YHR013C / ARD1

Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR013C / ARD1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-5.11|P-value:1.21E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.22|P-value:9.80E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:3.82|P-value:5.92E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.48|P-value:2.29E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.89|P-value:1.40E-9 ID:SGTC_178|Compound:4092-0806|FD-Score:6.06|P-value:4.89E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:10.70|P-value:2.30E-27 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.11|P-value:8.64E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.47|P-value:3.27E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.36|P-value:3.32E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.23|P-value:1.01E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.34|P-value:3.84E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.25|P-value:5.39E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.56|P-value:2.93E-18 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.87|P-value:4.56E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.40|P-value:3.02E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.16|P-value:6.86E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.49|P-value:2.15E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.34|P-value:3.80E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.58|P-value:1.57E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.22|P-value:5.89E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.49|P-value:2.19E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.24|P-value:5.53E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.41|P-value:2.96E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.37|P-value:3.40E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.16|P-value:7.20E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.52|P-value:1.92E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.91|P-value:4.09E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.78|P-value:6.96E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.91|P-value:3.99E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.37|P-value:5.18E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.15|P-value:7.53E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.48|P-value:2.25E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.33|P-value:4.01E-4 ID:SGTC_1619|Compound:st003326|FD-Score:5.38|P-value:2.97E-8 ID:SGTC_1635|Compound:st007035|FD-Score:3.67|P-value:1.08E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.89|P-value:4.42E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.50|P-value:2.67E-6 ID:SGTC_1922|Compound:5578187|FD-Score:3.55|P-value:1.70E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.72|P-value:8.19E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.75|P-value:7.76E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.17|P-value:6.62E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.21|P-value:6.11E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.45|P-value:2.59E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.74|P-value:8.23E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.22|P-value:5.92E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.53|P-value:1.78E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.28|P-value:4.82E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:7.44|P-value:3.13E-14 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.01|P-value:2.65E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.74|P-value:4.21E-23 ID:SGTC_2651|Compound:1327-0036|FD-Score:8.09|P-value:1.58E-16 ID:SGTC_2785|Compound:7756463|FD-Score:3.09|P-value:9.42E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.18|P-value:6.79E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.18|P-value:6.88E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.29|P-value:4.54E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.29|P-value:4.66E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.51|P-value:2.05E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.36|P-value:3.57E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.18|P-value:6.90E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.24|P-value:5.44E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.22|P-value:5.56E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.31|P-value:4.24E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.25|P-value:5.33E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.11|P-value:1.21E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.22|P-value:9.80E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:3.82|P-value:5.92E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.48|P-value:2.29E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.89|P-value:1.40E-9 ID:SGTC_178|Compound:4092-0806|FD-Score:6.06|P-value:4.89E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:10.70|P-value:2.30E-27 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.11|P-value:8.64E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.47|P-value:3.27E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.36|P-value:3.32E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.23|P-value:1.01E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.34|P-value:3.84E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.25|P-value:5.39E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.56|P-value:2.93E-18 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.87|P-value:4.56E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.40|P-value:3.02E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.16|P-value:6.86E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.49|P-value:2.15E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.34|P-value:3.80E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.58|P-value:1.57E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.22|P-value:5.89E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.49|P-value:2.19E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.24|P-value:5.53E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.41|P-value:2.96E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.37|P-value:3.40E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.16|P-value:7.20E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.52|P-value:1.92E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.91|P-value:4.09E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.78|P-value:6.96E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.91|P-value:3.99E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.37|P-value:5.18E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.15|P-value:7.53E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.48|P-value:2.25E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.33|P-value:4.01E-4 ID:SGTC_1619|Compound:st003326|FD-Score:5.38|P-value:2.97E-8 ID:SGTC_1635|Compound:st007035|FD-Score:3.67|P-value:1.08E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.89|P-value:4.42E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.50|P-value:2.67E-6 ID:SGTC_1922|Compound:5578187|FD-Score:3.55|P-value:1.70E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.72|P-value:8.19E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.75|P-value:7.76E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.17|P-value:6.62E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.21|P-value:6.11E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.45|P-value:2.59E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.74|P-value:8.23E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.22|P-value:5.92E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.53|P-value:1.78E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.28|P-value:4.82E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:7.44|P-value:3.13E-14 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.01|P-value:2.65E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.74|P-value:4.21E-23 ID:SGTC_2651|Compound:1327-0036|FD-Score:8.09|P-value:1.58E-16 ID:SGTC_2785|Compound:7756463|FD-Score:3.09|P-value:9.42E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.18|P-value:6.79E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.18|P-value:6.88E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.29|P-value:4.54E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.29|P-value:4.66E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.51|P-value:2.05E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.36|P-value:3.57E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.18|P-value:6.90E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.24|P-value:5.44E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.22|P-value:5.56E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.31|P-value:4.24E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.25|P-value:5.33E-4

Top fitness defect scores for YHR013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 10.70 5.3 µM 2.30E-27 182 6.58E-27
2 SGTC_2582 agaric acid 9.74 100.0 µM 4.21E-23 redox potentiating 69 1.01E-22
3 SGTC_673 1082-0474 8.56 110.0 µM 2.93E-18 RSC complex & mRNA processing 14 5.71E-18
4 SGTC_2651 1327-0036 8.09 5.0 µM 1.58E-16 36 2.87E-16
5 SGTC_2565 isoliquiritigenin 7.44 100.0 µM 3.13E-14 5 5.15E-14
6 SGTC_178 4092-0806 6.06 87.5 µM 4.89E-10 ergosterol depletion effects on membrane 37 6.76E-10
7 SGTC_163 1327-0036 5.89 7.5 µM 1.40E-9 50 1.90E-9
8 SGTC_1619 st003326 5.38 88.7 µM 2.97E-8 60S ribosome export 3 3.82E-8
9 SGTC_241 5hr heat shock (37°C) + cantharidin 4.47 155.4 µM 3.27E-6 cell wall signaling 59 3.88E-6
10 SGTC_1505 k297-0037 4.37 20.6 µM 5.18E-6 11 6.09E-6
11 SGTC_545 4218-0007 4.23 221.0 µM 1.01E-5 19 1.17E-5
12 SGTC_2575 plumbagin 4.01 510.0 nM 2.65E-5 superoxide 37 3.04E-5
13 SGTC_1454 4239-0054 3.91 42.6 µM 3.99E-5 39 4.54E-5
14 SGTC_1425 4048-4433 3.91 7.3 µM 4.09E-5 copper-dependent oxidative stress 41 4.64E-5
15 SGTC_1642 st009582 3.89 77.7 µM 4.42E-5 RPP1 & pyrimidine depletion 16 5.01E-5
16 SGTC_100 0086-0128 3.82 49.6 µM 5.92E-5 copper-dependent oxidative stress 54 6.68E-5
17 SGTC_1428 4049-0204 3.78 61.7 µM 6.96E-5 17 7.83E-5
18 SGTC_1949 st076024 3.75 69.1 µM 7.76E-5 30 8.72E-5
19 SGTC_2489 cantharidin 3.74 73.4 µM 8.23E-5 cell wall signaling 51 9.24E-5
20 SGTC_1635 st007035 3.67 42.4 µM 1.08E-4 229 1.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.294 5.38E-68 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.272 4.17E-58 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.271 1.36E-57 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.266 1.79E-55 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.265 5.75E-55 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.252 1.27E-49 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.249 1.54E-48 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.247 1.17E-47 YIL125W KGD1 hom Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
0.246 1.45E-47 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.241 1.06E-45 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.241 1.50E-45 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.240 4.22E-45 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.238 2.17E-44 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.235 1.74E-43 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.235 2.12E-43 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases