P-value:1.70E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:10.70|P-value:4.24E-23 ID:SGTC_900|Compound:1112-0045|FD-Score:6.56|P-value:8.47E-10 ID:SGTC_940|Compound:3232-1287|FD-Score:3.83|P-value:2.20E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-4.38|P-value:2.81E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.55|P-value:1.48E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.04|P-value:1.87E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:7.13|P-value:2.98E-11 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.69|P-value:3.55E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.44|P-value:3.02E-7 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.43|P-value:8.36E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.90|P-value:3.40E-6 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.99|P-value:1.21E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.95|P-value:1.45E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.75|P-value:2.92E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.81|P-value:2.40E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.06|P-value:1.69E-6 ID:SGTC_1712|Compound:st032288|FD-Score:10.50|P-value:3.51E-22 ID:SGTC_1740|Compound:st038286|FD-Score:4.70|P-value:8.13E-6 ID:SGTC_1742|Compound:st038235|FD-Score:4.67|P-value:9.24E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-5.35|P-value:4.30E-7 ID:SGTC_1754|Compound:st042065|FD-Score:12.20|P-value:1.54E-29 ID:SGTC_1760|Compound:st045453|FD-Score:14.50|P-value:1.37E-40 ID:SGTC_1781|Compound:st038725|FD-Score:9.58|P-value:7.07E-19 ID:SGTC_1797|Compound:st048695|FD-Score:3.60|P-value:4.83E-4 ID:SGTC_1800|Compound:st050079|FD-Score:7.34|P-value:8.07E-12 ID:SGTC_1801|Compound:st050089|FD-Score:7.52|P-value:2.48E-12 ID:SGTC_1803|Compound:st050068|FD-Score:13.70|P-value:9.59E-37 ID:SGTC_1818|Compound:st052136|FD-Score:4.32|P-value:3.68E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.59|P-value:4.96E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-4.02|P-value:1.08E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:16.00|P-value:3.59E-49 ID:SGTC_1917|Compound:st066507|FD-Score:4.66|P-value:9.59E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.43|P-value:8.19E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.83|P-value:4.68E-6 ID:SGTC_1943|Compound:st076331|FD-Score:3.39|P-value:9.36E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.65|P-value:5.09E-10 ID:SGTC_2006|Compound:4011487|FD-Score:4.33|P-value:3.49E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.38|P-value:3.96E-7 ID:SGTC_2055|Compound:5235184|FD-Score:-4.12|P-value:7.69E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.02|P-value:1.13E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.70|P-value:3.48E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.50|P-value:2.19E-7 ID:SGTC_2290|Compound:7904846|FD-Score:3.87|P-value:1.90E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.43|P-value:8.27E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.58|P-value:5.14E-4 ID:SGTC_2416|Compound:tofa|FD-Score:5.93|P-value:2.67E-8 ID:SGTC_2556|Compound:citropten|FD-Score:4.71|P-value:7.57E-6 ID:SGTC_2585|Compound:alliin|FD-Score:-3.55|P-value:5.54E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.25|P-value:4.84E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:5.44|P-value:2.98E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.82|P-value:2.18E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.39|P-value:9.24E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.60|P-value:1.41E-15 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.56|P-value:8.55E-10 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:20.50|P-value:2.99E-79 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.70|P-value:3.43E-4 ID:SGTC_2835|Compound:9006588|FD-Score:5.88|P-value:3.41E-8 ID:SGTC_2873|Compound:9040596|FD-Score:5.35|P-value:4.47E-7 ID:SGTC_2907|Compound:7721985|FD-Score:-3.36|P-value:9.87E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.24|P-value:1.49E-11 ID:SGTC_3102|Compound:9121669|FD-Score:-3.60|P-value:4.64E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-5.48|P-value:2.34E-7 ID:SGTC_3152|Compound:9099253|FD-Score:16.80|P-value:5.60E-54 ID:SGTC_3154|Compound:9100113|FD-Score:5.31|P-value:5.53E-7 ID:SGTC_3216|Compound:9129716|FD-Score:3.44|P-value:8.08E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.65|P-value:4.00E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.89|P-value:3.13E-8 ID:SGTC_3333|Compound:9141820|FD-Score:3.38|P-value:9.58E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.95|P-value:2.80E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:9.44|P-value:2.22E-18 ID:SGTC_58|Compound:0957-0393|FD-Score:-11.10|P-value:9.75E-25 ID:SGTC_61|Compound:0978-8327|FD-Score:4.25|P-value:4.75E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:5.30|P-value:5.73E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:6.03|P-value:1.55E-8 ID:SGTC_206|Compound:4546-0025|FD-Score:15.10|P-value:7.17E-44 ID:SGTC_221|Compound:trifluoperazine|FD-Score:21.00|P-value:1.98E-83 ID:SGTC_227|Compound:fluconazole|FD-Score:5.65|P-value:1.04E-7 ID:SGTC_232|Compound:clozapine|FD-Score:22.00|P-value:2.98E-91 ID:SGTC_264|Compound:promethazine|FD-Score:4.40|P-value:2.65E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:15.60|P-value:1.22E-46 ID:SGTC_308|Compound:4092-1169|FD-Score:4.43|P-value:2.39E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.37|P-value:2.94E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:6.29|P-value:3.86E-9 ID:SGTC_443|Compound:clozapine|FD-Score:3.88|P-value:1.87E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:8.21|P-value:2.40E-14 ID:SGTC_447|Compound:ml7|FD-Score:6.57|P-value:8.09E-10 ID:SGTC_449|Compound:xestospongin c|FD-Score:7.85|P-value:2.76E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-10.70|P-value:2.77E-23 ID:SGTC_528|Compound:3492-0019|FD-Score:7.45|P-value:3.88E-12 ID:SGTC_535|Compound:2293-4129|FD-Score:7.81|P-value:3.79E-13 ID:SGTC_562|Compound:3772-2733|FD-Score:5.50|P-value:2.21E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:4.09|P-value:8.88E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.74|P-value:2.95E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:5.15|P-value:1.12E-6 ID:SGTC_699|Compound:0375-0592|FD-Score:3.92|P-value:1.62E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.51|P-value:6.31E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:-3.62|P-value:4.39E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.90|P-value:1.70E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:10.70|P-value:4.24E-23 ID:SGTC_900|Compound:1112-0045|FD-Score:6.56|P-value:8.47E-10 ID:SGTC_940|Compound:3232-1287|FD-Score:3.83|P-value:2.20E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-4.38|P-value:2.81E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.55|P-value:1.48E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.04|P-value:1.87E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:7.13|P-value:2.98E-11 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.69|P-value:3.55E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.44|P-value:3.02E-7 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.43|P-value:8.36E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.90|P-value:3.40E-6 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.99|P-value:1.21E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.95|P-value:1.45E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.75|P-value:2.92E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.81|P-value:2.40E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.06|P-value:1.69E-6 ID:SGTC_1712|Compound:st032288|FD-Score:10.50|P-value:3.51E-22 ID:SGTC_1740|Compound:st038286|FD-Score:4.70|P-value:8.13E-6 ID:SGTC_1742|Compound:st038235|FD-Score:4.67|P-value:9.24E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-5.35|P-value:4.30E-7 ID:SGTC_1754|Compound:st042065|FD-Score:12.20|P-value:1.54E-29 ID:SGTC_1760|Compound:st045453|FD-Score:14.50|P-value:1.37E-40 ID:SGTC_1781|Compound:st038725|FD-Score:9.58|P-value:7.07E-19 ID:SGTC_1797|Compound:st048695|FD-Score:3.60|P-value:4.83E-4 ID:SGTC_1800|Compound:st050079|FD-Score:7.34|P-value:8.07E-12 ID:SGTC_1801|Compound:st050089|FD-Score:7.52|P-value:2.48E-12 ID:SGTC_1803|Compound:st050068|FD-Score:13.70|P-value:9.59E-37 ID:SGTC_1818|Compound:st052136|FD-Score:4.32|P-value:3.68E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.59|P-value:4.96E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-4.02|P-value:1.08E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:16.00|P-value:3.59E-49 ID:SGTC_1917|Compound:st066507|FD-Score:4.66|P-value:9.59E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.43|P-value:8.19E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.83|P-value:4.68E-6 ID:SGTC_1943|Compound:st076331|FD-Score:3.39|P-value:9.36E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.65|P-value:5.09E-10 ID:SGTC_2006|Compound:4011487|FD-Score:4.33|P-value:3.49E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.38|P-value:3.96E-7 ID:SGTC_2055|Compound:5235184|FD-Score:-4.12|P-value:7.69E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.02|P-value:1.13E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.70|P-value:3.48E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.50|P-value:2.19E-7 ID:SGTC_2290|Compound:7904846|FD-Score:3.87|P-value:1.90E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.43|P-value:8.27E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.58|P-value:5.14E-4 ID:SGTC_2416|Compound:tofa|FD-Score:5.93|P-value:2.67E-8 ID:SGTC_2556|Compound:citropten|FD-Score:4.71|P-value:7.57E-6 ID:SGTC_2585|Compound:alliin|FD-Score:-3.55|P-value:5.54E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.25|P-value:4.84E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:5.44|P-value:2.98E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.82|P-value:2.18E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.39|P-value:9.24E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.60|P-value:1.41E-15 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.56|P-value:8.55E-10 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:20.50|P-value:2.99E-79 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.70|P-value:3.43E-4 ID:SGTC_2835|Compound:9006588|FD-Score:5.88|P-value:3.41E-8 ID:SGTC_2873|Compound:9040596|FD-Score:5.35|P-value:4.47E-7 ID:SGTC_2907|Compound:7721985|FD-Score:-3.36|P-value:9.87E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.24|P-value:1.49E-11 ID:SGTC_3102|Compound:9121669|FD-Score:-3.60|P-value:4.64E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-5.48|P-value:2.34E-7 ID:SGTC_3152|Compound:9099253|FD-Score:16.80|P-value:5.60E-54 ID:SGTC_3154|Compound:9100113|FD-Score:5.31|P-value:5.53E-7 ID:SGTC_3216|Compound:9129716|FD-Score:3.44|P-value:8.08E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.65|P-value:4.00E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.89|P-value:3.13E-8 ID:SGTC_3333|Compound:9141820|FD-Score:3.38|P-value:9.58E-4

Top fitness defect scores for YHR012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_232 clozapine 22.00 119.0 µM 2.98E-91 NEO1 3 9.63E-108
2 SGTC_221 trifluoperazine 21.00 10.3 µM 1.98E-83 NEO1-PIK1 10 1.78E-98
3 SGTC_2697 mebhydrolin 20.50 72.4 µM 2.99E-79 NEO1 4 1.59E-93
4 SGTC_3152 9099253 16.80 49.5 µM 5.60E-54 NEO1-PIK1 4 1.36E-63
5 SGTC_1844 rapamycin 16.00 4.0 nM 3.59E-49 11 6.70E-58
6 SGTC_301 4119-0100 15.60 24.5 µM 1.22E-46 NEO1 5 6.69E-55
7 SGTC_206 4546-0025 15.10 72.0 µM 7.17E-44 NEO1 7 1.27E-51
8 SGTC_1760 st045453 14.50 10.4 µM 1.37E-40 NEO1-PIK1 14 9.71E-48
9 SGTC_1803 st050068 13.70 52.4 µM 9.59E-37 NEO1-PIK1 5 3.48E-43
10 SGTC_1754 st042065 12.20 16.1 µM 1.54E-29 NEO1-PIK1 14 1.18E-34
11 SGTC_888 0916-0002 10.70 7.0 µM 4.24E-23 NEO1 8 4.94E-27
12 SGTC_1712 st032288 10.50 53.4 µM 3.51E-22 calcium & mitochondrial duress 22 6.04E-26
13 SGTC_1781 st038725 9.58 66.3 µM 7.07E-19 NEO1 19 4.90E-22
14 SGTC_43 0570-0105 9.44 72.5 µM 2.22E-18 ERG2 12 1.90E-21
15 SGTC_2679 rapamycin 8.60 1.0 nM 1.41E-15 35 3.91E-18
16 SGTC_445 e6 berbamine 8.21 66.0 µM 2.40E-14 NEO1-PIK1 11 1.12E-16
17 SGTC_449 xestospongin c 7.85 11.2 µM 2.76E-13 NEO1-PIK1 5 2.01E-15
18 SGTC_535 2293-4129 7.81 48.2 µM 3.79E-13 NEO1 13 2.92E-15
19 SGTC_1801 st050089 7.52 28.4 µM 2.48E-12 NEO1-PIK1 31 2.69E-14
20 SGTC_528 3492-0019 7.45 172.0 µM 3.88E-12 calcium & mitochondrial duress 89 4.56E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.750 0 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.731 0 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.549 1.06E-263 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.545 7.06E-259 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.524 2.59E-236 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.508 2.49E-219 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.505 2.86E-216 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.498 4.26E-209 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.491 9.67E-203 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.479 4.52E-192 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.470 1.15E-183 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.456 1.02E-171 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.455 1.37E-170 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.443 2.59E-161 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.430 1.67E-150 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton