YHR015W / MIP6

Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR015W / MIP6

Click on Significant Values for Screen Details ID:SGTC_213|Compound:1246-0773|FD-Score:-3.19|P-value:6.52E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.83|P-value:5.36E-5 ID:SGTC_263|Compound:alizarin|FD-Score:6.49|P-value:9.45E-12 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.02|P-value:1.45E-5 ID:SGTC_442|Compound:cape|FD-Score:4.04|P-value:1.35E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.35|P-value:2.35E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.89|P-value:2.55E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.20|P-value:6.30E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.72|P-value:8.56E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:4.93|P-value:1.54E-7 ID:SGTC_565|Compound:1418-0001|FD-Score:3.05|P-value:7.31E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.66|P-value:6.92E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.34|P-value:3.83E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.33|P-value:2.57E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.64|P-value:1.21E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.09|P-value:6.29E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.37|P-value:2.23E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.44|P-value:2.01E-6 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.79|P-value:6.37E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.26|P-value:3.37E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.16|P-value:7.49E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.30|P-value:3.99E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.40|P-value:2.37E-6 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.20|P-value:4.21E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:2.96|P-value:9.84E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.32|P-value:2.71E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.97|P-value:1.82E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:5.08|P-value:6.83E-8 ID:SGTC_1644|Compound:st010134|FD-Score:-3.41|P-value:2.91E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.65|P-value:1.15E-4 ID:SGTC_1749|Compound:st037932|FD-Score:7.18|P-value:5.70E-14 ID:SGTC_1766|Compound:st045414|FD-Score:3.39|P-value:2.06E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-4.06|P-value:2.05E-5 ID:SGTC_2016|Compound:5121758|FD-Score:-3.76|P-value:7.19E-5 ID:SGTC_2020|Compound:4017018|FD-Score:-3.18|P-value:6.84E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.93|P-value:3.54E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-3.47|P-value:2.35E-4 ID:SGTC_2117|Compound:5521686|FD-Score:2.97|P-value:9.67E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.30|P-value:4.46E-4 ID:SGTC_2285|Compound:7945142|FD-Score:4.70|P-value:5.21E-7 ID:SGTC_2286|Compound:7945697|FD-Score:5.62|P-value:2.85E-9 ID:SGTC_2322|Compound:7413319|FD-Score:2.98|P-value:9.24E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.91|P-value:3.94E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.61|P-value:8.36E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.15|P-value:5.00E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.00|P-value:8.56E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.99|P-value:1.64E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.26|P-value:4.88E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.14|P-value:5.23E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.16|P-value:7.34E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.93|P-value:2.13E-5 ID:SGTC_2713|Compound:st079149|FD-Score:2.99|P-value:9.00E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-4.30|P-value:6.82E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.34|P-value:3.73E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.23|P-value:5.76E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.34|P-value:2.51E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.24|P-value:3.65E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-3.15|P-value:7.60E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-4.04|P-value:2.16E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.30|P-value:2.85E-4 ID:SGTC_3058|Compound:9093861|FD-Score:6.08|P-value:1.59E-10 ID:SGTC_3066|Compound:9117245|FD-Score:-3.13|P-value:8.00E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.02|P-value:8.07E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.19|P-value:6.52E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.83|P-value:5.36E-5 ID:SGTC_263|Compound:alizarin|FD-Score:6.49|P-value:9.45E-12 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.02|P-value:1.45E-5 ID:SGTC_442|Compound:cape|FD-Score:4.04|P-value:1.35E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.35|P-value:2.35E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.89|P-value:2.55E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.20|P-value:6.30E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.72|P-value:8.56E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:4.93|P-value:1.54E-7 ID:SGTC_565|Compound:1418-0001|FD-Score:3.05|P-value:7.31E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.66|P-value:6.92E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.34|P-value:3.83E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.33|P-value:2.57E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.64|P-value:1.21E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.09|P-value:6.29E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.37|P-value:2.23E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.44|P-value:2.01E-6 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.79|P-value:6.37E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.26|P-value:3.37E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.16|P-value:7.49E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.30|P-value:3.99E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.40|P-value:2.37E-6 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.20|P-value:4.21E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:2.96|P-value:9.84E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.32|P-value:2.71E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.97|P-value:1.82E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:5.08|P-value:6.83E-8 ID:SGTC_1644|Compound:st010134|FD-Score:-3.41|P-value:2.91E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.65|P-value:1.15E-4 ID:SGTC_1749|Compound:st037932|FD-Score:7.18|P-value:5.70E-14 ID:SGTC_1766|Compound:st045414|FD-Score:3.39|P-value:2.06E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-4.06|P-value:2.05E-5 ID:SGTC_2016|Compound:5121758|FD-Score:-3.76|P-value:7.19E-5 ID:SGTC_2020|Compound:4017018|FD-Score:-3.18|P-value:6.84E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.93|P-value:3.54E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-3.47|P-value:2.35E-4 ID:SGTC_2117|Compound:5521686|FD-Score:2.97|P-value:9.67E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.30|P-value:4.46E-4 ID:SGTC_2285|Compound:7945142|FD-Score:4.70|P-value:5.21E-7 ID:SGTC_2286|Compound:7945697|FD-Score:5.62|P-value:2.85E-9 ID:SGTC_2322|Compound:7413319|FD-Score:2.98|P-value:9.24E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.91|P-value:3.94E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.61|P-value:8.36E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.15|P-value:5.00E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.00|P-value:8.56E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.99|P-value:1.64E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.26|P-value:4.88E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.14|P-value:5.23E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.16|P-value:7.34E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.93|P-value:2.13E-5 ID:SGTC_2713|Compound:st079149|FD-Score:2.99|P-value:9.00E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-4.30|P-value:6.82E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.34|P-value:3.73E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.23|P-value:5.76E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.34|P-value:2.51E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.24|P-value:3.65E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-3.15|P-value:7.60E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-4.04|P-value:2.16E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.30|P-value:2.85E-4 ID:SGTC_3058|Compound:9093861|FD-Score:6.08|P-value:1.59E-10 ID:SGTC_3066|Compound:9117245|FD-Score:-3.13|P-value:8.00E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.02|P-value:8.07E-4

Top fitness defect scores for YHR015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1749 st037932 7.18 54.2 µM 5.70E-14 3 3.46E-13
2 SGTC_263 alizarin 6.49 107.9 µM 9.45E-12 iron homeostasis 22 4.30E-11
3 SGTC_3058 9093861 6.08 49.5 µM 1.59E-10 4 6.16E-10
4 SGTC_2286 7945697 5.62 125.0 µM 2.85E-9 20 9.39E-9
5 SGTC_1592 4',5'-dihydroxyflavone 5.08 8.8 µM 6.83E-8 60S ribosome export 1 1.88E-7
6 SGTC_547 1120-0019 4.93 610.0 nM 1.54E-7 azole & statin 16 4.02E-7
7 SGTC_2285 7945142 4.70 200.0 µM 5.21E-7 9 1.27E-6
8 SGTC_1136 pergolide 4.44 1.1 µM 2.01E-6 28 4.54E-6
9 SGTC_1404 3909-7820 4.40 48.3 µM 2.37E-6 60S ribosome export 6 5.30E-6
10 SGTC_1340 1486-1359 4.30 257.0 µM 3.99E-6 11 8.64E-6
11 SGTC_2627 acetyl isogambogic acid 4.26 100.0 µM 4.88E-6 TSC3-RPN4 35 1.04E-5
12 SGTC_1338 1486-1223 4.16 76.0 µM 7.49E-6 16 1.56E-5
13 SGTC_442 cape 4.04 100.0 µM 1.35E-5 13 2.72E-5
14 SGTC_402 epigallocatechin gallate 4.02 10.0 µM 1.45E-5 23 2.90E-5
15 SGTC_2626 ethyl orsellinate 3.99 100.0 µM 1.64E-5 33 3.27E-5
16 SGTC_1513 0337-0559 3.97 19.0 µM 1.82E-5 17 3.60E-5
17 SGTC_2710 st078562 3.93 53.7 µM 2.13E-5 16 4.18E-5
18 SGTC_451 chloral hydrate 3.89 100.0 µM 2.55E-5 55 4.94E-5
19 SGTC_584 0986-0246 3.66 15.4 µM 6.92E-5 heme requiring 17 1.27E-4
20 SGTC_2413 inermin 3.61 26.1 µM 8.36E-5 67 1.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 7.12E-13 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.121 2.44E-12 YHL021C AIM17 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.102 2.79E-9 YIL158W AIM20 hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.090 1.94E-7 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.087 4.63E-7 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.086 6.29E-7 YNR051C BRE5 hom Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
0.085 9.14E-7 YMR158W-B_d YMR158W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
0.083 1.45E-6 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.082 1.82E-6 YER114C BOI2 hom Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication
0.081 2.88E-6 YMR028W TAP42 het Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
0.078 5.84E-6 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.078 6.16E-6 YOR371C GPB1 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication
0.076 1.07E-5 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.073 2.06E-5 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.073 2.36E-5 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)