HIPHOP chemogenomics database

YHR015W / MIP6

Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR015W / MIP6

Click on Significant Values for Screen Details

Top fitness defect scores for YHR015W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1749	st037932	7.18	54.2 µM	5.70E-14		3	3.46E-13
2	SGTC_263	alizarin	6.49	107.9 µM	9.45E-12	iron homeostasis	22	4.30E-11
3	SGTC_3058	9093861	6.08	49.5 µM	1.59E-10		4	6.16E-10
4	SGTC_2286	7945697	5.62	125.0 µM	2.85E-9		20	9.39E-9
5	SGTC_1592	4',5'-dihydroxyflavone	5.08	8.8 µM	6.83E-8	60S ribosome export	1	1.88E-7
6	SGTC_547	1120-0019	4.93	610.0 nM	1.54E-7	azole & statin	16	4.02E-7
7	SGTC_2285	7945142	4.70	200.0 µM	5.21E-7		9	1.27E-6
8	SGTC_1136	pergolide	4.44	1.1 µM	2.01E-6		28	4.54E-6
9	SGTC_1404	3909-7820	4.40	48.3 µM	2.37E-6	60S ribosome export	6	5.30E-6
10	SGTC_1340	1486-1359	4.30	257.0 µM	3.99E-6		11	8.64E-6
11	SGTC_2627	acetyl isogambogic acid	4.26	100.0 µM	4.88E-6	TSC3-RPN4	35	1.04E-5
12	SGTC_1338	1486-1223	4.16	76.0 µM	7.49E-6		16	1.56E-5
13	SGTC_442	cape	4.04	100.0 µM	1.35E-5		13	2.72E-5
14	SGTC_402	epigallocatechin gallate	4.02	10.0 µM	1.45E-5		23	2.90E-5
15	SGTC_2626	ethyl orsellinate	3.99	100.0 µM	1.64E-5		33	3.27E-5
16	SGTC_1513	0337-0559	3.97	19.0 µM	1.82E-5		17	3.60E-5
17	SGTC_2710	st078562	3.93	53.7 µM	2.13E-5		16	4.18E-5
18	SGTC_451	chloral hydrate	3.89	100.0 µM	2.55E-5		55	4.94E-5
19	SGTC_584	0986-0246	3.66	15.4 µM	6.92E-5	heme requiring	17	1.27E-4
20	SGTC_2413	inermin	3.61	26.1 µM	8.36E-5		67	1.51E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.123	7.12E-13	YDR481C	PHO8	hom	Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.121	2.44E-12	YHL021C	AIM17	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.102	2.79E-9	YIL158W	AIM20	hom	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.090	1.94E-7	YFL038C	YPT1	het	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.087	4.63E-7	YNL268W	LYP1	hom	Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.086	6.29E-7	YNR051C	BRE5	hom	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
0.085	9.14E-7	YMR158W-B_d	YMR158W-B_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
0.083	1.45E-6	YDR270W	CCC2	hom	Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.082	1.82E-6	YER114C	BOI2	hom	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication
0.081	2.88E-6	YMR028W	TAP42	het	Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
0.078	5.84E-6	YOR202W	HIS3	hom	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.078	6.16E-6	YOR371C	GPB1	hom	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication
0.076	1.07E-5	YPL028W	ERG10	het	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.073	2.06E-5	YDL201W	TRM8	hom	Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.073	2.36E-5	YDR291W	HRQ1	hom	3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)